Wow, I take this for my asthma. Years ago I found out not all asthma are the same. Some is from immune reactions and some from low NO production in lung tissues. Citrulline increases NO productions and helped reduced the amount of asthma attacks.
Excellent video, Nick. You really have a knack for explaining the research in concise, easy to understand ways. As a functional medicine doc that has an interest in osteoporosis, this paper is really exciting.
I live on L-Citrulline, L-Arginine and creatine! Ever since I upped my dosage to 3G/day my blood pressure has stabilized and my energy is much improved. I was a walking zombie before that. This bone stuff is just icing on the cake!
You can imagine how helpful this could be for postmenopausal women. Osteoporosis along with sarcopenia can really slow us down. I appreciate your many insights regarding supplementation and the mechanisms whereby this amino acid can assist with building or maintaining the integrity of our bones.
The data are pre-clinical... but I find them both interesting and compelling enough to consider supplementation. Sometimes, I have a "why wait?" approach myself ;)... esp when the downsides are likely negligible
Thank you, Nick! I'm so glad to hear that the cause of your bone degradation was found and that you've been able to arrest its progress if not reverse it! I'm especially interested, since I'm a menopaused female, and need all the help I can get to fight bone loss. Thank you for your time in putting out such helpful content. God's blessings to you!
Many Thanks! Thank you for all your hard work,I look forward to every video. Recently diagnosed with Osteopenia,so this is excellent news for me.Will find supplements. Never expected this today!😊
Check out a guy called Jeff Bowles. There are interviews here on YT. High dose Vitamin D3 and K2 may be useful for you along with the supporting supplements.
Many elderly/older folks (65+yo) suffer from weak/weaker bones that lead to reduced lifespan from falls, inability to exercise, etc. I wonder if supplementation of L-Citrulline would be effective therapy? Thanks for your work.
The first time I used L citrulline I had this tingling feeling all over my limbs. A good feeling tingle. Not like the neuropathy I had before keto. But a good kind of tingling. That only happend a couple times. Since then I have not gotten the tingle. Almost as if I was deficient and the citrulline replenished something. Still use it frequently and never get the tingle.
Im pretty sure thats because L-Arginine directly causes more pulmonary vascular dilation. Thats why it is commonly found in preworkout supplements. And L citruline is the base for L arginine synthetization.
As a guy in my late 50's, I was blasted with all the ED commercials. They made me curious as to how they worked. I investigated and found that we could almost replace them by using L-Arginine and L-Citrulline. L-Arginine is 'closest' to the production of NO. I tried that, and had to be very careful with the dosage, otherwise I would get swimmy headed. L-Citrulline I could take with no problems. I now take a large dose of powdered L-Citrulline (I use Bulk Supplements L-Citrulline) with my tea (I use an old pill-bottle as a scoop). After taking it for a couple of weeks, morning-wood returned. It's interesting to see that it also helps bone growth.
Once again, I’ll mention that my number one rule for nutrition is: eat real food! Therefore, my takeaways from this episode are: 1. There’s some good micro nutrition in watermelon and cucumbers. 2. It’s great to hear Nick has reversed his osteoporosis!
I love your enthusiasm..it's contagious. Very good content as always. I wish allulose allowed to be sold in Canada..I will wait! Can get those treats here.
Thank you for bringing these interesting Studies to our Attention. My dietary license really is just a worthless piece of paper when you compare it to the everchanging landscape of nutritional sciences. There is so much to learn and sometimes it is hard to keep up and check on studies after a few years to see if they still hold up. No wonder most general Doctors have no clue about nutrition, its very time intensive to keep up to date. These videos help immensely to cut down the time investment. Kudos!
Thanks Snake Ace (cool name btw). Yes... our degrees "age out" in so far as the crystalized knowledge passed on often becomes obsolete rather quickly... it's T1/2 is short... but I LOVE THAT!
Wow. This is fascinating, Nick. (And as someone with Osteoporosis and Crohn's Disease, *really* right up my alley. I think I'll join you on the Citrulline train! 🙌)
Osteoporosis at a young age? Had no idea it was possible. I was told over and over that since I eat no vegetables I would have weak bones. Instead I have fallen through roofs, off of ladders, been in several car accidents including being hit by a pickup truck while in a Bobcat and have never broken a bone.
Really great explanation of a neat study! If I could imagine a criticism it would be around your process of selecting things to cover, and the frequency with which there is a connection to your personal life or the foods you favor. But then I remind myself that your stated channel goal is not to be a balanced journalism destination or video encyclopedia or one-stop shop for people trying to figure out what to eat. Rather, the goal (as I understand it) is to get people curious and excited about science. And a good way to do that is with a storytelling approach. Keep up the excellent work!
"frequency with which there is a connection to your personal life or the foods you favor" ... I'm intentional about this when I can be... if there's a relationship to my personal narrative that draws me interest to a particular topic, I think you deserve to know... I also find people respond to transparency and authenticity. So, that is what I aim to provide.
I've been supplementing with both L-Arginine 5 g per day, and L-Citrulline 4 g per day for quite a while now, for the nitric oxide benefits. This is the first I've heard of any bone benefits though. It should be noted, if you do choose to supplement with either/both these amino acids, for the greatest benefit it is generally recommended to take them on an empty stomach, especially no protein for at least 1 hour before and after ingestion, to avoid competition with other amino acids for absorption. First thing in the morning, mixed in a large glass of water, is what I do.
@@gsts379 The citrulline tastes ok in a big glass of water. It's mild. The arginine not so much. It has a stronger slightly unpleasant taste I can't really describe, but I always have to rinse my mouth out after drinking it.
Love your enthusiasm Nick, it's infectous. Have you done a video, or is it documented anywhere, on the steps you took to overcome your osteoporosis - medication, supplements, exercise, etc?
So, nitric oxide is important for both bones and boners... Seriously, you can get reputable L-citrulline in bulk, which will provide c. 3g per heaping teaspoon. It is slightly citrus-y tasting, and goes well with anything that has blueberries in it.
This is good news. I have been taking L-citrulline for it's blood flow benefits, to know it could be helping to keep my bones strong is great. Arugula is another good source of L-citrulline.
Wow - another excellent video - thank you Nic!! I have severe osteoporosis (hip is -4.5 T) and have refused to take meds (fortunately, as bad as my numbers are, I've never fractured)... I'm going to give Citruline a try!
I'm glad you found this video interesting. That's a pretty low score. Certainly I would consider the fundamentals (D3, Calcium), but nothing wrong with an anabolic if your doctor recommends it. Side effect profile often pretty low. Also see prior video on my channel on bone-brain cross-talk and sclerostin... you may find interesting.
@@nicknorwitzPhD thank you- I will look at that video! I have been taking D3, mag, MK7, and other supplements for many years - even dabbled with strontium citrate for a bit. My last DXA (2022) had only gone down a tiny bit from the one I'd had 5 years before - so I was pleased, considering I'm not on a drug. Since 2022, I've upped my protein consumption, and increased my exercise to include WAY more weight training (not just weight bearing) - and I've actually built muscles - I don't think I've ever had muscles before!! :D I follow Gabrielle Lyon and others so am really concentrating on that muscle-building bone thing... Oh - and with the fact that I'm only 4'10" and tiny-boned, I'm thinking, based on what I've read about how they interpret DXAs, that my scores are a little better than on paper. Anyway, thanks so much for your content - you always explain it to the non-science folks - and you're a breath of fresh air!! Keep doing what you're doing!! :)
@@nicknorwitzPhD yikes... I just had another DXA yesterday and my spine went from -3.3 in 2022 to -3.4... but my hip went from -4.5 in 2022 to -5)... considering an anabolic as you suggested - any idea which I should pus for - Forteo, Tymlos or Evenity?? (I've been doing all of the things - high-quality animal protein, low (not keto) carb, no refined crap, resistance, vibration, 12K steps a day... been taking D3, Mag, etc for years - tracking with Cronometer so I know I'm getting all the things). Thanks Nick! :)
Nick, can you share what you did to correct your osteoporosis? I’m a 63 yr old male 10 weeks out from lumbar disc replacement x2. My surgeon said I just made the cutoff for bone density for surgery. I’m taking D3K2 and collagen supplement now. Any info would be appreciated. Don’t see an endocrinologist until September. Great channel! Thank you for making everything understandable.
I think we have different etiologies, so I'm not sure my protocol would be helpful to you. Sorry you don't have an appointment until September. D3/K2 (MK7) and calcium and regular exercise all seem reasonable starting points.
@@nicknorwitzPhDI am 63 year old male. Osteopenia discovered at 40. This month dexascan finds osteoporosis. Untreated over the 23 years. Your video took me to my genetic data which found I have CT genotype at rs3736228, with the T allele associated osteoporosis risk. (Slight risk). My data does not include SNP associated with A745V mutation unfortunately. Wonder if I should obtain genetic test for this mutation. Will look into L citrulline. Thanks for sharing this info.
In my water bottle are 3g each of both L-citrulline (increases nitric oxide for my runs) and beta-alanine (delays fatigue during resistance training). Thank you, Dr. Nick.
Thanks Nick!; I'll be using for my ultra trail running training and races from here on out; sounds so promising and I can use one less soreness and ache or two to recover from!
I love RxSugar. I'm disappointed Walmart stopped stocking it. I've also noticed King Soopers is having difficulty keeping it in stock. I'm wondering if they have production problems.
@@nicknorwitzPhD I have healed well but have inherited osteoporosis. Thanks for keeping us informed of possible ways to slow progression or even reverse it.
Why wouldn't eating beets to increase plasma nitric oxide work? I'm 66 and just took a fall that could have shattered my left tibia, sustaining a large contusion that bled internally, collecting along the front of my leg above the sock, but no discoloration of the large, displaced swelling. Just grateful I didn't catch my knee. Anyway, I love beets.
Nothing wrong with beets IMHO. Can't say whether it would work. Pools of NO in the body are distinct and it would be a leap to assume beets are going to stimulate the same pathways in osteocytes.
Great video. L-citruline added to my carnivore + small amount of fruit diet helped increase some gym output. I wonder if it did help my joints too. They have felt stiff since I stopped using it.
Wow, this is fascinating! You provide stellar content and I love your enthusiasm. My husband and I are of the age where bone density decreases, (especially for my husband). I blame it on the years of taking an H2 blocker. We are on a meat based diet, but he cannot stop his stomach medicine. He is still plagued with acid. I fear a fall that will produce a fractured hip. I think I should supplement with l-citruline. Do you mind sharing what brand you are taking?
Wow! Didn't realize my preworkout energy drink was also helping my bones also. I knew about the endothelial benefit, but not the bone. Thanks- good to know because my 86 y.o. mom drinks it daily as well. So mine has citrulline malate- apparently that makes it more absorbable?
Nick, what are your thoughts on diet composition and timing for someone who has had a total abdominal colectomy for UC. I can't find anything on Pubmed as to whether fiber is a good thing for someone with the majority of the large bowel microbiome gone. Is an animal based diet better? If you do not know, could ask around I would really appreciate it. I am trying to help a female, late 30's who is several years post surgery. She has no stoma and has been told to drink lots of water but no guidance on what she should eat. Great breakdown of the study thanks!!!!
hey Nicholas just wanted to let you know how much I enjoy your channel . But because I am from the south my hearing can't keep up with your talking . You kept saying treadmill running task and I heard treadmill running cats . I was so excited to see that .Well maybe next time.
@@wplants9793 Closed Captions or subtitles are useful since my visual processing is faster than my auditory processing. I can turn up speed but still read enough to make sense. One problem -- often the transcription has errors: etiology -> ideology; arginine -> argy; L-Citrulline -> El Citrine or Eline. I really can't complain about Lachnospiraceae (bacteria name) -> lacos PR or Latinos!
Some people are sensitive to allulose. It's possibly you're particularly sensitive and you could get GI upset from a ~10g dose, although that would be at the extremes of sensitivity. I don't think there's any reason to believe "damage" was done in any sense. Sorry you're not feeling well. How do you know you were hypoglycemic? Do you have diabetes?
Higher arginine via citrulline (or arginine alone) causes an increase of cold sores for me but also lowers my BP. Even when I balance this with lysine, I get breakouts. Any ideas?
Here one intervention specifically examined (in a preclinical expt) was Cit. So that’s what I talked about. Also Osteocyte NO ≠ endothelial NO etc., per se. Probably some correlation tho. And I think it’s reasonable to speculate that other NO boosting interventions may have a similar effect. Dunno
![These Molecules Reversed Aging by... YEARS! [TRIIM Study Explained - Study 216]](/img/n.gif)
Wow, I take this for my asthma. Years ago I found out not all asthma are the same. Some is from immune reactions and some from low NO production in lung tissues. Citrulline increases NO productions and helped reduced the amount of asthma attacks.
Carnivore diet might help you.
@@kenadams5504 Already doing a keto version of it :-) I have been asthma free for 2 years now.
Propably because of pulmonary vascular dilation effects from L-Arginine which L-Citruline is the base of.
Thanks for sharing! I didn’t know it could be used for asthma… glad you feel it worked in your n = 1
Interesting! I get worsened asthma after everything I eat...How much citrulline did you take and how did you take it?🪷
Excellent video, Nick. You really have a knack for explaining the research in concise, easy to understand ways. As a functional medicine doc that has an interest in osteoporosis, this paper is really exciting.
Much appreciated!
Nick knack paddy wack give a dog a bone
I live on L-Citrulline, L-Arginine and creatine! Ever since I upped my dosage to 3G/day my blood pressure has stabilized and my energy is much improved. I was a walking zombie before that. This bone stuff is just icing on the cake!
Impressive response!
You can imagine how helpful this could be for postmenopausal women. Osteoporosis along with sarcopenia can really slow us down. I appreciate your many insights regarding supplementation and the mechanisms whereby this amino acid can assist with building or maintaining the integrity of our bones.
The data are pre-clinical... but I find them both interesting and compelling enough to consider supplementation. Sometimes, I have a "why wait?" approach myself ;)... esp when the downsides are likely negligible
Biohack
Don’t wait on standard practice protocols
17 yrsssss
@@YeshuaKingMessiah I appreciate some guidance as to what substances are safe to experiment with and which are not.
Thank you, Nick! I'm so glad to hear that the cause of your bone degradation was found and that you've been able to arrest its progress if not reverse it! I'm especially interested, since I'm a menopaused female, and need all the help I can get to fight bone loss. Thank you for your time in putting out such helpful content. God's blessings to you!
Many Thanks!
Thank you for all your hard work,I look forward to every video.
Recently diagnosed with Osteopenia,so this is excellent news for me.Will find supplements.
Never expected this today!😊
Check out a guy called Jeff Bowles. There are interviews here on YT. High dose Vitamin D3 and K2 may be useful for you along with the supporting supplements.
“Life has a way…” Rafiki 🐒
Great info - I wish as a young man this info was available via the internet - but grateful that it is here now .. many thanks.
Glad it was helpful!
You are excellence in action, Nick! 🎉
So kind of you Lori! - with gratitude, Nick
Many elderly/older folks (65+yo) suffer from weak/weaker bones that lead to reduced lifespan from falls, inability to exercise, etc. I wonder if supplementation of L-Citrulline would be effective therapy? Thanks for your work.
I wonder too...
❤😮Thanks Nick!! I always click, watch, and learn!! 👍
Awesome! Thank you!
The first time I used L citrulline I had this tingling feeling all over my limbs. A good feeling tingle. Not like the neuropathy I had before keto. But a good kind of tingling. That only happend a couple times. Since then I have not gotten the tingle. Almost as if I was deficient and the citrulline replenished something. Still use it frequently and never get the tingle.
Im pretty sure thats because L-Arginine directly causes more pulmonary vascular dilation. Thats why it is commonly found in preworkout supplements. And L citruline is the base for L arginine synthetization.
Interesting 🤨
As a guy in my late 50's, I was blasted with all the ED commercials. They made me curious as to how they worked. I investigated and found that we could almost replace them by using L-Arginine and L-Citrulline. L-Arginine is 'closest' to the production of NO. I tried that, and had to be very careful with the dosage, otherwise I would get swimmy headed. L-Citrulline I could take with no problems. I now take a large dose of powdered L-Citrulline (I use Bulk Supplements L-Citrulline) with my tea (I use an old pill-bottle as a scoop). After taking it for a couple of weeks, morning-wood returned. It's interesting to see that it also helps bone growth.
One other point: NO also allows for dilation of blood vessels/veins (hence the morning wood), which helps regulate blood pressure.
@@GlueTubber I'm aware... someone already made a bone and boner joke too
Once again, I’ll mention that my number one rule for nutrition is: eat real food! Therefore, my takeaways from this episode are:
1. There’s some good micro nutrition in watermelon and cucumbers.
2. It’s great to hear Nick has reversed his osteoporosis!
I don’t mind you having that takeaway :)
I love your enthusiasm..it's contagious. Very good content as always. I wish allulose allowed to be sold in Canada..I will wait! Can get those treats here.
"SORee!" ;)
Thank you for bringing these interesting Studies to our Attention. My dietary license really is just a worthless piece of paper when you compare it to the everchanging landscape of nutritional sciences. There is so much to learn and sometimes it is hard to keep up and check on studies after a few years to see if they still hold up. No wonder most general Doctors have no clue about nutrition, its very time intensive to keep up to date. These videos help immensely to cut down the time investment. Kudos!
Thanks Snake Ace (cool name btw). Yes... our degrees "age out" in so far as the crystalized knowledge passed on often becomes obsolete rather quickly... it's T1/2 is short... but I LOVE THAT!
RD license truly is a joke
Bought out by FDA etc who are trying to kill us
Keep educating urself pls 😀
Wow. This is fascinating, Nick. (And as someone with Osteoporosis and Crohn's Disease, *really* right up my alley. I think I'll join you on the Citrulline train! 🙌)
🚂🚂🚂🚂
Osteoporosis at a young age? Had no idea it was possible. I was told over and over that since I eat no vegetables I would have weak bones. Instead I have fallen through roofs, off of ladders, been in several car accidents including being hit by a pickup truck while in a Bobcat and have never broken a bone.
Unlucky 🧬
You should get a DEXA scan. You will learn your bone density and body fat levels.
Really great explanation of a neat study! If I could imagine a criticism it would be around your process of selecting things to cover, and the frequency with which there is a connection to your personal life or the foods you favor. But then I remind myself that your stated channel goal is not to be a balanced journalism destination or video encyclopedia or one-stop shop for people trying to figure out what to eat. Rather, the goal (as I understand it) is to get people curious and excited about science. And a good way to do that is with a storytelling approach. Keep up the excellent work!
"frequency with which there is a connection to your personal life or the foods you favor" ... I'm intentional about this when I can be... if there's a relationship to my personal narrative that draws me interest to a particular topic, I think you deserve to know... I also find people respond to transparency and authenticity. So, that is what I aim to provide.
@@nicknorwitzPhD Appreciate the transparency!
@@allisonal for sure!
I've been supplementing with both L-Arginine 5 g per day, and L-Citrulline 4 g per day for quite a while now, for the nitric oxide benefits. This is the first I've heard of any bone benefits though. It should be noted, if you do choose to supplement with either/both these amino acids, for the greatest benefit it is generally recommended to take them on an empty stomach, especially no protein for at least 1 hour before and after ingestion, to avoid competition with other amino acids for absorption. First thing in the morning, mixed in a large glass of water, is what I do.
How does the citrulline taste? Any significant side effects?
@@gsts379 The citrulline tastes ok in a big glass of water. It's mild. The arginine not so much. It has a stronger slightly unpleasant taste I can't really describe, but I always have to rinse my mouth out after drinking it.
Love your enthusiasm Nick, it's infectous. Have you done a video, or is it documented anywhere, on the steps you took to overcome your osteoporosis - medication, supplements, exercise, etc?
So, nitric oxide is important for both bones and boners...
Seriously, you can get reputable L-citrulline in bulk, which will provide c. 3g per heaping teaspoon. It is slightly citrus-y tasting, and goes well with anything that has blueberries in it.
Flavor tip noted 🫐🫐🫐
Any other tips? Take with or without food? Morning or evening? Unpleasant side effects? Thx
This is good news. I have been taking L-citrulline for it's blood flow benefits, to know it could be helping to keep my bones strong is great. Arugula is another good source of L-citrulline.
Or "rocket" as they say across the pond ;)
Wow - another excellent video - thank you Nic!! I have severe osteoporosis (hip is -4.5 T) and have refused to take meds (fortunately, as bad as my numbers are, I've never fractured)... I'm going to give Citruline a try!
I'm glad you found this video interesting. That's a pretty low score. Certainly I would consider the fundamentals (D3, Calcium), but nothing wrong with an anabolic if your doctor recommends it. Side effect profile often pretty low. Also see prior video on my channel on bone-brain cross-talk and sclerostin... you may find interesting.
@@nicknorwitzPhD thank you- I will look at that video!
I have been taking D3, mag, MK7, and other supplements for many years - even dabbled with strontium citrate for a bit. My last DXA (2022) had only gone down a tiny bit from the one I'd had 5 years before - so I was pleased, considering I'm not on a drug. Since 2022, I've upped my protein consumption, and increased my exercise to include WAY more weight training (not just weight bearing) - and I've actually built muscles - I don't think I've ever had muscles before!! :D I follow Gabrielle Lyon and others so am really concentrating on that muscle-building bone thing... Oh - and with the fact that I'm only 4'10" and tiny-boned, I'm thinking, based on what I've read about how they interpret DXAs, that my scores are a little better than on paper.
Anyway, thanks so much for your content - you always explain it to the non-science folks - and you're a breath of fresh air!!
Keep doing what you're doing!! :)
@@nicknorwitzPhD yikes... I just had another DXA yesterday and my spine went from -3.3 in 2022 to -3.4... but my hip went from -4.5 in 2022 to -5)... considering an anabolic as you suggested - any idea which I should pus for - Forteo, Tymlos or Evenity?? (I've been doing all of the things - high-quality animal protein, low (not keto) carb, no refined crap, resistance, vibration, 12K steps a day... been taking D3, Mag, etc for years - tracking with Cronometer so I know I'm getting all the things). Thanks Nick! :)
Nick, can you share what you did to correct your osteoporosis? I’m a 63 yr old male 10 weeks out from lumbar disc replacement x2. My surgeon said I just made the cutoff for bone density for surgery. I’m taking D3K2 and collagen supplement now. Any info would be appreciated. Don’t see an endocrinologist until September.
Great channel! Thank you for making everything understandable.
I think we have different etiologies, so I'm not sure my protocol would be helpful to you. Sorry you don't have an appointment until September. D3/K2 (MK7) and calcium and regular exercise all seem reasonable starting points.
Thid was a great story - and the research was absolute fun!
Glad you enjoyed the personal element and data :).
Thanks Doc, NASA might care about this.
Perhaps… 🚀
arginine is an essential amino acid for mice but not humans ? L-citrulline seems good at fattening mice as well.
What was your diagnosis and gene mutation? Great info as always!
Here: pubmed.ncbi.nlm.nih.gov/30972028/
@@nicknorwitzPhDI am 63 year old male. Osteopenia discovered at 40. This month dexascan finds osteoporosis. Untreated over the 23 years. Your video took me to my genetic data which found I have CT genotype at rs3736228, with the T allele associated osteoporosis risk. (Slight risk). My data does not include SNP associated with A745V mutation unfortunately. Wonder if I should obtain genetic test for this mutation. Will look into L citrulline. Thanks for sharing this info.
In the future, please display nutrients as x grams / 100 grams. Much easier to grasp and accurately compare. Thanks.
In my water bottle are 3g each of both L-citrulline (increases nitric oxide for my runs) and beta-alanine (delays fatigue during resistance training). Thank you, Dr. Nick.
You're welcome wings_nut!
Thanks Nick!; I'll be using for my ultra trail running training and races from here on out; sounds so promising and I can use one less soreness and ache or two to recover from!
"ultra trail running" - I'm jealous!
I love RxSugar. I'm disappointed Walmart stopped stocking it. I've also noticed King Soopers is having difficulty keeping it in stock. I'm wondering if they have production problems.
2hr45 marathon jesus...good on you - what a flex. I did a half ironman in my peak of 5hr 10min...those were the days.
Haha… thank you. Good for you Zeal!
Great info
Thank you!
I know you suggested 3 grams dosage for a 70kg male. Is there a loading phase?
Nick,
Thanks great review. I have had a fracture also. I just started L-Citrulline a month ago. I will increase my dose.
Sorry about your injury
@@nicknorwitzPhD I have healed well but have inherited osteoporosis. Thanks for keeping us informed of possible ways to slow progression or even reverse it.
I love your videos! I learn so much from them.
Glad you like them!
Why wouldn't eating beets to increase plasma nitric oxide work? I'm 66 and just took a fall that could have shattered my left tibia, sustaining a large contusion that bled internally, collecting along the front of my leg above the sock, but no discoloration of the large, displaced swelling. Just grateful I didn't catch my knee. Anyway, I love beets.
Nothing wrong with beets IMHO. Can't say whether it would work. Pools of NO in the body are distinct and it would be a leap to assume beets are going to stimulate the same pathways in osteocytes.
Except the oxalate level, which is pity. Although I understand that eating a calcium source along with an oxalate rich food helps.
Thanks you so much! I plan to supplement for my bones!!
Category: Speculation that more like to help than hurt
You are incredible man
Thank you friend :).
Great video. L-citruline added to my carnivore + small amount of fruit diet helped increase some gym output. I wonder if it did help my joints too. They have felt stiff since I stopped using it.
I'm a fan of "toggling and observing" ... your n = 1 is a powerful thing.
@@nicknorwitzPhD Yeah for sure. Trying something then taking it away is a strategy I like to employ.
@@sterlingkeful340 Just don't try to do that with giving a steak to a hungry dog
wouldn't consumption of nitrate rich foods that are then subsequently converted into NO be just as effective as mega dosing L-citruline?
Is this usefull for old people tho? I think NO production from arginine is reduced from the age of 40, also greens are a good source of NO.
Thank you!
Welcome silver!
Your thumbnail makes you look like science Jesus
Is that your way of complimenting my beard? 😉
@@nicknorwitzPhD
I have compliments for every single part of you, including your beard.
You're the nice secular boy I've always fantasized about.
Wow, this is fascinating! You provide stellar content and I love your enthusiasm. My husband and I are of the age where bone density decreases, (especially for my husband). I blame it on the years of taking an H2 blocker. We are on a meat based diet, but he cannot stop his stomach medicine. He is still plagued with acid. I fear a fall that will produce a fractured hip. I think I should supplement with l-citruline. Do you mind sharing what brand you are taking?
Pretty sure he said what brand he’s taking, but he talks so fast you’ll have to concentrate to catch it!
@@CandyLindTXthanks! I will listen again. 😂
Can you give us the name of the specific mutation you have?
Here: pubmed.ncbi.nlm.nih.gov/30972028/
Wow! Didn't realize my preworkout energy drink was also helping my bones also. I knew about the endothelial benefit, but not the bone. Thanks- good to know because my 86 y.o. mom drinks it daily as well.
So mine has citrulline malate- apparently that makes it more absorbable?
Ya, I've heard 2:1 citrulline malate is good. Not an expert on formulation, but from what I have read...
Nick, what are your thoughts on diet composition and timing for someone who has had a total abdominal colectomy for UC. I can't find anything on Pubmed as to whether fiber is a good thing for someone with the majority of the large bowel microbiome gone. Is an animal based diet better? If you do not know, could ask around I would really appreciate it. I am trying to help a female, late 30's who is several years post surgery. She has no stoma and has been told to drink lots of water but no guidance on what she should eat. Great breakdown of the study thanks!!!!
luckily I have osteopenia AND high high cholesterol-family history of heart disease so I will def be adding this to my supplements.
Glad you found the video useful... obviously it's not medical advice... but I thought cool preclinical data!
@@nicknorwitzPhD the medical advice I get from my dr is not about nutrition its about rosuvastatin and pcsk9is.
Thanks for sharing this type of information, Nick!
My pleasure!
Which is better Nicholaus??? L-Citrulline or Citrulline Malate???
Ideally 2:1 Citrulline Malate
Is there any human studies about it's effects on those who have no osteoporosis or other diseases?
Unfortunately no studies that I know of in humans for Citrulline for low BMD. Speculative
I just bought L-Arginine, is it useless? 😐
hey Nicholas just wanted to let you know how much I enjoy your channel . But because I am from the south my hearing can't
keep up with your talking . You kept saying treadmill running task and I heard treadmill running cats . I was so excited to see
that .Well maybe next time.
if you press the more button at the top, there is a transcript button you can select to follow along with.
Turn on CC
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Click on settings - looks like a gear, bottom right of TH-cam screen. Find "speed". You can slow down Nick or speed up others who talk too slowly.
@@wplants9793 Closed Captions or subtitles are useful since my visual processing is faster than my auditory processing. I can turn up speed but still read enough to make sense. One problem -- often the transcription has errors: etiology -> ideology; arginine -> argy; L-Citrulline -> El Citrine or Eline. I really can't complain about Lachnospiraceae (bacteria name) -> lacos PR or Latinos!
Going to make an n=1 of this if my bone scores aren’t good in a new test.
Good luck 🎲
So watermelon for the win.
You’re gonna be eating a lot of it!
Nick I'm wondering why RxSugar chocolate bars messed up my gut by eating just one bar? I know I am Hypoglycemic so maybe that's it?
Some people are sensitive to allulose. It's possibly you're particularly sensitive and you could get GI upset from a ~10g dose, although that would be at the extremes of sensitivity. I don't think there's any reason to believe "damage" was done in any sense. Sorry you're not feeling well. How do you know you were hypoglycemic? Do you have diabetes?
Higher arginine via citrulline (or arginine alone) causes an increase of cold sores for me but also lowers my BP. Even when I balance this with lysine, I get breakouts. Any ideas?
The increase in cold sores is significant. Thank you for sharing. I have a bag of citrulline I plan to start using for high BP.
Are there no citrulline in animal foods?
I take a preworkout with citrulline every day. Is it safe to take daily long term?
I have no reason to believe otherwise
Is it then the NO that causes better bone health? Why not just improve that?
Here one intervention specifically examined (in a preclinical expt) was Cit. So that’s what I talked about. Also Osteocyte NO ≠ endothelial NO etc., per se. Probably some correlation tho. And I think it’s reasonable to speculate that other NO boosting interventions may have a similar effect. Dunno
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Nick. How do i get RXSugar products in Canada?
Smuggling
What about meat? Am I getting enough of the magic on a carnivore diet?
0.250gr x 70kg = 1.75gr
Insert innuendo here
I'm missing the joke...
@@nicknorwitzPhD Referring to citrulline may boost arginine hence boosting nitric oxide, helping with erectile dysfunction. Sorry
Just make more NO. Just now chewing on gum infused with nitrites. NO is a miracle gas.
Immediately made me think of this: th-cam.com/video/YbYWhdLO43Q/w-d-xo.htmlsi=ULpcNKjpIXBbzCAI