Paracetamol (Acetaminophen) hepatotoxicity and its management.

This animated video illustrates the mechanisms of Paracetamol (Acetaminophen) induce hepatotoxicity.
It compares the production of toxic intermediate NAPQI under both therapeutic and toxic concentration of paracetamol.
Glutathions plays important role in transforming NAPQI into water soluble no toxic metabolite that is readily excreted by the kidney
This video also explain why paracetamol induces hepatotoxicity even under normal therapeutic doses in some unfortunate people.
lastly this video briefly explains the pharmacological bases behind using N-Acetyl Cysteine as antidote for paracetamol poisoning

[@godzillajuvana6342]

the pace of explanation is perfect for me who keeps on forgetting what is what and very understandable.

[@ajayjat1914]

Just incredible explanation!
Huge thanks teacher!

[@elizabethominde-ogaja3433]

This is the best account of paracetamol metabolism and toxicity that I have seen any where. Thank you, thank you thank you. Have you made any other videos?

[@brianchuma3152]

This is very good tutorial ......it makes medicine more easier

[@aliaub75]

Perfect explanation...barak Allahu feekum. My dua and thoughts go to the beautiful people in Gaza.

[@mistykidowo]

Love the way you explain things. Thanks

[@ClassofEmergencyMedicine]

very good video. a must for exam going students

[@samitasapkota6026]

very perfectly explained..Thank you!!

[@A2G_tricks]

wow its perfect so nicely explain . thanks

[@caitygart]

Wonderful explanation, thank you so much!

[@shb9337]

Great helpful explanation

[@rehanulislam2419]

Very nice presentation.

[@rusulabdalkreem9098]

عاشت ايدك دكتورة على هذا الشرح العظيم

[@d-ii-b]

كل الحب لأخوتن في غزة ❤

[@nakatokaren505]

Thank you very much. This has helped summarise my assignment.

[@marwaemad7728]

thank you so much what a beautiful explanation

[@katherineswart474]

excellent video-recommended

[@smartprogramming1107]

Very nice explanation madam keep it up god bless you

[@radhwanabdulla6806]

Jzk well done . I hope you have more videos to watch

[@ahmedali-bk2rx]

بلقرأن شرح رهيب
عاشت ايدكم وربي يوفقكم ❤❤❤❤

[@radhwanabdulla6806]

Great Jehad

[@sylvesterstallone1165]

Thank u very much for this nice explanation😊

[@alesandrom5636]

Great 👍

[@monielf-7340]

Superb work 👏🏽LOVE IT ❤

[@ABDULLAHMALIK]

excellent explanation

[@Call_Ins]

Thanks for the video

[@nabinkumaryadav9351]

Thanks a lot ..it helps me a lot

[@lauriegunn9573]

Nice, but if there anyway we can take NAC orally to offset problems with proloned need for Tylenol for pain??

[@rn6041]

Amazing!Thank you

[@ghadeeradel5471]

ممتاز ,بالتوفيق يارب ,thank you

[@SAPANAACHARYA-gz2xm]

super explanation

[@ghaziturki9756]

Helpful🌺🌺🌺🌺

[@laugh_with_jenny3011]

You are superb

[@harshithcherla9521]

Thank you!

[@ADDZZ361]

Thank you very much sis !

[@hi-s]

Awesome

[@philadelphiachr922]

THANK YOU OMG MUCH NEEDED

[@ahmedayesh3728]

very nice

[@alhumairahassan1643]

good video

[@ayaaya2007]

Thanks ❤

[@sireenma98]

Thank you so much, It really helped me
I'm so proud of our Palestinian doctors

[@brightizogie9734]

Ur voice is very romantic....can't stop watching over n over again....I love u

[@itssomeone4407]

Amazig allah bless you

[@mohsentavakoli6319]

thx

[@sureshnerlekar4713]

What a fantastic way of explanation of this article ,by diagrammatic way and the speed at which it is narrated,to understand the procedure.THANQ.Sameway can you explain ,disintegration,toxicity and treatment of Ibuprofen.normal & overdose.?

[@PharmacologyAnimation]

Thank you so much.
Regarding ibuprofen there is a detailed video in this channel titled NSAIDs which covers the side effects of ibuprofen. That video was narrated by Professor Susan Brain the former Head of Pharmacology Department at Kings College London University.

[@eeshaumer607]

thank you thank you thank you thank you thank you thank you thank you thank you

[@susanclara6611]

Congratulations

[@JohnSmith-ox3gy]

My liver thanks you. I will be more considerate of paracetamol usage and try to limit it to use only when having high fever.

[@sylvesterstallone1165]

A veryyyy nice video
I liked it
But What is the usual toxic dose of paracetamol?

[@MuhammadAli-ml9bt]

wow

[@anwark20]

❤❤❤

[@grmka8623]

Hocam 🧿🧿

[@user-ge3gt4yk6w]

I hop you and your doctor are still okay🥺🙏

[@Ravifddccvf]

Paracetamol is immunosuppressive drugs?

[@radhwanabdulla6806]

Salam from London

[@PharmacologyAnimation]

Salam Radhwan. Have we met before in london? if not I am happy to meet you at KCL.

[@billiewilly401]

will I die from taking 25 im 15

[@nozt0lgia716]

Will I die from taking 4 of them

[@Dr.Thalekkallan]

7.5 gram is toxic level

[@gjzztrrettmmggrrertzhgyena4950]

WwwwwwaaaaaaWWWWW 💚🧡💚🧡💚