Oh so cool! I love the quality and procedures in your videos! Very interesting using acetic anhydride instead of acetyl chloride. I'll have to try this as I have a good quantity of acetic anhydride that I need to use. I bought it thinking I'd use it alot but actually haven't cracked it open 1 whole year later!
How? I just looked at the structure of mephedrone and its acetophenone with the alkyl chain extended, branched, and aminated. It seems like a bad starting point.
@@BackYardScience2000 the part two of that video had to go on the back burner since the material I was trying to analyze was amorphous. Makes XRD a little difficult. But I’m setting up a new lab that will be dedicated to more videos. Setting it up is the next two months of my life though haha.
It would be very useful for you if you could hook up with someone who can run an nmr for you. That would take out all of the guesswork about the identity of your products.
What do you mean due to the loss of vacuum in the system? Dont you keep the vacuum pump running during the distillation? Or do you pull the vacuum, close the system then run the heat to distill product? I always thought they say to keep the vacuum pump running during the whole process and have a vacuum constantly pulling on the atmosphere inside the system? Im confused lol
I believe the abnormal boiling point during the vacuum distillation is the result of my pump heating up considerably as it runs, this would increase the vapour pressure of the oil and whatever solvent impurities that have been captured in it. So as the pump runs, it heats up the oil, increasing the vapour pressure of the oil, increasing the pressure in the system, increasing the boiling point, and this would happen slowly over time as the pump slowly heats up. That's my theory.
Thank you for that information. But, could this reaction be done by a substitution of benzene for the toluene and acetyl chloride for the acetyl anhydride to yield acetophenone instead of the p-methylactophenone?
@@martinheidegger1125 Yes. You can do that. Acetyl chloride is also very good reagent. But consider two things Acetyl chloride is highly toxic. And if you use acetyl chloride the by product will be HCl (a strong acid), in case of acetic anhydride it results in acetic acid as the by product (weak acid). So for acid sensitive reactants acetic anhydride is better. Also, HCl is more toxic compared to acetic acid. So reactions with Acetyl chloride should be done with care .
@@yogi5752 apakah dia membohongi kita dengan tayangan ini ? Apakah jika kita mencobanya akan terjadi ledakan . Atau memang tayangan memang benar cara membuat p2p
One time I saw one old secondhand book in a book shop’s in Northern Iran- Rasht, written by a professor( i think the writer was French or American, im not sure), the content was about dozens test guide with pictures about making many different kinds substance, compounds..which in this day’s you can’t find in internet or google.. like extracting HCN from Bitter Almond.. The descriptions was so simple and clear, unfortunately I decided to buy it later cos it was expensive and most worse i did not take a note about writers and the name of book..
whats a name of glassware for collecting different fractions which no need disconnecting them(i mean about end of liebig condenser)? Sorry for little offtop guys and thx for your help
No way. I mean you cannot use it directly. But, There will be reactions by using Acetic acid and some other uncommon catalyst (refer green chemistry journals). But most of the times yield will be very low.
Question: Is this how it goes for you kids? You're at some school at insert random U.S. university and one lucky rando from class gets to, "create a youtube" channel that pertains to chemistry? Like do you all have to draw straws and the lucky one gets the worm or is it like The Price Is Right from back in the tube T.V. days and someone inevitably gets the score by one point? I mean, right in lab class it would seem....
__Flat-bottomed flask under vacuum__ - PLEASE! DON'T DO THIS ANYMORE! Even NO vacuum filtration! For vacuum filtration we have Bunzen thick-walled flasks.
Production quality is perfect i think you just need little bit more time to get more popular thank you for making these videos
Oh so cool! I love the quality and procedures in your videos! Very interesting using acetic anhydride instead of acetyl chloride. I'll have to try this as I have a good quantity of acetic anhydride that I need to use. I bought it thinking I'd use it alot but actually haven't cracked it open 1 whole year later!
Any synthesis that contains toluene is amazing! 👍And beautiful music!
Any synthesis that includes acetic anhydride I click away from. Why watch something that is basically banned.
Очень качественные видео, спасибо
p-Methylacetophenone can be precursor for mephedrone, due very similiar structure, so some countries might maded it illegal
How? I just looked at the structure of mephedrone and its acetophenone with the alkyl chain extended, branched, and aminated. It seems like a bad starting point.
Its like calling dopamine amphetamine also almost alike.
Explosions&Fire sent me, great stuff man! Keep it up!
Good to see you here! Still waiting on that iodomethane part 2 video as well. LoL! 😉
@@BackYardScience2000 the part two of that video had to go on the back burner since the material I was trying to analyze was amorphous. Makes XRD a little difficult. But I’m setting up a new lab that will be dedicated to more videos. Setting it up is the next two months of my life though haha.
Neat video on organic chemistry. Cool.
nice! does the last distillation absolutely need to be done under vaccum?
I love your video, what is the name of that book you have?
It would be very useful for you if you could hook up with someone who can run an nmr for you. That would take out all of the guesswork about the identity of your products.
He can also do the TLC for preliminary analysis as well.
If he has reference compound then he can also do the confirmatory analysis with TLC alone.
What do you mean due to the loss of vacuum in the system?
Dont you keep the vacuum pump running during the distillation?
Or do you pull the vacuum, close the system then run the heat to distill product?
I always thought they say to keep the vacuum pump running during the whole process and have a vacuum constantly pulling on the atmosphere inside the system?
Im confused lol
I believe the abnormal boiling point during the vacuum distillation is the result of my pump heating up considerably as it runs, this would increase the vapour pressure of the oil and whatever solvent impurities that have been captured in it. So as the pump runs, it heats up the oil, increasing the vapour pressure of the oil, increasing the pressure in the system, increasing the boiling point, and this would happen slowly over time as the pump slowly heats up. That's my theory.
Вполне возможно.
Thank you for that information.
But, could this reaction be done by a substitution of benzene for the toluene and acetyl chloride for the acetyl anhydride to yield acetophenone instead of the p-methylactophenone?
Sorry I meant substituting acetyl chloride for acetic anhydride?
@@martinheidegger1125 Yes. You can do that. Acetyl chloride is also very good reagent.
But consider two things
Acetyl chloride is highly toxic.
And if you use acetyl chloride the by product will be HCl (a strong acid), in case of acetic anhydride it results in acetic acid as the by product (weak acid).
So for acid sensitive reactants acetic anhydride is better.
Also, HCl is more toxic compared to acetic acid. So reactions with Acetyl chloride should be done with care .
@@yogi5752 apakah dia membohongi kita dengan tayangan ini ? Apakah jika kita mencobanya akan terjadi ledakan .
Atau memang tayangan memang benar cara membuat p2p
Can you also use acetyl chloride instead of acetic anhydride?
Yes
which book do u have?
One time I saw one old secondhand book in a book shop’s in Northern Iran- Rasht, written by a professor( i think the writer was French or American, im not sure), the content was about dozens test guide with pictures about making many different kinds substance, compounds..which in this day’s you can’t find in internet or google.. like extracting HCN from Bitter Almond.. The descriptions was so simple and clear, unfortunately I decided to buy it later cos it was expensive and most worse i did not take a note about writers and the name of book..
Hi i'm iranian🙌
whats a name of glassware for collecting different fractions which no need disconnecting them(i mean about end of liebig condenser)? Sorry for little offtop guys and thx for your help
Its a cow adapter
isn't the actual liquid yellow?
As soon as I saw that nile hot dog logo I zoned out!
i love it
Altarnwtive fiedel craft reaction zinc powder video please
Can glacial acetic acid be used instead of acetic anhydride?
I don't think so but acetyl chloride can be used.
No way.
I mean you cannot use it directly.
But, There will be reactions by using Acetic acid and some other uncommon catalyst (refer green chemistry journals). But most of the times yield will be very low.
What book do use for the synthesis?
Vogel’s practical organic chemistry 5th edition, page 1012
Please metylpropiophenone synstesis and distill
No
GL!
which vacuum pump do you use ?
RS-1 3CFM 1/4HP Single Stage Rotary Vane Vacuum Pump
are you not afraid it will rust or explode?
Already full of rust... somehow still kicking and I'll use it till it dies, then get I'll pick up a nice pump
@@corrosion-chem Yeah it should be a diaphragm pump. Diaphragm vacuum pumps are insanely expensive.
Question: Is this how it goes for you kids? You're at some school at insert random U.S. university and one lucky rando from class gets to, "create a youtube" channel that pertains to chemistry? Like do you all have to draw straws and the lucky one gets the worm or is it like The Price Is Right from back in the tube T.V. days and someone inevitably gets the score by one point? I mean, right in lab class it would seem....
Based
__Flat-bottomed flask under vacuum__ - PLEASE! DON'T DO THIS ANYMORE! Even NO vacuum filtration! For vacuum filtration we have Bunzen thick-walled flasks.
Yes
Flat-bottomed flask under vacuum? Come on! Safety first! ;)
What's name abook?