THIS is Why There is Confusion about Lean Mass Hyper-Responders with high LDL on Ketogenic Diets
ฝัง
- เผยแพร่เมื่อ 7 ก.ค. 2024
- Chapters
0:00 -- Introduction, 3 goals
1:02 -- Part 1, Defining LMHR
4:10 -- Part 2, LDL-C and ASCVD risk
9:00 - Point 3, Why the Confusion?
25:22 -- Conclusion
Part 3 features: Spencer Nadolsky, Layne Norton, Mohammed Alo, Thomas Dayspring
Videos:
LDL lowering: • How to LOWER LDL on Ke...
Response to Layne Norton: • Dr Layne Norton gets a...
Meta of RCTs: • NEW STUDY Proves it's ...
OreoVsStatin: • Oreos are the Most Pot...
Discussion on PlantChompers: • High LDL on a Keto Die...
Discussion on Physionic: • When Oreos outperform ...
TheProof with Dave and William Cromwell: • High LDL Cholesterol o...
Paper References
Meta of RCTs
ajcn.nutrition.org/article/S0...
OreoVsStatin
pubmed.ncbi.nlm.nih.gov/38276...
Lipid Energy Model
pubmed.ncbi.nlm.nih.gov/35629...
LMHR paper in CDN
cdn.nutrition.org/article/S24...
JCL Editorial
www.lipidjournal.com/article/...
Cooper et al. BMI, Thyroid, LMHR www.ncbi.nlm.nih.gov/pmc/arti...
LDLR in mice in ketosis
pubmed.ncbi.nlm.nih.gov/26498...
LDLR in humans on LCHF
pubmed.ncbi.nlm.nih.gov/30408... - วิทยาศาสตร์และเทคโนโลยี
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I was so engaged in the delivery and content of your argument that when finished I left the site dazzled but realized I’d forgotten to hit the thumbs up so I came back & did. You’re a warrior, man, of the truth and you bring the data & studies to support your assertions and counter arguments. It’s a beautiful thing. I’m counting on people like you to change the medical world for the better for us all if they don’t crush you first. They are coming at you and you did an excellent and bold job pushing back. Keep at it my friend and thank you for doing so.
Deeply appreciated!
You make it so clear that only an MD can misunderstand it!
Funny. In all seriousness, I don't know how I can be more clear. I hope you found my "accusations" at 9:00 minutes and beyond well reasoned, if quite direct.
@@nicknorwitzPhD Paraphrasing, "Here's the published research; I've cited it for you more than once; you're not only ignoring it, you're claiming that it doesn't exist. Therefore, you're just flat wrong." How much more well-reasoned could you have been?
Laughed out loud.
Lame Norton isn’t a MD
@@robbanks1436 Yeah I was wrong LOL
Your frustration is long overdue and frankly surprising it's taken this long to surface. Don't allow these nay sayers get to you the work you do is so needed and appreciated. Only with clear verifiable and unbiased data can we learn and understand what the facts are. The false data is getting so bad that many people don't believe anything a MD has to say.
You are so right about that. My distrust for standard medicine has been growing in leaps and bounds as I see it reflecting more ignorance, corruption, and greed all the time. So very sad for our country. Yet, I still have hope but we all must speak out and confront them. We need a country-wide organization that represents medical patients on a whole range of issues with an education arm to make the public aware of things and organize those that have concern,a lobbying arm of keto and carnivore people and other Americans who want to see more transparency, functional doctors in insurance networks, naturopathic doctors, real supplement accountability, a quarterly magazine to educate members of our organization of new upcoming issues and old ones not adequately addressed. And more.
"getting so bad that many people don't believe anything a MD" ... that's - sorta' - what I'm so afraid of and pointing out ... when egos are so large they can't see their own clear misinformation, it gets called out, and discredits the community ... dangerous situation
Don’t quit Nick! We need doctors like you to explain this stuff. And yes ..we can learn more from doctors on TH-cam because our doctors don’t care to take the time to learn or want to bother to explain things to us. I have absolutely zero faith in mainstream medicine anymore.
This vid should be watched by everyone in medical school. What a great presentation. For me, as a non-scientist, non- medical person, such a presentation helps me spot and learn to identify the useless crap in arguments.
no way
Thank you. Appreciate it.
Regarding Dayspring and others mentioned here, this is human ego on full display. This represents the inability to backtrack and say, maybe I was wrong or what I believed was possibly wrong. The curiosity has left the building. To Nick and team, nicely done and very necessary.
Even those who are Dayspring fans can't deny his arrogance is a bit "much," and there are some examples here where he's clearly speaking as an expert on something he hasn't taken the time to properly research. That may sound arrogant coming from me, but for those who watch the video in full, I think it's undeniable. Doesn't mean he isn't smart and informed on other matters or in general, but... here... on this specific topic...
Solid intro. Thanks for not wasting my time. The doctors making mistakes publicly, need to be called out and given a polite opportunity to retract or correct. And if they persist, they must be held accountable. Maybe create a LMHR Disinformation Hall of Shame.
"The doctors making mistakes publicly, need to be called out and given a polite opportunity to retract or correct. And if they persist, they must be held accountable." 100% agree.
I’m content to let you scientists fight out the truth about LMHR’s and LDL. Thank you for your work. Meanwhile, I will continue to live my life in the healed condition from day-by-day agonising IBS (and many other issues) Fatty meat ,eggs and a little fish for me👍
I completely understand where you are coming from, per my commentary about my own background mentioned just after 9 min into this video and covered/disclosed elsewhere.
I went full Carnivore in December 2023 and I have lost 35lbs in 3 months to get to my target weight. I wanted to be healthy again and get away from Carbs. I am now off all my blood pressure meds, I feel young again. My Migraine headaches are gone and now I'm on a Keto Diet. My Doctor was concerned but she had been on a Keto diet for 3 years and understood. She wanted to do an EKG and blood work as she was concerned. I just went on Medicare and physicals are not a thing. So I have no idea what my numbers are but damn I feel good now. I wake up in the morning and feel like a million bucks. When I was eating the IC it diet I always felt lethargic. Once my Doc saw my blood pressure she told me to quit my meds. I'm happy and won't change a thing. 😄
That's an encouraging personal story for me Annette and congratulations on your success. That's a situation I can relate to personally having gone keto six months ago to address an IBS (SIBO) condition that developped as a result of a food poisoning instance. However, I have suffered a relapse of my symptoms three weeks ago, so I'm not completely out of the woods yet.
@@JesusMartinez-mk6fc I certainly don’t have all the answers and am forever ‘tweeting’ and experimenting with what I eat. I don’t think my gut is totally healed, but am sure I am more comfortable eating high fat / low fibre foods. I’ve spent years and years trying to discover why eating food ends up causing me gut pain, all the whole trying to eat ‘healthily’ according to nutrition advisors and guidelines. Good luck with your journey.
Your integrity and clarity is sky high. Loyal to the scientific endeavor. Great work.
Thank you very much!!!
I actually think that his integrity is very suspect. He says nothing about all of the carnivore doctors that say that LDL-C is meaningless and cite LMHR as the justification for their proposition. I don’t think he’s a charlatan in the same way that they are but birds of a feather.
@@davidzip8841 why is Nick responsible for any of those folks? How does “Birds of a feather” apply when Nick takes bgreat pains to distinguish his view from others?
Its difficult to get someone to understand something when their job depends on them not understanding it.
I'm not sure I'd ascribe the intent to mislead to all these cases... in many I think it's as simple as ignorance. It's hard to know intent
Exactly!!!
Keep it up, Nick!
Here is why. They're scared! A lifelong career in what you believed is wrong is a huge mountain to climb if motivated to do so.
As I battle with my PCP who thinks I'm going to drop dead of a heart attack despite all the metabolic improvements I have made. I think of her position being governed by protocols established with outdated studies, if she changes her position what are the liability implications of patients, insurance and big pharma contracts.
So keep it up! That mountain needs to be climbed! ❤
LMHR is a very specific phenotype for which high LDL may have a different implication. NN is not seeking to disprove the entirety of the lipidology field. This is a specific case. Many of you need to slow your roll.
I just dropped all my meds because my doctor is annoying and I don’t want to talk about it anymore. They don’t deserve my time or money. He’s fat and I’m not. Who should be telling who how to eat?
I respect people who say “I don’t know” because most of them will persevere in finding out. Science is all about finding out. I am intensely interested in learning more. Thanks NN.
You're welcome!
I have high HDL, high LDL, trig below 70, BMI 21. I am not worried about high LDL because on balance of all risk factors (obesity, high blood pressure, UPF intake, prediabetes - all now reduced/resolved) I would rather have high LDL than multiple other factors with a much higher association with CVD. My LDL is way up, but my blood pressure is way way down. Along with GERD, arthritis, sleep apnea, depression, psoriasis, all resolved.
This is a very clear hypothesis; maybe that's why some doctors can't grasp it?
What if I make into a music video?
@@nicknorwitzPhD tiktok dances are popular with Doctors and nurses....
@@nicknorwitzPhDBe sure it doesn’t have more than 3 chords.
Absolutely brilliant Nick! Very nuanced, polite, yet challenging to detractors. Well done!
Thanks for this. And thanks for listening
Fantastic job! Too many are "Don't confuse we with the facts! My mind is already made up!" and or their ego wont let them change their stance on the subject. If this video does not work, keep doing what you and Dave are doing and move forward and ignore the peanut gallery.
Yes! Thank you!
They will continue to attack you, you are young, intelligent, not willing to simplify follow, but actually have a scientific mind that looks for facts. This goes against their rules. Please stay strong, the world needs you and you are being an positive role model for others like you. At this point in human history when society has lost all trust in the medical profession, you are a ray of hope.
☀️☀️☀️☀️☀️
Thank you, Nick, for this Clear Restatement of your position and current science! Carry on!
I will carry on. People are finding surprisingly hard to beat down 😅
You should have 10X more subscribers. Your content is far more grounded in intelligence, as well as critical , discerning, and nuanced thinking than anyone else in this space! You're pushing back at something that you said you're beginning to find frustrating. Well I find it (the willful ignorance and misleading and misinforming criticisms) infuriating. I am SO glad that someone of your intelligence and intellectual honesty is weighing in on this topic.
"You should have 10X more subscribers. Your content is far more grounded in intelligence, as well as critical , discerning, and nuanced thinking than anyone else in this space!" You're making my day!
It seems to me that jealousy makes people nasty. Keep it up Nicolas. You are doing excellent work.
Thank you very much!
Best video ever! Finally someone who stands up against the corrupt mainstream doctors! 👍👍
Glad you liked the video ☺️…
It is clearly corruption when doctors choose their easy paycheck from the drug companies over their patients lives.
Recognizing the tremendous knowledge of the functional need of the human body for LDL, and how the levels of LDL respond to varying dietary and health factors, I believe that we should agree that LDL is a very important, indeed a critical component of overall health.
You are my favorite nerd to watch & I watch a lot of them. You are engaging, respectful, knowledgeable and come across so genuine and educated. You know youre shit and you stand up for yourself against some major assholes (Layne). Thankful for your content! 👏🏽
Thanks 😊
Thank you for a science logic based argument. Excited to see your voice rise because you are greatly needed in this world.
More to come! And thanks!
Kudos. You are encouraging intelligent, unbiased discussions in the hope it will lead to better health outcomes for both individuals and the general population.
Thanks 😊
Well-crafted address to set the record straight! I think I've watched every video on your channel. I appreciate your diligence and rigor!
Thank you so much :). I appreciate it!
Thank you for such a clear and concise overview of the disperate position that your detractors have taken. It clearly show them up for what they are. Keep up the superb work you do.
Thank you kindly
An entirely logical response which is easy to follow and understand. Well done, Nick. I'm glad you took the time to produce this piece as it helps many who are influenced by this specific misinformation. The misinformation is resultant from either ignorance, ego, monetary reasons or a combination. But whatever the reason, it's harmful of them to mislead. I hope you keep us informed of any responses by those individuals. Thanks.
Appreciate this. It’s sounding like I achieved my goal and I hold out hope, especially for Layne and Dayspring
Conversation and debate are not dead despite what you see in colleges. These individuals, Doctors, should be amenable to an open discussion regarding this very important topic. They are hiding in plain sight and it’s quite obvious why. Keep up the outstanding work. Thank you
Thank you for watching, evaluating and engaging openly and honestly
Nick I love your content , knowledge and N-1 experiments. To be brief I have been following you, Dave Feldman and all others in the LMHR community for the past 2 years. I myself am a LMHR, 58 years old with a CAC score. Ugh 😑. However and this is a big HOWEVER. I have only been low carb for 2 years. I went low carb after receiving a CAC score. Prior to going low carb my LDL was always 100 or lower often in the 80’s and these #’s of course are all un pharmacologically derived. I have my lab work going back 15 years as I kept all my annual lab reports. So, I have deduced my CAC score was NOT from LDL but from damage I caused from 56 years of eating SAD. Since going Low Carb I have the trid and have then being keeping my LDL low by adding back carbs roughly 50 to 60 grams a day and now my LDL is around 140 versus 200 when I am less than 20 grams a day. Ok, here is my question. When I get my blood work all numbers are great. Low fasting glucose and insulin, high HDL 70 ish and low Triglycerides 42. A1C around 5.4 LPIR less than 25 etc. But my oxLDL and LpPla2 are high / outside of range. My theory and I am not a medical professional or a scientist 😊 is my LDL is oxidizing because of the glucose spikes I get when adding back carbs. Yes, I wear a CGM and will get 140 and 150 spikes when I eat the carbs. I am insulin sensitive because I go back to 95 after the carbs which I include with the meals just to get my LDL to under 200. I have tested this and my LDL averages around 140 if I have roughly 20 grams of carbs with each meal. So what are your thoughts? I am theorizing the glucose spikes are damaging my LDL and causing me to have high OxLdl. My next experiment is to go back low carb under 20 grams a day for two weeks and then test OxLDL. I am pretty sure my LDL will go above 200, my triglycerides will be in the 30’s and my HDL will be above 80. I have a BMI of 23. When I went Low carb 2 years again I went from a 34 waist to a 32 and now have all new clothes and not to be vain but effortlessly have 6 pack abs. Something I could NEVER achieve eating SAD and working out like crazy. I have never heard you or Dave put your brain power to glucose spikes possibly damaging LDL. If glucose spikes are damaging then I would NOT ADD BACK the carbs just to lower LDL. Thought 💭?
If low carb sends TG and HDL in the right direction, it will NOT be far-fetched to assume the LDL is equally in the right direction. The problem arose because LDL has been labeled "bad cholesterol " by the medical community. The nuances in the case of LMHR should be considered. It is well-known that inflammation is at the root of many diseases including cardiovascular and metabolic ones. Does cholesterol, a saturated lipid, cause inflammation? Saturated lipids do not have bonds that enable reactions and hence unable to cause inflammation.
Interesting perspective. Dayspring hereby labels you “LDL Denier and Heretic”.
"The nuances in the case of LMHR should be considered." - With this, I agree fully.
We should ignore the last 100 plus years of science?
@@danielmccarthyy Actually Dayspring hasn't called me anything directly. He has historically avoided any engagements with me in any form. It's an interesting behavior pattern.
@@northerncoloradotransparen1454 Please elaborate.
Great delivery of forward thinking arguments for the new sciences of cholesterol and lipidology. Keep presenting the data and studies, the medical world will be changing finally, and you will be one of the pioneers for this along with many others. Thank you for all the work you do!
Thanks a million
I see people like NN and DF as explorers. Rather than denigrating them, real scientists should be cheering them on.
I agree… not that I’m biased or anything 😂
Hurts them to lose those easy kickbacks from big pharma. That corruption won’t fall easily.
@@nicknorwitzPhD Just keep doing what engineers do. Figure stuff out.
Great presentation and happy you kept your calm
Thanks... I wonder what % of viewers agree?
Thank you for your research. May you be blessed.
Thanks! I feel that way most days
I’m glad you are keeping this. Attia seems to be misusing his position by simply parroting Dayspring. & it's obvious that Daysprimg is not listening. Hopefully they will see their errors, correct them, & move on.
Nope… he’s not listening 🙉
THANK YOU SOOOO much for this refreshing video!! I am one of your superfans!!!!
AWE! You're making my heart melt 😉
@@nicknorwitzPhD Is that a good thing for metabolic health?😜
@@sunshinemama9143 A molten heart... don't think so... is there a med for that?
I don’t even understand the debate. Let’s just say hypothetically that the lmhr cohort is at risk, what’s the solution? It’s obviously not the standard diet and pharmaceutical protocols because that’s clearly not working for the majority of people.
The debate is that there are a group of individuals that hate keto/carnivore and will deny any evidence of positive health outcomes from those dietary patterns. They will frame any study suggesting such as a scam and pseudoscience and any attempt to convey or discuss the nuanced science as grift.
Basically, they think the LMHR phenotype, the Lipid Energy Model, and all of Nick and team's work and literature is made up, pseudoscience grift.
One sweet potatoe per day is ,apparently, sufficient to prevent ldl elevating further in lmhr's. The carbs would partially decrease ketogenesis and its therapeutic affects , though.
the majority of people don't actually follow the recommended diets, they eat the SAD diet
It's good to see this all in one place. I've bookmarked this one.
Sweet!
This might be my most liked post you have done.
Very clear on what your goal is and your view. And how a few doctors are either ignorant or are “well let’s say not being completely honest”.
Thank you
Glad you enjoyed it and thought it had value.
Thank you for the work you are doing.
My pleasure!
This is a good video. Rational. Calmly presented. Nuanced. Subbed.
Welcome aboard!
Thank you for all you do!
My pleasure!
Excellent and clear!
Glad it was helpful!
This was awesome. Clear, to the point, unflinching. Much needed in this medical / industrial complex. Bravo!
You’re welcome
Brilliant....Still following everything you put up because I'm a LMHR.
Glad to have you following
👏👏👏so good!! Grateful for your very important work!!
Thank you too!
You gave us, in the past, how to eat and lower our ldl, which I appreciated.
I did. Thanks for noticing.
Thanks Nick appreciate your candor.
Always!
Love your content. To me a true scientist questions his current beliefs constantly and is always looking for evidence to contradict his beliefs. That's how knowledge grows. Anyone who doesn't do that loses my respect
Much appreciated!
Love a classy clap back 😬🙌🏾
👏👏👏
Thank you for the work y'all are doing, and for making the effort to inform us, which mainstream medical would never do!! I am a hyper-responder.
There are more and more LMHR (or there are more and more being noticed...)... awareness is generally good imho
Amazing video Nic! Sometimes a man has to do what he doesn't like but he does it because it's necessary. Congratulations! You've always been quite clear and nuanced in all your videos. This video was no exception and dare I say, you've taking it up quite a huge notch. This video is super clear, transparent and nuanced and a bulletproof response that draws the line on the sand to those opposing critics - most of which I've watched unfairly ridicule you - and that are not only perpetrating a disservice to the scientific community but to the advancement of learning and science. Keep up the groundbreaking work! 👏🏆👏
Appreciate that Jesus.
Excellent discussion.
Cheers!
A closed minded Doctor can be critically dangerous. Their egos are shameful. Thank you, Nick. Keep up the good fight!
🥊🥊🥊
Stuff like this makes me appreciate how people like Dr Mike handle disagreement.
Thanks for your work
you're welcome :)
Thank you for teaching me!!!
Welcome!
I think I’m a LMHR, too.
13 months carnivore, refused all medications.
Thank you for all you do , I loved this video 😊
So glad!
I love your pursuit of truth. It comes across in your vids. This is the kind of world I want to live in where actual science drives the narrative. That said, there are those “professionals” with their version of truth which, I think, is more an expression of position, ego and righteousness than it is of observable facts and ground truth. We are seeing an upwelling of that in recent years.
Maybe the best way to deal with this is to just maintain YOUR position of truth and let those who resonate with truth find you, and let those who resonate with ego find them. Both are OK, but I just know the kind of world I want to live in.
Very nicely put
Very informative, and fair to tour detractors.
Glad you think so.
Maybe the problem is you cannot teach an old dog (Dayspring, for example) new tricks. I recently met with 3 different cardiologists in a hospital after experiencing a new (relatively minor) angina episode. I've been eating low carb and more animal-based for about 5 years, and the stricter I've become, the higher my cholesterol has risen. I'm lean and similar to an LMHR but not quite (LDL-C 250 mg/dL, HDL 55 mg/dL, Trigs 75 mg/dL). I did have a triple bypass in 2016. Now, 8 years later, all 3 cardiologists felt my current angina was from my elevated cholesterol. I introduced the LMHR concept to all 3 cardiologists. They weren't interested in hearing what I had to say but I told them anyway. I ended up getting a 64-Slice CT angiogram that revealed all my bypasses were open and clear. I sometimes wonder whether they found out about my good looking CT angiogram and what they thought of it. My guess is they never followed up to see and just moved on to their next patient, carrying on with their standard beliefs. I did get some feedback from my family doctor, however. He's more familiar with me than the other cardiologists because I've been his patient for about 10 years. He knows I don't take a statin and never will. He reviewed my CT angiogram results and agreed that they revealed my bypasses were all looking great. Then he said... are you ready for this?... he said I should take a statin to lower my cholesterol. Ouch! NOTE: The general consensus is that the angina I experienced was likely on old, "native" artery that was getting tight and blocking blood flow to a small region of my heart. The angina has gone away now, maybe on its own or in part because I am now taking baby aspirin and a low-dose beta blocker (which can help alleviate angina).
" I introduced the LMHR concept to all 3 cardiologists. They weren't interested in hearing what I had to say " ... that's unfortunate. Irrespective of what their perceptions might be, the fact that a patient walks away with the notion that his doctor's are close minded to learning more is... telling
@@nicknorwitzPhD Yes, it's "telling" and it's pretty darn common. And yet quite a few doctors I follow changed their entire paradigm of treatment simply because a single patient told the doctor what they did and the doctor listened. A few that come to mind are Dr. David Unwin, Dr. Brian Mowll, and Dr. Steven Gundry (patient Big Ed).
Nick, I've met Dave a few times. He applies more caveats to his position than a teenager trying to explain a scratch on the family car!
I have been one of those Carnivores: "I don't care about My LDL. It was 200 when I was 19, and it's 250 now that I am low-carb. I am NOT a LMHR. My wife appears to be!" But she has a CAC of ZERO. And the doctor no longer threatens her with a statin (She is like 360+ LDL, normal weight, not low-carb, but usually in ketosis!).
Part of the problem... Doctors have lied to us about SO MANY THINGS. Our trust is gone. And as a layperson, I do see your results and I think "It doesn't matter... Blaming LDL for the plaque is like blaming firemen for fires, or scabs for cuts!"
But the more I listen, the more nuanced this becomes. It's almost like the message needs to be: "LMHRs: We don't know if it is safe. And even if our studies show that it is/might be... It does NOT say anything about High Cholesterol in NON-LMHRs. Or in unhealthy people eating a SAD diet. And it will PROVE NOTHING other than what the LIMITED data will show us for a small sample size of people!".
These studies are interesting because CONFUSION about why something isn't doing what you expect (think particle physics), it usually means you are on the verge of discovering something (a new particle, or in LMHRs... a different reason for LDL).
Finally, Malcom Kendricks has some numbers about statins. 30yrs of statins might add 2-3 days of extra life... Are they worth the side-effects?
"He applies more caveats to his position than a teenager trying to explain a scratch on the family car!" -- LOL!
Thank you so much for this video!
You are so welcome! 🙏🏻
Chris McCaskill was having (yet another!) go (yesterday) at the (in his opinion) “limited” scope of your LMHR research study results / findings once again yesterday. This division of thought / belief / re LDL doesn’t seem to be going away anytime soon!
I like Chris as a person. He's coming from a different angle. I texted him this AM aim to follow by encouraging him to watch and engage on this video and the topics covered herein. I realize it's going to stir emotions, but I hope the net effect of the discussion that arises is productive. I am optimistic. I feel like I was direct, but fair.
@@nicknorwitzPhD That’s brilliant Nick. Let’s hope these silly social-media driven diet divisions and associated cherry--picked science data can be steadily outclassed by such courteous, intelligent debate.
Thank you for treating this in a sane and logically consistent way. To be honest I've stopped listening to Layne after initially listening to his work intently. The loudness wasn't being helpful. So I'm instead going back to the papers and trying to read carefully.
Good for you! Hopefully you feel I can do better
Awesome video and
Very informative
Glad you liked it
Excellent presentation. . 👍🏻
Thanks!
Could you do an explanatory video about the “ normal “ population please. You explain things so well.
I am not capable of understanding the technical papers and my Dr does not explain.
Quite happy that I am in no way a lean mass anything but I do need to be keto for T2 diabetes.
Stay tuned for my conversation with @theProof (Simon Hill). I hope we will cover the distinction about LDL/ApoB in the "normal" population vs LMHR in depth, approaching it from new angles with new articulations. I'm counting on him to "push me" there.
@@nicknorwitzPhD Looking forward to that discussion, I am relieved when two people from opposing views are able to sit together and talk science. You rarely ever see that, unfortunately..
Finally someone honest and most importantly - non biased and prejudiced .
Appreciate it :).
great talk!
Thank you very much Mr Entertainer 47
Thank you for your presentations & for providing links to the papers. I asked another TH-camr to provide links to her cited studies. She gave me the excuse that she can’t because TH-cam frowns on this practice. She asked me to email her. I now assume she has nothing to back up her video presentation on hormones. Thanks for being honest & informative!
You are so welcome! 🤗
Dr Nick, always enjoy your videos. Straight and to the point! Once you have solved all of the world's cholesterol problems 😉, would you consider doing a video on MTHFR? I recently found out I have the heterozygus gene mutation and am in the process of doing research. It's hard because there are very few people I trust to provide good information on this topic. You would be the perfect resource!
Great content!
Appreciate it!
all of this drama over something in which there are no guarantees. I truly appreciate your scientific curiosity Dr. Norwitz.
you're welcome!
Layne is still reviewing his community college books….
Excellent video. You are probing for answers I have searched for for years. I would love to see Dave back on Peter Attia’s podcast (or you) to discuss the topic.
I think it will happen...
HAHAHA I love it - Science Waaar!!! But seriously its nice that you are trying to have a proper discussion.
Glad you enjoy it! More to come.
I needed this. I am up and down as to what to do with my extremely high LDL and ApoB I am this category for sure. My doctor is having a melt down.
THANK YOU! Been Carnivore for 14 weeks. Just got a thyroid & lipid panel (NOT fasting) and the numbers freaked me out! I've never cared about cholesterol until getting my results today! 617 total, LDL 456, HDL 111- BUT TG: 210... although I had just eaten 2 eggs/3 pcs bacon & coffee with protein powder. Should I be concerned? (I'm hypothyroid, menopause & 10 lbs overweight)
There’s no helping Dr. Alo, the most ridiculous doctor on the internet.
High praise 😅
That guy is something else. 😅
He blocked me on social media because I consistently challenged his posts. 🫠
That guy! 😅 He blocked me on social because I kept correcting the misinformation in his posts. Total clown 🤡
Thank you Nick, I am a LMHR. Doctor is going to give me Statin.
When it becomes about 'likes', 'shares' and 'views' and not about imparting a message. There are too many smart folks who started off in the right place but became ego driven 'personalities'
Super clear Dr N! Loving your work as always 😍 Haters always gonna hate.
Until you make them your fans 😉
@@nicknorwitzPhD 🥰
Thanks for slowing down your speaking tempo. For us layman trying to learn it is helpful.
You are welcome
Hello Nick! I have two quick questions:
1. Does the LMHR study consider the formation of soft plaque? I've read somewhere that plaque formation was not a good predictor, supposedly.
2. Is BMI not a bad measurement as it leaves out people with a lot of muscle?
TY so much for your work!
1/ Yes includes soft plaque.
2/ BMI isn't as good as body comp, but we are limited but he available data and for large populations BMI is pretty good.
I was wondering your views on the following case study:
Takemura et al. 2024,
"The impact of dietary fat type on lipid profiles in lean mass hyper‐responder phenotype"
Clin Case Rep. 2024 Feb; 12(2) e8485.
Note, the patient did not have the LMHR triad of high HDL-C & low TG, had the inverse (had high LDL-C and high TG in response to a ketogenic diet, but lean (BMI 23). HDL-C remained low (heavy smoker)). What was interesting is that high TG levels dropped in response to switching from high saturated fat to unsaturated fat ketogenic diet, although LDL-C remained high. It wasn't until carbohydrates were introduced that LDL-C dropped to normal range, yet TG levels remained relatively unchanged from the unsaturated fat ketogenic diet levels.
Interesting all the different individual variables and responses to diets.
Best video yet. Unfortunately, air tight, irrefutable spiciness in regard to many not willing to address new information is fully necessary.
Necessary but not sufficient
I am wondering if my diet classifies as ketogenic? Though my carb. intake is moderate, I consume my calories within a 3 hr. time period. I estimate that my body has consumed its glycogen stores after roughly 16 hours and is in a fasting state for about 3 hrs. I ask because my ldl is in the 2-300+ range. My BMI is low. In short, does a daily true fast override moderate carb. consumption for ketogenic classification?
As a LMHR genotype, I have been cautious. While I am in ketosis for a significant portion of every 24 hour period; due to IF; during my feeding window, I eat significantly more carbs than someone on a ketogenic diet would.
The results are
Non-HDL: 214
HDL: 60
Trig: 100
So in my current state I don't match the phenotype, however, I am definitely the genotype and if I were on a strict ketogenic diet (rather than diurnally transitory keto), I'd be something like:
Non HDL: 300+
HDL: >80
Trig:
LMHR is not a genotype
@@nicknorwitzPhD yes, i realize that. More correctly stated, I am of a genotype (and have the environmental conditioning) that is compatible with expression of the LMHR phenotype. The evidence of this is that if I consume a strict ketogenic diet I have the triad, and I am able to accurately modulate the magnitude of the variables in the triad by varying my carbohydrate intake.
My father was extremely lean so was my maternal grandfather. My son is 5'9" 108 lbs and I am 6'1" 135 lbs. I used to he on a high carb crap diet and my LDL was absolutely fine according to my doctor, but all my other markers were horrible. Now, on a low carb diet (~50g/day) every one of my other labs (besides non HDL cholesterol) are *perfect*.
People who understand science understand you very well, I guess it is hard to change some rigid beliefs, especially if your career was based on that specific belief. You are doing an amazing job and keep doing what you are doing, facts are there, people will have to change their views or they will stay behind 😊
Amazing job Nick, regards from another LMHR.
Thank you Nick! We support your selfless search for our optimal health while encountering the falsehoods & closedmindedness from obvious big pharma advocates. Keep up the awesome work!
Not sure on their motives. Could just be ignorance. Could be ego defense. Doesn’t really matter. Data and logic are data and logic
Do you agree with cardiovascular researcher, Dr. Malcolm Kendrick, that LDL particles, whether LARGE FLUFFY or small dense, cannot/do not damage the coronary glycocalyx and endothelium? So, no matter how many LDL's a person has floating around, there can be no atherosclerosis UNLESS something else (INSULIN RESISTANCE with high glucose) has first damaged the coronary intimal lining.
NO WAY
@@northerncoloradotransparen1454 You are obviously an expert. Care to elaborate on your comment? Is large fluffy a problem? Is LDL always a problem irrelevant of size? Is there never anything else involved?
@nicknorwirtzPhD I applaud you for bringing this forward. Alas, I think the egos will not allow them to acknowledge they are flawed. It doesnt stop the message. This video is more about letting the public know than expecting any change from them. IYKYK. keep up the good work bud.
Maybe I do... Maybe I don't... either way, best to state I want to open the dialogue because it's true... whether or not I think certain people will actually be open to learning (and teaching humbly and open-mindedly)
Hi Nicholas, with high LDL, why is there no mention of small dense LDL? Has this fallen out of favour? I thought SDLDL was the main common pathway? Thanks.
Thanks for making this. It was very clarifying and I hope everyone watches it. I understand better your issues with Thomas Dayspring and for me, I hear nonstop that you and Dave have proved that Ken Berry is right and the idea that high cholesterol can be harmful is a lie (quoted from his best-selling book). I think it was an important clarification to hear you say that LDL can be associated with increasing risks of heart disease.
Thanks for your words Chris. Question: can you actually point me to where Ken says that high cholesterol is never harmful?
@@nicknorwitzPhD Yes, chapter 5 of his best-selling book leaves absolutely no doubt. He makes it clear higher is better. Here's just one quote: "the published fact that most patients who have a heart attack have a cholesterol level of less than 200." No mention of FH. Just mentions that it's a lie and we'll look back on the cholesterol theory of heart disease with shame and embarrassment.
@@PlantChompers Haven't read his book. If there is a video (esp from the past year) where he or Shawn or any major low carb influencer says explicitly "LDL doesn't matter" in heart disease and you can provide a link, I'm happy to try to be a voice of nuance and reason.
@@nicknorwitzPhD They're all over the Internet, no? They go further to say higher LDL is better. If you're up for a game of whack-a-mole, you can start with Chaffee. th-cam.com/video/fpiRxen9gNk/w-d-xo.htmlsi=G4bu5LKIzY8nRvPA
@@nicknorwitzPhD I responded with a link but I guess TH-cam didn't like the link and deleted it?
Now I am a little confused. I am not sure whether I am LMHR anymore, HDL 118, TRI 59, LDL 187 (less than 200). My BMI is 16.7, and my body fat is 12% (female). I have low carb high protein and high fat diet.
Nuanced medicine doesn’t fit into a one size fits all treatment algorithm. Most docs really don’t understand this stuff to begin with and rely on treatment algorithms to come up with a plan.
Keep up the good work. Fan of your channel.
I'm guilty of believing the LMHR group was pushing high LDL-c was "ok". My fault. YES, agree no one is pushing or should be pushing it is ok. Agree, we don't yet know what we don't know. Agree with all things case by case, person by person.
Good reply 😊😊😊