4:42 Now imagine how much fun I'm currently having doing air and water-sensitive reactions with alkylplatinum compounds, on the 20-50 mg scale... (well, at least I do have access to specialized glassware and lab equipment for this sort of reaction. But it can get very frustrating very quickly!)
I feel your pain. Every single complex (apart from 1 rhodium complex) I made during my PhD was highly sensitive. Gloveboxes ftw. Having to use 20-50 mg of ligand at a time due to a difficult, lengthy synthesis is always a pleasure...
Didn't you know? Every molecule is a drug and should be illegal. Chemistry is an evil devil that should not be shown on such a delicate advertiser-friendly platform like TH-cam... one could make the dangerous weapon of mass destruction Dihidrogen Monoxide....
That's a good idea since I am sure the whole monetization on TH-cam doesn't bring in much profit with all this fantastic content getting flagged all the time. Than again I still have hope for TH-cam some where down the line. It would be really hard for new people to discover these videos if it were on a more obscure site. Lets face it, we have to accept that at the moment, TH-cam still is the best platform for discovery. They just keep going down hill and I don't think it will always be that way. Unless TH-cam steps up and changes something.
Maybe for the smaller scale version of this reaction could be useful to use a stronger and dehydrating electrophile such as propionyl chloride or propionic anhydride.. But one of the drawbacks on this way of thinking is that you should deprotonate and isolate the acetonitrile in a separate step before the Nu attack . Howerver your work has been great thank you very much for this kind of chemistry that i love
Why is the multiplet so weird? I'd expect a simple quadruplet but it looks more like a doublet of quadruplets? Is it something to do with the carbonyl next to the nitrile; partially tautomerizing to the enol on nmr time scales?
why did the sodium methoxide not deprotonate to do an aldol reaction or something? are the nitrile/chlorophenyl groups more electron withdrawing than the ester? or did it happen and is just an impurity? if so why is it not significant?
in intro level organic chemistry classes you are generally taught to use the same alcohol for the base as the group on the ester, as to avoid transesterification (the alkoxide group displaces the starting alkoxy on the ester, resulting in a mixture of products). in this case though the final product doesn’t have an ester group, so it doesn’t matter in the end.
Do you know why it got flagged or was it without reason? If it was, maybe we should think of setting up some sort of petition as that can't possibly be intentional.
Mit1mit2mity4 It's because TH-cam automatically flags videos it deems "inappropriate" or "not advertiser friendly" What ever that means. The thing is there are no concrete rules. And to add insult to injury the TH-cam algorithms take down the video without any human intervention. Which is to say no one actually watches the video to see if it's legitmate, or in other words they don't care. It really is a sad state of affairs and it needs to fixed.
Thing is that more often than not, it works well. And though youtube sometimes flags the wrong content, they're also a big fan of science videos so they surely want to help. As would the green brothers who have enough pull and contacts to start looking for a fix. But this is all assuming that it's a mistake, which may not always be the case, as youtube may look to flag videos that show the step by step synthesis of (highly) dangerous compounds.
yeah i can't find your name on my subscriber list either (although granted it's pretty shoddy). Maybe youtube glitched out or something. Really sorry this happened. Bug me again if my next upload also goes to you. I'll complain to youtube if this keeps happening. Anyway really sorry.
It's been so long I forgot why you're trying to create a medication. Is it for the millions of Americans that can't afford it on their own so they can just make it themselves?
not exactly. it's too complicated for anyone to make themselves, even if it could be made for free. I did this more as a challenge, to show that amateurs, if properly mobilized, can fight corporations should the need arise. I'm just one guy that managed to do this. Imagine if half a dozen people smarter than me got to work on it. It'd be blatantly illegal of course. but if the choice for a sick person is this and death, one must consider their options.
This video was reuploaded because youtube flagged the previous one. If youtube flags this one as well then i'll just upload it to vid.me.
I hate you, TH-cam
that's the future from now on
NurdRage thought I was a time traveler thinking this video was so familiar.
Huh, I thought I was getting the weirdest deja vu feeling. Glad I'm not crazy
Looks like youtube would flag anything now.
"My performance problems for the last 8 months was because I wasn't large enough" - NurdRage, 2017
Since you had to re-upload and the old comments are gone, I wanted to say thanks again for explaining the spectrum analysis. Very informative!
4:42
Now imagine how much fun I'm currently having doing air and water-sensitive reactions with alkylplatinum compounds, on the 20-50 mg scale...
(well, at least I do have access to specialized glassware and lab equipment for this sort of reaction. But it can get very frustrating very quickly!)
I feel your pain. Every single complex (apart from 1 rhodium complex) I made during my PhD was highly sensitive. Gloveboxes ftw.
Having to use 20-50 mg of ligand at a time due to a difficult, lengthy synthesis is always a pleasure...
Why did TH-cam flag this?
maybe because its chemistry. TH-cam tends to flag a lot of my chemistry videos.
Didn't you know? Every molecule is a drug and should be illegal. Chemistry is an evil devil that should not be shown on such a delicate advertiser-friendly platform like TH-cam... one could make the dangerous weapon of mass destruction Dihidrogen Monoxide....
Knowledge is illegal and/or copyrighted.
Great... another Global Flood..... What animals are we going to save this time?
we should do a mass migration to another video broadcasting website
That's a good idea since I am sure the whole monetization on TH-cam doesn't bring in much profit with all this fantastic content getting flagged all the time. Than again I still have hope for TH-cam some where down the line. It would be really hard for new people to discover these videos if it were on a more obscure site. Lets face it, we have to accept that at the moment, TH-cam still is the best platform for discovery. They just keep going down hill and I don't think it will always be that way. Unless TH-cam steps up and changes something.
Too bad there aren't any. Because monopolies.
Maybe for the smaller scale version of this reaction could be useful to use a stronger and dehydrating electrophile such as propionyl chloride or propionic anhydride.. But one of the drawbacks on this way of thinking is that you should deprotonate and isolate the acetonitrile in a separate step before the Nu attack . Howerver your work has been great thank you very much for this kind of chemistry that i love
My bod is ready for this project to be complete.
AAAAA-HHHHHAAAAA-HHAAAA))))))))))))))))))))))))))
Awesome, continue!
why doesn‘t the methoxide itself directly react with the ethyl propionate in an nucleophilic/electrophilic reaction?
Why is the multiplet so weird? I'd expect a simple quadruplet but it looks more like a doublet of quadruplets? Is it something to do with the carbonyl next to the nitrile; partially tautomerizing to the enol on nmr time scales?
they're diastereotropic.
NurdRage So they are ^^ thanks!
I’ve never had to google search so many words lol!!
why did the sodium methoxide not deprotonate to do an aldol reaction or something? are the nitrile/chlorophenyl groups more electron withdrawing than the ester? or did it happen and is just an impurity? if so why is it not significant?
it probably is. But the impurities are washed out during the washing step. so you see very little of them.
What lab do you use for NMR's ?
Why didn,t thenitrile group get hydrolised when he
added HCl ?
ashutosh sharma Nitriles are very resistant to hydrolysis, so brief contact with room temperature acid shouldn't hydrolize them too much.
It's better use CH3CH2COOCH3 , because You use metoxide CH3O-.... or do I make a mistake?
in intro level organic chemistry classes you are generally taught to use the same alcohol for the base as the group on the ester, as to avoid transesterification (the alkoxide group displaces the starting alkoxy on the ester, resulting in a mixture of products). in this case though the final product doesn’t have an ester group, so it doesn’t matter in the end.
How many tries did it take you to get the final product of this synthesis? It looks extremely time consuming
Hi, I'm in Canada. Is it tricky to get glassware here?
Not at all.
Nah. I have bought a bunch fro the USA and China. I think the last time I bought something was 2020.
Ok, youtube is shit! Noone deserves to go trough this!
I keep buying more glassware!
Doesn't the methoxide attacking the carbonyl in ethyl propionate cause a big loss of yield ?
Not really. Transesterification is probably a main side reaction, but it leaves the ester functionally intact for the nucleophilic attack
did you re-upload this? I swear I saw this video before.
youtube flagged the original
makes sense
Do you know why it got flagged or was it without reason? If it was, maybe we should think of setting up some sort of petition as that can't possibly be intentional.
Mit1mit2mity4 It's because TH-cam automatically flags videos it deems "inappropriate" or "not advertiser friendly" What ever that means. The thing is there are no concrete rules. And to add insult to injury the TH-cam algorithms take down the video without any human intervention. Which is to say no one actually watches the video to see if it's legitmate, or in other words they don't care. It really is a sad state of affairs and it needs to fixed.
Thing is that more often than not, it works well. And though youtube sometimes flags the wrong content, they're also a big fan of science videos so they surely want to help. As would the green brothers who have enough pull and contacts to start looking for a fix.
But this is all assuming that it's a mistake, which may not always be the case, as youtube may look to flag videos that show the step by step synthesis of (highly) dangerous compounds.
"My performance problems for the past 8 months were because I wasn't large enough." - NurdRage 2017
Why did you decide to make pyrimethamine?
A company was overcharging for it. I think someone wound up in prison (Search "turing scandal")
wait wasent this uploaded already?
TH-cam flagged the original
ahh, i see that you added reupload to the title now. thanks
Why was this flagged?
Because it`s chemistry and, apparently, it scares some people.
because to simpletons, chemistry, even INORGANIC chemistry = making drugs. Idiots...
Wow TH-cam wow
Hi😊
at last!!!!!!
Vid.me ising down, now.
yo waddap
Dude what the fuck is this? Apparently I'm subbed to this, but I don't know anything about science lol. You seem hella smart though.
wait hold up... you got forced sub to my channel? that's odd. Is this the first video of mine you've seen?
I have no idea, man lol. I don't remember subbing to a science channel.
yeah i can't find your name on my subscriber list either (although granted it's pretty shoddy). Maybe youtube glitched out or something. Really sorry this happened. Bug me again if my next upload also goes to you. I'll complain to youtube if this keeps happening. Anyway really sorry.
So TH-cam isn't just unsubscribing people from channels now, they're subscribing people to random channels? Google is a weird company.
I'd be pissed off if YT did this to me but at least you got auto subbed you to a great channel, haha
Primeiro
first
Good job
It's been so long I forgot why you're trying to create a medication. Is it for the millions of Americans that can't afford it on their own so they can just make it themselves?
not exactly. it's too complicated for anyone to make themselves, even if it could be made for free. I did this more as a challenge, to show that amateurs, if properly mobilized, can fight corporations should the need arise. I'm just one guy that managed to do this. Imagine if half a dozen people smarter than me got to work on it. It'd be blatantly illegal of course. but if the choice for a sick person is this and death, one must consider their options.
Who else clicked on this video because H3C?