Natriuretic Peptides | ANP, BNP & CNP | Atrial Natriuretic Peptide, Brain Natriuretic Peptide | Lab
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- เผยแพร่เมื่อ 4 ต.ค. 2024
- Natriuretic Peptides | ANP, BNP & CNP | Atrial Natriuretic Peptide, Brain Natriuretic Peptide | Labs for Congestive Heart Failure (CHF).
Atrial Natriuretic Peptide (ANP), Brain Natriuretic Peptide (BNP), C-Type Natriuretic Peptide (CNP).
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Pulmonary hypertension from Pulmonary artery/PE and copd can cause BNP to go up.
It therefore can go up despite it being ‘non-cardiac’ in origin due to the same issues of increased afterloads.
BNP can also go up in severe hypertension with hypertrophic cardiomyopathy - but it is a heart failure due to hypertension, not necessarily fluid overload and can be managed without diuretics at all (I.e. pain etc).
What’s important is not mental heuristics, but understanding why the natriuretic peptides are released and its intended effects - vasodilation and natriuresis to lower blood pressure.
Also, there is very little vasodilation (if any) in the venous system, therefore saying that “venous” vasolidation relieves preload is homeopathic at best.
Preload is very low pressure and isn’t the main driver of dilatative myopathy, it is often after load. If not, furosemide and fluid restriction would’ve seen a far better mortality benefit for CCF than our current 4 pillars, of which only spironolactone has a certain diuretic effect.
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CNP - cerebral naturetic peptide? Or is that the same as BNP?
CRP - C- reactive protein: elevated in inflammatory situations like stress, infection, malignancy; initiated via IL-6
C-peptide - one of three peptide segments of proinsulin; it is cleaved away during posttranslation and is in equal molar amounts to endogenous insulin (the A+B peptides, connected via disulfide bonds). It is also used to determine the level of insulin production in diabetics, however, is not present in exogenous insulin such as Humolog, Lispor, etc.
If there is insulin resistance , how C-peptide look like?
@@ThatsWhy- Not 100% sure, but in insulin resistance the body is not responding to insulin or has decreased from normal response then C-peptide would be high in the serum
@@AmunRa00 it will be low because it is accumulated in the blood , right?
You mean positive feed back !! 🧐
@@ThatsWhy- Why would it be low if there is resistance? I don't think you can call it "positive feed back" because you need a positive response, but the body (adipose, liver, muscle, kidney) is not doing that. Therefore, since insulin + C-peptides are released in equal molar amounts both would be high in a state of insulin-resistance -- insulin receptors do not dimerize and no cell signaling for glucose uptake.
So in insulin-resistance/T2DM both C-peptide and glucose will be high in the serum.
Can you explain the rouleaux formation and reactive neutrophilic lecocytosis.
Ok
I was wondering about something you said in the video. You said, "If the BNP is not elevated, then the problem is in the lungs." Could the kidneys be the problem because they are not doing their job and holding onto water?
So, I just want to say the highest BNP I've ever seen was around 10,000 pg/ml.
Yes I’m brandon
So when the heart muscle is stretched related to CHF (and doesn't usually return to normal size) will the BNP always be elevated after initial diagnosis or is BNP elevation only present during acute CHF exacerbations?
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book say 22-27, no 22-77 level , clarify
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What does ECF mean?
Extracellular fluid.
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