While the section on caffeine was interesting, it was not necessarily correct in all aspects. While your perception of fatigue is altered whilst adenosine is competitively inhibited by caffeine, the effect is largely physiological. The competitive inhibition of adenosine results in the brain producing more dopamine and activates various neural circuits. The activation of these neural circuits causes the pituitary gland to secrete various hormones which activate the adrenal glands. The adrenal glands then in turn release adrenaline, which increases heart rate, blood pressure, muscular strength, and glucose metabolism. The adrenal glands also release the steroid hormone cortisol, which increases heart rate, blood glucose, blood pressure, respiration and muscular tension. So while the initial loss of fatigue is due to the inhibition of adenosine, the alertness that results is from the physiological response to the stimulant.
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While the section on caffeine was interesting, it was not necessarily correct in all aspects. While your perception of fatigue is altered whilst adenosine is competitively inhibited by caffeine, the effect is largely physiological. The competitive inhibition of adenosine results in the brain producing more dopamine and activates various neural circuits. The activation of these neural circuits causes the pituitary gland to secrete various hormones which activate the adrenal glands. The adrenal glands then in turn release adrenaline, which increases heart rate, blood pressure, muscular strength, and glucose metabolism. The adrenal glands also release the steroid hormone cortisol, which increases heart rate, blood glucose, blood pressure, respiration and muscular tension.
So while the initial loss of fatigue is due to the inhibition of adenosine, the alertness that results is from the physiological response to the stimulant.