Vitamin B12 (Cobalamin) Deficiency - Causes, Symptoms, Diagnosis & Management - Hematology Series
ฝัง
- เผยแพร่เมื่อ 10 พ.ย. 2017
- 😍🖼Animated Mnemonics (Picmonic): www.picmonic.com/viphookup/me...
- With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep...
Disclaimer: I use affiliate links....
►👨🏫💊Antibiotics Lectures: www.medicosisperfectionalis.c... ... Check out my brand new "Electrolytes" course at www.medicosisperfectionalis.c... and use the PROMO code: ELECTROLYTES50 to get a 50% discount. In cases of vitamin B12 deficiency, both Homocysteine and Methylmalonate are elevated.
RDW is elevated in Vitamin B12 deficiency as well as in folate deficiency.
Strict vegans are at risk of developing vitamin B12 deficiency.
To make red blood cells during hematopoiesis, DNA replications require the presence of vitamin B12 and folate.
Folate is stored in your liver for months.
Vitamin B12 is stored in your liver for years.
Vitamin B12 (cobalamin) deficiency = Megaloblastic anemia+ Neurological Symptoms.
Folate deficiency = megaloblastic anemia [withOUT neurological symptoms]
► Get my notes and cases at / medicosis ...
My FAVORITE BOOK to study Pathology and pathophysiology for step 1 USMLE is Goljan, you can check it out here: goo.gl/9ojg6M
(Disclaimer: The medical information contained herein is intended for physician medical licensing exam review purposes only, and are not intended for diagnosis of any illness. If you think you may be suffering from any medical condition, you should consult your physician or seek immediate medical attention.)
Disclaimer: these links are affiliate links so that I get paid a percentage of the sale, to support the channel, however, the customer is not affected as they pay the same price.
Click the Subscribe button to get new videos every week.
To watch all my Hematology videos, check out this playlist: • Hematology/ Oncology
Like my page on Facebook:
/ medicosis
Follow us on Twitter: / medicosis
Follow us on Instagram here: / medicosisperfectionalis
The funniest thing is that I have a playlist containing only mnemonics, yes, MEDICAL MNEMONICS, here: • Medical Mnemonics
Remember: Cobalamin deficiency is a megaloblastic anemia plus neurological symptoms, whereas folate deficiency is just a megaloblastic anemia. If you like my videos, please consider leaving a tip at www.paypal.me/perfectionalis/
► Visit my website: www.medicosisperfectionalis.com/ My Favorite Productivity App: airtable.com/invite/r/2zH40fus/ 📱Save on your mobile phone bill: fbuy.me/q6bMj 🏦 Qbank (TrueLearn): truelearn.referralrock.com/l/...
![ความรักของยักษ์เขียว (ทศกัณฐ์) - เดี่ยว ไออุ่น [OFFICIAL MUSICVIDEO 4K]](http://i.ytimg.com/vi/yCCy-QVHqK8/mqdefault.jpg)
![B12 Deficiency and Neurological Disease [Explained by Neurologist]](/img/n.gif)
► 💊Antibiotics Lectures: www.medicosisperfectionalis.com/products/courses/antibiotics/
💉 📜 My Notes, cases and courses www.patreon.com/medicosis/
😅 If you like mnemonics, try Picmonic: www.picmonic.com/referrals/JK55NQXQQB9JLC119
📕📗 Books that I recommend, www.amazon.com/shop/medicosisperfectionalis
Hello sir i want to know something sir i am herion addict and my vitamin b12 is very low can i use vitamin b12 injections in addiction of herion please help me sir tell me i am a addict by mistake and from india my english is not good but i try you understand my problem and help me sir please reply
Hi dear,
How are you?
I strongly recommend that you talk to your doctor!
@@MedicosisPerfectionalis hello sir i am fine and now in recovery and using cyanocobalamin for increase vitamin b12
Stay safe
Appreciate video content! Sorry for chiming in, I would appreciate your thoughts. Have you heard the talk about - Taparton Sturdy Nerves Takeover (should be on google have a look)? It is a good one off product for Getting rid of Neuropathy minus the headache. Ive heard some incredible things about it and my cooworker finally got excellent results with it.
📝 Download my handwritten notes: www.medicosisperfectionalis.com/
Your channel is a million times more informative than my lectures, thank you so much for everything!
My pleasure 😇
🩸 Hematology Playlist: th-cam.com/play/PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU.html&si=tomFsUjAgOKhOJVq
I firstly appreciate you for your time and explanation, but you need to expand your explanation time than this.
This is much more helpful than a whole lecture at college. Thanks a lot!
Thank you so much 😊
So i've watched 26 videos of this playlist within 3 or 4 days, and i'm speechless!!! I really like how your videos are not that long and by the same time are full or usefull information, plus the way you explain is so clear and you even make me laugh at some words of yours which is quite interesting and positive! I really ENJOY watching your videos. Thanks again and wish you all the best in your life!.
Thank you so much! I appreciate you!
that was great! waaaay more than I anticipated from TH-cam but I learned a lot. thank you.
My pleasure 😇
Vitamin B12 stored in the liver for YEAAAARS
Is it really so?
Your voice in my head...What a amazing teaching skills ...You are the great....
I cant belive that you´ve just made a reference to Oasis, this channel is incredible! Thanks for your videos and effort, cheers from Argentina.
Thank you so much!
I appreciate you!
Would you please help me by sharing?
Thank you! these videos are great. very easy to understand. keep them coming please.
Sure!
Thank you so much for watching!
Thank you for all the videos. They're extremely helpful.
You’re very welcome 😊
@@MedicosisPerfectionalis does this causes sevier back pain in waist
I watch all ad on your vedio,,
i didn't watch it because I am busy but feel that content is perfect,,
Thank you so much 😊
Thanks so much for this incredible explanation with drawings! I really enjoyed it.
My pleasure...Welcome to the channel :)
No man, we can't thank you enough !
This touches my heart! Thanks for your encouragement!
thanks alot doctor you always make it clear👏✌👌
You’re always welcome...Thanks for taking time to leave this nice comment!
Most informative so thank you for taking the time of explaining this in great detail. My Hematologist has written a report to my doctor noting that I have developed mild Pancytopenia and have already started on B12 injections last month. My B12 is within normal range however the HoloTC (Holotranscobalamin)level was abnormal so is still being looked into as to why. I have been having severe Hemiplegic Migraine with other Neurological conditions over the past 3 years.
Best of luck to you!
Just saying, I am a committed vegan and obtain B12 from cereals. Keeping well after circa 10 years. Animal products also have their drawbacks, especially red, processed meats and dairy, best avoided. Good video, thanks and best wishes. 🕊️🧡✨
You’re so cool 👏🫶🏻 thanks for doing these videos. You are very good at explaining and it’s fantastic what I’m learning from your channel ❤
Thank you so much!
American Academy of Neurology:
People with inflammatory bowel disease may also be at risk for
developing nerve damage and other neurological problems, according to
research that will be presented at the American Academy of Neurology’s
59th Annual Meeting in Boston, April 28 - May 5, 2007.
Inflammatory bowel disease includes digestive disorders such as
ulcerative colitis and Crohn’s disease that cause swelling and/or
bleeding in the intestines. For the study, researchers compared 103
people with Crohn’s disease and ulcerative colitis to 51 people with
other digestive disorders, such as irritable bowel syndrome, gastritis
and chronic heartburn.
The researchers found that those with inflammatory bowel disease were
about four times more likely to develop neuromuscular conditions,
including carpal tunnel syndrome and small fiber neuropathy, which
causes pain and lack of feeling in the feet. Those with bowel disease
were also more than six times more likely to also have a disorder called
sensorimotor polyneuropathy, a nerve disease that can cause weakness,
pain, and numbness. These diseases were more common in women with bowel
disease than men.
“Inflammatory bowel disease patients commonly suffer from several other
medical conditions, like B12 deficiency and glucose intolerance. These
nerve conditions we have reported are often not diagnosed by their
primary care physicians,” said lead study author Francisco De Assis
Gondim, MD, MSc, PhD, Professor of the Federal University of Ceará in
Ceará, Brazil, and a member of the American Academy of Neurology.
“People with inflammatory bowel disease who develop new symptoms, such
as pain or numbness in the feet, should see a doctor.”
Excellent explanation of pathogenesis and diagnosis of Vitamin B12
Thank you 🙏
Great work sir🙌 thank you so much :)
Most welcome 😊
So b12 deficiency produce iron defiency too?
08:17 I sense an Oasis fan... geez Dr Medicosis Perfictionalist is just Perfection!!
Who's "Oasis"?
The thanks is for you 😍
You’re very welcome 😊
thank you for the explanation. you forgot to add tests for pernicious anemia including anti-intrinsic factor Ab and anti-parietal cells Ab.
You're right.
You are doing such a great job. Your videos made it so easy for me to understand everything. Thankyou :)
Awesome 👏
Please share!
Very Interesting, thank you,
My pleasure 😇
Yayyy our genius has a video about my presentation title 💃
Thank you 🙏
Pleas biochemestry lecturs like the hematology lecturs that is very helpful thhanks budy
Sure! Stay tuned!
Nice explanation ,Thanks
My pleasure 😇
I m new at your channel it's wonderful thanks for sharing your precious knowledge with us..
May Allah bless uh ❤️❤️❤️
Thank you 🙏
You too!
This B12 is a promiscuous vitamin. First it binds to R protein, then to intrisic factor and in the end to the transcobalamin
Thank you so much!
사토릴리 My pleasure 😇...Sorry for the late reply.
God bless you soo much,I appreciate all your videos and efforts,you're so brilliant and innovative in educating us....I love you. thank you.. I appreciate you ♥️♥️♥️♥️keep up the good work
Thank you so much 😊
I love your videos! Just too funny! :)
Thanks a million! 👍👍
brilliant as usual
Thanks 🙏
Greetings of the day Sir, you are doing a great job. Your lectures are very impressive, precise, understandable & providing great concepts. Sir I want to ask you does Gastric sleeve surgery can cause Vitamin B12 deficiency. Thanks
Yes, it can, but to a lesser degree than Roux-en-Y gastric bypass. Here is a link to an abstract of a systematic review on the subject. pubmed.ncbi.nlm.nih.gov/24091055/
Explaination is good
Always ❤️for your work...
Thanks 😊
Can you please help me by sharing?
I surely can't Thank you enough...
Don’t mention it! Thanks for your comment!
@@MedicosisPerfectionalis I have got University exams in two weeks. With your Help and GODs Grace ill surely pass my exams.. 😊
I certainly hope so...Best of luck to you! Keep in touch!
chat.whatsapp.com/FVtPrBmTgTF9KhmnwXa3fF join this for b12 deficiency
you're the best thanks a lot
My pleasure 😇
"That's the story Morning Glory! "
😂😂
Perfect*__*
Thank you very much 🌸
My pleasure 😇
If alcohol prevents folate absorption and folate deficiency is a cause of macrocytic anemia then alcoholism can cause both megaloblastic (folate def) and non-megaloblastic (chronic alcoholism)?
Big like, as usual awesome 👏.
Thanks 🙏
Colorfully explained woowwwww ..thank you so much😊
Thanks, dear :)
I think I am getting addicted to your videos 🤣🤣
I really hope I can get into medical school and be a good doctor
I feel I understand almost all the concepts you discuss.
Probably the challenging part is to memorise it. I hope I eventually get there.
Wow so you are watching these videos even though you are not a medical student?? Then there is so much hope you will become a doctor...an amazing one!
By the time you will read all this in medschool, you will memorise it and better than your classmates because you will be studying it for the second time again!
@@starrysky1588 I really hope so. But the problem is that I cannot study medicine in my country as they mainly offer it for Highschool graduates. I got admitted in NewZealand as an international student but I don’t have money to study. My university will start in three months and I don’t know how to pay my fees yet lol 😂
If no miracles happen, I may kiss my offer goodbye 🙈
@@ahmadaljazeeri9287 Oh I see! Don't worry God will create some solution for you. Why don't you try in a more affordable country like Pakistan? We have a lot of international students here. And don't worry people in countries like new Zealand or Australia work part time and can pay their fee. Looking at your passion, I wish so much that you become a doctor someday!
@@starrysky1588 thank you Zahra sister :) I will do my best and try hard to one day become a doctor. I appreciate your encouragement so much!
Thank you! SO complex. PS: some chronic parasitic infections eat our RBCs and B-12. Over several years time they cause Malabsorption, chronic fatigue, B-12 anemia. Hookworm, Babesia, and Fish Tapeworm. Case numbers exploding. Doctors do not know about this!!! And the lab tests for them are often false-negative. 😖🤬 Thanks for helping us.
Good to know. Indeed
Exactly, to bad they don’t test here in the states until they’ve caused lots of damage and making tons of $ off of people and insurances. It’s a cheap test and cheap treatment. Unfortunately they recommend we treat our animals for them at least twice a year but not humans even when we are around them on a daily basis. Not including all the other places we can be exposed to them such as restaurants, unwashed fruit ect.. it just doesn’t make sense to me. Thankful we are able to get the treatment for them from a local place that was willing to get us some. One time treatment. One pill then one more 6 weeks later to treat eggs that may have not been rid of. They recommend doing this at least two times a year to be safe.
@@MariaReyes-jp4lb my sister is dying because she can no longer absorb B12. Do you know if it's possible for her to buy these pills before it's too late? Thank you.
@@ccassidy2006 many people have even taken the animal parasite med as it has the same exact ingredients and tested to be safe. She should detox once done with the treatment. Simple.
@@ccassidy2006 I am so sorry i just now saw your question. I hope she healed and still alive and better. I’d try anything. Take ivermectin or fenbendazol (not sure of the spelling but they are anti parasitical and also detoxes heavy metals ect,) hugs ♥️🙏.
What is the cause of low transcobalin? How would you treat this?
Loved it!
Thank you so much 😊
Thanks Dr Mcdreamy!
Haha 😂
I came to this video in the hopes that it would help me understand my B12 deficiency after seeing a neurologist for my symptoms. It was very helpful in understanding the processes; however, I just wish the doctors could tell me the REASON for my deficiency. I’ve been receiving injections but I’d still like to know why.
Sometimes, it’s difficult to identify the cause.
If your symptoms are getting better with the treatment plan, then you’re on the right track. If not, see another doctor.
I wish you the best!
Do you have stomach or digestion issues? Mine is from celiac disease which ruined my stomach lining so I couldn’t take in vitamins and got really malnourished
@@oxyroid I do have GI issues. I go to the bathroom numerous times a day. I normally can’t plan long outings from home because I’m afraid I’ll need to use the bathroom. It’s pretty terrible. I’ve mentioned this to my doctor many times but she has not had an interest in testing me for anything.
@@meggbaker9380 look into SIBO if you haven't already.
Fish tape worm!!!!! Yikes, and I love sushi. However, I'm still having a blast learning stuff I may never need to know. I try not to mention any of this in social settings as it tends to annoy some people. And I don't as a rule mention parasites.
You’re right.
Sir I m getting ur all points i wants to remember these all like a story in mind but I don't know how to make it possible
Allways You are the best. 💖💖💖💖💖💖💖💖💖💖💖💖💖💖💖 thank You very much for this great thing.. go a head🌹🌹
Thank you 🙏
can explain why fetal neural tube defect occur in vitamin b12 deficiency?
You can work on a course to teach Professors how to really teach , Thank you Million times.
I appreciate you!
thank youuuu
Okayyy. this is myy fvrt youtube channel
Thank you 😊
I have some questions - To which protein is cobalamin bound in the liver? Is it still transcobalamin? Is it correct that amylase cleaves cobalamin and „animal protein“ as it actually serves as an enyzme for carbonhydrate metabolism? Thanks a lot!
Desastroes Desolat specify😂🤦♂️you keep on contradicting yourself instead of asking a question
I had no idea what you said but I tried to agree with it😂😂😂😂😂😂
As usually: Good video! Thx!
Yes this is good
Thanks 🙏
Any cure for pernicious anemia?
you are amazing
I am truly humbled...So glad you liked my videos!
Thanks for your brief videos. What is the solution. Please I need reply if uiu have time or is it in your previous video.
Solution of what?
I mean food or medicine for this vitamin in your body thanks.
you are the best!!
Thank you so much 😊
"they will get divorce" XD
+Sheena Marie Tubiano :)
Sheena you are medical student
You're Indonesian?
What are the neurological side effects ?
Peripheral neuropathy is the most common.
Also subacute combined degeneration of the spinal cord, as well as dementia.
Please, can I do just homocistein to see if I have b12 deficiency? In my country there isnt that acid test.
2 years ago i used metformin for weight loss, i lose wieght but got ice pick headach which i never experienced in the past, after that i got grey hair in th area of ice pick headache. Than i stop using metformin and from past 1 and half years im using vitamin B12 sublingual, Now i get less pain and some of grey hair turn blach. But now due to my stress and depression nothing works, my hair turns grey faster. Im 32. Now what can i do. Also premature grey hair is not in my family genetics .
Try to take B12 injections. Very big difference. Your r protein could be not created by body and b12 not absorbed. Move to another city out of depressive environment.
Thanks
+Malak Hamadto Don’t mention it!
Does taking cobalamin under the tongue by pass the whole process with intrinsic factor? Can it be absorbed by those who have trouble absorbing due to their intrinsic factor?
Thank you
You're welcome 😇
We know ,what lovely doctor...
We want u to do CVS videos...what do u think
Will do all topics one day...That’s my dream!
I enjoyed this I have a B12 deficiency, ..will check out the , macrocytic
I wish you the best of luck
Help me to get rid of neurological problem and eye blurness if yours is fixed ?
Love you sir ❤
Why proprionyl CoA replaces acetylCoA?
Excellent video..!
Question, why are 90%+ of B12 supplements sublingual to foster absorption directly into the bloodstream..?
Although the salivary gland production of amylase and gastric acids appears to provide the R-Protein..., the sublingual pathway seems to bypass the R-Protein, protease cleaving of R-Protein, hook up with Intrinsic Factor, and eventual connection with Transcobalamin to shuttle B12 safely to liver and other areas of body via bloodstream.
Stated differently, do B12 sublingual supplements get effectively shuttled to liver and other body areas in proper manner and form..?
Thank you..!
What b12 dose do you recomend for maintnece as a vegan?injectable..
Regards
Liked and previously Subscribed.
Thank you 😊
Hi thank you for this video. I am not in the medical profession and I am getting in touch because I keep getting elevated vitamin b in my blood results even when I am not taking vitamin tablets. It keeps coming up as abnormal on my blood test results but my healthcare professional does not explain why. I heard you can still have a vitamin b definitely with elevated vit b in blood. Could you help at all? Could the elevated vitamin b in blood mean I am not processing it correctly? Thank you so much.
my god.... Every commercial is from headspace... and its making me lose my mind...
Doctor b12 also helps in lumbar canal stenosis??
Hi, would you help me clarify if this anemia is or not hyperchromatic? In italian wikipedia page it says: "it used to be called hyperchromatic anemia" and one of my professors wants to hear "hyperchromatic" during the exam but i'm not sure :/
There is no such thing as hyperchromatic or hyperchromic anemia...It’s self-contradictory!
Why would it be self-contradictory? You could have less RBCs (anemia) but the ones present could be very pigmented (I don't know any condition but logically it's possible).
Check Harrison’s internal Medicine...It states that clearly; when RBCs acquire more hemoglobin, they become larger, not darker! I am also aware that Robbin’s pathology still uses the term hyperchromic!
Fun fact: it's actually quite rare for a vegan to be B12 deficient these days. Plant-based milks and vegan products are now fortified with both B12 and folate
But worldwide, that's a small percentage.
@@MedicosisPerfectionalis You are incorrect. The best source is not from animal products. b12 is made from bacteria....however the world is more sterile now. We used to get our b12 from pond water (water is now treated) and we triple wash our produce (soil )...so it's affect the general population (meat eaters and vegans). Animals are supplemented with b12 so why not get it directly and cut the middleman? go plant based
Do you have evidence that B12 deficiency didn’t exist before we sterilized the water?
D Ou is never heard that one😂 sounds made up
MedicalS
Synthetic supplements😷👎
I have kidney disease 3 stage but the doctor telling me I can’t eat things that have potassium I been eat spinach because I heard is good for the iron but not for my kidneys check that out now I feel weak I had to go to a health store and bring up the iron so tell me what is good that I can eat that won’t affect my kidneys 😩
Medicosis when is the best time to take B12 and can it be taken with B1 and B6 and Magnesium together?
Multivitamin tablets can contain all three...So, no problem.
greatt video
"Thats the end of the story... morning glory" wtf dude 😂😂
Savage mode
Nice video
Thanks 🙏
So, if I am hearing you correctly; basically, I can be a vegan for eight years at a time followed by a meat fueled cheat year?
Also, Love your videos!
ممتاز ربنا يوفقك 👍🏼 و تحيا مصر😅
I have had a ileo anal j pouch and 3 stoma’s made out of my terminal ilium. Is it reasonable it assume that my ability to absorb B12 will have been compromised?
what's the underlying path of glossitis and lemon yellow skin?
Good question, tell us if you looked it up :)
how about other b vitamin (B1,B6,B9,B5) gets absorbed in body similar to B12 ? If someone has B12 deficiency will there be problems with other B vitamins as well ?
All the b vitamins work together, if you are b12 deficient then you need to take a b complex too.
Thank you for another excellent video, liking, sharing..!
I have question toward bottom.
My Feb 2023 bloodwork labs show flags for slightly low CBC values of below, slight anemia:
RBC 4.08
Hemoglobin 12.8
Hematocrit 39.2
MCV High Normal 96.1
All other values normal.
Watching this video, I'm thinking rather than iron deficiency it could be slight B12, Folate deficiency.
I don't have any iron deficiency symptoms of fatigue, pallor, weakness, brain fog, none, all good..!
I do eat a moderate amount of meat, eggs, dairy, with goal of eating more of these. Otherwise, excellent real whole food eat the rainbow type diet for decades.
I'm 65, male, super healthy, great skin color, excellent energy, very active, exercise regularly, BMI = 24, no meds, no medical conditions.
I work in Sprouts Farmers Market Vitamins Department last 10 years and have access to B12 Methylcobalamin, Methyl Folate, B6 combination supplements I could take.
Is there any way to tell if my slight anemia is iron deficiency, or B Vitamins deficiency, other cause (i.e. determine specific anemia type)..?
If I start eating more meat, both iron deficiency and B vitamin deficiencies most likely would be resolved... But it would be nice to pinpoint what's really going on with my scenario.
My doctor blood lab comments mentioned just slight anemia, we'll monitor moving forward.
Sorry for long comment, but wanted to try and set the scene properly.
Thank you..!
according to some studies, b12 stores deplete after 6 months.
Hi iam facing more problems due to b12 deficiency dizziness pins numbness etc I am taking pills of b12 since last 8month but I am not feeling well what to do
So i watched more than 25 lectures of this playlist only today😢tomorrow is my exam
I wish you success!
Awesome....
Thank you so much 😊