Brain-Body Immune Axis Controls Inflammatory Response
ฝัง
- เผยแพร่เมื่อ 4 ก.ค. 2024
- Paper: www.nature.com/articles/s4158...
Chapters
0:00 - Introduction
0:48 - Inflammatory insult activates cNST
2:20 - Vagus nerve signals to CNS
2:44 - Look! I’m green!
3:42 - cNST controls immune response
5:34 - Two Vagus Tracks
6:26 - Closing - วิทยาศาสตร์และเทคโนโลยี
On occasion, when listening to videos taped in other languages that are being delivered as though from an automatic rifle, I slow the playback speed to 75% - thereby facilitating comprehension. I thought of that today while listening to Nick's excited, passionate, and time-aware presentation, and I recommend it for any of us who are actively trying to repair the shreds of our own chemistry, biology, and microbiology backgrounds so that we may follow, relearn, and learn from Nick's presentations, which are made at a "graduate-level kitchen chemistry" level of description and explanation, to enable many of us to hang on. That said, this one is particularly interesting, and I look forward to putting on the hip waders to get through the published article from start to finish ... though I may take a couple of weeks to do so! What a catalyst for curiosity! Thanks, Nick.
OMG Thank you! I love this! "Catalyst for curiosity" is possibly the greatest compliment I can imagine.
@@nicknorwitzPhD A compliment, yes, but based on hard fact. Your work here is so important. Thanks!
@@zuleikadobson Thank you!
Just tried slower speed. Excellent!
For those with more masochistic taste, may I recommend the 2x speed button?
I'm a case study for this. No one could figure out my wheat issues. Went to an allergist because I had trouble breathing when I ate anything even cross contaminated with wheat. Allergy tests stone cold negative. Sent me off to gi. Came back inconclusive for celiac. (6+ weeks out from gluten consumption b/c I couldn't do the challenge.) Genetic test was positive. I've been strictly gluten free for years and on a whim decided to eat a roll at dinner. I was fine. Without going into too much detail, my stress level is significantly lower than when i first received the tentative celiac diagnosis.
I'm very happy for you.
Did you get your eosinophil count checked or other inflammatory markers? There are some eosinophilliac diseases.
Same - no celiac but wheat ruins me when I am stressed out, work out and sick from a chronic infection (borrelia). Sometimes I can tolerate wheat and other times it makes me feel like I’m in so much pain I’m being cut by a hundred knives, and all my joints feel as if it’s bone on bone osteoarthritis. Never had my arthritis checked but I don’t think it’s actual bone on bone, but after wheat they just hurt. I used to live by a bread factory and I’d smell the bread on the city bus going downtown and Is get instant joint pain in my shoulders and elbows, when I was worn down it’d hurt so much i couldn’t sleep at night. Just from smelling bread 🙈
I love the way you bring us the latest scientific information ❤🎉😊
So nice of you
Nick, you never cease to amaze me! Toodles!
TYVM! Toodles!
Thanks Doc. Enthusiastically and soberly presented as always.
My pleasure!
Springer has a small book on psychoneuroimmunology by Yan that I had to read in one of my Ph.D classes that confirms this conceptual framework you discussed.
Good move., Abandoning back stories and introductions is the best way forward.
First of there was the Big Bang, then the dinosaurs...
Wow! That was over my head.
Listen again I guess 😉
Dreaddly interesting : ) The concept of modulation is important and almost ubiquitously overlooked, and or misunderstood so thank you for bringing it forth. My delving always brings me back to vitamin d as the major modulatory enabler across the board in all cells, ever so important in immune modulation.
Thanks for reviewing this article, is there any research on diet/lifestyle practical habits which impact the cNST?
Very elegant study. Thanks Nick
My pleasure!
So how do I calm my auto immune disease?
Eat a Proper Human Diet, spend time outdoors in nature daily getting sunshine and fresh air, get quality sleep time, develop a hobby that helps calm you like meditation, yoga, t'ai chi, qigong, etc.
As doing a cold tub soak is not easy (at least not for me), My latest hack, get a 30 gallon trash can, put it in the tub. Fill with cold water. Soak a leg. Soak an arm. Soak whatever is aching. You can soak for one minute and get relief. If you have more time, check out sally norton’s mineral bath recipe (2 cups Epsom salt, ½ cup sea salt, ½ cup potassium bicarbonate, ⅓ cup baking soda, 1 tablespoon borax)- enjoy mixed in a nice hot bath. A snorkel makes it
Even better. You can feel bubbles massaging your scalp etc
Stop eating carbs
Carnivore, fasting, heal your gut wall.
@@Gengh13No, whole foods plant based, SOS diet helps among other lifestyle factors.
super interesting thanks Nick
You're welcome!
There's a whole area of research into psychoneuroimmunology now, very interesting
Could this be an (in part) explanation for the placebo effect?
Thanks Nick for a Gram-positive video! (1/10 Pun). What are your thoughts on measuring LPS to assess intestinal permeability? Similar question for Zonulin, Lactulose-Mannitol Test and PEG 400. Do you think any of these are viable measurements for intestinal permeability? A video on this topic or something similar in the future would be super interesting!
Lol... don't traumatize me. Not a fan of micro... so much SKETCHY! Re the tests you mention, I think they have some utility, especially if tracked over time in an individual to see if various interventions have any effect. That said, they're not that accessible to most people and I'm not sure how "noisy" they are, which could mean a disrupted signal when interpreting the effects of possible interventions... so I wouldn't be too trigger happy about them... but I'm no expert on those tests either.
@@nicknorwitzPhD Haha agreed! And thank you for your insight re these tests; potentially an area that could be explored more to monitor responses to diet therapy and or their associations with other chronic health conditions. Anyway looking forward to the next vid!
Vagus nerve can be regulated (or maybe, optimized control) thru breathing techniques such as Wim Hof’s and others. I think there are studies showing this effect on the inmune system
Nick, I had to erase 300 words of how keto and your LMHR papers have changed my life, by putting my psoriasis and PsA into remission while providing me tools and studies to help educate my rheumatologist regarding my elevated LDL, to be sure you'd read this part.
On the topic of the brain-gut-inflammatory triad and the confounding paradox that both vegan and carnivore diets each have positive impacts on health despite being polar opposites, a great common denominator I found in my health journey seems to be a return to a more balanced omega-6:3 ratio.
Could you explore some of the research done on this specific subject of Omega-3 fatty acids and autoimmune disease and see where the research takes you?
It would be amazing to learn how your mind synthesizes the information, particularly the large study done in the early 2000s on Omega-3s and inflammation.
A BSc with good instincts reaching out to a PhD with better intellect. Thanks :)
Very kind and you and a reasonable suggestion. I have a longish list of things I need to do first, as that would be more than a single paper review, but feel free to reply/ping me about it again later this summer and I can consider what data there are.
@@nicknorwitzPhD
Thanks for the reply, Nick. While I've never found a way to monetize my extraordinary gift, over the years it has become abundantly clear that I have an uncanny ability to get in early on TH-cam channels of people whose pages will eventually grow so large that my comments will become lost in the fray. But for a brief while, when the channel isn't spilling over its own banks-so to speak-these opportunities to briefly interact and communicate with great minds on the bleeding edge of ideas is a true privilege. Hurray to the democratization of knowledge that TH-cam, however imperfect, allows. #CitizenScientists!
I'll check back with you later this summer. Keep up the good work!!!
Did they include Wim Hof in this experiment?
Nope. Sorry.
@@nicknorwitzPhD One of the key novelties of Wim Hof was his example of being able to calm the immune response to LPS.
Not only him but also all of the trained volunteers...
Now they found with which part of his brain he does it.
When i was consistently doing the breathing exercises i felt much less "inflamed" as vague as that sounds. @@ArrosticiniVore
Are there any ways to stimulate this center of the brain currently with retail devices that are safe (something like brainwave caps, or binaural stimulation beats)?
Nice, now let’s look at the receptors that respond to LPS and release neuropeptides etc.
Do people with severed vagus nerve are more or less susceptible to viral diseases? That would be a nice test case to see how important this connection really is and how the body adapts to its absence.
Wonder if stellate gangelion block would have the same effect
Toodles 😂
This is cool science, thanks for the update 👊😎
A lot of people are saying toodles today. I love it!
If you supress the inflammatory response like this, does that increase the risk of other infections and potentially the risk of cancer?
This was excellent. BTW,what happened to your latest lmhr video? I planned to watch it after this one and have searched and searched and cannot find it. Did you remove it?
It was him interviewed by a different channel, I think is the one you’re referring to.
Which one? I don’t think anything was removed.
transcutaneous auricular vagus nerve stimulation!
I need another brain axis to process everything in that video 🤯
Neurogenesis!
This knowledge might also come in handy when the next Pandemic strikes!
With the bottom up signals from inflammatory insults, doesn't that leave us with the "chicken or egg" conundrom as well as a self perpetuating cycle that could start at either end?
I think, generally, the 'start' is the peripheral insult and the top-down process is modulatory; however, there are negative and positive feedback cycles such that if the cNST loop is dysfunctional (impaired) you can get run-away inflammation because there isn't dampening of the pro-inflammatory response nor compensatory up regulation of the anti-inflammatory response.
@@nicknorwitzPhD thanks so much for taking the time to respond 🙏🙏🙏
I think this is fascinating and could have profound consequences for analysis and treatment of auto-immune diseases. There is so much we don't know. Just one quibble: you took your hat off before you tipped it.
Ha... I can take that quibble.
With respect, when presenting/reviewing data, it may be nice to touch on the ethics (or lack of) of animal experimentation
Mice died.
@@nicknorwitzPhDPlease make sure to let us know about the diversity of the lab team also.
Three chronic infections I have (and flare form, from time to time) are of gram negative bacteria …hmm…
LPS? You’ll make Dr Steven Gundry very happy.
Maybe there will be a day when my son's celiac disease can be treated this way.
I think gluten avoidance makes sense of celiac...
All the talk about inflammation, fructose, glucose, insulin and carbs in general is so yesterday. S
What are the implications of this finding
Listen to the end.
"leaverage" lol
Mice with ulcerative colitis, rejoice! LOL
Long covid... i can't believe how clueless all those health gurus are... 🤬
Guy has the sharpest chin in the world
Who, me? Is that an insult or compliment?
@@nicknorwitzPhD Neither really, just an observation. Its a good video btw, its just not a big surprise to me that the brain modulates the immune system, so does consciousness I expect, which is why stuff like laughter helps T-Cells and other processes and stress reduces it.
The chin is just what stood out to me, lol. If anything, its probably a good thing. Don't take it personally. The internet will eat you alive if you take stuff like that personally.
You subjects are pretty excellent and mind blowing. But with all due respect, I feel you might want to improve upon your presentation and audio. It gets a bit cacaphonic minutes into the content. For hooking your audience for longer watching time, I suggest you look into this.
"cacophonic" (with an 'o') if you're gonna nit-pick I'm going to poke back. But in all seriousness, appreciate the feedback. Still relatively new to this (a few months into trying to be serious), and balancing this with research and school is tricky. I appreciate your patience and I iteratively try to improve and work out the kinks.
Picky, picky, picky. This is not McDonald's.
@@nicknorwitzPhD No offence man. Genuine opinion. Guys like you are a blessing here, bringing the scientific knowledge to common populace and other curious minds.
"leaverage"?