Epigenetics - our bodies' way to change the destiny written in our DNA | Moshe Szyf | TEDxBratislava
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- เผยแพร่เมื่อ 2 ต.ค. 2016
- What we thought of as something fixed, DNA is actually very cleverly modified according to current environmental needs. Even before a baby is born, it already knows what world to prepare itself for. Moshe in this talk sheds light on his groundbreaking findings.
Moshe Szyf is one of the poineers in the field of epigenetics. Szyf’ lab has proposed three decades ago that DNA methylation is a prime therapeutic target in cancer and other diseases and has postulated and provided the first set of evidence that the “social environment” early in life can alter DNA methylation launching the emerging field of “social epigenetics”. The Szyf’ lab is interested in understanding basic epigenetic mechanisms and their broad implications in human behavior, health and disease as well as in developing epigenetics’ based therapeutics and diagnostics.
This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at ted.com/tedx
You know the other day I was thinking, how do instincts work? How does an organism have knowledge already programmed in? I thought, it must be coded into it's genes. Then I began the searching, days later here I am. I must say epigenetics is truly one of these most fascinating areas of science I've ever come across, I can't wait to learn more
I agree. I do think, however, that just as we are finding out the is more to the story that DNA (epigenetics), I am certain we will find out there is yet even something else that fills in a lot of the gaps. I don't think there is simply enough data in DNA to build an organism. Rather, it's more of a config file for certain features. Epigenetics expands on that configuration, but the actual complete schematic is outside of our understanding of genetics.
Next step for you is: mannolis kellis series with lex fridman
What is most interesting is we have a choice in what we think, believe and turn on and off in our own genetic code and pass onto our offspring.
Sins of the parents visiting the next generation.
I’m the foster momma of a baby. Our baby is 11 months old and was born to a drug addicted, homeless mother.
We have had our foster baby from the day she was released from the NICU at 4 days old and I’ve recently stumbled on the subject of epigenetics. This answers so many of my questions. I have been adding fish oil, vitamins D3 and K2 to her formula. I’ve been adding probiotics to counteract the damage to her intestinal biome cause by the drugs. I have her in physical therapy and occupational therapy and I took her to OMM for the first 10 months of her life (she’s been released from OMM🥳). I wore her for the first 6 months of her life. I’ve worried about our baby and wondered if anything I’ve done will give her a better life. I’m in tears. Thank you for this lecture because it gives me hope for her future.
THIS MAKES ME SO HAPPY AND GIVES ME SO MUCH HOPE FOR HUMANITY YAAAAY EPIGENETICS ROCK❣️❣️❣️
This is a very vital piece of Science.
I thought he was missing part of his head at first. This sounds promising. I need this stuff.
JustKeith watch videos of William Walsh talking about methylation cycle. Walsh is the person who revealed the correlation between methylation cycle and mental health. He and others show how diet and microbiome also effect health. This TED talker has contributed very little to the field.
JustKeith i thought the same thing as soon as i saw your comment while the video starts! 😂😂
Epigenetics
@@jcjensenllc you might find more value to science and humanity from another scientist, but let's not dismiss the value here. If this causes just one person to be a more nurturing, touching and involved parent than he or she otherwise would have been, then this talk has served humanity well. The change of one person's trajectory could change the world, a community, or many generations for the better.
JustKeith and Robert Jafari, he is not missing part of his head. He is wearing a skullcap, known in Hebrew as a kippa. It is worn by orthodox Jewish males, showing that they recognize that God is above them.
One of the best thing on internet.
I love Ted as much as the next guy but jeez this has created such a spark within me, really profound in (hopefully an obvious way of) the importance of cultivating love
i'm down with dna preparation for the shift.
welcome to evolution! vibration will be the new tape measure.
break your ego,break the filter.
Here lyes the key to a healthy beautiful life and yet we fail to acknowledge it. We need singularity in this world as we are all interconnected one way or another. The world needs us and the dots are lined up just look at what we are watching.
I have watched a lot of ted talks over the years, and I can say that this is by far one of the best and well composed tedTalk that I have ever seen.
Aside being a great talk, this is an incredible piece of science.
Hello. I am 23 years old. I want to ask that is it possible to grow tall by changing my thought process? Through my subconscious mind?
@@maishayartonahi Hello! It is possible to grow tall by changing your thought process, standing up straight, and practicing stretching exercises. 🙏
I agree
@@maishayartonahi無理です。あなたにはあなたにしか出来無い能力が有ります。それに気づいて発揮しながら幸せに暮らして下さい。無理を通せば道理が引く事は危険です。
This is really a great talk on epigenetics. For 2 decades I investigated function of many different genes by deleting and inserting into genome. Learned something new that will help shape new strategies like looking at genes expression profile in Autism spectrum disorder.
Thank You for puting a lot of effort in a science that we cannot imagine... May force be with You sir...
Amazing. One of the best Ted talks I've seen.
One question though, what are these drugs they used to increase/decrease methylation? Or, can this be done by the individual through other means? Absolutely fascinating stuff, I'm extremely interested.
In short, being healthy decreases methylation, including lowering stress, not using drugs, exercise, sleep, etc.
Find Dr. Bruce Lipton, Biology of Belief (fascinating)
Literally just changed my entire life plan to study this when I go to University
Based.
Fabulous talk. Thank you. :)
It makes me wonder/worry about the long-term effects of postpartum depression on the baby. I'm sure there are studies out there, but this would explain more of it.
exactly !! many cases are brought to my mind . i can see this as generational .as an older person i have often wondered about
generations of famlies that fail to thrive.
on another thought .they extend great support to new mothers in france .
Wow! So much potential to make the society and the environment better. I am hopeful
this is why attachment parenting produces the best outcomes.
I keep thinking of the show Mind Hunter
Great research, gives hope to those with diseases like cancer, how can we change our cells to turn back to healthy cells
this hits hard. I got a girlfriend who has been mistreated her entire life and she has such a difficult time expecting anything else from the world except the worst and its probably because she's been programmed that way
You have to show her that the world is a beautiful place...
It is all how you look at it..
Kumari Kumari that will only work if she believes what she sees. The brain has a way of interpreting events how it wants to instead of how they are
Incredible. The adoption have an impact in the individual as well indeed confirm the experiment... epigenetic is incredible.
Excellently Explained about basics of Epigenetics.. Thanks from Hindustani.
So optimistic and explanatory
Excellent
This makes a good case for longer paid famiy leave. Society would benefit as a whole,
On the surface yes that sounds like a good, but a short-term solution. However, who pays for all that "leave" time? And for how long? That is a big question that no one, especially politicians really want to look at, responsibly.
How about we also focus on affordable housing? Which would give women back the choice they really want: to be a full-time stay-at-home mother OR to work away from home when they see fit to do so (because their partners can afford to shoulder the cost of housing, alone).
Oh wait, politicians don't want to talk about compounded interest/ banking reform either! That's too bad, because it could lift a burden off of young families, forever changing their children's epigenetics !
@@pkeggle4085 its simple really we tax the rich more
You have it, rite now. Strange times we live in.
As we live in capitalism, they'll probably leave the leave time as is and try to develop drugs to give to the kids to deprogram the lack of parent presence in childhood
The difference between my 2 kids is like night and day. I always wonder if nurture had to do with 1 kid not caring much about food and 2nd kid always wanting food. I ate a lot of good food while pregnant with my first. Food was more scarce with my second because of my circumstances. And personality traits between my kids is so much different. My first I returned back to work 6 weeks later, he had to be in daycare as an infant, formula fed, he slept in a crib, he is now 7 and has bad ADHD, anxiety, and shows signs of autism. My 2nd I did not return to work, breastfed for 18 months, co-slept, and he is now 5, very giving, social kid, loves exploring, more typically developed. I always regret not getting the chance to spend more time with my first, I’ve always felt guilt and responsibility for things he struggles with because I felt like I had no choice but to go back to work.
Fascinating 👍
MAHABHARAT HAVE REFRENCE FOR THIS CONCEPT where abhimanyu Arjun's son learned war skills in the Womb of his mother when Krishna was telling the story to subhadra abhimany 's mother. Maybe abhimanyu 's methylation pattern was designed accordingly to prepare him for war.
Hare Krishna hare Krishna Krishna Krishna hare hare hare ram hare ram ram ram hare hare.
04.27.19 SYNCHRONICITY!! Some time ago, perhaps years ago, my son wrote the word, "Bratislava" on my note pad next to my computer keyboard, that I have been seeing all month while doing my financials. However here is the Synchronicity...for whatever reason or meaning...I am watching a video and it is titled, 'TEDxBratislava
It's the capital of Slovakia.
@@JT-yq8br Oh, J T Thanks for the info! I think I'll review this video again! I learn more with each repeated viewing!
Such a great speech.
Wow. This says a lot about the value of stay-at-home mothers! a
Institutionalized day-care & returning to work after a few wks/months a failed idea-- rather than several years later like mothers used to do.
But this was before housing costs out paced what working young fathers could afford or support. This could even be a call for a return to affordable housing, by reforming how banks use compound-interest that often pushes out the 1st-time home buyer, by doubling or tripping the actual cost of a financed home.
It's a thought.
what great thinking !
really makes aprent how truely bad our system is .
I agree
Fascinating!
"If we can program genes, can we deprogram them" OMG!!!
Fh
Dr Joe Dispenza & Bruce Lipton have proof you can. Their on you tube, have a good day😊
@@jackiejack2031 can you send the link to the exact video you’re referring to please
@@lukejacobs8077 search Bruce lipton speech . He is wearing blue shirt .the video is 2hour 36 min long .that's the real video with full proof
Wonderful performance 👏
I am sad for the monkey who was given to the surrogate mom. Thank you for your sacrifice.😢 Moving forward, this ted talked now marked me to be more kind. I realized, that I raised myself alone. 😢 Knowing so, I will be kinder to myself first. ❤ I love you my daughters. ❤❤❤ Sorry mommy is raising herself and then you two. I will do my best, even if at times my best is only 50%.
"Even before a baby is born, it already knows what world to prepare itself for." - What if baby is a born in a very hostile and aggressive enviroment?
According to research in epigenetics, you should be able to influence your gene expression through natural health practices. Such as eating truly healthily wholefoods, stopping negative/and doom and gloom thoughts, practicing self-care like grooming rituals, living in a clean home environment and embracing spiritual practices like prayer and fasting, along with seeking out fellowship to build community with like-minded individuals...such as going to church as an example.
Consider reading the book "The Blue Zones" by David Fourtner about super-centurions that live like this, or "The Makers Diet" by Jordan Rubin, founder of Garden of Life Foods, that covers much of this topic in very practical ways, successfully.
If you live in a dangerous area and can not move away, being in control of your thoughts will still be key to your gene expression and health. The body is always listening- it's listening for direction, listening to what we say and what we think and what we see in our minds. Keep your mind clean and focused on positive things, even if only in your imagination...you can always dream. And from those dreams you can create a plan to change your material circumstances for the better, all the while protecting your gene expression.
All the best to you, on your noble endeavors.
@@pkeggle4085 I will download this video because of your True and Profound Wisdom.
Thank you; you've given voice to my thoughts, and I, too frequently silence them.
awesome AWESOME awesome . . .
Excellent speach!
Damn this is too interesting!
Really really interesting!
One of the best video in youtube
Wow! Thank you!
Good talk but needed more of it. Thank you.
Interesting, thank you.
very clear explaination
great opening line...."it all came to light in a dark bar in madrid". lol....classic!
a dark bar in madrid where a lot of the most important ideas are born. I'm not kidding.
Babies orphaned in Europe, raised by overworked caretakers that did not have anyone holding and cuddling them grew up totally cold, unresponsive and lacking in normal compassion and no empathy.
Is that what happened to Tom Riddle?
Everyone loves someone..its' how the heart is programed...
At times a thief steals so that they can feed their family ...
Now parents need to change everything for their childrens goodness
During pregnancy if a women is stressed, depressed, abused and malnutrished, her child will exhibit in physical, emotional, mental and problems.
The vast ocean lies unexplored
. We are just playing with the pebbles washed on the seashore
with which method the maps of dna methylation are produced?
Needs way more views. Only 75 comments? I don't want to live on this planet anymore. XD
We inherited social behavior from animals, ours ancestors learned social behavior be good to protect their life. There many eyes to look for predators around, more choice to survive. That we are until now. Heart beat together in any creature.
I binged on fries while I watched this, I must be the 4th 🐒!! Extremely fascinating.
WOW!!!!!
Very interesting! But I don't understand how the "decrease DNA methylation" drugs can act on the target genes specifically without altering other gene expressions
I think it will alter other gene expression, which will influence other behaviour patterns. We might not recognize that because we are focusing on the effect of DNA methylation over a certain habit, which is the case of study among others.
Too short ! I need more
11:08 Stress increase diseases.
Revelation! I knew I wasn't wrong when I wanted my mother and father and extended family to love me more.
now I want to know that how this epigenetics can help in curing cancer.
I wonder how you get methylation drugs. I need them.
Environment must change epigenetics of human being. In an old saying, 'a stone laying nearer to a jasmine plant, can smell like jasmine.
日本では【三歳の子供の魂は百歳迄も続くのだ】と形容します
Should be more well known
It is probably not more well known, because it contradicts the Neo-Darwinian evolution theory.
Very interesting, open eyes, open minds.
Modify DNA with care and Love. Experience on the monkeys
When I watched this there was translation script in korean, but here isn't.
🙌🏻🙌🏻🙌🏻🙌🏻❤
👏👏👏
If a person is severely disabled from birth could they change it? I really want to change my dna to be a normal person.
OK I was loved dearly all throughout childhood, by my parents and my grandparents. In fact my leacher said I had too many mothers. Being an only child you’d expect to say, Oh she was spoiled rotten. No, I wasn’t in fact. My family weren’t cuddlers. They weren’t rich, they were hard working. It was instilled in me from being young you must work hard for a living. You must look after your own affairs. You must do the right thing, responsibility is extremely important and comes before all else. It was a strict up bringing, carefully cared for and yes I knew I was special and loved. But I was also very lonely, even isolated, shy and often quite ill whilst growing up. Without knowing it I was under a lot of pressure to conform. Do what I was told. As were my parents to provide. My responsibility was to be a respectful child and never go against what my family believed.
maybe you needed more closeness and love . i know i did .
👏👏👏👏👏👏
I looked at my phone randomly and i thought he didn't have half his head. I was very happy for him when i realized it was just a hat. What's the proper name for that hat?
I thought it was called a yarmulke or yamuka
@@katemonroe7572 hi! yes, it can be called a kippah which is the hebrew word. or yarmulka, which is the yiddish word. both words are used and mean the same thing. hope this helps ❤
My mom tried to convince me of epigenetics dor the past 20 years. I'm still not convinced
How do you uncode the dna ? Say with mental illness - how does one uncode this condition and improve the condition?
It’s always the mother): but I accept that.
This kind of makes you realize that we need to rethink gene splicing and GMO technology. Thats all based on genes being a read only blueprint.
This epigentic science would then seem to support attachment style parenting. Aka leaving the child to “cry it out” on their own in the crib is not a good idea
Well ,what if their are triplets? How will the mother cuddle all the children at once?
Que massa!!
If only he could elaborate twice as much with each paragraphs , give us some facts
Epigenetics Dr Joel wallach💥💥
pretty sure very few geneticists are gonna tell you "poor people are poor because their genes made them poor" 7:06
hes not saying that . hes saying epi genetics
are responsible and indeed can be generational.
La forza del destino non è definitiva.
If epigenetics allows successful adaptation between environments and cultures on Earth, can epigenetics allow the very same success on another world?
Is it possible to change your DNA to make you run faster?
Lorena Barcena dna is immutable in one person. What u can do is reprogram ur cells to read and transcript different parts of your DNA
Lorena Barcena yes in a Joe Rogan interview with trainers they speak about some kind jumping exercises. Look it up.
Lorena Barcena i had to go dig it’s episode 1108 of joe rogan with the super brilliant Peter Attia... they speak about force plate treadmill( they measure the force you hit the treadmill while running divided by your weight and can predict each runner finish order). The whole interview is a GEM of science bio hacks and muscles biology etc etc.
Of course you can. There is a video on tedx labeled do athletes actually get faster. Mind blowing
@@ClaraGD can height increase at the age of 24 for a female ?
The Bible said our behavior goes back 7 generations based on our parents lives. same thing.
That’s interesting as the Celts would base decisions for use of resources on seven generations, as in the impact on all of them. We have certainly lost that ability. We aren’t going to even leave the planet!
Pre Abrahamic cultures like Hindus, Buddhist, Pagans in Europe, and Natives in South and Central America were some of the most enlightened. Before the puritanism of the Christianity Islam and Judaism changed the course of the world's history.
Mankind is notorious of mixing medical knowledge with things of money and value, and with everything other that could possibly be used for advantage or for benefit that is not deserved. This is why all the feelings and instincts are mixed from where they originate, to wrong possible directions and addresses. There is wrong and false picture of the human being and wrong knowledge regarding things of medical knowledge and knowledge about human anatomy that is not corrected and which functions in wrong ways with different things in the world. The background for all this is the advantageous pursuits that are not right and not allowed generally.
Well, it’s not all genetics. But it’s not all environment through epigenetics either. There are many instances of babies of the poor and unsuccessful being adopted by the rich and successful who end up killing their adoptive parents because they were incapable of achieving in school and work and they sorely resented the adoptive parents’ attempts to help them to achieve success.
Think about it, two or three generations of people that have no father in their life, think about it!
Muy determinista, la interpretación que hace de los efectos de los mecanismos epigenéticos. Sus interpretaciones sobre los resultados de los experimentos demuestran una mirada aporofóbica y clasista. Su discurso plagado de causalidades (relaciones lineales y necesarias entre causas y efectos), denotan una fuerte mirada reduccionista. Hacer extrapolaciones lineales de resultados de experimentos en laboratorios, a sociedades humanas es una práctica biopolítica muy peligrosa. Los mecanismos epigenéticos y sus formas de herencia, son una cosa. La aporofobia, es otra
I want the drug they gave to those rats xD
i feel bad for animals that were used in the experiments.....
The destiny of DNA includes the epigenome and all the possible ways it can change DNA and subsequently gene expression so the title doesn't really make sense, DNA is still ultimately in control of the car because without DNA you have no epigenome and so the epigenome must be subservient to DNA.
Oh by the way, the Bible tells us that "the iniquities of the fathers, are passed down to the sons unto the 3rd and 4th generations". I would speculate that these traits are past down via the genome or DNA of the parents. Read the last chapter of 'Numbers'. ...etc..etc.
i always wondered about that verse. ty.
So if the father was mean the children will also be mean?
@@user-cf2ky4fc1c your answer may be found in John 8:44. 8:28 and Mathew 23:15
maybe there is something here tied to the trend in fatherless homes in america on the rise following the introduction of welfare... and the decline of healthy masculinity in america :/
Aye matey. Yarghhhh
says the incel
Healthy masculinity??define that please and the whole fatherless ane homeless stuff is a cop out
kyle you are right.
1st
You gotta b jojjjin
Nurture
Someone should ask him his opinion on eugenics. He seems to be walking down the same path, ironic.
how exactly?????????
No not at all. He’s saying quite the contrary: how genes are not end all be all as they can be expressed or suppressed by behaviour. That’s the literal opposite of eugenetics.
But science needs to stop experimenting on animals for real damn that's torture
Does this only apply to mothers? How about fathers?
enviroment
Ignore the woke new age BS of no meats no dairy.
Follow the Eastern cultures.
Lard, ghee, kefir, fish - all have extremely important microbiome positive ingredients.
Is this related to psychology?
Coco Bonkers
maybe more physiology than psychology but the field is scientific discovering is ever-changing.
Coco Bonkers
or maybe it does have to do with psychology. i really have no idea.
Yes, so far and little as I know there are some research linked epigenetics to cognitive (learning&memory) also more reasearch in mental health such as schizophrenia, autism, depression, bipolar, drug addiction, psychopathy, suicide. Check out “behavioral epigenetics” and dig for yourself. I think this field of studying is still at its beginning, there is a lot more to be done. But if you come from the psychology end, you may familiar with the term “nature&nurture” means genetics&environments - which tell the story of two factors that make you who you are.. so when epigenetics comes to the light, epigenetics fits right into the between of nature and nurture.
Check out the work of Dr. Richard Davidson
Bio Energetics
What is with the what?
Way too simple. Ignores family history. Increased incidence of mental health issues in families UNRELATED to parenting, environment. If this premise is true then everyone who has a supportive environment, nurturing mother, etc. will have no mental health issues. This is simply not true. Look at the heritability of bipolar disorder-very heritable.
Of course you cannot ignore Adverse Childhood Experiences, BUT childhood resilience is also important and THAT may be heritable or maybe a function of basic personality.
It is my opinion that both are important and human behavior is very complex!
bipolar parent would be a prime example of how this works .
F...... comercial brake
Please tell me if there is God or not?
What does it matter if there’s a god or not? Listen to your self and love yourself and those around you. God is irrelevant to our humanity
Yes there is. Call him Jesus
i will say this . there is order in the universe.
there is a driving force to that order.
God Is both that universe and the driving force .
if you think of GOD as a verb instead of a noun, its easy to understand .
God is real and he loves you and wants to have a relationship with you.