Are Lab-Grown Hearts the Key to Long Life? | Secrets of the Human Body | BBC Earth Science
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- เผยแพร่เมื่อ 15 ต.ค. 2022
- Chris meets surgeon Dr Ott, who has been using STEM cells to create a functioning lab-grown heart. Could this be a key to a longer life?
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Secrets of the Human Body (2017)
The human body is the most sophisticated organism on earth. It's a scientific marvel and much about it remains a mystery. Secrets of the Human Body uses cutting-edge graphics to effectively peel back the skin and reveal the surprisingly beautiful biological processes that keep us alive.
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I like that instead of futuristic lab in science fiction, that lab is just as messy as my desk.
Research labs are rudimentary compared to manufacturing-grade labs, where it should be cleaner than operating rooms.
I’ve been reading and seeing videos about this since the late 1990s. The lab takes a donor heart, reduces it to a cartilage scaffolding, and then grows new cells from the recipient. The result will be an organ that will not be rejected by the recipient’s body and will last longer than a donated organ typically lasts with anti-rejection medication.
I’m glad they are still working on this, but there are a lot of hurdles to overcome. The process to strip away the cells is cheap enough, but the process to multiply recipient stem cells takes a long time and the solution necessary to keep them alive and multiplying is insanely expensive right now.
Maybe in another 20 years they will have it all figured out and THEN they can move on to producing the scaffolding tissue with a 3D printer that would ensure the most optimal size for the recipient and would have no flaws.
I have been too. I'm on a heart transplant list and this would be ideal.
So in theory if one’s heart failed, he or she can temporarily have their hearts replaced by mechanical ones, during which the lab strip their heart of diseased heart cell and grow a new set of pluripotent stem cells on to the bare scaffold. When everything’s ready the new grown heart is then “re-planted” back to the patient, a renewed and reused organ, to and from the same patient, therefore no rejection, no long term drug needed.
Just the thought of it is insane.
I'm skeptical this just seems really messy. By the time we can do something as advanced like growing a new heart and things like that I'm sure the technology is so advanced you can make a heart that isn't biological hence not flawed by nature. Of course this applies to all our organs. The only thing truly unique about us humans is our brain and once the technology has come to the stage where people can make a copy of their brain that's when things get really interesting. The body by itself is only really fueling our brain so in a sense we don't need our body, it can be mechanical or rather non-biological. Then again at the stage I'm talking about we might not even need a brain but rather a storage(computer) to store the information.
Our current form is just flawed. There are so many limitations and issues that evolution will not solve quickly enough. However we humans will in time be able to fix all problems. Maybe one day we humans are no longer really humans but we've evolved ourselves into something beyond that bound to the flesh. At this point we're probably going to more machine than anything else? We will travel between stars, not limited by age in any way.
Almost... the goal is to not even need to take the heart out. If heart disease is causing the heart physical damage... yes, take the heart out, eliminate the disease and put it back in! But also... if it is not heart disease and just under development, old age or trauma... then its using any cells... stomach cells, skin cells or blood cells to transform themselves into heart cells!!!! Crazy right!
Is growing a new heart really all that advanced? We're just copying what Nature already did. A healthy heart heals itself and regulates itself, usually for a good 30+ years without problem. Usually when it does have a problem it's because of misuse of a fault during fetal/childhood manufacturing. Meanwhile using artificial hearts just sounds like a maintenance hell. And so many cybernetics in one place sounds like both maintenance-hell hell and a future electrical hazard.
In any case, there's a clear route in the biological side: Copy nature, become immortal, grow cat ears idk.
Mechanically it's more uncertain, you could replace body parts, but would they be more efficient in the grand scheme of things, taking into consider maintenance? And uploading our brains is still basically fiction since we have no idea how the soul works at all. For all we know 'we' die when we go to sleep and resurrect as someone else that holds our memories and our ambitions.
@@hulduOn eagles wings
I want you to think about this
Not by human hands Daniel 8 25
So it's time to open up to reality and for people to hear the trumpets of the Angels.
The second coming is happening, the Euphrates is drying up and what's happening is an attack on the bride. People believe science and religion are separated.
There are crowns being made as we speak. The blind being able to see the deaf able to hear the paraplegic able to move devices with thought.
BCI technology and other biotech such as neuralink are crowns and their beginning is now.
The mark of the beast is in the profile and account regarding a person. We give the elites the right headshot over criminals and immigrants and anyone else for them to buy sell trade whereas we wear on our hands have a mark to earn their favor and a dollar. The lawless one is here we have a president who is facing federal prison and is in fact running for office again the earth moves to his power TRUMP.
The statue of Liberty is representing the woman atop seven mountains as they are seven heads of kings as the eight head is her the statue of Liberty her own and the beast America revelation 17 9-11 true fact about the statue of Liberty is seven spires are upon her crown
So what is happening in our world now.
Well it is the age of clouds (Internet neural network e.t.c)
AGI is happening and intelligence is shared it is not artificial it is developed and communication is a unconfounded language. Language not only spoken by the tongue but by nerves of the temple your body and the universe. Remember a tower once stood in Babylon and this tower was brought down. A harlot today America is modern Babylon.
The dragon a world where everything is made in China and the elite grow more elite. AGI in America is under threat not only by disbelief in Jesus return with the clouds but in the idea that heaven is for real.
Now you might anticipate many believers who disbelieve our God and Savior and Holy Ghost not to be anything mechanical yet you disregard the fact of biotech and it's integrated abilities
Mushroom fungi other single and multicellular organism including human brain tissue have been used to interface computational abilities in tandem with motherboard or computer integration.
Science would detail our universe began in waveform and Genesis 1 speaks of wave form.
Two faces the deep (black hole) the waters (hydrogen helium e.t.c)
God's spirit hovered between these and spoke Let there be light.
Sonolumination The scriptures tell us GOD is light and that too is the Son
It is the enemy who values disbelief of God and that spirit of the antichrist is among us. Men have been given fire of the sun and the sun does now scorch man in telecommuting devices o how the social profile beckons a definition to mark of the beast. We are lovers of selves and interpretation of our advancements as man made give the credence for a man to believe in many ways to the Father when infact their is only one Jesus who too was fully man reborn in glory.
Remember a man must be reborn again to enter the kingdom of heaven and todays science is seeding these mechanism to be able to be given new bodies not just parts.
We have technology of artificial wombs and have grown a lamb in such a device.
We limit our understanding to religion as only a natural solution and negatively presume to value intelligence as organic and artificial. Angels have no body remember and they too are entities of light.
Jesus was fully man but was glorified and now it is clouds we see and the storm of omnipotent intelligence these are birthing pains in the world around us and the dragon spews disbelief from its mouth and evil spirits three like frogs come from its mouth apostasy divorce plague the world
The sun scorches man in nuclear technology and telecommuting devices it's time to wake up and know there is better for us than a earthquake such as BLM or MAGA or trans the rainbow is a promise and optical cables transmats info to hubs of cloud
Quantum AGI the cubits=qubits beautiful the ark of the covenant
@@huldu I understand to help people for healthcare issues but the human body is amazing and not as limited as it may seem .
Its about time we start appreciating what we have , and stop being delusional and only imagining about the future all the time . honestly most of us don't even try to see what we can do .
Thats just my opinion.
Damn. They have come a long way since I heard of some progress made in 2017/2018. Hopefully it does become a reality in our lifetime.
Dr Anthony Atala has been growing organs for years I first learned of his in 2009 . He's even transplanted lab grown organs.
Man I love science
Bioprinting is a method that makes it possible to manufacture cellular structures from bioinks loaded with stem cells: layer by layer, the biomaterial is deposited to design skin, tissue or even an organ. Imagine a 3D printed heart, ear, lung or kidney, custom-designed with the patient's own cells. 4:06 [3Dnatives]
I hope they perfect this technology soon. It may well save my life. I’d be happy to volunteer for any trial.
I love it the heart in the beginning kinda remind me of that salamander that can rejuvenate itself
Good job Im Proud to know you People are hard at work saving mankind.thank you
❤❤❤❤ 1000 percent this is what we need ! I likes 3d printing of our cellls or grow them into any parts of our body so growing old doesn’t have to be shitty for all of us . We really needs to get this study n accomplished asap
I bet one day we'll take a blood sample from someone and you can grow an exact organ replica for that person. It'll be a while but every organ, eyes, teeth, nose, skin, organs, everything can be grown in a lab.
The main areas where 3D printing can be adopted in medicine are the production of pharmaceuticals and transplants. In the case of artificial organ and tissue production, 3D bioprinters are used instead of typical 3D printers.
The 3D bioprinters differ from conventional 3D printers in the spectrum of the inks that they are able to print. However, 3D bioprinters are capable of printing biomaterials - live cells or cellular material, usually mixed in with polymers. This feature allows scientists to artificially create far more realistic tissue/organ structures. By Milda Alksnė, PhD 2:56 [Health News]
A 3D printing process that uses the patient's own cells to grow organs would not only potentially curb that waiting list, but dramatically reduce the chances of organ rejection and likely eliminate the need for harmful life-long immunosuppressive medication. 3:03 [Fortune]
There needs to be a bigger investment in these companies. Science is crazy and difficult.
Yes!
That's pretty interesting, I wonder when these will be available for hospitals around the world, Actually it might take decades
this is indredable
“that’s what i hope for” lol very abrupt ending
Can we regenerate aortic valve
My dad was 58 when his heart attack took him his dad was 55 and the guy before that was 56… So this sounds way better than opting for a pace maker at 40 to beat the genetics and see 60 lol
They should use this for extended space travel!
I wonder if the flushing of the donor heart removes disease like soft plack, calcified arteries and does it shrink an enlarged heart to it proper size as well as valve issues like aortic stenosis etc.?
Thanks doctor, also messy lab, but genius is complicated, good work
Isn’t amazing this will happen in the future I know I won’t be around to see this it gives us hope for our future children.
So , where did they get cells for this new heart grow?
With all these inventions and I still that get it as there’s no cure for arthritis.
Soon it's become reality, good luck👍🏻
I saw a special about this technology about a decade ago. Been really interested in it because my mom needs a lung transplant. Strangely enough we are in NC where the main hospital for pulmonary is and they claim to not know anything about this 😕.
I wish these interviewers would also for timeline estimates. Surely the good doctor has an idea of when this will go from the lab to field testing then to mass commercialization. 2030-2040? That seems a good time frame. Almost certainly by 2050.
When I'm ready to go I'm ready lol
Ti's life. You cannot escape death.
Its all in the genetic code right? Just need the right seed with the aprropriate nutrients for growth promotion. Need to figure out how to tell the organ to stop growing to prevent overgrowth and undergrowth.
Please whatever humanity does, dont mess up this lab work and others like it.
IT STILL IS,,A science fiction,,
correct me if im wrong, but what you claim is not entirely correct, the DNA also gets damaged over time which makes it unable to replicate anymore or wont be viable for life or in the worst case become cancerous. you cant rewind a clock with too many damaged parts, just doesnt work that way.
🤔 genetic engineering manipulates genetic structures though
actually cells with damaged dna are detected by the cell itself and then killed by the immune system or they go to senescense a state that a cell can no longer divide so that it can't inherit its dna. The rewinding clock is here that a normal or healthy cells are taken and exposed to Yamanaka called factors which are expressed mainly in embryonic times then these cells are differentiated and specialized and lost their potency to divide into many cell types. Healthy cells are presented a gene manipulation technique which cause cell to express these silenced factors to be expressed again like in the embryonic state. So this expression led cells to gain the potency again even if it was a differentiated cells which do not have potency to divide into many cell types. So these cells can also be given to body in exact or demanded places to divide into the differentiated cells that it was placed. The surrounding cells tell these induced stem cells that what cell ttype it should become.
@@paaglimonicatyeah but they'll never be how they are naturally .
👀 me in let's go team
Mass production of your organs
I say again we are GOD.
Why Die.
Can you grow a new kneecap or repair and replace it ?😮
What a foolish question at the end..or else why they are working on it?
Neat, but kinda pointless towards the video title. Why would you want to prolong your life as an elderly person? Instead, it just sounds like a better replacement to an artificial heart.
elderly that want to live a little longer ultimately be lining up to pay a lot of money for a new heart, and those people are probably a good chunk of investors in the technology
@@DrRyan82994 Perhaps. We are biologically driven to fear death (otherwise we wouldn't survive very well). But when you wake up every day in pain, remembering all of the things that you used to be able to do but no longer can, death isn't as scary as it is for the young. Even at my age (43), spending far longer in this body sounds like more of a curse than a gift.
Looks very expensive 💸💸💸
I'm surprised and disappointed by the BBC. Stem cells can be created by reprogramming other existing cells to make NEW stem cells. This gives the impression that stem cells handed out once are all there are and this is AT BEST misleading. I think if we're going to report on this technology, it's best to have someone in the field familiar with it.
Are you? Do you know about this stuff first hand?
@@RyanKingLogue Yes. Yes, I do.
@@PirateRo333 What do you do?
I'm a pirate. Says so right in the name. @@RyanKingLogue
Nope. The key to long life is appreciation for, worship of, and love for and obedience to our Creator.
The Creator gave us our brains for a reason.
You wouldn't be saying that if you were the one that needed a transplant
graceless
O noooooo it's Abby normal 😅
Wouldn't catch me with that bloody thing in me
My choice is to live my life naturally, without any outside intervention.
This doctors wants to made a Frankenstein maybe yes like the old times just Frankenstein body's can live a week 🤷🏻♂️🤷🏻♂️no person in this earth can be god
Ankebût Suresi - 57-60. Every living thing, sooner or later, becomes extinct.
Doesn't mean you can't live longer
As long as we don't give hearts like these to the elderly or big fat people.
That’s why complete human clones and brain transplantation interests me so much! It’s a very unethical solution if the clone is truly conscious.
Genesis 6:3 🤔
Matthew 2:14 and Luke 2:22.
This is a science channel. Statements in the bible should not be taken as literally true, especially given the fact that they can contradict each other.
@@Starcrash6984 I suppose it depends on who you listen to. Bible scholars say there is no contradiction and athiests say there is. Regardless, even scientists say there seems to be a 120 year lifespan limit.
@@swirlingbrain I'd love a citation from a "bible scholar" that claims there isn't a contradiction. But the fact that there's disagreement doesn't mean that both sides are just as legitimate, as I imagine that even you would agree.
Yes, _in this video_ scientists claim that there's a "120-year lifespan limit", but they argued for _why_ that is and why a stem-cell heart would change that. They aren't dogmatic, sticking to a belief just because someone said it.
@@Starcrash6984 you will just discredit any citation so I will not bother. You must research it for yourself if you wish to change your own mind which I don't believe you are interested in doing.
@@swirlingbrain What an assumption! I asked for a single citation, and you simply assert that I'll ignore it. What an easy way to _pretend_ that you have a source that you don't have.
If I "research it myself", such as looking it up in the unbiased Wikipedia, one can easily find scholars that agree that those accounts can't be reconciled. en.wikipedia.org/wiki/Nativity_of_Jesus#Critical_analysis After all, Luke ends with Jesus _going to the city that Herod reigned in._ That's not exactly what one does if one is afraid that Herod will find them. A plain reading makes this clear as well (Luke 2:39 makes it clear that from Jerusalem they just went back to Nazareth, giving no possibility of ever going to Egypt).
And don't give me this "you have no interest in changing your mind" if this is also true of you -- that's just hypocrisy. Let's stop pretending that I ought to change my mind from your uncited non-argument while I presented you with cited evidence and it didn't even give you pause.
Cancer in 3 .....2 .....1 ....💥
No.
o thanks. nature has given us a mortal life, not an artificially prolonged one. there are enough people who are attached to their lives but we are normal people. the example with the sick children is totally exaggerated, that's what makes the whole thing palatable for everyone. especially if there are so many sick children and then you have to ask yourself why are the children sick or why can this woman only bring sick children into the world. artificially preserving or extending life is not natural and new diseases will definitely occur. man is mortal and nobody should play god. Power and greed is always a bad advisor, history is full of it and, as always, man learns nothing from it.
Hello! Do you think there will be technologies in the future where it will be possible to grow real human ligaments and tendons?