Paligenosis and safe regeneration makes far more sense to me than simply increasing apoptosis all the time. Original thinking like this is also very helpful, thank you to all.
Brilliant concept indeed. Makes me wonder if this concept actually better reflects (as opposed to "stem cells") the behavior of our ancestors-the first animal, and perhaps other kingdoms such as fungus or plant..
Thanks, Very Interesting. Paligenosis reminds me of what Valter Longo observed in fasting experiments. Don't recall if it was in humans or lab animals, but after several days of there was a kill off old cells (immune cells I think) during the period when mTORC1 was low and autophagy was ramped up, then a regeneration of cells during refeeding, when mTORC1 was ramped back up. But maybe I'm reading too much into this and there is no overlap in what is happening. Jason mentions ROS and autophagy as kicking off process, so simplistically, I wonder of this is one way exercise helps, especially when done in unfed state.
Absolutely Mind-Blowing. Do stresses activate Paligenosis? Gives you a new perspective on stresses like fasting and exercise and who knows what other stresses might actually be beneficial.
Interesting video, just a small note on etymology: the Greek root for "again" is "palin" with an N, not "pali". So the word should be palingenosis. See the very similar term palingenesis.
Agreed that the Greek is "palin". "pali" is a variant prefix version, however, for neologisms (see: en.wiktionary.org/wiki/pali-#English. Examples: "palilaia" "paliperidone"). We chose the variant to avoid confusion with a former controversial vice presidential candidate.
This process may have a lot of overlap with Michel Levin's research as well. I am betting these reversals of differentiated states also have their own unique, electric potentiations across the cell itself that describe them from this space.
Are they referring to low dose rapamycin (once weekly, bi weekly etc) or rapamycin dosed daily? Obviously rapamycin taken daily/ at higher cumulative doses is going to block paligenosis thats no suprise and is common knowledge, however i'm curious as to whether ldr has a similiar or significant effect as well.
Kidney damage is a rapidly growing problem--exacerbated by both metabolic syndrome and Covid. I wonder whether paligenosis is a potential treatment for kidney damage and, if so, where the research, if any, stands.
Paligenosis is when mature, differentiated cells have to retool to enter the cell cycle. Quiescent cells are cells not in the cell cycle. Differentiated cells that are mitotically quiescent and undergo paligenosis do stop being quiescent. But differentiated cells can autoduplicate (and be non-quiescent) without all the retooling and dedifferentiation of paligenosis. And non-differentiated cells can be mitotically quiescent and then emerge from quiescence. Thanks for the chance to clarify!
Paligenosis and safe regeneration makes far more sense to me than simply increasing apoptosis all the time. Original thinking like this is also very helpful, thank you to all.
just more supportive praise ;-) EXCELLENT questions (both planned and emergent), Sheekey!
Brilliant concept indeed. Makes me wonder if this concept actually better reflects (as opposed to "stem cells") the behavior of our ancestors-the first animal, and perhaps other kingdoms such as fungus or plant..
Love the 'professional stem cell' concept. Thanks Eleanor, very interesting interview with lots of food for thought.
Thanks, Very Interesting. Paligenosis reminds me of what Valter Longo observed in fasting experiments. Don't recall if it was in humans or lab animals, but after several days of there was a kill off old cells (immune cells I think) during the period when mTORC1 was low and autophagy was ramped up, then a regeneration of cells during refeeding, when mTORC1 was ramped back up. But maybe I'm reading too much into this and there is no overlap in what is happening. Jason mentions ROS and autophagy as kicking off process, so simplistically, I wonder of this is one way exercise helps, especially when done in unfed state.
Absolutely Mind-Blowing. Do stresses activate Paligenosis? Gives you a new perspective on stresses like fasting and exercise and who knows what other stresses might actually be beneficial.
there is also a hormesis response involving hyperbaric oxygen therapy.
So much shared love.
So rapamycin would inhibit polygenosis which should lessen the possibility of cancers to some extent? Is that correct?
Sheeky would skin cells be regenerative or just replaced ?
thanks for this
Interesting video, just a small note on etymology: the Greek root for "again" is "palin" with an N, not "pali". So the word should be palingenosis. See the very similar term palingenesis.
Agreed that the Greek is "palin". "pali" is a variant prefix version, however, for neologisms (see: en.wiktionary.org/wiki/pali-#English. Examples: "palilaia" "paliperidone"). We chose the variant to avoid confusion with a former controversial vice presidential candidate.
Are there non toxic stimulus used to trigger to bottom of the stomach cells to rejuvenate? Rapamycin, something else?
This process may have a lot of overlap with Michel Levin's research as well. I am betting these reversals of differentiated states also have their own unique, electric potentiations across the cell itself that describe them from this space.
I’m trying to multitask but keep monotasking 😍.
Are they referring to low dose rapamycin (once weekly, bi weekly etc) or rapamycin dosed daily? Obviously rapamycin taken daily/ at higher cumulative doses is going to block paligenosis thats no suprise and is common knowledge, however i'm curious as to whether ldr has a similiar or significant effect as well.
Kidney damage is a rapidly growing problem--exacerbated by both metabolic syndrome and Covid. I wonder whether paligenosis is a potential treatment for kidney damage and, if so, where the research, if any, stands.
Me to!
❤❤❤
Way above my pay grade.
Wondering if they'll ever get to the relevant information or if I'm wasting my time and all he did was some experiments with the Yakima factors
Yakima? Or Yamanaka?
@@laulaja-7186 all I could get out of my lousy text-to-speech software I'm disabled and have to use it
Isn't then paligenosis = quiescence? Cell quiescence is known decades ago. It's only playing with terminology.
Paligenosis is when mature, differentiated cells have to retool to enter the cell cycle. Quiescent cells are cells not in the cell cycle. Differentiated cells that are mitotically quiescent and undergo paligenosis do stop being quiescent. But differentiated cells can autoduplicate (and be non-quiescent) without all the retooling and dedifferentiation of paligenosis. And non-differentiated cells can be mitotically quiescent and then emerge from quiescence. Thanks for the chance to clarify!