I love the new series ever wonder why! As I ask “why” all the time. Gonna love that. And I am not a big fan of blindly memorising I am even scared of it. So I now know why ı like your channel &thank you!
Top notch stuff. Incredibly well explained. Liked + Subscribed + Notified. EDIT: Why is HAGMA normochloremic? HAGMA = Increased organic acids --> Dissociates into conjugate base & H+ --> Bicarb consumed to buffer H+ Net effect: Increased AG + Preservation of electroneutrality. Transcellular shifting of Cl not required
HAGMA is normochloremic because in this case no negative ion is being lost so no negative ion(i.e chloride) is gained. So chloride levels remain stagnant while bicarbonate levels drop Bicarbonate levels drop not because it is being lost but because it is being converted to carbonic acid by accepting a proton from the excess of organic acids in blood...... I think😅
I m so happy to hear that you enjoy Sowell It is proof that you have a healthy non extremist mind I love this channel even more now We need more stuff like NAGMA 2021!
Good content.. but to me at least, the "Why?" intro was a bit too much.. like we got the point bro.. there's a lot of whys in medicine lol, 3 examples were already good enough.. no offense intended.
Legend Senna once said "If you no longer go for a gap that exists, you are no longer a racing driver", and since you say the gap does NOT exist... I'm sorry to say this but you ain't no racer anymore..
Nope! Because in HAGMA, the original problem is not the loss of HCO3-, the original problem is a gain of an unmeasured anion (negative ion), therefore as a result of this gain of a negative ion, the body will lose another negative ion (HCO3-) to preserve electroneutrality. Chloride doesn’t enter into the equation. Does that make sense?
But isn't acidosis a result of H+ ions? Isn't that positive ion? And isn't there is a loss of HCO3 due to a reaction with the H+?-@@MedicosisPerfectionalis
too much blabbering..here's a summary.. the AG is the space filled by anything else besides HCO3 and Cl. remember acidic compound will dissociate to from Hydrogen ions and Anions. The H+ from weak acids are buffered by the existing HCO3- while the A- anion constitute the Anion gap @ unmeasured anions. if you have a bigger gap, it basically means there's an "additional" anion which can be either endo/exogenous origin. --> hence why ingestion and organic acidoses are HAGMA. if the gap is normal, essentially nothing "additional" is gained, just simple loss (HCO3 loss and Cl reuptake) --> hence why the GAP is unaffected. AG doesnt tell you the severity of acidoses, but it give some clue to the potential causes.
the first dang time i can tell it plainly in my head. not with all shitty terminology . n yest HAGMA mean external acid , so nothing is filling in its place, instead acid forms are adding up .
Trying an answer to the Q: in NAGMA acidosis is due to loss of carbonate (by the doofuses) to which the Cl (-) gain is the correcting response, the quick-fix of the electroneutrality law. In HAGMA the acidosis is due to increased H (+) therefore the balancing response will be perhaps Na(+) gain in plasma (?). I might be wrong - just trying to take the challenge😊.
@@MedicosisPerfectionalis Thank you for your feedback - I am going to find the second part, as the curiosity (the same that killed the cat...) is unbearable. Is there a title to the II. part?
🧪 Acid-Base Lectures: www.medicosisperfectionalis.com/
I love the new series ever wonder why! As I ask “why” all the time. Gonna love that. And I am not a big fan of blindly memorising I am even scared of it. So I now know why ı like your channel &thank you!
Wow 🤩
You’re amazing!
The same is here. Finally all makes sense and work together.
Top notch stuff. Incredibly well explained. Liked + Subscribed + Notified.
EDIT: Why is HAGMA normochloremic?
HAGMA = Increased organic acids --> Dissociates into conjugate base & H+ --> Bicarb consumed to buffer H+
Net effect: Increased AG + Preservation of electroneutrality. Transcellular shifting of Cl not required
Thank you so much 😊
HAGMA is normochloremic because in this case no negative ion is being lost so no negative ion(i.e chloride) is gained. So chloride levels remain stagnant while bicarbonate levels drop
Bicarbonate levels drop not because it is being lost but because it is being converted to carbonic acid by accepting a proton from the excess of organic acids in blood...... I think😅
Hey medicosis i passed my hematology exam thanks to you and i just wanted to say thanks :)
Congratulations 🎉🎊🎈
That’s amazing!
I m so happy to hear that you enjoy Sowell
It is proof that you have a healthy non extremist mind
I love this channel even more now
We need more stuff like NAGMA 2021!
Thank you so much!
I appreciate you!
Maga. ;)
Super and marvelous and completely understandable video even if we start from 0
Thank you 🙏
Thanks sir! Never going to miss any of your valuable videos and lectures!
My pleasure 😇
Thank you so much 😊
Im amazed by how good you're teaching this stuff.
Thank you 😊
Thomas sowell ❤️
Great, great, great video. Thank you. All makes sense now.
Thank you so much!
I understood that why NAGMA is hyperchloremic ....very well.... but am confused why your introduction says why NAGMA is normochloremic
I misspoke.
NAGMA is hyperchloremic.
Hey medicosis you explained so well
Just wanna say thank you
My pleasure 😇
Vera level💯💚
I cannot thank you enough ❤
The pleasure is all mine!
Would you please help me by sharing?
Tnx fpr reccomendetion of the books. Give us more that.
Thank you 🙏
Awesome lecture on the web
Thank you so much 😊
I love Thomas sowell
I adore him :)
Great video
Thank you so much 😊
You are awesome !
Thank you 😊
thank you sir❤❤
Perfect
Thank you 🙏
Good content.. but to me at least, the "Why?" intro was a bit too much.. like we got the point bro.. there's a lot of whys in medicine lol, 3 examples were already good enough.. no offense intended.
Thank you for your honesty!
Our professors have to learn from u.
Thank you ☺️ for your kind words!
goated video
Thank you!
"there us no easter bunny, there's no tooth fairy, and there's no anion gap!"
Great video, thanks a ton
My pleasure!
Legend Senna once said "If you no longer go for a gap that exists, you are no longer a racing driver", and since you say the gap does NOT exist... I'm sorry to say this but you ain't no racer anymore..
Medicoosiis ❤️
Thank you 😊
I'm sorry, but why is there no compensation of chloride electrolyte in HAGMA? Is it because there is no loss of bicarbonate?
Nope! Because in HAGMA, the original problem is not the loss of HCO3-, the original problem is a gain of an unmeasured anion (negative ion), therefore as a result of this gain of a negative ion, the body will lose another negative ion (HCO3-) to preserve electroneutrality. Chloride doesn’t enter into the equation.
Does that make sense?
@@MedicosisPerfectionalis yes, makes perfect sense. Thank you!!
@@MedicosisPerfectionalis omg 🤯🤯🤯
@@MedicosisPerfectionalisdufass you r a genius
But isn't acidosis a result of H+ ions? Isn't that positive ion? And isn't there is a loss of HCO3 due to a reaction with the H+?-@@MedicosisPerfectionalis
thank you sir
My pleasure 😇
any guy cool with thomas sowell is cool with me
🙏
Dude, mmol/l … this should be used
Get to your point quickly
🙌🙃
😊😊
dear god how do you do this???????????????????????????????????????????????????????????? TOPPP NOOOTCH
Thank you so much 😊
too much blabbering..here's a summary..
the AG is the space filled by anything else besides HCO3 and Cl.
remember acidic compound will dissociate to from Hydrogen ions and Anions. The H+ from weak acids are buffered by the existing HCO3- while the A- anion constitute the Anion gap @ unmeasured anions.
if you have a bigger gap, it basically means there's an "additional" anion which can be either endo/exogenous origin. --> hence why ingestion and organic acidoses are HAGMA.
if the gap is normal, essentially nothing "additional" is gained, just simple loss (HCO3 loss and Cl reuptake) --> hence why the GAP is unaffected.
AG doesnt tell you the severity of acidoses, but it give some clue to the potential causes.
the first dang time i can tell it plainly in my head. not with all shitty terminology . n yest HAGMA mean external acid , so nothing is filling in its place, instead acid forms are adding up .
of all the things you say in your videos, you won't say "ass" 🤣
Haha 😂
Because I am a polite boy 😅
Your Vedios are amaizing ,but you are making vedios for earning dollors ,if u help humanity you should free all vedios like NINJA NERD,DR NAJJEEB
Trying an answer to the Q: in NAGMA acidosis is due to loss of carbonate (by the doofuses) to which the Cl (-) gain is the correcting response, the quick-fix of the electroneutrality law. In HAGMA the acidosis is due to increased H (+) therefore the balancing response will be perhaps Na(+) gain in plasma (?). I might be wrong - just trying to take the challenge😊.
You’re correct in the first half!
@@MedicosisPerfectionalis Thank you for your feedback - I am going to find the second part, as the curiosity (the same that killed the cat...) is unbearable. Is there a title to the II. part?
Arey NAGMA murder ho jayega
302 lagg jayega
Yes doofus 🤣🤣🤣
:)