💉 📜 50 hematology cases: www.medicosisperfectionalis.com/ 😅 If you like mnemonics, try Picmonic: www.picmonic.com/referrals/JK55NQXQQB9JLC119 📕📗 Books that I recommend, www.amazon.com/shop/medicosisperfectionalis/
Homocysteine in the blood creates a hypercoagulable state. Therefore, all the complications of homocysteinemia have to do with the damage that can be caused by excess clotting: ie thromboembolic nasties such as CVA, DVT, MI, etc. In the blood homocysteine also causes megaloblastic anemia. Now, medicosis perfectionalis, I'm not sure if you wanted the non-blood complications, but I'll go ahead and give those. Excess homocysteine can deposit in the eyes (causing myopia and ectopia lentis) the bones (causing brittleness and deformities) and the brain (causing intellectual impairment). But if your homocysteinemia is temporary due to a folate deficiency, it should not get so bad that your eyes, brain, and bones are affected. That happens in babies with the genetic defect.
Folate deficiency leads to homocysteinaemia. Homocysteinaemia causes hypercoagulable states and thrimboembolitic nastis, Right? Then the same folate deficiency causes pancytopenia due to ineffective Haemopoiesis. This means we have thrombocytopenia due to pancytopenia, leading to increased bleeding due to defective clot formation. Now tell me, does folate deficiency cause hypercoagulable or hypocoagulable states?
@@MovieBox_Prothrombocytopenia doesn’t stop blood from clotting in hypercoagulable state. In hypercoagulation you just need a little push from platelets to start clotting, you don’t need a lot of them. The same thing happens in lupus with APS: there is thrombocytopenia and still hypercoagulable state.
I'm very impressed with your videos. Such a nice, clear explanation of a somewhat complex topic. Clarity, I find, is the most difficult thing to find in videos these days. Some people should absolutely not be making videos. But you sir are gold, very clear and precise. Thanks again, I'm not even a biology or medical student but I understand what you're saying very clearly. 💪
I think the beauty of your video is you try to help us remember things, which unlike many professors I know who are just trying to show you how smart they are, listing out facts after facts in their lectures.
Thank you...I had the same feeling with my professors, unfortunately. That’s why I would like to change that. I want every medical student not to suffer. I will tell the silliest jokes, and make fun of myself so that a student can remember forever...Have fun!
You are great! I have an exam today in two hours, and had 5 lectures of anemia that I couldn't understand because our doctor is so bad at teaching.. yesterday I only studied from your videos and I really feel confident to take the test. Thank you so so much 💕💕
Complications are osteoporosis and fat deposit in blood vessels🙏😊thnk u and I really appreciate ur way of teaching. I am going to have my exams next month ur videos really help me out, always.
HOMOCYSTEINE: Vit B12: homocysteine and methylmalonic acid are both raised B9: homocysteine levels are elevated but methylmalonic acid levels are normal Both used in conversion of homocysteine to methionine as part of DNA synthesis METHYLMALONIC ACID: VitB12 (NOT B9) is required in odd-chain fatty acid synthesis where it acts as a co-factor in the conversion of methylmalonyl coenzyme A to succinyl coenzyme A VitB12 Def gives neurological symptoms Propionyl-CoA and methylmalonyl-CoA are dangerous in high amounts because these odd chain fatty acids will accumulate and incorporate into the myelin of the neurons in the central and peripheral nervous systems, making myelination unstable. The conversion of methylmalonyl-CoA to succinyl-CoA is catalyzed by methylmalonyl-CoA mutase which requires vitamin B12 as a cofactor. Lack of vitamin B12 thus leads to the build-up of methylmalonyl-CoA and propionyl-CoA (a precursor of methylmalonyl CoA) in the neuronal lipids. This is the reason why B12 deficiency is associated with neurologic complications.
CLL is a leukemia, and non-Hodgkin’s is a lymphoma...But, when CLL is accompanied by small lymphocytic lymphoma (CLL/SLL), the SLL is a non-Hodgkin’s lymphoma.
Hi again! I was wondering how come this video and B12 are not part of the Biochemisty playlist? It took me a few mins to realize these B12 and Folate videos were made in 2017, not in 2020, like the playlist. I was waiting for Vitamin C, K, etc etc, I'm sure you have them around too.
Hey 👋 Lisa, How are you? New videos are coming soon to my Biochemistry playlist...I will finish all the vitamins including updates to B12 and folate. Thank you so much 😊
I don't understand why/how goat milk can decrease the intake of folate? By the way, these videos are very helpful even though I am a DVM student not an MD student. Because of that, I would really like to be able to tell future client owners what goat milk can do...
Hai... I really admire the way you make us understand with your beautiful explaination and the graphic illustrations that will stick in our mind... I am request for microbiology video... please... thank you in advance... love you...
How sensitive are serum folate and erythrocyte folate tests to supplementation and food? E.g. I take 500mg oral methylfolate for 5 days. Then I don‘t take folate supplements for 5 days. Then I do a blood draw. Are any of the results relevant? How about if I‘m supplementing methylB12 oral: will this influence folate test results? (asking for a friend)
How does a folate deficiency and a mutation in the MTHFR Gene, C677T strand, impact a persons development? I.e. more high risk for stroke, seizures, seizure disorder? Thank you!
I think I am dying doctor I have low folate. And I am experiencing vitamin b12 deficiency. Numbness. Drop foot. Tititus. Muscle tingling. Neck and back ache and sweating when asleep. Jesus man I think I have an auto immune disease 😊 I need some help man
No grass on your plate, no hair on your head. (Folate&B12) Bacteria & Green Leafy Grasses If your a diabetic cannibal, strung out on prescription meds. Drinking alcohol. More wonderful products brought to you by the medical community.
No difference...Any acid can be referred to by adding the suffix “-ate”: pyruvic acid is the same as pyruvate, lactic acid is the same as lactate...and so forth.
hm... but apart from that are you sure? been nagged on ob/gyn rotations that we must recommend FOLATE not folic acid and it's not the same and that folic acid has been associated with birth defects...?
@@vityazsix If people have the mthfr gene mutation, which is around 60% of population, you're methylation process doesnt work properly then you should take Methylfolate (already methylated form) not Folic acid as its synthetic and will build up in your system causing some significant problems. You can be tested for the gene mutation. Pregnant women especially should know prior so they know what they should be taking. Same with methylcobalamin (B12) not cynacobalamine 🙂
Hey nice presentation, but how can one fix the b12 or folate deficiency properly, like can grains or other foods stop or slow down the fixing of these deficiencies? thanks
Can you explain a case (mine) in which there’s decreased Hb (10.7) and Hct (35.3), MCV is normal (84.9), WBCs normal (5.82), Platelets high (354), Serum Folate 9.9 (normal), Vitamin B12 normal (613), Ferritin 7. Symptoms are very heavy/painful periods, fatigue, foggy brain, sleep disturbances, anxiety, headaches, muscle pain, numbness/tingling/burning sensation in extremities.
Ok...Thank you! What does your doctor think? Also, The numbness/tingling/burning sensation could be unrelated to your anemia...You can talk to a neurologist.
Medicosis Perfectionalis Doctor just thinks I’m anemic due to heavy periods. I’ve already seen neurology and everything is fine in that area. I consume plenty of folate in my food. I do have an MTHFR mutation so maybe I’m not converting things appropriately. But it seems most doctors don’t give MTHFR mutations the time of day. Does my vitamin B12 look ok to you? Are there any other tests I could request to have done? Should I supplement with folate? Which kind of I have MTHFR mutation? How about vitamin B12? Would love to hear your diagnosis.
@@MedicosisPerfectionalis sorry I'm kinda lost. Hmm, so if you have folate deficiency it can affect rbc which will lead to macrocytosis? And alcoholism is another factor too? thank you so much.
My haemoglobin levels normal. My hematocrit levels low (I think) looking at my own blood test results. Red blood cell count little high 4.82 instead of 4.80. Ferritin level low and folate level low. Confused!!!!!!!!!!
Thank you for such a good explanation! But, a small doubt. Can jaundice be caused because of folate deficiency as there can be ineffective erythropoiesis and destruction of erythroid progenitors?
Sir my husband as vitamins B12 and D3 difficiency ... I was carrying at 13 weeks came to know baby was with anencephaly... reason may be those deficiency or no... so that I can plan for other baby .... pls sir pls reply... 🙏
Folate doesn't worsen neuropathy. If a patient has both vitamin B12 deficiency AND folate deficiency, then supplementing folate alone will mask the symptoms of anemia, and if the doctor forgets to supplement B12, then the neurological symptoms may worsen because they are not being addressed.
Thank you! What a great video 🌺 1 question, increase homocysteine leads to thrombosis, and thrompocytopenia leads to bleeding, so what is the final result? 😳
No problem...I just wanted to clarify...So, you have a patient with anemia, thrombocytopenia and increase homocysteine level...and your question is; “will they bleed or clot?”...Is that your question?
Can you please say that why neurological effects not improve by giving folate in vit B12 deficiency , can you please explain the reason 🙏🏻 I've searched a lot ,but i couldn't find it Please reply my comment as soon as possible 🙏🏻🙏🏻
@@MedicosisPerfectionalis Can you please also answer this that how high level of folic acid metabolites can worse function of vit B12 in vit B12 deficiency 🙏🏻🙏🏻
@@MedicosisPerfectionalis And which metabolites they are By which mechanism Please please answer my questions Want to say thanks for your beautiful explanations We appreciate you sir 🙏🏻🙏🏻
Hi! Can you help me with something? I have to little folate (5), my mcv is 95, b-evf 0.44 but my hemoglobin is 14. So this means i dont have anemia right? 😊
💉 📜 50 hematology cases: www.medicosisperfectionalis.com/
😅 If you like mnemonics, try Picmonic: www.picmonic.com/referrals/JK55NQXQQB9JLC119
📕📗 Books that I recommend, www.amazon.com/shop/medicosisperfectionalis/
I wish I can 😢
Im from Syria .. I don't have any bank account ..🚶
Homocysteine in the blood creates a hypercoagulable state. Therefore, all the complications of homocysteinemia have to do with the damage that can be caused by excess clotting: ie thromboembolic nasties such as CVA, DVT, MI, etc. In the blood homocysteine also causes megaloblastic anemia. Now, medicosis perfectionalis, I'm not sure if you wanted the non-blood complications, but I'll go ahead and give those. Excess homocysteine can deposit in the eyes (causing myopia and ectopia lentis) the bones (causing brittleness and deformities) and the brain (causing intellectual impairment). But if your homocysteinemia is temporary due to a folate deficiency, it should not get so bad that your eyes, brain, and bones are affected. That happens in babies with the genetic defect.
Folate deficiency leads to homocysteinaemia. Homocysteinaemia causes hypercoagulable states and thrimboembolitic nastis, Right? Then the same folate deficiency causes pancytopenia due to ineffective Haemopoiesis. This means we have thrombocytopenia due to pancytopenia, leading to increased bleeding due to defective clot formation. Now tell me, does folate deficiency cause hypercoagulable or hypocoagulable states?
@@MovieBox_Prothrombocytopenia doesn’t stop blood from clotting in hypercoagulable state. In hypercoagulation you just need a little push from platelets to start clotting, you don’t need a lot of them. The same thing happens in lupus with APS: there is thrombocytopenia and still hypercoagulable state.
At 1:29 when you say "pay attention please", how did you know I was playing on my phone?
My seventh sense can pierce through your soul 🤫
LMFAO SERIOUSLY
😁😁😂😂
@@MedicosisPerfectionalis
Why 7th what about 6 😊😂
That’s already taken ☺️
Thank you for not slide reading! Thank you for TEACHING!
You are so welcome
I'm very impressed with your videos. Such a nice, clear explanation of a somewhat complex topic. Clarity, I find, is the most difficult thing to find in videos these days. Some people should absolutely not be making videos. But you sir are gold, very clear and precise. Thanks again, I'm not even a biology or medical student but I understand what you're saying very clearly. 💪
Awesome 👏 Thanks 🙏
I think the beauty of your video is you try to help us remember things, which unlike many professors I know who are just trying to show you how smart they are, listing out facts after facts in their lectures.
Thank you...I had the same feeling with my professors, unfortunately. That’s why I would like to change that. I want every medical student not to suffer. I will tell the silliest jokes, and make fun of myself so that a student can remember forever...Have fun!
Medicosis Perfectionalis that’s brilliant :)
Thanks, dear!
i noticed he sounded a word out slowly so you could see the parts of it and understand instead of just memorizing the word
Yup! Indeed
You are great! I have an exam today in two hours, and had 5 lectures of anemia that I couldn't understand because our doctor is so bad at teaching.. yesterday I only studied from your videos and I really feel confident to take the test. Thank you so so much 💕💕
Very nice...that’s amazing....and how was your exam?
@@MedicosisPerfectionalis It was good! I think I'm getting an A+ on this one hopefully ^^
Excellent! Good luck! Please consider sharing these videos with others, it really helps me! And I am truly grateful! Thanks a ton!
@@MedicosisPerfectionalis Sure thing! 🌼
Appreciate it!
Complications are osteoporosis and fat deposit in blood vessels🙏😊thnk u and I really appreciate ur way of teaching. I am going to have my exams next month ur videos really help me out, always.
Homocysteinemia:
thrombosis, eye down and out, intellectual disability, megaloblastic anemia
i was told mine is low. light headed, blurred vision, depression, fatigue i been getting
can food allergies cause deficiency
Hyperhomocisteinemia: Thrombosis, pregnancy complications (abortion, pre-term, neural tube defects), osteopenia
I'm pharmacy student! You help me alot sir.
I'm just so late I have just found your channel. Youre a blessing, thank you for everything you put here for free. 😰😱🖤
Thank you 🙏
ME TOO JUST FOUND THIS CHANNEL AND I LIKE IT A LOT
3:20 the enzyme isn't homocysteine synthase, rather it's "homocysteine methyltransferase" or "methionine synthase"
Yes...All the mistakes in my videos are corrected on my website.
My website is: www.medicosisperfectionalis.com/
you are perfect .... I'm very amused when I watch your videos
Thank you so much 😊
Please be the hero we don't deserve and do a cardio playlist (with EKGs would be perfect).
Excellent! I hope so!
Thank you so much! I wish all my professors were this clear and concise 😊😊😊
Wow...that’s a boat load of a complement...Thank you :)
At 3:15, that's not homocysteine synthetase. It's methionine synthetase.
I highly appreciate your time and effort and contribution. Keep it up
Yes! You’re right.
It’s methionine synthase (or homocysteine methyltransferase).
YOU ARE THE BEST. MAY GOD BLESS YOU.KEEP IT UP
God bless you too...Thanks a million...Please consider sharing with friends, it really helps me...I wish you all the best, and thanks again :)
You are my favorite teacher
Thanks 😊
Please share!
Ur voice for some reason make the info stuck in my head 🤣🤣🤣 thanks anyway
My pleasure 😇
Best explanation, thank you 🙏
Very Helpful video sir
Complication of homocysteinemia is osteoporosis, Parkinson disease, dementia, stroke
Excellent teaching love from India 🇮🇳
Thank you 🙏
Complications of homocysteinemia are DVT & Atherosclerosis
Yes!
Thanks again ❤️.... U make me to memorize all the things right away....
You’re always welcome 🙏
Dear professor
GREAT AS ALWAYS ...
One mistake-
Homocysteine is converted to methionine with the help of enzyme-methionine synthase. U have said Homocysteine synthase
You're right, it's called methionine synthase or homocysteine methyl transferase.
Great video! Thank you for sharing.
Thank you for watching!
HOMOCYSTEINE:
Vit B12: homocysteine and methylmalonic acid are both raised
B9: homocysteine levels are elevated but methylmalonic acid levels are normal
Both used in conversion of homocysteine to methionine as part of DNA synthesis
METHYLMALONIC ACID:
VitB12 (NOT B9) is required in odd-chain fatty acid synthesis where it acts as a co-factor in the conversion of methylmalonyl coenzyme A to succinyl coenzyme A
VitB12 Def gives neurological symptoms
Propionyl-CoA and methylmalonyl-CoA are dangerous in high amounts because these odd chain fatty acids will accumulate and incorporate into the myelin of the neurons in the central and peripheral nervous systems, making myelination unstable. The conversion of methylmalonyl-CoA to succinyl-CoA is catalyzed by methylmalonyl-CoA mutase which requires vitamin B12 as a cofactor. Lack of vitamin B12 thus leads to the build-up of methylmalonyl-CoA and propionyl-CoA (a precursor of methylmalonyl CoA) in the neuronal lipids. This is the reason why B12 deficiency is associated with neurologic complications.
Your video give me huge information.....so I wish you success
Thanks, bro
How can differ between CLL and nonhodgkin lymphoma????
CLL is a leukemia, and non-Hodgkin’s is a lymphoma...But, when CLL is accompanied by small lymphocytic lymphoma (CLL/SLL), the SLL is a non-Hodgkin’s lymphoma.
@@MedicosisPerfectionalis thanks....but how differ between it by clinical feature or investigate??
Because I read difficult distinguished between it
Amazing work and good explanation .thank u
My pleasure 😇
Thanks,nice explanation
Thanks for your nice comment...I appreciate it
thank you very much !!! wish u all the best ♥️♥️
you are truly amazing ;thank you
+Sophie Bai Thank you for your great words! You made my day! Keep Studying hard!
Sophie Bai , agreed!
awesome work sir ....conceptual method.....thanks sir
You are very welcome!
I loveeee urrr video an u😔💞thanks for your work it's really help us alot
My pleasure 😇
Nicely explained
Thanks:)
The answer is b12 deficiency and b9 deficiency
You are the best 🤗🤗🤗
Really very very very helpful !!! 👍
Superb...Glad you liked it!
Thank you so much
My pleasure!
Veryyyyyy good excellent excellent excellent ...........
Thanks a lot 😊
Hi again! I was wondering how come this video and B12 are not part of the Biochemisty playlist? It took me a few mins to realize these B12 and Folate videos were made in 2017, not in 2020, like the playlist. I was waiting for Vitamin C, K, etc etc, I'm sure you have them around too.
Hey 👋 Lisa,
How are you?
New videos are coming soon to my Biochemistry playlist...I will finish all the vitamins including updates to B12 and folate.
Thank you so much 😊
@@MedicosisPerfectionalis You always reply so quick. Looking forward to the updates. We all appreciate it.
Thank you so much 😊
I don't understand why/how goat milk can decrease the intake of folate? By the way, these videos are very helpful even though I am a DVM student not an MD student. Because of that, I would really like to be able to tell future client owners what goat milk can do...
Did you find why goats milk block folate..?
@@ranicefreire2611 Yes: see my note to Ali.
Hi, why neurological symptoms can only be present with b12 deficiency and not in folate deficiency?
Because we need B12 as a cofactor to make myelin.
EXCELLENT. GREAT .THANKS SIR
You’re always welcome. Best of luck 👍
Awesome info if I take metheltrexate and I take folate will this be enough to valance the problem because I can not stop taking metheltrexate
Thanks again
My pleasure 😇
King of medicine ❤
Thank you 🙏
My fdoctor said my folate is severely low
Amazing video 🌸❤️🌸
Thanks ❤️
Thanks
You bet
thank you soooooooooooo much
You’re very welcome! Good luck!
Hai... I really admire the way you make us understand with your beautiful explaination and the graphic illustrations that will stick in our mind... I am request for microbiology video... please... thank you in advance... love you...
Thank you so much...Which microbiology video would you like to see?
@@MedicosisPerfectionalis gram negative and positive cocci...
thx alot
good luck
+My Study You are welcome!
Good luck to you as well!
U are a genuis man thank u so much❤❤❤
My pleasure 😇
انت اكثر من رائع
Thank you 😊
Correction: Thank you Methionine Synthase instead of Homocysteine Synthase @3:17
You're absolutely right
How sensitive are serum folate and erythrocyte folate tests to supplementation and food?
E.g. I take 500mg oral methylfolate for 5 days. Then I don‘t take folate supplements for 5 days.
Then I do a blood draw.
Are any of the results relevant?
How about if I‘m supplementing methylB12 oral: will this influence folate test results?
(asking for a friend)
The co factors to choline is vitamin b1,2,3,5. ❤
I don’t think it always have to be b12 with neurological it also can be zinc or choline.:) 😅
How does a folate deficiency and a mutation in the MTHFR Gene, C677T strand, impact a persons development? I.e. more high risk for stroke, seizures, seizure disorder? Thank you!
I don’t know 🤷♂️
The only thing I know is that folate is necessary for the development of the neural tube (brain and spinal cord)
I think I am dying doctor I have low folate. And I am experiencing vitamin b12 deficiency. Numbness. Drop foot. Tititus. Muscle tingling. Neck and back ache and sweating when asleep. Jesus man I think I have an auto immune disease 😊 I need some help man
Do a blood test. And take folic acid tablets.
2:11 its methionine synthase enzyme not homocyteine synthase right ??
Yes, you’re correct!
I have corrected it on my website:
www.medicosisperfectionalis.com/
Homocysteinemia will lead to a hypercoaguable state
Yes!
No grass on your plate, no hair on your head. (Folate&B12)
Bacteria & Green Leafy Grasses
If your a diabetic cannibal, strung out on prescription meds.
Drinking alcohol.
More wonderful products brought to you by the medical community.
Explain please .. I have hair loss.. so I need b12 and folate to regrow thinning spots??
When u teach I love to study constantly @🙃🙂
Brilliant
Thank you very much!!!! that's very helpful I really wish you all the best ..
Same to you!
what's the difference between folic acid and folate?
No difference...Any acid can be referred to by adding the suffix “-ate”: pyruvic acid is the same as pyruvate, lactic acid is the same as lactate...and so forth.
hm... but apart from that are you sure? been nagged on ob/gyn rotations that we must recommend FOLATE not folic acid and it's not the same and that folic acid has been associated with birth defects...?
www.ncbi.nlm.nih.gov/m/pubmed/24494987/ maybe...I am not sure!
they say folic acid is synthetic, binds to the receptors blockong folate and is not as effective
@@vityazsix If people have the mthfr gene mutation, which is around 60% of population, you're methylation process doesnt work properly then you should take Methylfolate (already methylated form) not Folic acid as its synthetic and will build up in your system causing some significant problems. You can be tested for the gene mutation. Pregnant women especially should know prior so they know what they should be taking. Same with methylcobalamin (B12) not cynacobalamine 🙂
Good speed.
I think methionine synthase rather than homoysteine synthase!?. Am I wrong?
Hey nice presentation, but how can one fix the b12 or folate deficiency properly, like can grains or other foods stop or slow down the fixing of these deficiencies? thanks
He said greens.
@@Noor-jw2tn what kinds of greens?
A friend just told me he creates too many red blood cells and he is supplementing with Folic acid? This makes sense?
How did he know?
. Bloodwork
How does the monoglutamate in the GI convert to THF in the blood?
Can you explain a case (mine) in which there’s decreased Hb (10.7) and Hct (35.3), MCV is normal (84.9), WBCs normal (5.82), Platelets high (354), Serum Folate 9.9 (normal), Vitamin B12 normal (613), Ferritin 7. Symptoms are very heavy/painful periods, fatigue, foggy brain, sleep disturbances, anxiety, headaches, muscle pain, numbness/tingling/burning sensation in extremities.
What was the reference range for ferritin in that lab?
Medicosis Perfectionalis 16-154 ng/ml
Ok...Thank you!
What does your doctor think?
Also, The numbness/tingling/burning sensation could be unrelated to your anemia...You can talk to a neurologist.
Medicosis Perfectionalis Doctor just thinks I’m anemic due to heavy periods. I’ve already seen neurology and everything is fine in that area. I consume plenty of folate in my food. I do have an MTHFR mutation so maybe I’m not converting things appropriately. But it seems most doctors don’t give MTHFR mutations the time of day. Does my vitamin B12 look ok to you? Are there any other tests I could request to have done? Should I supplement with folate? Which kind of I have MTHFR mutation? How about vitamin B12? Would love to hear your diagnosis.
Medicosis Perfectionalis Hello?? You never got back to me.
thank u
My pleasure 😇
What was the answer to the question?
What do you think? I want you to try to answer it first, then I will help you with it...Deal?
I have high b12 1044 and low folate levels
Awesome
Thanks a lot
Regarding cANCA and pANCA
I am confused about diseases related to them.
Kindly would you update us?
Thank you.
Made a video about them in my Rheumatology playlist
Hi! Thank you for this. Just wanna ask, does this also work in alcoholism? I mean folic acid deficiency in alcoholism. Thank you.
Yes
@@MedicosisPerfectionalis sorry I'm kinda lost. Hmm, so if you have folate deficiency it can affect rbc which will lead to macrocytosis? And alcoholism is another factor too? thank you so much.
Alcoholism can lead to folate deficiency which causes macrocytic megaloblastic anemia (high MCV).
@@MedicosisPerfectionalis omg thank you! ❤️ Really a big help. ☺ ❤️ Please create more content. Your videos really help a lot! ❤️
@@MedicosisPerfectionalis I think alcoholism/chronic alcoholism is more associated with non-megaloblastic anemia, not megaloblastic anemia?
My haemoglobin levels normal. My hematocrit levels low (I think) looking at my own blood test results. Red blood cell count little high 4.82 instead of 4.80. Ferritin level low and folate level low. Confused!!!!!!!!!!
Thank you for such a good explanation!
But, a small doubt. Can jaundice be caused because of folate deficiency as there can be ineffective erythropoiesis and destruction of erythroid progenitors?
The process you are describing is not sufficient to cause jaundice...Remember, for jaundice to appear, the serum bilirubin level has to be 2 or more.
@@MedicosisPerfectionalis But isn't that the same process by which mild jaundice is caused in Vitamin B12 deficiency?
Sir my husband as vitamins B12 and D3 difficiency ... I was carrying at 13 weeks came to know baby was with anencephaly... reason may be those deficiency or no... so that I can plan for other baby .... pls sir pls reply... 🙏
Can it cause numbness and pins and needles in hands and feet cos I get that alot
I have folate deficiency but every time i take metafolte i get severe anxiety...
How can i get pass thus problem ?please help..
green veg
My folate is low, but B12 is normal. I dont understand why. Is that possible
I'm 22 but feel sleepy and tired most of the day 😢
My b12 is at 1044, and i have low folate
Sir my son age 3.10 years and having normal B12 and Folic acid levels and increased homocysteine 17.8( Normal
Looove🤩🥰
Thank you 😊
Does low folate prevent b12 being metabolised? Can folate cause worsen neuropathy if supplementation is given
Folate doesn't worsen neuropathy. If a patient has both vitamin B12 deficiency AND folate deficiency, then supplementing folate alone will mask the symptoms of anemia, and if the doctor forgets to supplement B12, then the neurological symptoms may worsen because they are not being addressed.
Thank you! What a great video 🌺
1 question, increase homocysteine leads to thrombosis, and thrompocytopenia leads to bleeding, so what is the final result? 😳
Final result of what?
@@MedicosisPerfectionalis I mean do they have both bleeding and thrombus events?
Who are “they”?
@@MedicosisPerfectionalis people with this anemia, sorry for unclear sentence.
No problem...I just wanted to clarify...So, you have a patient with anemia, thrombocytopenia and increase homocysteine level...and your question is; “will they bleed or clot?”...Is that your question?
I am vegan. I take 1000 mükrogramms of B12 and 800 mükrogramm of 5-mthf quatrofolic folate, is that too much?
Talk to your doctor, I don’t know
Tq
It's called lyme babesia. You welcome
Can you please say that why neurological effects not improve by giving folate in vit B12 deficiency , can you please explain the reason 🙏🏻
I've searched a lot ,but i couldn't find it
Please reply my comment as soon as possible 🙏🏻🙏🏻
Because you need vitamin B12 (not necessarily folate) to myelinate the nerves.
@@MedicosisPerfectionalis
Can you please also answer this that how high level of folic acid metabolites can worse function of vit B12 in vit B12 deficiency 🙏🏻🙏🏻
@@MedicosisPerfectionalis
And which metabolites they are
By which mechanism
Please please answer my questions
Want to say thanks for your beautiful explanations
We appreciate you sir 🙏🏻🙏🏻
i have buring sensation lower back.some time hand.vittamin12normal
so florate test also normal or not
Hi! Can you help me with something? I have to little folate (5), my mcv is 95, b-evf 0.44 but my hemoglobin is 14. So this means i dont have anemia right? 😊
And my b12 is at 300.
What are the normal values (reference range) for your lab?
Also, how about the RBC count, hematocrit?
What are the normal values (reference range) for your lab?
Also, how about the RBC count, hematocrit?
You are my favourite teacher 🥰🤍
Thank you 😊
❤❤❤❤❤❤❤