Peter Attia Dives Deep on STATINS (side effects & the best alternatives)
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- เผยแพร่เมื่อ 7 ม.ค. 2024
- Statins reduce risk of cardiovascular disease but also come with mild to severe side effects. Nowadays, there are several alternatives - each with their own list of pros and cons.
Here's what Peter covers:
(00:32) How statins work to lower cholesterol
(01:12) The percentage of people who develop muscle aches while taking a statin-and how to reverse it
(01:32) The percentage of people who develop insulin resistance while taking a statin
(02:48) A subset of people taking statins experience increased transaminases
(03:18) Do statins impair mitochondrial function?
(10:01) Why many people supplement with ubiquinol while taking a statin
(11:11) Do statins increase neurodegenerative disease risk?
(14:57) The only 4 statins Peter Attia prescribes
(15:32) Ties between desmosterol levels & dementia risk while taking a statin
(19:59) Statin alternative #1 - PCSK9 Inhibitors
(21:37) Statin alternative #2 - Ezetimibe
(25:03) Statin alternative #3 - Bempedoic acid
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I wish for once these 2 could speak in a less scientific way.
90% of what they’re talking about goes over my head but it sounds really important
Apparently What is the role of CCSVI Venous Hypertension and proper/improved Cerebrospinal Blood flow Impacting circulation and homeostasis balance? #CCSVI #BloodFlowMatters #spasticity #perfusion
Horizontal sleeping causes Reflux of De-Oxygenized blood towards the stenosed Hypoxic brain
CCSVI is Science Confirmed Recognized Medical Condition STUDIES show causative factor MS Varicose Veins Fatigue Atrophy Inflammatiion Thyroid issues Covid-19 Heart function matters Cramps Mental Health problems Bowel & Bladder affairs insomnia Senescene Psych unusual behavior!
So happens, to mention apparently, Neurogenesis and Homeostasis, are often side effects of Venous Angioplasty treating CCSVI!!
Apparently sooner treatment best possiblity Symptoms easing or disappearing.
1/1 #CriticalHealthcare_Research #CCSVI
Neurogenesis is the process by which new neurons are formed in the brain. Neurogenesis is crucial when an embryo is developing, but also in certain brain regions after birth and throughout our lifespan.
qbi.uq.edu.au › brain-basic
Homeostasis is an internal feedback system that stabilizes and balances our body's chemistry, so that our organs work smoothly and efficiently with each other. Sickness is the disruption of homeostasis, which doctors treat with medicine.Oct 20, 2016
www.bmj.com› bmj.i5643
For me atorvastatin was terrible,
I had continues bladder infections , muscle pain , foggy memory , loss of energy , dry skin issues and felt terrible after being pretty healthy 62 old women . After I stopped taking atorvastatin it took me year to recover and feel good and myself . Six years later feel great , I watch my carbs , exercise , walk a lot and my cholesterol is little elevated , but much improved and close to 200, however my quality of life is great and feel great . No statins for me .
300 and lower is healthy and if over 60 200 is low. Big pharma pushed 200 as high to sell more statins
@@DJ-Illuminate under 150 is healthy
@@DJ-Illuminate that’s a questionable assumption.
@@erastvandorenthey keep changing that number used to be over 200 if you starve your brain of cholesterol you will get dementia
It’s a killer
I don't understand how he supports main side effect of Statins is is 7% muscle soreness (?). Most of the large trials have a run in period of 4-6 weeks where ~30% of the treatment group drop out because they can't tolerate the side effects of Statins. In these trials subjects have to prove they can tolerate Statins before they are included in the analysis of side effects ! Check out the Feb 23 cohort study in Orthopaedic Journal of Sports Med showing 40% with tendonopathy on Statins (especially forearms/elbow). When your doc says you get a 30% reduction in risk from taking Statins for a 7% risk of side effects, you should be aware that the reisk reduction number comes from the big trials which show 3% of the placebo group die, Vs 2% of the treatment group. According to big pharma and the AHA this is ~30% better! According to you it should be 1% and don't forget the twisted way they measure side effects.
Could partially be nocebo effect. People expect side effects and they tend to get them more.
I have been on stations for 5 years and thought i had muscles ache at start but it was really becasue i was working out more no other side effects it passed as muscles got used to being used. Most people are fat and sedentary.
absolutely agree with you
Thanks for sharing this info!
I've been on statin for about 30 years is it draingerous to go off them??
I have a large salad for lunch with protein and a medium salad with a little protein for dinner, water with electrolytes every morning. I've been doing this for 2 years, lost 50 lbs, NO MORE MEDS, sleep like a baby. Age 61. Anyone can do this. F meds.
Kinda extreme, but the results are what matter when saving a life.
I'll second your results!
Thank You for this post.
I agree, meds end up unbalancing the body and you'll need to keep adding new ones to cover up the additional problem the med created. I'm surprised they talked about cholesterol and didn't mention how taking/eating Omega3 helps enormously. It all comes down to your diet and your physical activity.
BULLSHIT to the nth degree. The MAJOR reason it worked for you is your GENETICS.
Statins definitely lower cholesterol but that really isn't the question that needs to be addressed, the question is do people taking statins live longer (and how much longer) than people who don't.
Everybody seems to focus on only cholesterol with statins what they also do which is very important is reduce inflammation of the heart, I've been on statins for a while now rosuvastatin 10mg every other day and on side effects.
@@liveloveride1676 That's true it does have anti-inflammatory properties and that's the benefit it provides because CAD is an inflammatory process, but lowering cholesterol doesn't really provide a benefit since it isn't really the problem.
To answer your question. If you hart attack survivor and take statins regularly for 5 years your life expectancy increases by 4 days. I do recommend to listen. DR Malhotra
@@Mathilda2zero here we go spelling police is on it again. Well done keep up good work.
@@Mathilda2zero Geg a life Karen.
My mother almost died from the statins. In 3 months, she loose cognitive functions, terrible head each, muscle pain... she was loosing her minds and she thought she will die soon. The worst experience ever with a drug.
Everybody’s got a story. The woman who held the record for living the longest in France, died at 122 and had smoked for 96 years. Does that mean smoking is OK?
I'm a 69yo ultra runner. I used Altorvastatin for several months and saw a significant decline in my endurance, performance, and energy level. I had no other side effects (aches, soreness). I wonder if I was experiencing some of his mitochondrial degradation Rhonda (sp?) was referring to. Things gradually improved once I quit taking the statin.
Im noticing this now even for just 10 mg of daily Rasovastatin
I have tried using statins 3 times and have had very similar reactions to yours. I am pleased to find out I am not imagining things.
I'm on 10 mg of daily Rasovastatin and notice no significant decline in my endurance, performance, and energy level
Why did u need as an ultra?
High CAC score + slightly elevated LDL-C levels.
I was diagnosed with calcification in one of my arteries plus high cholesterol of 6.9. Was put on 40 mg of Atorvastatin for 6 weeks, was absolutely devastating for me. Muscles ached badly to the point it was hard to walk, couldn't think properly, got so irritable, angry, anxious & felt so depressed, sweating all the time I didnt want to go out anywhere. I had never felt so bad in all my life. Honestly my husband & kids said they thought I had lost the plot because I was spaced out all the time & were really worried. I am usually so active at age 68.
I went to the doctor & he changed me onto Rosuvastatin 10mg. Still felt the same as I was on Atorvastatin. Went back to the doctor and he changed my Rosuvastatin to 5mg. So far I feel great. Slight muscle ache occasionally, but nothing that bothers me, but not feeling anxious or depressed and feel I have my life back again.
Along with my family we are keeping very vigilant to monitor for any side effects.
if your cholesterol is still high you should combine it with ezetimibe, that's what I did and the numbers came right down and no side effects
I hear you ! Feel like that now!
Further to my post about my Statin use, I am no longer taking any of them.
I had a scary episode where I lost control of my arms and legs, plus I was like an absolute zombie for about 15 minutes.
I made a decision to come off them, now I feel great again, with no muscle pains and I can think & speak properly again.
I am regulating my cholesterol with diet & exercise.
Some people can take statins quite successfully, but I am in the percentage of people that have serious side effects from them.
40mg?!? Holy crap... like Attia says, studies have proven peak effectiveness at 10mg. I guess 99% of the doctors prescribing statins didn't get the memo.
Make sure you’re taking coq10.
You hit the nail in the head fools for doctors and prices, insurance Co prohibited meds. You both, Andrew H. Brad Cher and many more should march to Congress and fight to change all of that. For every patient that you see there are countless others that can't afford good healthcare and trusted advice. I appreciate you ❤
Thanks for all your great advice. I really enjoy watching your videos, they provide a lot of knowledge and are very helpful on a daily basis in choosing food when shopping, etc. Thank you ❤✨
My dad has been on statins for 30 years with no side effects. He's 90 and does pushups every day and still goes to the gym. I went off mine and 9 years later my calcium score quadrupled. Now im back on.
Stay on your statin, 30 years no side effects, I don't believe you will even need the next 3 yrs as new breakthroughs coming so stay healthy until then as new studies and breakthroughs are coming.
@@quantumfx2677 Yes, most don't realize that breakthroughs are coming.
@@quantumfx2677 Eh, statins have been shown to have more or less zero impact on improving mortality. It takes 2.5 years of statin use by 100 patients who have had a cardiac event in the past to reduce future cardiac events by 1%. So it basically reduces cardiac events by 0.4% per year.
The editing on this with the overlays is rock solid.
Great conversation and thank you. I'm a fit 56 year old male who has just recieved a calcium score of 22 with LDL at 3.3 and HDL at 1.3. My doctor has just told me to take statins for the rest of my days to maintain my LDL level below 1.8. My father, a very fit man at 83, last year had an aortic dissection which was the driver for my own calcium score testing.
Over my life, I have maintained an aversion to any form of pharmacological interventions and my immediate reaction was a definitive NO, preferring to seek a more natural means to achieve an LDL lowering first, before going down that track.
This was very informative and insightful and perhaps I will consider the Bempedoic pathway in the future, once it is approved in Australia (I think it's still up for consideration).
Cheers and big thanks from Sydney - Dave
I’m like you. Keep the faith.
@@kevinmontgomerymusic After research on the matter, I have come to the conclusion that our GPs can be very single-minded and even espouse primitive views when it comes to prescribing drugs. I'm treading cautiously - there is a lot of misinformation out there (including from sources such as your own doctor)!
Good luck Kevin - it's a bit of a minefield! Cheers - Dave
Its a low calcium score for 56, of course zero would be the best, I can't see why you cannot go on a low dose statin,
just for preventative measures,
That’s a super low calcium score… anything under 100 is really not that bad at all👍
LDL doesn’t tell the full picture.
It is an antiquated test.
LDL particle testing is much more indicative of cardac risks linked to cholesterol. As of now there are 13 identified types of LDL lipoproteins and most are not just harmless, but beneficial.
Some people have low LDL but have choked arteries, while some have much higher and calcium scores zero.
There is information even on TH-cam on this. You can look up on cholesterol myths.
Caused coughing for me. Aggravated my asthma which RARELY bothered me prior.
My dr. prescribed statins for me about a year ago. I had an allergic reaction (swelling of my face) to Crestor. My insurance company would not approve Repatha until I tried another statin (which we knew I had a high probability to having an allergic reaction to). So I tried Lipitor and my face swelled up again. I am on Repatha now and have had great results with no side effects. It is frustrating that I had to have TWO allergic reactions before my insurance company would approve Repatha.
It was worth a try
Great discussion, thanks!!
Excellent video, Really like the shorter clips. Thanks,
I came here to find Peter’s recommendation on statins and I’m not sure I found that.
Thank you for this information. My heart dr. wanted to put me on stating. He was not happy. Should I start with Benbadoic acid? What is its generic name.?
Oh, sweet. Lowering the cardiovascular risk by 1.8% and simultaneously rising T2D risk by 4%, that will increase the cardiovascular risk by 25%. That the golden bullet!
And you know why after 30 years, they never followed up on the original statin trial or do an addition study of them, they knew that 1% cardiovascular risk/event can flip on the pendulum to show no cause for benefits. They know it, and job security of addition big Pharma for additional drugs to treat chronic disease side effects they cause. I will let you in on a little secret, that original trial group, the ones on the continued statin showed an increase of cardiovascular events more then the none statin control group. The closed down the trial in long term follow up as to not have to document the crime
@@user-jb3bg9og7b . I read the drug prescription information on every FDA approved statins. Usually, it is section 14 to check. There they disclosed studies and the absolute risk reduction. And it is miserable. You need to make your own table with proc and cons for, and it will be very unfavorable to the drug. Anyway, Piter admitted the fact that Apob100 is causal and, consequently, everything to lower it is good. I got it. I don't admit the same.
Instead go plant based. Your liver makes cholesterol and consuming animal products raises cholesterol. Legumes and beans make you strong.
Peter has been captured. @@user-jb3bg9og7b
Cleveland clinic did a study of 151,000 patients and tracked new onset of diabetes after taking a statins, 48% higher risk of developing diabetes after a period of taking statins. That % was after adjustment for family history, BMI and age. Original % was 71% higher developing diabetes. Yeah take your statin, get ready for long ride of other issues @BloodPressureBoss
Extraordinary presentation. Way above my familiarity, but still illuminating regarding the paucity of real data manifest in much of internet content. Nice job
Is there a link to the sources cited?
I had hypertension but my doctor gave me the opportunity to change my lifestyle.
I went raw vegan and that fixed all my problems.
I was also pre diabetic.
Now I'm 42. Training 5 to 6 days a week. Enjoying my life.
Thank you for this information. Do you happen to know if The Pritikin Wellness Institute - which is supposed to be the 'gold standard' in heart health - provides all of these additional tests that you mention?
Gold standard by whose measure? Besides, if the patient isn’t willing to use the cure, it’s not gonna do people much good. Some people would consider the side effect of eating very low fat, similar to muscle aches.
Statins have been very good for the health of big pharma profits. That's it.
True dat! lol. And we could make the list bigger.
💯👍
And that is why the literature is so screwed up.
Totally wrong
Wait till you need one, also all stains are now genric, cost very low now.
Did not understand much of this conversation. Yet, it was still very interesting.
Thanks for the info
Okay experts, gurus and aficionados ... has there EVER been a valid, quality, interventional study on the efficacy of statins as a secondary preventative measure in heart attack survivors?
No opinions please. Guide me to valid resources. I'm having trouble finding any.
In my opinion there are so many questions about the damage that Statins can do and with benefits being so minimal ( 84 people have to take a Statin for 5 years to prevent one heart attack) especially if the sole reason for taking it is a high LDL or ApoB count, that I personally would take the default position to not take one. I would need a lot of persuasion indeed. Let's wait and see if PCSK 9 inhibitors are the harmless miracle drugs that they are touted to be.
Is that supposed to mean that only one heart attack was prevented? How was that determined? So 84 people would’ve done the same without the statin?
I know dozens of people, some family that were prescribed statins and all had muscle aches and most had bad IBS.
This is most interesting, but a question if I may? I was diagnosed with severe calcification of the aoerta, My lipids were all in range, But I was told that I would be on statins for the rest of my life to coat the calcification and prevet break up etc. So with statins the K2 I am taking will not help dissolve the calcification. Also the side effects of sever muscle cramps is not fun. Is there a viable alternative? From up in the Canadian North.
Atherosclerosis is REVERSIBLE! PLEASE READ DR. SHERRY ROGERS BOOK CALLED, "THE CHOLESTEROL HOAX". My mom was told from an X-ray that she has severe Aortic Atherosclerosis. She is currently taking, Nattokinase 16,000 units per day, Kyolic Aged Garlic 2400 mg daily, Vitamin E( tocopherol and tocotrenol) 1 tsp of Cod liver oil daily, Vit d3 10,000 units per day along with Mega Vit K2 and Policosanol 40 mg per day. This is enough to Melt the Plaque away👍👍👍👍
You make things understandable. Thank you
I've been prescribed Ezetimide along with 40mg Atorvastatin. Is it a good combination, or can I just take one of them? We don't have many of the tests mentioned here in Peru. I had a serious heart attack a year ago, 2 stents in, was never really overweight, but dropped from 72kg-60kg. No sugar now, reduced salt, less carbs, 7km fast walks 3 times a week, 1.5hrs light weights etc 3 times a week, height 1.69m, living in Cusco at about 11000ft. Cardiologist reckons familiar hyper-cholesterol likely cause of attack. On Valsartan, Bisoprolol, Forxiga, Clopidogrel+aspirin & Atorvastatin. HDL 41.8, LDL 75.34, VLDL 19.86. Heart function was 43% up from 40% at last echocardio 6 months ago.
I suggest you look in Xtend-life catdio range like CX8 and VasqFlow and Quinol. The owner of the company created them after heart surgery despite having been so healthy. The last 25 years he was focused on anti aging before sll of this gurus you see today
Stop taking both!! Worst medication you can take!! He’s flat out lying
heart disease was the cause of your heart attack. Do not have to be overweight to have heart disease.
Good luck! Heart treatments will be much better from 2025 to 2030.
Get off of statins. They are worthless for coronary heart disease and have numerous adverse side effects.
Dr Ford Brewer advises low dose (5mg) rosuvastatin or pitavistatin mainly for control of arterial inflammation, do you agree?
As a side note,have low cholesterol numbers but found the small particle size is high. I had the advanced test.
My doctor knew nothing about these factors. I have been through 3 primary physicians and cant find a competent one
Yes I switched Drs because of lack of knowledge and a reluctance to do the small particle test. When I said that I was off my statin he pressured me to get back on the statin. I think he knew that the test would show I did not need a statin. I had myopathy while taking statins. Now with other Dr taking me off all meds looking at total life style. Exercise eating correctly etc etc.
I lost my libido with an ED problem. Also, my liver enzyme level slightly increased after 80 mg of atorvastatin with 10 mg of Ezetimibe. However, I have no other issues. Advice something.Thanks.
Attia grossly minimizing bempedoic side effects. Tendon ruptures, increased gout to name a few. Yes, rare, but in similar range as some of statin side effects. So to say "no side effects" while pointing to rare statin side effects is disingenuous. Every drug has side effects. He knows that.
I love Attia for his information. However I have a friend with gout problems that is starting to use B ACID so I’ll make sure that he knows this!!! Thank you
Life has side effects.
same thing happened to my dad, Statin use coincided with systemic tendon problems, destroyed shoulders and gout. He's off them now but at 86 the joint damage is not repairable. The cholesterol / gout and BP is fully controlled by diet now. Doctor could care less that diet beat the statins and gout meds hands down....That's what's wrong with medicine today. No money in diet.
That was the research I saw as well. I dislike it when someone speaks so authoritatively but then speaks selectively. He does enough go-backs that he could’ve hit this. The fact that he didn’t bothers me
He starts right off by saying 7% is no small number of people
I've been on atorvastatin for 10 years. I take it with coq10. No issues and low ldl.
Great discussion and I appreciate the excellent questions from the interviewer. I have appreciated Peter's input on many occasions and this is no different. I did have to chuckle when he talked about checking markers for insulin resistance after starting statins. I can't get my patients to stop eating Cinnabons. He obviously has very motivated, high-paying customers!
What about natural alternatives? Do you explore?
This was AWESOME
My LDL was 177, plaque score 86. I've been on 20mg Lipitor for a little over 3 months. Just had more bloodwork done, the Statin lowered my LDL to 74. I started taking CoQ10 with the Statin, I've had no side effects at all so I will continue. I'm 56.
I was on lipitor it caused such brain fog I was scared to drive
what was your tri gyc and HDL number?
@@jron20r51 I find out next week
My doctor didn't like me having both elevated blood sugar and cholesterol so he put me on a 10 mg statin and low dose metformin about a year ago. I feel great, no side effects and my stats are now perfect.
@jron20r51 Tri was 52, Hdl 56. Now they're 37, 54. Those numbers were good even when my LDL was 177.
Farnesyl pyrophosphate in the Mevalonate Pathway is attenuated by statins. It is involved in the synthesis of CoQ10. It depletes CoQ10 in the mitochondria, reducing in a dose dependent manner the production of ATP responsible for cell firing in musculature, which in turn causes muscular pain and dysfunction. Why is there so much confusion on this matter.
absolutely , any Dr. can know the insulin resistense , by measureing insulin (kraft assay) a lengthy test , but , the most indicative/predictive thing to actually track.
Statin drugs and liver cirrhosis + low platelet levels ?
Been taking statins for 30 years! It took my Cholesterol from 350 to 150, triglycerides from 400 to 200. 68 years old and my arteries are as clear as a child’s! My father suffered lots of strokes and clogged arteries as he had the same cholesterol issue as myself but couldn’t tolerate statins! Ive had no such problems!
You will ….. 😢
@@Badhabit4590 after 35 years dipshit?
@@Badhabit4590 don’t believe everything you see on youtube
You better check those arteries again!
@@ca9777 what kind of stupid ass comment is that?
41 year old healthy adult male here , distance runner , cross country skier and work out regularly , my total cholesterol is 268 , my LdL is 176 my HDL is 50 and my triglycerides are 212
Have you had a coronary artery calcium scan? If you have no calcium build up, you’re numbers may be fine. If you’ve got buildup those high numbers are a problem.
If your trigs are 212, I've got news for ya on the "healthy" part
"triglycerides are 212"
stop eating high glycemic carbs and sugar and this will go down
Potentially scary numbers (Tri-HDL ratio). I would definitely get a CAC score to check that out.
Could you please share your take on bempedoic acid and fatty liver ,can we take it to treat fatty liver ?! Greatly appreciated 🙏
I have high HDL, Tri’s, and low LDL. And fatty liver. I’m not concerned with high cholesterol, but the fatty liver concerned me. I’m fairly active. 5’11” about 185lbs. Feel pretty good. Probably eat too much sugar, cookies, pasteries. But overall eat well.
I’m curious if I can help the fatty liver without affecting cholesterol too much. I do need to exercise more and eat better and will be doing that.
Quit sugar.
this above - quit sugar. including breads and fruits. your TRI will plummet. Note: low LDL in the presence of high TRI likely means you're elevated pattern B (SD LDL). This is not desireable.
Especially fructose
Too much sugar will elevate triglycerides. Limit sugar intake.
Cut out the unnecessary sugars. Run and lift weights 5 to 6x a week. No alcohol and see what happens in a few months.
My aunts almost 90 and has been taking statins for years with no side affects
And your point is?
Thankfully statins gave me agonizing muscle pain. Always thought something that unbearable just can’t be good.
common sense is so uncommon these days, especially among medical "professionals"
Unbearable for you. Thankfully, most people aren't you.
@@DaveG-qd6ug Common sense if often wrong, so I'm very glad it's uncommonly used by medical professionals when trying to get at the truth about this stuff. Truth isn't determined by popular intuition and the "feelz."
@@tomscully7489 You sound like you have sand up your vagina. Maybe there’s a pill for that. It turns out there’s better ways to control cholesterol.
Did the muscle pain come on all at once or gradually over a period of time?
He said phytosterols (plant sterols) can be worse than cholesterol if you have a defective ATP binding cassette. If you don't have that, are they still worse than cholesterol?
Hes a snake
@@user-pf5xq3lq8iwhy do you say that?
If you don't have the defective ATP tape then plant sterols will help you. If you do have it, then they will harm you.
My friend a private office worker in the US ARMY takes Statins' with no side effects as far as he tells me . some do maybe for every body's different in a way one can not understand Natural selection or Creation being hard to tell the difference when people only have so much ability skill in knowledge.
Does a PCSK9i (Repatha) cause insulin resistance? After about 6 months on Repatha (no statin) my A1C went up to 5.7. Now taking Metformin, not only for glucose regulation but also in hopes of anit-cancer and longevity benefits.
No, it doesn't. Entirely different mechanism.
PCSK9 inhibitors, are associated with increased risk of mortality. Not sure that's better than being on a statin.
@@buckmurdock2500 proof? Btw, statins show a 9-33% reduction in the all-cause mortality.
you believe everything you read online huh lol@@buckmurdock2500
Does the symptom of muscle soreness related to taking a statin happen all at once or over a specific period of time?
Over different period. In my case after one or two months. Also can affect different muscles of the legs.
not a problem for me and i work out hard
I found the comments regarding Metformin on Lactate to be really interesting. I've been taking Berberine to help with insulin sensitivity and gut health for the past year (I'm not diabetic, but have a family history). This along with other changes helped me to drop 40 lbs along with a lot of other benefits. I'm a very active cyclist, and so the lactate threshold comments were interesting to me. I don't feel like I've noticed issues for myself, but I also am not measuring it. Does anyone know if Berberine has similar issues with Lactate production as Metformin?
I am not sure but I am curious if you saw a drop in cholesterol numbers on Berberine? My dietician suggested I try it for cholesterol.
@@rusted8track314it lowered mine, but i stopped it because it was making me feel weak and lightheaded
Do you get lightheaded sometimes? I stopped berberine because I would get dizzy every time I stood up. Went away once I stopped taking it .
@@SeanonyoutubeHow much were you taking?
@Seanonyoutube You have be careful of other meds as Berberine can amplify the effects. I have been on 500mg twice a day 20 minutes before meals.
I just watched a video with Dr. chaffee titled you’ve been lied to about cholesterol and heart disease. Very very good interview.
only if you're a cholesterol denier.
@@buckmurdock2500😂
So many doctors have no idea. Eventually they will wake up.
@buckmurdock2500 one example; one friend took stating for 14 yrs & had quadruple bypass. Another said he had low cholesterol and didn't take statins and later had dbl bypass. Read yesterday paper in nih or the like and the list of culprits in plaque was way more then just cholesterol. Why do you blame just cholesterol?
Excluding extremely high cholesterol a study shows people with higher cholesterol live longer than ones with lower cholesterol.
When did you start on meds ? At 6 yo ? Your body was making cholesterol then wasn't it. There is nothing bad about cholesterol. Your body doesn't make bad cholesterol. If you think it does you aren't very bright. 2+2=4 And if you say cholesterol is the only ingredient for plaque, which you are, you aren't very bright.
You are a self help denier ! Quit blaming others.
Dr. Attia's statement that 7% of the people develop muscle aches is misleading. The way the Statin trials are done is they have a "run-in" period of something like two weeks where the participants are taking the drug before they begin collecting the data. During that time about 25% of the participants cannot tolerate the drug and they immediately drop out of the study. Statistical Data is then collected on the remaining participants who think they can tolerate the drug. So the number isn't 7%. It's more like 32%. Those "muscle aches" are the result of the Statins breaking down your skeletal muscle. How do we know whether or not the Statins are also not breaking down Heart Muscle? We don't. (see Diamond and Ravnskov "How statistical deception created the appearance that statins are safe and effective in primary and secondary prevention of cardiovascular disease" )
i refused statins until my september 2023 MI, now i am on 10 MG rousovistain and 10 mg Setia. i get constipated from statins so now i just live with it.
So what shoild people with high lipoprotein do?
Ive been off Atoravastatin for 8 months, but still hsve my "sore muscles"
So what other "mild snd transient" side effects do i have?
Total cholesterol was 3, now 5, it was effective, just not very safe.
Sore muscles… but it at least protected your most important muscle…. The heart
My mother was put on Lipitor medication in her 70s. It created a lot of pain and motor problems for her and she ended up breaking her hip and later her pelvis. That started the decline to the nursing home. I will never take statins!
Yes, there are natural alternatives to reduce cholesterol
@@theancientsancients1769 Yes, stop consuming animal products ! !
Actually vegans have more bone loss...because of too little protein...not meat, protein....the reason is not adequate.
Opps
Seems like a good idea to just avoid the seed oils as primary prevention
He reads the various studies just gives his opinion. Thanks
Psyllium fiber, olive oil and garlic helps get rid of that cholesterol..need it every day and its takes couple of months for full effect
What amount of each would you take per day? Do you take garlic supplements or just cook more with garlic and olive oil? TY
He quotes relative risk for benefits, but absolute risks for side effects. Sham science by Peter. Use the same for both.
Thanks for pointing that out. They danced around that elephant during the whole meeting.
Most people aren’t aware enuff to catch things like that - and the reason he’s quoting the numbers like that is because that’s what the literature presents. Because the literature was paid for by pharma, manipulated into showing a benefit and then presented without any of the raw data. Peter is lost - unfortunately, people think he’s a longevity expert but he is still making the huge mistake of trusting pharma paid for studies without looking at the raw data (which they have kept hidden, wonder why).
this is your brain on nutrition conspiracy theories, keto and fasting cranks--listen to the part where he tries to make the implication that people are getting insulin resistance from statins lol which is complete horseshit--but then walks it back and says well actually we don't know what's causing the insulin resistance or the t2 diabetes after they go on the statin--but posits the whole "well what else done it???" umm well a ton of confounding factors beyond statins--there is emerging evidence its genetic but probably caused by pre existing obesity and sedentary lifestyle--but blame the statin lol lol this is the sham these people pull and the games they play with their sophistry - sickening really........
EXACTLY 😂
Yes, the relative vs absolute benefit statistic is always used by drug companies to amplify the perception of benefit. Yet that's what pharmacy reps quote, and that what many doctors look at. It's misleading. If I understand it correctly: If 4 in 10,000 people in a control group (no statin) develop severe cardiac related issues and only 3 in 10,000 from the statin group do so in longitudinal studies, it is reported as a 25% reduction in relative risk. However, it's really only a 0.01% absolute benefit (I fabricated data).
Wow. I’ve struggled for years with muscle tears etc. I have recently been diagnosed with type ll.
I have to take vacations from Crestor. To control pain. Did not know the insulin resistance correlation .
A massive analysis series published from 2013 to 2014 by Naci and colleagues group comprising all the different statins looked at statin side effects and tolerability, dose comparison effects, and benefits to primary and secondary prevention of major coronary events and all-cause mortality. It would appear that simvastatin has the best tolerability and dose effects. This is just my interpretation of the data though and I'm not a doctor so this isn't medical advice. All the citations are listed below though for anyone interested. Due to my diet and lifestyle, my non-HDL is less than 60mg/dL, but if I needed to take a statin, I'd choose simvastatin based on the present data.
"Comparative tolerability and harms of individual statins: a study-level network meta-analysis of 246 955 participants from 135 randomized, controlled trials" by Naci, Huseyin, Brugts, Jasper Jan and Ades, Tony (2013) Comparative tolerability and harms of individual statins: a study-level network meta-analysis of 246 955 participants from 135 randomized, controlled trials. Circulation: Cardiovascular Quality and Outcomes, 6 (4). pp. 390399. ISSN 1941-7705
"Comparative benefits of statins in the primary and secondary prevention of major coronary events and all-cause mortality: a network meta-analysis of placebo-controlled and active-comparator trials" by Huseyin Naci, Jasper J Brugts, Rachael Fleurence, Bernice Tsoi, Harleen Toor, and AE Ades
And lastly,
"Dose-comparative effects of different statins on serum lipid levels: a network meta-analysis of 256,827 individuals in 181 randomized controlled trials" by Huseyin Naci, Jasper J Brugts, Rachael Fleurence and AE Ades
I tried a statin for my high cholesterol given to me by my cardiologist, in just 2 weeks I had such incredible leg pain and muscle cramps , I could not live that way. After listening to many podcasts on bio identical hormone replacement therapy and particularly Estradiol orally , i worked with an MD who specializes in woman’s health, within only 6 weeks, my cholesterol dropped by 2.00 points , I couldn’t believe it, I also was able to drop one BP pill. My cholesterol continues to drop with each blood test….. so statin or hormones ??? Something to consider.
Wait, 2.00 as in "2" or as in "200"??
If you read his book, he’s very clear saying statins are good and effective. Not a fan of his though he offers a couple of good tips on training, and the link to longevity in his book.
Yes, he's been changing his tune somewhat on statins, I've noticed. (ie a bit more negative or...nuanced shall we say)
statins show the smallest of imporovment in mortality .04% Dt. Atilla is NOT even follwoing the best study we have doen in 1994 Shame on him
@@patriciahoke4722
source?
maybe cause we've got new studies?!@@danx1216
@@danx1216I think he would say that the time horizons of those studies are not long enough, and that just because we don’t see a significant change in all cause mortality over five years does not mean that statins won’t be beneficial in minimizing CVD over a period of 10-30 years.
Isn't the natural cholestorol production quite important? ... If so, isn't it dangerous to be inhibited?
The production would only be reduced in those who are high risk of a heart attack or stroke.
Medication is used to treat unnatural levels of production caused by unnatural diet.
Yes, bad to inhibit. Who's cholesterol is not affect by cholesterol meds ?? And why would they be taking them if they aren't doing anything to their cholesterol. Makes not a bit of sense.
It's actually not very important at all after a certain age. We lose the ability to clear cholesterol with age, so suppressing production is necessary to keep it in balance with age.
@@tubetime39 the medication lowers everyone’s cholesterol. The medication however, wouldn’t be prescribed to everyone, only to those who need the reduced cholesterol production.
Bempedoic acid doesn't have the same efficacy on LDL
He said that of the 12 or more studies looking at statins and dementia they all showed either no effect or a beneficial effect, but shortly after that he said he wouldn’t prescribe a statin if desmosterol test showed patient was at risk of dementia.
I have myalgia and fatigue after one dose of statins, its a very clear side effect for some.
I have idiopathic lower extremity neuropathies
( my mom had it also)
My gerontologist took me off Lipitor and they improved somewhat.
My labs have stayed ok and I have no real risk factors for heart disease so I am staying off them for now
i did try cholestoff which you seem to dismiss as maybe dangerous :24 for someone with poor gut health. I have heard of PQQ mentioned as an adjunct to COQ10, and would have like to hear more. I was surprised that Hydrophilic Statin therapy NOT more or less effective concerning Brain Health.
I was expecting a bit of push back about Metformin (since Berberine claims some success using the same underlying mechanisms cAMP). Similarly i would have liked to hear why pravastatin even made the list of 4 in that i should be able to enjoy similar result using Red Rice Yeast ?
The problem that I have found with red yeast rice is, it’s efficacy, varies from one bottle to the next from one producer to the next. So I had one good bottle of JARROW and my cholesterol went down from 220 to 178 and by LDLC went from one 12 to 88. I was so excited because I didn’t want to take a statin finish that bottle started another bottle same dose 1200 with Coke Q3 months later. My cholesterol was back up to 201 and LDL to 112 my doctor says the recommendation now is for LDL to be 66 so I’m way off target, think I’ll try a low-dose statin
I havr been on 3 Statins all with terrible side affects even affected stomach lining. After two failed back surgeries and being diagnosed along with Neuropathy. Cholestrolol runs geneticaly in my family. Diet does not bring it down. I was told by my Docter if you don't go on Repatha for instance then you can assume you are going to have a stroke ! My husband had a stroke so, I know what devastation it can be.So, that is the last thing I need but... I am so, on the fence about Repatha ? Diabetes factor and in some cases no energy and muscle pain as well as the Ins. will not cover it 1,OOO.OO bucks every mo. even after Doc. sent paperwork in and said I was a candidate due to Statin reaction and how very high my Cholestrolol is. Anyone else have the same story ? On the fence about taking Repatha ? Thanks in advance
Start taking garlic( raw or aged garlic in capsule form) EVERY DAY faithfully! You will definitely start seeing results! If you take capsules, make sure to take Kyolic Cardiovascular Reserve(2400 mg daily). In addition take VITAMIN E ( NOT THE SYNTHETIC FORM). GET OFF THESE STATINS ASAP!!!! THEY ARE TOXIC; ALL DRUGS ARE TOXIC! Do your own research on the health benefits of both of these👍👍🔥
My husband has had excellent cholesterol his entire life. He is 69 and 12 years ago had four stents in his legs from atherosclerosis and Christmas Day had a stent placed in one of his heart arteries when he had out of control a-fib (can’t recall official name cardiologist called it). Obviously , neither of these were from high cholesterol. He has had labs of a young, healthy person all along. Maybe it’s just something genetic?
Is he diabetic? Or pre-diabetic?
@@chadaustin9239 no, neither of these.
@slay2525My heart went into A-fib one day and wouldn't return to normal, I had 2 blocked arteries, 1 was 100% blocked, the other was 95%, I passed out for a few seconds and ended up driving myself to the hospital for a double bypass
What if you have genetically high cholesterol? Should you take statins then?
No
If you have high cholestrol in lets say your 50s but have 0 calicum score what is it we are treating? My whole family on my mothers side has had or has high cholesterol but no heart disease....i cant take statins they destroy me ....not that i would anyway ....
One interesting side effect of the statin regime I am on was massive hair growth. Before statins, I was as bald as a q-ball. Within two weeks after starting statins, no other changes in diets, meds, behavior or environment, and I had a full head of thick, luxuriant, flowing hair. I've had to head to the barber weekly to manage my hair; which is fine with me. There have been a few other favorable side effects, including a much-improved libido.....could be that the hair brings in more good-looking chicks. Not sure about the negatives. I guess we'll find out next time I do the big lipid tests.
Could you tell us which statin and what dose you were taking?
Encouraging. It may be to do with lowering conversion of Testesterone to DHT. DHT causes baldness and lower libido due to lowered testeterone
Trying to limit heart attacks by reducing cholesterol is like trying to heat water by shining a flashlight into it.
Low dose statin + Ezetimibe is effective and not much $ either if one can't afford the crazy costs of the others mentioned in this excellent vid.
Down side is it might give you dementia.
There's nothing in the literature to suggest that.
Ezetimibe turned my poop into little pellets. All statins have given me horrible leg muscle pain. I wonder why acceptable total cholesterol labs have gone from 275 to 200 over the last 25 years. My personal opinion is that it’s the pharma industry has pushed for it to sell more statins. 🤷♀️
@@beachbumetta that's a common theory and easily deconstructed. Statins are cheap, nobody is getting rich from them and they should probably be used more liberally.
Unfortunately, the way that they're prescribed comes from the clinical trials which were aimed at preventing heart attack not ASCVD.
Once heart attack prevention is required the disease is already taken hold and the dose required to lower the risk of a heart attack is quite high. For ASCVD prevention, the doses can be rather small, but unfortunately medical care in this country is broken and the prescribing guidelines aren't updated.
I take Welchol (colesevelam). Any info on that? I'm taking it because I heard that statins had issues.
just go carnivore / zero carbs and you can forget about medications.
The only safe way to reduce your risk is fix your diet- statins are dangerous.
It’s just as bad as statins.
@@user-ud5sm2de4l "just go carnivore / zero carbs and you can forget about medications."
um, no
@@user-ud5sm2de4lyeah definitely, go carnivore and raise your cholesterol even more by eating primarily meat….
I suspect that studies involving sterols do not involve those which are derived directly from fruits and vegetables. Perhaps plant sterols /phytosterols are related to higher cholesterol in those who take them in some concentrated pill form. That I can buy but the idea that sterols from fruits and vegetables raise cholesterol, and are oxidizing: I will never believe that.
I wish she had clarified that point because some people might think that he means something else.
good try Gomer, cholesterol doesn't exist in plants.
@@buckmurdock2500 Sterols do exist in plants, which is what the person is talking about. It’s the plant version, which is often suggested to lower cholesterol because it’s supposed to bind to sites instead of animal cholesterol.
So do the positives outweigh the negatives with Statins and Is elevated cholesterol really a big deal
Yes, that is the "jugular" question.
We need a debate berween Dave Feldman and Peter Attia.
David Diamond
That debate would be a slaughter with Feldman being the bloody mess. Feldman has exhausting N of one data, which means virtually nothing scientifically and one single recent study to back up his hypothesis while Attia is can and will back up his opinions by hundreds of peer reviewed studies. It's not a fair playing field. And on that note, Peter has said many times that familia hypercholesterolemia is a totally different ball game.
It literally exists: th-cam.com/video/kRxeyaNWmHw/w-d-xo.htmlsi=QX4O0eiTyRzHbZSK
Attia would win. He'd be wrong but he'd win.
@@eatfatlivelong1529 Dave is far more scientific. Attia really isn't
Why suggest Bempedoic acid when side effects are in clinical trials were muscle spasms (3.6% of treated patients, as compared to 2.3% under placebo), pain in the back or in a limb l, gout and gastrointestinal problems such as diarrhea. A less common but more serious adverse effect was tendon rupture in the rotator cuff of the shoulder, the biceps tendon or the Achilles tendon
I have been doing keto for 3 months to lower triglycerides, as well as taking a lot of Berberine and phosphatidylcholine. My triglycerides did drop from 169 to 147, but my ApoB went up from 119 to 120, and my A1c went up from 5.6 to 5.8. My LDL went from 118 to 134. My Omega 3 is high, and my Omega 6 is within normal range.
I have also been intermittent fasting for a couple years, with an eating window between 10:00 a.m. to 6:00 p.m.
I am an athlete with under 10% body fat and work out 7 days a week in one form or another, so I do eat a lot of calories. The past few months I have doubled the Salmon, Cod, tuna and sardines. I eat 4 eggs per day and eat lean bison and elk 2-3 days per week, along with non starchy vegetables; i.e. broccoli, culiflower, cabbage, brussell sprouts, spinach, mixed greens, carrots, onions and mushrooms.
Any thoughts on why my A!c, ApoB and LDL are increasing?
I think I’m jealous
Do one bell end
@@stebilbo3703 ?
You tried keto and saw minimal improvement. Your next experiment is to eat grains and legumes, then repeat the tests
@@albieoval1657 I have been eating pressure cooked black and pinto beans as well the past few months.
I walk 12,000 steps per day. I believe that has more impact than a statin. Am I wrong?
12000 steps a day is great, walking is great exercise, I dont believe you can out walk out run out cycle a bad diet . If one is still eating junk food and high intake of animal saturates from meat diary etc then from experience crap diet wins in long run . 12k walks with an unprocessed diet mostly plant based diet , and a little bit of fish and a little bit of animal calories is the way to go , oh and losing weight a huge plus to get well inside your bmi range makes huge difference on all parameters . Thats my take on all this and personal experience ,
12k steps a day and any exercise
Lose weight
Cut the alcohol
Less salt
Avoid saturated fats ( lean chicken , lean pork , fish )
Increase plant based food to reach calorie goals ( pulses lentils type stuff ), better microbiome gut as well .
If only it were that simple, it isn't though.
I had this therapy as a safe alternative 2 statins. It was prescribed by one of the world's top cardiac endocrinologists possibly the top one. For familial hypercholesterolemia high triglycerides low HDL higher ldls, bad reaction to all statins, maximum dose fish oil Lavazza or e s t e r six per day /, to drop triglycerides massively maximum dose welcome divided dose eight per day. I had absolutely no side effects that I know of, wonderful Labs normal, took 4 years realized was getting heart failure signs change diet plan to ornish MD, drop the will call eventually to be able to better utilize vitamin D orally generally now have good numbers not quite optimal but normal and permanent kidney damage from Pryor administration of statins particularly happening with Lipitor. And this happened under the Aegis of the biggest teaching Hospital in the state
What's your ApoB?
I am not finding information about stopping statins after 10 years of use (40 mg). Please direct me to some help.
Read “The Great Cholesterol Myth “ by Sinatra, MD Cardiologist. It covers the stats, studies, who should take a statin, many other helpful alternatives and what test markers are good to get tested.
Problem with all meds is That they always treat the symptoms and not the disease. So the disease continues. The normal state for humans is to be active and low carb. We have messed up our own health with lifestyle choices.
Speaking for myself I won't ever be persuaded to touch a Statin after watching my brother in law nearly die from pancreatic toxicity and my father in law memory was so bad he was like someone with advanced dementia which reversed within weeks when taken off statins. Neither of them have any cardiac history and simply age related recommendation by their GP's.
trust me jon that wasn't due to the statin - causation correlation fallacy bud
@@RealChrisHatch No, keyboard warriors on youtube aren't to be trusted...nice try though
add my mom to the memory loss list
Sometimes you don't need a RCT to tell you what is going on right before your eyes mate. And don't forget statins significantly increase calcification of coronary arteries which the statin crowd now say is a good thing which I think is hilarious. @@RealChrisHatch
I’m watching my mother fade away with these stupid statins. She gets swelling on the feet which means heart failure and probably kidney failure. God forbid but my sister who has a power of attorney over her care doesn’t want to budge doesn’t want to believe that the statins she was put on was the cause of her dementia, my hands are tied unless I take her to court. Why don’t they do a study? It seems very suspicious to me that they’re not willing to do a study as to how this drugs can cause dementia can cause all kinds of problems they can cause type two diabetes there still in denial. Smh 🤦🏻♀️
I will be re listning to all of this advice. Just found my husband s A1c is up with his atorvastatin ,and my doc wants me to have a heart scan to check calcium , talking about statins. Gee with no thyroid function I am taking 150 levoxyl and trying all I know to stay healthy.... I need all your knowledge here,thanks
It's not my place to give any advice but best of luck to you and your loved one!
Atorvastatin at very high doses have the highest frequency of the onset of type 2 diabetes. Unfortunately, rather than using a polypharmacy approach, many doctors simply ratchet up the dose disregarding the dose response curve. Atorvastatin effects tend to flatten out at 20mg and rosuvastatin tends to flatten out at 10mg. If one can't get a PCSK9i, then a low-dose statin plus ezetimibe might do the trick without raising A1c.
You need another viewpoint. Increase HDL to TG is the way.
I developed liver problems with Statin- Lipitor!! Why not mention this dangerous side effect??
You sure its not from obesity
I was prescribed Atarvostatin beceause of a family history.Not that it was high.Low and behold I am now pre diabetic.Coincidence or caused by statins? I wasnt prediabetic before taking statins.
I'm prescribed statins and candasartan . Also been around the prediabetes stage . But as a rule outside of smoking and drugs , these three all have in common a bad diet and not enough exercise
were probably on your way. Maybe the statin accelerated the inevitable.
Insulin resistance and diabetes is a risk of taking statins. Using statins as a first-line preventative therapy is usually terrible advice.
I think I read that 9-12% of people on statins will get type2diabetes. So I am not surprised.
I was on low dose atorvastatin for only 5 weeks and went from fine to pre-diabetic. I lobbied my cardio to write a script for pitavastatin which has a much better profile for glucose control. In fact, it is a preferred statin for someone with diabetes because it doesn't increase the glucose in blood.
The risk reduction with statins is not so impressive when you look at absolute risk vs relative risk, something not mentioned in this video.
Bingo!
Attia is disingenuous and should not be taken seriously
If there is an effect on mitochondrial…it is really small. That last line should’ve been: it is unknown. Honest answer.
When you age you'll wish you had a small bit more of mitochondria. Just a hunch.
tell me this i know a woman took statins and she had dementia she stoped statins and now she dont have dementia tell me why