Here in South Australia, they are going to stop the Advertising of Fast and Processed Foods on our Public Transport, some in the community weren't happy, wonder who they were.
Metabolic is the key word. Thank you Nick Norwitz, you explained this clearly. Inflammation is a huge cause for most afflictions. People don't pay attention to inflammatory reactions in their bodies because they never do an elimination way of eating to discover what foods cause them pain which is a result of the inflammation. Knowledge is power.
I use it low dose off label for chrons for over a year . Lost 3 kg on scale and 2+ dress sizes because of inflammation. Prior I was carnovorish fasted 5/2 and work out 5 times a week
Excellent, systematic, impartial discussion. When I stopped eating carbs, my metabolism changed radically. My hormones adjusted, inflammation evaporated, body reshaped, lost weight, and even my palate went from craving sweet to savory. No drugs.
Absolutely love your content, I watch every video. Would love to do a podcast with you and talk about proper use of GLP1 medication’s. We have thousands of people utilize micro dosing protocols, only when paired with proper lifestyle interventions.
My functional medicine healthcare provider put me on low dose GLP-1 8 weeks ago for inflammation due to autoimmune disease. It's been life changing! I was at a healthy weight to begin with & was worried about losing more, so far I've not & all is well.
Your information is spot on! I work with a couple of people that are currently taking GLP-1's and I see them every single day walk into the office with 2 ginormous mountain dews from the local gas station and then proceed to eat at fast food restaurants for lunch. It drives me absolutely crazy because they are obviously not learning that good nutrition is key to being healthy...they think that their shot is the cure. Furthermore, your discussion on supermarkets was absolutely true. I remember growing up and our supermarkets being comprised of more produce and meats/seafoods and being much smaller in scale. Now the entire middle section of the supermarket is crappy food that is killing people! Then walking around the supermarket and seeing a cart with children in it and what their cart is filled up with...4 12 packs of soda, 3 boxes of cereal, chips and crackers. It breaks my heart!
that is ridiculous that those people continue to gulp giant sodas and eat crap, education needs to come along with the Ozempic prescription and stern warning, these are the people that will gain all the weight back after they one day have to quit the drug, these are the people that are metabolically unhealthy and they don't realize that losing a bit of weight is not going to help it
It's the wonderful bed hair at 1:05 for me xd. Love the video NICK! As always, logical and informative without bias, purely for the sake of knowledge, curiosity and research! Proud to be a follower, and keep up the exquisite videos!
I had that one unicorn horn on the side... noticed after... decided to roll with it and not re-record. Had other things to do ;). I'm happy to have you as a follower!
I agree that we should be trying to prevent these health issues more rather than just treating them after they occur. And a big part of that is eating more whole fresh foods and meats and much less sugars and starches.
@@nicknorwitzPhDHave you noticed the persistent mantra of the news media that good food is expensive. That “Fact” is repeated so often that it is just burned into societies consciousness, and it can’t be questioned. Please delve into this, If you haven’t already.
The inflammation issue is amazing. I’m old, lost a lot of weight, reduced glucose, & changed my daily food choices but have not been able to reliably reduce my inflammation so the news here is important to me. Also, not interested in taking a pill or getting a shot so consuming healthy food that may naturally increase GLP-1 is definitely on my radar. Thanks!
@@jimbeaver27 I do thank you. I register ketones everyday with great fasting glucose readings. I fast for 48 hours a couple of times a month but inflammation persists so I have been concentrating on gut microbes lately.
@@jimbeaver27 no, I usually jog 30 to 60 minutes each day & meat/fish are included in my 2 meals with healthy fats during a 7-8 hour eating window each day. I do consume leafy greens occasionally but no grains/sugars/starchy vegs. Berries are the only fruit I have & that is a rare occurrence. I also quit drinking alcohol 5 years ago. Still working on a regular strength training routine.
As always , another fabulous video to add to the arsenal of tools in the reeducation of metabolic health ! Thank you , Nick ! You and Ben Bikman are truly my go-to guys!
GLP 1A may reduce inflammation, but so does a diet void of sugar, processed foods and seed oils. If paired together.....perhaps beneficial. I just can't get past the idea that everyone wants a quick fix. If they take a GLP1A and keep eating crap food, is it really a good thing? I just can't get on board yet....that is a good thing.
I agree with you, change your diet/lifestyle not go for the quick fix. I just hope more people start to wake up as to what Processed and Ultra-Processed foods are doing to our health and go for a long-term 'healthy' fix rather than a short term... What is going to happen when those finding relief on GLP-1's start coming off them, but haven't changed their diet/lifestyle?
My wife of 34 years weighs 100lbs, walks 30K steps a day, eats ZERO sugar, low carb, high animal protein, no seed oils, whole Foods, lifts weights, no alcohol, no smoking, high VO2 max, good D3, current on all cancer screening, endurance athlete, and Doctoral candidate. Lived this way since 2018. High scores on Oura and Apple health for sleep, readiness, resiliency. Picture perfect fit for your definition of someone willing to do the hard work, no quick fixes here. She also has been wracked with pain from a 15 year old spinal fusion with broken pedicle screws. Micro dosing GLP-1 prescribed by her pain Dr has reduced the inflammation in her back so much she is free from pain for the first time in over a decade. Free! Life changing. Not everyone wants a quick fix. Just sharing a real story and experience.
You will see later on that these drugs also will cause digesting problems. I`m going through some issues because side effects from a similar drug from three years ago! It was two-fold, help with type2 diabetes and lose some weight! It has caused some stomach issues that is troubling for me today! This new craze reminds me of Fen- Phen weight lose drug back a many years ago that killed so many people! Lifestyle change is the only answer with a clean food keto diet. great topic!
Thanks to the Keto/Carnivore-ish lifestyle, I am now beginning the 'eat more, move more' phase - seems to be especially important for the elderly crowd (over 65)
Keto/Low carb/Carnivore is a good start. But now you have to make a serious effort to remove processed foods from your diet. Their contribution to inflammatory conditions is only just beginning to be understood. Staying active is a given.
My brother is 50 years old. 170 kilos. Pain all over his body. Have high blood pressure, diabetes etc. Everything that comes from metabolic syndrome. Pap machine... I convinced him to go all out carnivore, high fat no lean meats but also no butter etc. In three days he said has NO PAIN in his knees and back. Sleeps better breath better feels better and have more energy. I only gave him a good multivitamine, magnesium citrate and to salt all his meals. He is on carnivore now for a month, never felt better for decades. Hi from Cyprus @@nicknorwitzPhD
@@floydffrogfloydffrog7453 It did take me a little while to recognize the risks of industrially processed seed oils. Funny enough, crackers continue to be my main craving. Linoleic acid (LA) can affect the endocannabinoid system (ECS) in a number of ways, including: *Increasing endocannabinoids* LA can increase the production of endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA). These endocannabinoids can stimulate appetite and energy metabolism, which may lead to weight gain _munchies, anyone?_
My obesity was caused by being repeatedly subjected to starvation as a child, leading to compensatory disordered eating. It wasn’t lifestyle choices that got me there, or too much sugar. Relatively the same thing happened in the Minnesota Starvation Experiment where subjects baseline weight altered to higher than it was before the experiment. I’ve since been able to get to a healthy weight, eat anything I please so long as I keep the calories to a sane level, but it doesn’t change the fact then when I feel hunger, it’s not mere annoyance and discomfort that my body experiences. It’s animalistic fear.
I am with you, Nick, on the changes in life style being the best interventions. For a short time, less than a year, I was able to control my rheumatoid arthritis with diet and time restricted eating. But when I travelled last summer, my inflammation returned. Trying to regain my former happy state with strict adherence to time-restricted eating, diet, and exercise. Too many variables...election stress may have negatively contributed.
I'm hopeful that at the very least this will be a good alternative to many looking towards lap bands and other surgical interventions which are probably way riskier.
I'll be happy when people finally see weight issues are not generally the bottom line issue but the metabolic condition that causes the added weight to begin with. As far as CICO I like to use the analogy of comparing a 2000 calorie diet of Bagels/Cream Cheese vs 2000 calories of Ribeye steak and in how the body responds metabolically.
Thank you Dr. Norwitz. There are so many doctors that have fallen hook, line and sinker for the deadly benefits of the Standard American Diet. I would only pray they would watch your channel to see the errors of their ways. Change comes so slowly!
I have a long history of joint pain that is most intense in my back and elbows. Last August I went on a GLP1 for weight loss and I hoped, pain relief. At the same time I went to work after raising my kids in the service industry where I obviously now move more. I have felt great since starting the GLP1 and I've slowly, but surely lost almost 20lbs. I decided to skip a week of injection around Christmas to avoid an gastric upset from bad choices. About day 12 from my last injection the pain and stiffness in my back and my right elbow was intense. A day or two after immediately dosing myself, the pain subsided. I so excited to know that this drug does indeed help someone like myself in a profound way other than weight loss.
GLP-1's make adopting a healthy lifestyle change so much easier if used that way. Unfortunately, they also make not having to adopt a healthy lifestyle easier.
Good video, Nick. I liked that you called the calorie paradigm a "mental virus." I couldn't agree more. Calories are units of heat energy, they have absolutely nothing to do with how living things extract energy from food. I wish you'd be more concise on that point.
the energy balance model is still scientifically sound. if you have a fat do you reduce its energy in and it loses weight. same with humans. myself and my husband both lost weight on reduced 'energy' diets.
@@nicknorwitzPhD I watch it halfway through, it's pretty unbearable, what does thermodynamics have to do with living beings? Thermodynamics only applies to closed systems my friend, we are not closed systems, what I meant by wanting you to address the fallacy of calories is that they have no relation to the energy that living beings use. Look how calories are calculated, they set food on fire and measure how many degrees a quantity of water is heated, what the hell does it have to do with what a living organism does? Are you a biochemist? ...
As someone who never bought into the CICO discourse, this video (and your channel as a whole) is a breath of fresh air. I am an unlucky (for modern times, at least) genetic outlier, capable of gaining weight with 1000 calories/day if I'm only moderately active (10K steps and that's it). I would have to literally starve myself to lose weight normally. Good food choices, independent from calories, and high volume weight training (20 weekly sets per muscle group) almost triple this miserable daily intake limit, allowing me to cruise at 15~20%bf on more calories, instead of being a fat starving man at almost 30%...
I’m you plus heart disease. I’m carnivore now and healthier than I’ve ever been. I started gaining weight and dieting at age 9. People don’t believe that there are people like us out there and blame everything on us. 😢 I’m on Mounjaro for inflammation despite my low weight and improved metabolism. The GLP-1 is literally saving my life thanks to help with inflammation and heart protection.
@@rjScubaSki I know that my metabolism is very efficient and adapts really quickly. For what it's worth, a DNA test confirmed this (95th percentile for adiposity, total body mass, and visceral fat%). I've been like this since I was 10; I always knew something was different for me. At a sedentary level, I can only eat as much as my petite wife (who's around 20% bf), sometimes less, despite being a 6ft man. The first time I decided to lose weight, I was completely sedentary and had to get so low that I fell into depression. I had no energy, zero libido, couldn't maintain an erection, and experienced brain fog... Not fun times. I had to learn how to manage my weight the hard way. On the positive side, I would survive any potential famine!
@@gsts379 I did keto, but had heart and sleep issues long term (similar experience to P. Saladino). I'm low-ish carbs now, which i eat mainly around diner (between 6 and 7pm). I can tolerate them as long as i'm really active, and my libido is better with them no matter the weight. I eat around 2/3 of my proteins from animal sources. Lots of plants, and "good" fats too (nuts, olive oil, fatty fish). Think high protein Mediterranean diet.
The neuro ophthalmologist at Harvard found that on semaglutide there is an increase of 4-7 fold incidence of non obstructive ischemia of the optic nerve. I mentioned the pathway of glp-1 in the hypothalamus in a previous post below. Arterioles also have the glp-1 receptor, anandamide and TRPV1. TRPV1 is a vasoconstrictor and this could cause the ischemia in these cases.
Fixing your metabolism is not easy for many people, but the reward is directly connected to the effort required. The more metabolic disfunction the more likely that the cause is a major part of your social life, it also is probably connected to addictive eating habits.
I don't think there's a linear relationship between effort and reward. The term "work smarter not harder" comes to mind. If you eat a SAD-style diet, even trying to cut calories, while exercising your butt off... you may end up working very hard and making very little progress. On the other hand...
Thanks! I'll definitely bring this up in the next class (I'm in my final year of studying nutrition, where calories still rule). I have a different question, if you don't mind: what about magnesium supplements? I recently had a conversation with an MD who said that taking a supplement is BS. Would love to see a video of you about mg 🌚
Magnesium supplements can be useful, and there are many forms. Some are more bioavailable and some are used as osmotics (e.g. as laxatives). I'm sure you can find many blogs on the different forms of magnesium and their uses. Proper electrolyte balance is important.
He's mentioned tahini in at least a few videos (I don't know if tahini butter is something different than just tahini, I've never heard it called tahini butter before). He uses it to "kickstart" ketosis and is a big fan of it. I bet if you search his channel for tahini, you'll find the video I'm talking about.
@@RickinICTI could understand from his videos that it’s safe to consume but I would love to hear from him more info, because it does have omega 6 in it and I am wondering what he does about it with tahini.
I am and have been extremely curious, about a documentary. I seen a long time ago. Can’t tell you where can’t tell you when, but in that documentary, they described people who had heart problems, as sugar actually scoring the inside of the arteries therefore, fat came along and filled the damage in so much so that it clogged arteries, causing a heart attack. I would like to know if there’s any studies out there that prove this?
The only thing I have against GLP-1 is that they ultimately WILL increase the general inertia to fixing the food environment. It’s surprising that even in countries where healthcare is provided almost exclusively through taxation, there is a preference to spend more on drugs rather trying to deal with the root cause.
For me, a healthy lifestyle is the most important, not just the diet, the exercises, sleep quality, clean air, individually, it’s the whole thing. Obviously it’s quite impossible to optimize everything to perfect in the modern world, as least we can try our best to.
We analyzed the inflammation and changes in the aorta by H&E staining. SOD, MDA, and GPx levels were determined as per the instructions of the kit protocols. ELISA was used to measure the levels of interleukins, whereas immunohistochemistry was carried out for the evaluation of MCP-1 expression. SRP treatment significantly suppressed vascular inflammation in BALB/c mice. Mechanistic studies demonstrated that SRP significantly inhibited the LPS-induced production of proinflammatory cytokines such as IL-2, IL-1, IL-6, and TNF-α in aortic tissue. Furthermore, it also inhibited LPS-induced oxidative stress in the aortas of mice, whereas the expression and activity of monocyte chemoattractant protein-1 (MCP-1) decreased after SRP treatment. In conclusion, SRP has the ability to reduce LPS-induced vascular inflammation and damage by modulating MCP-1.
Has anyone seen any research on almost instant mental "clarity" I was looking at getting ADHD diagnosis. But started mounjaro 3 days ago and with in 30mins it was like some one flicking a switch in my brain. Something I was not aware of or been told about or seen. With only stuff I can find is mental health in long-term as you lose the weight, gain confidence etc.
And it's not just the lack of food noise. But basic every day tasks like cleaning which I struggle with massively and barely did one such task a week. I've done 4 such tasks just this morning. My brain is no longer racing 24/7 it feels calm and stuff I struggled with if I think it needs doing it now takes effort not to do them as it's now a persistent thought and not fleeting. Where food has gone from persistent addiction type thoughts to the fleeting easily ignored thoughts boring tasks used to be. I hope this feeling continues. Is this what it feels like for normal people.
That could be linked to reduced inflammation as well. Many mental health issues are improved with a reduction in inflammation. I am glad you are seeing that benefit. Consider transitioning to a low.carb diet to increase the effects and eventually help you to come off the meds.
The mental clarity is available with zero drugs. I was carnivore for 120 days, dropped 40 lb, then maintained about 100 carbs or less per day over a year. 69 y.o. No meds. Great metabolic health. Impressed my doctor!
My brain immediately jumps to this question: Research shows consuming allulose can stimulate the release of GLP-1. So if I played “connect the dots”, fully understanding this is conjecture/hypothesis, might allulose consumption lead to a decrease in inflammation via the GLP-1 pathway elucidated in this vid?
I wondered this too. But there are a couple of catches I think. (1) Keeping a "sweet tooth" alive and kicking. (2) Adding it to WHAT? If food, it is likely to be baking or dairy, maybe. eg cheesecake springs to mind. So then we have those dairy probs at play, and maybe even some flour (even if, say, processed almond flour). Fruit is already sweet, sugary veg isn't really a thing, so where does it come into useful play that doesn't bring in (1) or (2)?. PS edit - Spellcheck corrected "vegs" to Vegas. 🤣
@@T-aka-T Keeping the sweet tooth alive? Hahaha! Just for giggles - I don’t mean this as a diatribe - but hear me out (and I hope this will prove fun and informative). I would go batshit if I couldn’t treat myself to my nightly sweets - and I consider myself pretty elite on the wellness front; for metrics I’m coming up on 62 y/o, maintained constant 10%-12% body fat for over a decade, V02 Max just above 52, am 6’ and 180lbs. None of that is gifted genetics, I work my ass off; and devour everything I can read and put into practice on supplementation, lifestyle, exercise, and dietary interventions. I pull every lever science suggests might produce a benefit. With all that, I keep a giant 2-pound jar of allulose right next to my espresso machine on the kitchen counter and use it almost daily. I don’t use it as much as raw honey, but I go to allulose several times a week. One of my favs is to use it to mask the nasty putrid sulphur taste of NAC powder (which I use because my daily volume of NAC and glycine dictates that powder is the far more cost effective strategy than pills). Over the holidays, I was able to convince family members to fully substitute allulose over sugar in holiday rum cakes, cookies, and one amazing bourbon chocolate pecan pie! And hot cocoa - best recipe ever is raw organic Cacao powder, allulose, and whole grass fed milk with a good spoonful of Organic Ceylon Cinnamon (and maybe some coconut oil if feeling the desire for some more healthy fats and flavor). Or my favorite cinnamon toast made from cracked-wheat sourdough, grass-fed butter or ghee, allulose (or raw honey), and heaps of organic Ceylon cinnamon. Ultra processed foods and crap like fructose corn-syrup don’t make it past my lips, not-ever-zero-exceptions, but I have found a way to keep my sweets so I don’t feel like I’m “giving up” my little indulgences. Someone else might suggest I’m doing it all wrong, but at 61 with a V02Max north of 52, I honestly don’t personally know another human my age I would trade places with health-wise. Until science shows me I’m making a big mistake, allulose is one of my go-to’s. Thing is, as time passes the body of research touting the great benefits of allulose just keeps getting better. Research it. Just sayin, I’d consider trying it before I’d ever consider trying to give up sweets…. I can’t. I’m weak…. All intended in fun, live well. :)
@@2BWiley2 Ah - so you HAVE kept your sweet tooth alive! 😁 (I killed mine with carnivore). And when I say 'killed', I mean gone - and now my detection senses are so high, any trace of sugar in, say, ham, is distinctly sweet tasting. Similarly, the stench of oxidised seed oil seeping out onto the street from "restaurants" is so offputting I don't even like fries anymore. I used to be a bit of a home chef. Never ate junk food. More like venison and ten veg, followed by croquembouche. Classic cuisine showing-off. Really can't be bothered now. The venison, yes, but haven't made gateau mousse au chocolat for yonks. I looked through your list of "food po rn" (the silly algorithm will get up-set by that) and it left me unmoved (which I was pleased to see, so thank you!). Christmas before last I knew I was over it when I passed the extra-special chocolate and thought, as it went by, "they look pretty" with a kind of zen-like detachment. Marvellous! I daresay I have done just as much research as you have - truly - but I don't "pull every lever" like a maniac 😏. I just eat meat, and it fixed everything.
@@T-aka-T If we’re lucky, we each find our way. Carnivore has proven a successful path for probably tens if not hundreds of thousands of people and growing - excellent for you! This is the way; enjoy and thrive!
@@2BWiley2 Thanks. Nearly 4.5 years now, after keto since 2014, so I'm pretty much a reliable convert. I'm just sorry the carni people have started to go political - for so long, we stayed right out of that toxic US stuff. I fear it will now damage our bottom-up case. Anyway, cheers to you, wherever you are. 🦘🙏
My T2 mother uses a daily GLP-1 with her slow release insulin. It hasn't reduced her weight despite her reduction in calories. However, her average blood glucose levels are markedly lower than with her slow release insulin alone. After a couple of decades of insulin dependence, her beta cells are pretty much fried even on the GLP-1. FWIW, people selling eggs and celery are also doing it for a profit.
Living a healthy lifestyle was what I expected you to say. And, of course, you're correct. I don't need prescription, and I get all the benefits with no side-effects--or the "side-effects" ARE the benefits.
At a BMI of 24.1, I'll have to pass despite way too much visceral fat, because of the gastroparesis risk. But, I do use allulose on the daily, sometimes just those 10g flavored RXsugar packets.
We have an epidemic and right now there isn't a quantum societal leap on the horizon to change the cause, as most of it is hard wired. GLP-1 RA and similar help reduce obesity and it's horrors. They are a great addition to our arsenal.
"Good metabolic health causes a healthy weight, NOT the other way around." - Dr Nick Norwitz PhD " It's not 'lose weight to get healthy,' it's 'get healthy to lose weight.'" - Dr Eric Berg DC “Calories are like the wheels on a car.” - Dr Nick Norwitz PhD IE The ‘car’ is your body’s hormones & metabolism: your complete physiology. Dr Norwitz is spot on! I'm presently eating a diet of clean carnivore foods to gain health. The weight loss I am experiencing is the welcome byproduct of my improving health.
Try psychedelics to get to the root of your addiction. If you go into it with that intention. There is many who have gotten out of their addiction that way.
I think in the last section in this video, there is more room for optimism about GLP-1 drugs being a positive force at a societal level than you express. Or, rather, there's a trail, at least fifty years long, of failed attempts to fix the growing obesity problem through social changes. But society is very hard to change, and so the obesity rate has kept steadily climbing and people's metabolic health kept getting worse. Until 2022-2023 or so, when the obesity rate in the US started dipping, with very little apparent reason other than the Ozempic boom (most Covid deaths were already done by that time, I believe). I think we will get those better foods in supermarkets - because people with better metabolic health will want to buy them. If we get walkable cities and bike lanes, well, it'll mostly be as a result of other advocacy - but one precondition for that working at all is people having bodies that physically can comfortably walk and bike places. If we want a return of social norms about communal eating, it might well help if we banish guilt about the sin of gluttony - by banishing gluttony itself. It'll be expensive and imperfect, sure. But that just means the good outcomes will happen expensively and imperfectly, rather than not happening at all.
You said "help if we banish guilt about the sin of gluttony - by banishing gluttony itself" --- this is an interesting concept. Your take is thought provoking. Kudos for that.
the eat less and move more paradym is the biggest problem, many obese people have for years gone on all the diets, lost weight then regained it, until the doctors start telling people about low carb diets nothing will change. Obese people need to know that if they stick to a keto diet they won't always feel hungry and their entire bodies will start to feel better, once they feel better and are satiated with real food they hopefully will be able to keep the weight off, and more importantly keep metabolically healthy (without any drugs)
As I already have delayed gastric emptying, I am afraid to take any of these medications, regardless of their many reported benefits. Hopefully, they'll be able to come up with something that doesn't have that effect. (Currently ketovore but still obese)
Well said: a healthy lifestyle causes weight loss, and not vice versa. Hence, it sounds to me more like Carbohydrate-Insulin Model of obesity (CIM) hypothesis is the one to take seriously.
The CIM is incomplete but a useful model that makes biological predictions that have generally held true at population scale. The "CICO" model isn't even a model of obesity. It's a post-hoc description and simple statement of physics that doesn't tell us about physiology.
There is bacteria in gut which is called akkermansia. It increases glp1 naturally and is known to regulation glucose metabolism which helps reduce type 2 diebetes. That should be safer option.
I watched the video and perhaps I missed it, but if blocking GLP-1 receptors in the brain attenuates the anti-inflammatory response, could you not just as easily attribute the anti-inflammatory outcome to a decrease in calories? As opposed to some sort of mechanistic action? Was a decrease in calories consumed observed by the regular mice compared to the GLP knockout in the brain mice?
This is interesting re metabolic health and inflammation. In my experience buying food from a proper small farm with good farming practices reduced my inflammation so much compared to the same foods but from the supermarket. And binging cereal one time made me cry in pain as my joints did not approve 🤔
This is interesting as my doctor has asked me to take a GLP-1 Agonist due to the fact insurance doesn't want to cover it... I decided not to due to multiple factors, the largest being cost, which I find interesting as they will cover TRT because that is off the charts low. But I'm obese, and have metabolic dysfunction, however I'm not sick enough for a corrective tool for that. I'm not sure if Id be more willing to try it or not at that point based off of what I've found out about it so far...
Interesting video as always. Thank you. Note: The total food supply available for consumption has increased. This is most certainly also a contributing factor. Personally, I still think calories are a great tool for people with specific goals and determining baseline. If we assumed only whole food like meat, fruit and vegetables existed and day to day diet and lifestyle was exactly the same then calories could be used as a tool to measure baseline to make adjustments as needed for specific goals, in the same way we adjust macros to meet specific goals.
Hi Dr Norwitz I know this is such a random comment, but was wondering about your thoughts on keto and AGEs. Often animal derived products are demonised for their higher AGE levels and deemed "unhealthy". Thanks so much!
I hated Ozempic. It didn’t curb my appetite, it caused intestinal distress, and didn’t lower my A1C. I’ve been off it for ten months and have been on a Keto diet with intermittent fasting. I’ve lost sixty pounds, lowered my A1C to normal, and feel immensely better. I also quit my statin snd blood pressure medications. Medications, in most cases, aren’t the answer. It’s a proper human diet.
It is sort of too much to ask, since you'll never get the very long term data before a medication is rolled out. It's not really feasible. But once it's present in a population one can monitor the population for risks that take longer to manifest.
What's your view of Ozempic versus a straight Semaglutide peptide? I've been delving into peptides and I'm wondering if some of the problems with Ozempic is that it may need to be cycled. Possibly the preservatives versus the peptide? I know most wouldn't want to mess with the straight peptide because it takes some learning to do correctly.
This is what I'm saying- GLP-1 has been a very important subject on the front lines of health and fitness for the better part of the last 4 years (at least in my business). Succinct, intelligent, and true. I appreciate your demeanor and content around a hot-button topic.
Allulose can increase endogenous GLP-1 production via actions on the Vagus nerve, it's true. But the degree of increase is far lesser than via pharmacotherapy. That's not a judgement, it's just a fact.
Inflammation can manifest in so many ways. I went low carb and pretty much cured the arthritis pain in my fingers. Eat properly and you don't need to take drugs.
@@nicknorwitzPhD I have seen information stating the utilization of akkermasia could naturally raise levels of glp-1 to a more healthy level in those people who's microbiome is out of balance or lacking. Also, thank you for being a clear source of science rather than a drugged up blow hard.
Doesn't this tie into the good effects of keto diet (the antiinflammatory properties)? And I am wondering, since there's been good outcomes for some alzheimers pati3nts put on a ketogenic diet (improvement in cognition) - and we are beginning 5o understand that some cognitive decline is inflammation driven, are there any studies of GLP-1 agonists on dementia patients??
I loved this video, but the main question is: what is a healthy diet? Vegan? Animal-based? Mediterranean? ... I think you are ketogenic, but, did you hear about less meat for longer life?
@@nicknorwitzPhD It's my wife who reads many things and I remember her saying not good things about GLP and Ozempic. Here is one of the essays she recommended reading. Google, midwesterndoctor the-great-ozempic-hustle
Seems clear that reducing inflammation by way of lifestyle changes is superior to an expensive drug. That said, it took investigating how the drug works that we find that it reduces inflammation. It’s obvious that inflammation reduction is key to meany diseases, and lifestyle changes are effective in preventing inflammation/ disease. However, marketing strategies seem to be a major issue, sell the cause, then sell the cure. Unfortunately it has become the business model for many of our problems. Just saying.
Hi Nick, I want that world too. No more junk foods. I know that won’t happen in my lifetime. But, people are waking up now. Junk foods are addicting and should come with a warning to eat at your own risk, may cause addictions & poor health out comes. Plus, you are literally paying for shitty health when you it them. Put that money towards something good instead.
So the GLP-1 drugs act in unexpected ways. That could be beneficial, which of course is emphasized by the researchers. What about unknown detrimental effects? Is it too much to ask for medicins to have all the effects catalogued BEFORE it is used in a large number of humans?
I lived a healthy lifestyle for four years and slowly increased my weight every year. The problem, for me, was/is SATIETY!!!! GLP1 cured that part. I am interested to see what my blood markers are at my next annual appointment. I would say the only downside is my RHR has increased by about 8 to 10. I have only seen this talked about sparingly. I am slowly reducing my dosage and watching my weight carefully.
Did your 4year healthy lifestyle include at least .8-1.2g of animal based protein per lb of body weight and high saturated animal fats as well as low carb? When my carb intake is above 30g total per day I can lose the satiety signaling.
@@noyebalmer8112 Yes on the protein. I use Cronometer to track diet and Whoop exercise/sleep/heart etc. Sat fat did help but also did mess up some biomarkers. tx, jt
@@YeshuaKingMessiah yes i was eating too many calories...albeit from healthy sources...I had a lack of satiety as I stated. Thanks for the feedback. jt
There is a crowd that says it's just calories and hormones don't play a major role in weight loss. There is also another crowd that says the only benefit of GLP-1 is weight loss and people that take them are just lazy. I guess both these sides are going to be wrong. Time will tell but I fully support the proper use of these medications.
Here in South Australia, they are going to stop the Advertising of Fast and Processed Foods on our Public Transport, some in the community weren't happy, wonder who they were.
I like that public policy change!
Government shouldn't decide who can and can't advertise. Thats far too close to them banning saturated fat for not being "healthy"
worse than smoking. need to ban alcohol ads as well.
@@NutritionPoliceNo different than corporate monopolies advertising. The hard part is which shit stinks less. Lol!
South Australia has some amazing fresh produce.
Metabolic is the key word. Thank you Nick Norwitz, you explained this clearly. Inflammation is a huge cause for most afflictions. People don't pay attention to inflammatory reactions in their bodies because they never do an elimination way of eating to discover what foods cause them pain which is a result of the inflammation. Knowledge is power.
Glad you found value in the video. And - yes - knowledge is power!
I use it low dose off label for chrons for over a year . Lost 3 kg on scale and 2+ dress sizes because of inflammation. Prior I was carnovorish fasted 5/2 and work out 5 times a week
Excellent, systematic, impartial discussion. When I stopped eating carbs, my metabolism changed radically. My hormones adjusted, inflammation evaporated, body reshaped, lost weight, and even my palate went from craving sweet to savory. No drugs.
In a world where quick fixes and pills tend to be what so many who struggle with weight are looking for we need more messages like this.
I’m glad you appear to have found the content valuable and balanced
Absolutely love your content, I watch every video. Would love to do a podcast with you and talk about proper use of GLP1 medication’s. We have thousands of people utilize micro dosing protocols, only when paired with proper lifestyle interventions.
Let's make it happen. Crazy time rn but maybe Feb or March?
Oh my gosh, this would be an awesome collab! I love Dr. Jones vids!!
Nick, you give me hope for this generation. I'm so proud of you. Keep fighting the good fight with that stellar sense of humor 👍
Thank you Cynthia. Very kind :)
My functional medicine healthcare provider put me on low dose GLP-1 8 weeks ago for inflammation due to autoimmune disease. It's been life changing! I was at a healthy weight to begin with & was worried about losing more, so far I've not & all is well.
Your information is spot on! I work with a couple of people that are currently taking GLP-1's and I see them every single day walk into the office with 2 ginormous mountain dews from the local gas station and then proceed to eat at fast food restaurants for lunch. It drives me absolutely crazy because they are obviously not learning that good nutrition is key to being healthy...they think that their shot is the cure. Furthermore, your discussion on supermarkets was absolutely true. I remember growing up and our supermarkets being comprised of more produce and meats/seafoods and being much smaller in scale. Now the entire middle section of the supermarket is crappy food that is killing people! Then walking around the supermarket and seeing a cart with children in it and what their cart is filled up with...4 12 packs of soda, 3 boxes of cereal, chips and crackers. It breaks my heart!
I’m glad the video resonated. These are hard but important discussions to have. They require nuance and compassion
that is ridiculous that those people continue to gulp giant sodas and eat crap, education needs to come along with the Ozempic prescription and stern warning, these are the people that will gain all the weight back after they one day have to quit the drug, these are the people that are metabolically unhealthy and they don't realize that losing a bit of weight is not going to help it
It's the wonderful bed hair at 1:05 for me xd. Love the video NICK! As always, logical and informative without bias, purely for the sake of knowledge, curiosity and research! Proud to be a follower, and keep up the exquisite videos!
I had that one unicorn horn on the side... noticed after... decided to roll with it and not re-record. Had other things to do ;). I'm happy to have you as a follower!
It’s simply scary how many people are on Ozempic right now!!
💯
It's certainly a cultural phenomenon
It's great, a grand science experiment ongoing before our eyes. Results are being solidified fast
I agree that we should be trying to prevent these health issues more rather than just treating them after they occur. And a big part of that is eating more whole fresh foods and meats and much less sugars and starches.
Making that happen on a broad scale will require a multifaceted approach. But education and awareness are big parts of the puzzle
@@nicknorwitzPhDHave you noticed the persistent mantra of the news media that good food is expensive. That “Fact” is repeated so often that it is just burned into societies consciousness, and it can’t be questioned. Please delve into this, If you haven’t already.
The inflammation issue is amazing. I’m old, lost a lot of weight, reduced glucose, & changed my daily food choices but have not been able to reliably reduce my inflammation so the news here is important to me. Also, not interested in taking a pill or getting a shot so consuming healthy food that may naturally increase GLP-1 is definitely on my radar. Thanks!
I'm glad you learned something. Best of luck on your journey.
Get into Ketosis and do some fasting. Ketones make a huge difference in fixing metabolic problems like inflammation.
@@jimbeaver27 I do thank you. I register ketones everyday with great fasting glucose readings. I fast for 48 hours a couple of times a month but inflammation persists so I have been concentrating on gut microbes lately.
@lisacee3237 I hope you are walking alot and not a vegan
@@jimbeaver27 no, I usually jog 30 to 60 minutes each day & meat/fish are included in my 2 meals with healthy fats during a 7-8 hour eating window each day. I do consume leafy greens occasionally but no grains/sugars/starchy vegs. Berries are the only fruit I have & that is a rare occurrence. I also quit drinking alcohol 5 years ago. Still working on a regular strength training routine.
This is one of your best vids, Nick. Well done.
I’m glad you feel that way. Thanks!
As always , another fabulous video to add to the arsenal of tools in the reeducation of metabolic health ! Thank you , Nick ! You and Ben Bikman are truly my go-to guys!
Thanks! Love Ben. Such a nice man.
GLP 1A may reduce inflammation, but so does a diet void of sugar, processed foods and seed oils. If paired together.....perhaps beneficial. I just can't get past the idea that everyone wants a quick fix. If they take a GLP1A and keep eating crap food, is it really a good thing? I just can't get on board yet....that is a good thing.
I agree with you, change your diet/lifestyle not go for the quick fix. I just hope more people start to wake up as to what Processed and Ultra-Processed foods are doing to our health and go for a long-term 'healthy' fix rather than a short term... What is going to happen when those finding relief on GLP-1's start coming off them, but haven't changed their diet/lifestyle?
@@MrRiceakthe weight pukes back on, regardless of
@@YeshuaKingMessiahit’s a Mindset. But it’s still hard. LOVE your name.
My wife of 34 years weighs 100lbs, walks 30K steps a day, eats ZERO sugar, low carb, high animal protein, no seed oils, whole Foods, lifts weights, no alcohol, no smoking, high VO2 max, good D3, current on all cancer screening, endurance athlete, and Doctoral candidate. Lived this way since 2018. High scores on Oura and Apple health for sleep, readiness, resiliency. Picture perfect fit for your definition of someone willing to do the hard work, no quick fixes here. She also has been wracked with pain from a 15 year old spinal fusion with broken pedicle screws. Micro dosing GLP-1 prescribed by her pain Dr has reduced the inflammation in her back so much she is free from pain for the first time in over a decade. Free! Life changing. Not everyone wants a quick fix. Just sharing a real story and experience.
Well Done Nick, of course we should ask the initial questions you open with. Clear explanation of the broad effects of the new drugs on our health.
Glad you found the question and discussion appropriate
Thanks Nick for another great video. I appreciate your even handed approach and looking at the science with little bias.
Thanks Melissa. I try my best :).
You will see later on that these drugs also will cause digesting problems. I`m going through some issues because side effects from a similar drug from three years ago! It was two-fold, help with type2 diabetes and lose some weight! It has caused some stomach issues that is troubling for me today! This new craze reminds me of Fen- Phen weight lose drug back a many years ago that killed so many people! Lifestyle change is the only answer with a clean food keto diet. great topic!
Your talks are so fascinating! Thanks so much.
Thanks to the Keto/Carnivore-ish lifestyle, I am now beginning the 'eat more, move more' phase - seems to be especially important for the elderly crowd (over 65)
Keto/Low carb/Carnivore is a good start. But now you have to make a serious effort to remove processed foods from your diet. Their contribution to inflammatory conditions is only just beginning to be understood. Staying active is a given.
You got this!
@@nicknorwitzPhD Thanks, Happy New Year! 🥳
My brother is 50 years old. 170 kilos. Pain all over his body. Have high blood pressure, diabetes etc. Everything that comes from metabolic syndrome. Pap machine... I convinced him to go all out carnivore, high fat no lean meats but also no butter etc. In three days he said has NO PAIN in his knees and back. Sleeps better breath better feels better and have more energy. I only gave him a good multivitamine, magnesium citrate and to salt all his meals. He is on carnivore now for a month, never felt better for decades.
Hi from Cyprus @@nicknorwitzPhD
@@floydffrogfloydffrog7453 It did take me a little while to recognize the risks of industrially processed seed oils.
Funny enough, crackers continue to be my main craving.
Linoleic acid (LA) can affect the endocannabinoid system (ECS) in a number of ways, including:
*Increasing endocannabinoids*
LA can increase the production of endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA). These endocannabinoids can stimulate appetite and energy metabolism, which may lead to weight gain
_munchies, anyone?_
Fascinating stuff man, and I'm not surprised
Brilliant Nick🎯🎯Happy new year.
Same to you!
My obesity was caused by being repeatedly subjected to starvation as a child, leading to compensatory disordered eating. It wasn’t lifestyle choices that got me there, or too much sugar. Relatively the same thing happened in the Minnesota Starvation Experiment where subjects baseline weight altered to higher than it was before the experiment. I’ve since been able to get to a healthy weight, eat anything I please so long as I keep the calories to a sane level, but it doesn’t change the fact then when I feel hunger, it’s not mere annoyance and discomfort that my body experiences. It’s animalistic fear.
I starved as a child also. I have always been so disciplined with food. I eat to live.
@ I hope you’re well 🙏
your vids are incredible and i admire your communication skills
Thanks :). I appreciate it!
Excellent presentation! Thank you for always sharing your knowledge.
Very welcome Bobbi :).
I am with you, Nick, on the changes in life style being the best interventions. For a short time, less than a year, I was able to control my rheumatoid arthritis with diet and time restricted eating. But when I travelled last summer, my inflammation returned. Trying to regain my former happy state with strict adherence to time-restricted eating, diet, and exercise. Too many variables...election stress may have negatively contributed.
Great video. Thanks for sharing.
Welcome 🙏🏻
I'm hopeful that at the very least this will be a good alternative to many looking towards lap bands and other surgical interventions which are probably way riskier.
Options are a great thing when people are informed enough to make the rights choice for themselves.
Thanks Nik, always enlightening.
Cheers
I must commend you for your very well chosen words considering your position as an MD in relation to your allopathic peers. VERRY PROFESSIONAL ❤.
I'm glad you found this valuable and reasonable. Currently a PhD... MD in May ;)
I'll be happy when people finally see weight issues are not generally the bottom line issue but the metabolic condition that causes the added weight to begin with. As far as CICO I like to use the analogy of comparing a 2000 calorie diet of Bagels/Cream Cheese vs 2000 calories of Ribeye steak and in how the body responds metabolically.
I'll take the steak... and maybe it 3500 ;)
Thank you Dr. Norwitz. There are so many doctors that have fallen hook, line and sinker for the deadly benefits of the Standard American Diet. I would only pray they would watch your channel to see the errors of their ways. Change comes so slowly!
I have a long history of joint pain that is most intense in my back and elbows. Last August I went on a GLP1 for weight loss and I hoped, pain relief. At the same time I went to work after raising my kids in the service industry where I obviously now move more. I have felt great since starting the GLP1 and I've slowly, but surely lost almost 20lbs. I decided to skip a week of injection around Christmas to avoid an gastric upset from bad choices. About day 12 from my last injection the pain and stiffness in my back and my right elbow was intense. A day or two after immediately dosing myself, the pain subsided. I so excited to know that this drug does indeed help someone like myself in a profound way other than weight loss.
GLP-1's make adopting a healthy lifestyle change so much easier if used that way.
Unfortunately, they also make not having to adopt a healthy lifestyle easier.
Maybe it helps people get off the Sugar Rollercoaster.
I agree the former is a better use case.
Good video, Nick. I liked that you called the calorie paradigm a "mental virus." I couldn't agree more. Calories are units of heat energy, they have absolutely nothing to do with how living things extract energy from food. I wish you'd be more concise on that point.
the energy balance model is still scientifically sound. if you have a fat do you reduce its energy in and it loses weight. same with humans. myself and my husband both lost weight on reduced 'energy' diets.
Enjoy: th-cam.com/video/9KbxdzPK8W0/w-d-xo.html
@nicknorwitzPhD 😜 I missed it! I wasn't a subscriber 5 months ago, I think... I"ll watch it now, thanks 😅
@@nicknorwitzPhD I watch it halfway through, it's pretty unbearable, what does thermodynamics have to do with living beings? Thermodynamics only applies to closed systems my friend, we are not closed systems, what I meant by wanting you to address the fallacy of calories is that they have no relation to the energy that living beings use. Look how calories are calculated, they set food on fire and measure how many degrees a quantity of water is heated, what the hell does it have to do with what a living organism does? Are you a biochemist? ...
Fascinating and thought provoking.
I’m glad you thought so. Thank you.
As someone who never bought into the CICO discourse, this video (and your channel as a whole) is a breath of fresh air. I am an unlucky (for modern times, at least) genetic outlier, capable of gaining weight with 1000 calories/day if I'm only moderately active (10K steps and that's it). I would have to literally starve myself to lose weight normally. Good food choices, independent from calories, and high volume weight training (20 weekly sets per muscle group) almost triple this miserable daily intake limit, allowing me to cruise at 15~20%bf on more calories, instead of being a fat starving man at almost 30%...
I’m you plus heart disease. I’m carnivore now and healthier than I’ve ever been. I started gaining weight and dieting at age 9.
People don’t believe that there are people like us out there and blame everything on us. 😢
I’m on Mounjaro for inflammation despite my low weight and improved metabolism. The GLP-1 is literally saving my life thanks to help with inflammation and heart protection.
Sounds crap. Do you think you have very adaptive non exercise active thermogenesis?
@@rjScubaSki I know that my metabolism is very efficient and adapts really quickly. For what it's worth, a DNA test confirmed this (95th percentile for adiposity, total body mass, and visceral fat%). I've been like this since I was 10; I always knew something was different for me. At a sedentary level, I can only eat as much as my petite wife (who's around 20% bf), sometimes less, despite being a 6ft man. The first time I decided to lose weight, I was completely sedentary and had to get so low that I fell into depression. I had no energy, zero libido, couldn't maintain an erection, and experienced brain fog... Not fun times. I had to learn how to manage my weight the hard way.
On the positive side, I would survive any potential famine!
Just curious if you are eating plant-based low fat or meat-based keto diet?
@@gsts379 I did keto, but had heart and sleep issues long term (similar experience to P. Saladino). I'm low-ish carbs now, which i eat mainly around diner (between 6 and 7pm). I can tolerate them as long as i'm really active, and my libido is better with them no matter the weight. I eat around 2/3 of my proteins from animal sources. Lots of plants, and "good" fats too (nuts, olive oil, fatty fish). Think high protein Mediterranean diet.
The neuro ophthalmologist at Harvard found that on semaglutide there is an increase of 4-7 fold incidence of non obstructive ischemia of the optic nerve.
I mentioned the pathway of glp-1 in the hypothalamus in a previous post below.
Arterioles also have the glp-1 receptor, anandamide and TRPV1. TRPV1 is a vasoconstrictor and this could cause the ischemia in these cases.
It is scary the way these drugs are so widely prescribed when there is so much we don't know about longer-term effects.
@ absolutely and a “research” paper can be made to make them look good, similar to manipulation of statistics.
Thank you for reminding us that the correct diet will help us more in the long run than these new drugs.
But how to we change the food ecosystem so more people eat a metabolically healthy diet for themselves?
Fixing your metabolism is not easy for many people, but the reward is directly connected to the effort required. The more metabolic disfunction the more likely that the cause is a major part of your social life, it also is probably connected to addictive eating habits.
No reward is not connected at all
There’s no reward in my case
My effort is high too
@YeshuaKingMessiah you made the effort, fixed yiur metabolism (worked very hard to do it) and recognized no reward?
I don't think there's a linear relationship between effort and reward. The term "work smarter not harder" comes to mind. If you eat a SAD-style diet, even trying to cut calories, while exercising your butt off... you may end up working very hard and making very little progress. On the other hand...
Is there a pill to help with sugar addiction?
Stay curious!
Stay Curious my man!
Thanks! I'll definitely bring this up in the next class (I'm in my final year of studying nutrition, where calories still rule). I have a different question, if you don't mind: what about magnesium supplements? I recently had a conversation with an MD who said that taking a supplement is BS. Would love to see a video of you about mg 🌚
Magnesium supplements can be useful, and there are many forms. Some are more bioavailable and some are used as osmotics (e.g. as laxatives). I'm sure you can find many blogs on the different forms of magnesium and their uses. Proper electrolyte balance is important.
Hey nick , can you make a video on tahini butter please ? Is it healthy ? Safe to consume ?
Many thanks 🙏
Why not just butter or ghee
I think he has one, at least it’s on his personal use of it for hacking his metabolism for ketosis
He's mentioned tahini in at least a few videos (I don't know if tahini butter is something different than just tahini, I've never heard it called tahini butter before). He uses it to "kickstart" ketosis and is a big fan of it. I bet if you search his channel for tahini, you'll find the video I'm talking about.
@@RickinICTI could understand from his videos that it’s safe to consume but I would love to hear from him more info, because it does have omega 6 in it and I am wondering what he does about it with tahini.
Tahini is healthy and safe. Enjoy.
I am and have been extremely curious, about a documentary. I seen a long time ago. Can’t tell you where can’t tell you when, but in that documentary, they described people who had heart problems, as sugar actually scoring the inside of the arteries therefore, fat came along and filled the damage in so much so that it clogged arteries, causing a heart attack. I would like to know if there’s any studies out there that prove this?
The only thing I have against GLP-1 is that they ultimately WILL increase the general inertia to fixing the food environment. It’s surprising that even in countries where healthcare is provided almost exclusively through taxation, there is a preference to spend more on drugs rather trying to deal with the root cause.
For me, a healthy lifestyle is the most important, not just the diet, the exercises, sleep quality, clean air, individually, it’s the whole thing. Obviously it’s quite impossible to optimize everything to perfect in the modern world, as least we can try our best to.
We analyzed the inflammation and changes in the aorta by H&E staining. SOD, MDA, and GPx levels were determined as per the instructions of the kit protocols. ELISA was used to measure the levels of interleukins, whereas immunohistochemistry was carried out for the evaluation of MCP-1 expression. SRP treatment significantly suppressed vascular inflammation in BALB/c mice.
Mechanistic studies demonstrated that SRP significantly inhibited the LPS-induced production of proinflammatory cytokines such as IL-2, IL-1, IL-6, and TNF-α in aortic tissue. Furthermore, it also inhibited LPS-induced oxidative stress in the aortas of mice, whereas the expression and activity of monocyte chemoattractant protein-1 (MCP-1) decreased after SRP treatment. In conclusion, SRP has the ability to reduce LPS-induced vascular inflammation and damage by modulating MCP-1.
Stop taking the Rx
Gain the wgt back
Has anyone seen any research on almost instant mental "clarity" I was looking at getting ADHD diagnosis. But started mounjaro 3 days ago and with in 30mins it was like some one flicking a switch in my brain. Something I was not aware of or been told about or seen. With only stuff I can find is mental health in long-term as you lose the weight, gain confidence etc.
And it's not just the lack of food noise. But basic every day tasks like cleaning which I struggle with massively and barely did one such task a week. I've done 4 such tasks just this morning. My brain is no longer racing 24/7 it feels calm and stuff I struggled with if I think it needs doing it now takes effort not to do them as it's now a persistent thought and not fleeting. Where food has gone from persistent addiction type thoughts to the fleeting easily ignored thoughts boring tasks used to be. I hope this feeling continues. Is this what it feels like for normal people.
Change your diet go keto.That's not an instant solution but way better in the long run.
That could be linked to reduced inflammation as well. Many mental health issues are improved with a reduction in inflammation. I am glad you are seeing that benefit. Consider transitioning to a low.carb diet to increase the effects and eventually help you to come off the meds.
The mental clarity is available with zero drugs. I was carnivore for 120 days, dropped 40 lb, then maintained about 100 carbs or less per day over a year. 69 y.o. No meds. Great metabolic health. Impressed my doctor!
My brain immediately jumps to this question: Research shows consuming allulose can stimulate the release of GLP-1. So if I played “connect the dots”, fully understanding this is conjecture/hypothesis, might allulose consumption lead to a decrease in inflammation via the GLP-1 pathway elucidated in this vid?
I wondered this too. But there are a couple of catches I think. (1) Keeping a "sweet tooth" alive and kicking. (2) Adding it to WHAT? If food, it is likely to be baking or dairy, maybe. eg cheesecake springs to mind. So then we have those dairy probs at play, and maybe even some flour (even if, say, processed almond flour).
Fruit is already sweet, sugary veg isn't really a thing, so where does it come into useful play that doesn't bring in (1) or (2)?.
PS edit - Spellcheck corrected "vegs" to Vegas. 🤣
@@T-aka-T Keeping the sweet tooth alive? Hahaha! Just for giggles - I don’t mean this as a diatribe - but hear me out (and I hope this will prove fun and informative). I would go batshit if I couldn’t treat myself to my nightly sweets - and I consider myself pretty elite on the wellness front; for metrics I’m coming up on 62 y/o, maintained constant 10%-12% body fat for over a decade, V02 Max just above 52, am 6’ and 180lbs. None of that is gifted genetics, I work my ass off; and devour everything I can read and put into practice on supplementation, lifestyle, exercise, and dietary interventions. I pull every lever science suggests might produce a benefit. With all that, I keep a giant 2-pound jar of allulose right next to my espresso machine on the kitchen counter and use it almost daily. I don’t use it as much as raw honey, but I go to allulose several times a week. One of my favs is to use it to mask the nasty putrid sulphur taste of NAC powder (which I use because my daily volume of NAC and glycine dictates that powder is the far more cost effective strategy than pills). Over the holidays, I was able to convince family members to fully substitute allulose over sugar in holiday rum cakes, cookies, and one amazing bourbon chocolate pecan pie! And hot cocoa - best recipe ever is raw organic Cacao powder, allulose, and whole grass fed milk with a good spoonful of Organic Ceylon Cinnamon (and maybe some coconut oil if feeling the desire for some more healthy fats and flavor). Or my favorite cinnamon toast made from cracked-wheat sourdough, grass-fed butter or ghee, allulose (or raw honey), and heaps of organic Ceylon cinnamon. Ultra processed foods and crap like fructose corn-syrup don’t make it past my lips, not-ever-zero-exceptions, but I have found a way to keep my sweets so I don’t feel like I’m “giving up” my little indulgences. Someone else might suggest I’m doing it all wrong, but at 61 with a V02Max north of 52, I honestly don’t personally know another human my age I would trade places with health-wise. Until science shows me I’m making a big mistake, allulose is one of my go-to’s. Thing is, as time passes the body of research touting the great benefits of allulose just keeps getting better. Research it. Just sayin, I’d consider trying it before I’d ever consider trying to give up sweets…. I can’t. I’m weak…. All intended in fun, live well. :)
@@2BWiley2 Ah - so you HAVE kept your sweet tooth alive! 😁 (I killed mine with carnivore). And when I say 'killed', I mean gone - and now my detection senses are so high, any trace of sugar in, say, ham, is distinctly sweet tasting. Similarly, the stench of oxidised seed oil seeping out onto the street from "restaurants" is so offputting I don't even like fries anymore. I used to be a bit of a home chef. Never ate junk food. More like venison and ten veg, followed by croquembouche. Classic cuisine showing-off. Really can't be bothered now. The venison, yes, but haven't made gateau mousse au chocolat for yonks. I looked through your list of "food po rn" (the silly algorithm will get up-set by that) and it left me unmoved (which I was pleased to see, so thank you!). Christmas before last I knew I was over it when I passed the extra-special chocolate and thought, as it went by, "they look pretty" with a kind of zen-like detachment. Marvellous!
I daresay I have done just as much research as you have - truly - but I don't "pull every lever" like a maniac 😏. I just eat meat, and it fixed everything.
@@T-aka-T If we’re lucky, we each find our way. Carnivore has proven a successful path for probably tens if not hundreds of thousands of people and growing - excellent for you! This is the way; enjoy and thrive!
@@2BWiley2 Thanks. Nearly 4.5 years now, after keto since 2014, so I'm pretty much a reliable convert. I'm just sorry the carni people have started to go political - for so long, we stayed right out of that toxic US stuff. I fear it will now damage our bottom-up case. Anyway, cheers to you, wherever you are. 🦘🙏
Thanks. MD from Germany.
My T2 mother uses a daily GLP-1 with her slow release insulin. It hasn't reduced her weight despite her reduction in calories.
However, her average blood glucose levels are markedly lower than with her slow release insulin alone. After a couple of decades of insulin dependence, her beta cells are pretty much fried even on the GLP-1.
FWIW, people selling eggs and celery are also doing it for a profit.
Thanks Nick. Good talk.
So, can allulose decrease inflammation?
It can, yes. Although nothing replaces a clean diet.
Living a healthy lifestyle was what I expected you to say. And, of course, you're correct. I don't need prescription, and I get all the benefits with no side-effects--or the "side-effects" ARE the benefits.
At a BMI of 24.1, I'll have to pass despite way too much visceral fat, because of the gastroparesis risk. But, I do use allulose on the daily, sometimes just those 10g flavored RXsugar packets.
We have an epidemic and right now there isn't a quantum societal leap on the horizon to change the cause, as most of it is hard wired. GLP-1 RA and similar help reduce obesity and it's horrors. They are a great addition to our arsenal.
"Good metabolic health causes a healthy weight, NOT the other way around." - Dr Nick Norwitz PhD
" It's not 'lose weight to get healthy,' it's 'get healthy to lose weight.'" - Dr Eric Berg DC
“Calories are like the wheels on a car.” - Dr Nick Norwitz PhD
IE The ‘car’ is your body’s hormones & metabolism: your complete physiology.
Dr Norwitz is spot on! I'm presently eating a diet of clean carnivore foods to gain health. The weight loss I am experiencing is the welcome byproduct of my improving health.
I genuinely just want to try one of these drugs to see if they help with alcoholism, I've run out of options at this point
I read recently that there are a slew of studies being done on this right now -- perhaps you could join one? Good luck.
Carnivore diet will eliminate 99% of the desire, keto will eliminate 80% of it. It's a carbohydrate addiction expressed through alcohol imo.
Have you tried the carnivore diet yet? People are having success quitting alcohol that way.
Ppl r getting sober on Carnivore. Hard to believe, but true.
Try psychedelics to get to the root of your addiction. If you go into it with that intention.
There is many who have gotten out of their addiction that way.
I think in the last section in this video, there is more room for optimism about GLP-1 drugs being a positive force at a societal level than you express.
Or, rather, there's a trail, at least fifty years long, of failed attempts to fix the growing obesity problem through social changes. But society is very hard to change, and so the obesity rate has kept steadily climbing and people's metabolic health kept getting worse. Until 2022-2023 or so, when the obesity rate in the US started dipping, with very little apparent reason other than the Ozempic boom (most Covid deaths were already done by that time, I believe).
I think we will get those better foods in supermarkets - because people with better metabolic health will want to buy them. If we get walkable cities and bike lanes, well, it'll mostly be as a result of other advocacy - but one precondition for that working at all is people having bodies that physically can comfortably walk and bike places. If we want a return of social norms about communal eating, it might well help if we banish guilt about the sin of gluttony - by banishing gluttony itself.
It'll be expensive and imperfect, sure. But that just means the good outcomes will happen expensively and imperfectly, rather than not happening at all.
You said "help if we banish guilt about the sin of gluttony - by banishing gluttony itself" --- this is an interesting concept. Your take is thought provoking. Kudos for that.
the eat less and move more paradym is the biggest problem, many obese people have for years gone on all the diets, lost weight then regained it, until the doctors start telling people about low carb diets nothing will change. Obese people need to know that if they stick to a keto diet they won't always feel hungry and their entire bodies will start to feel better, once they feel better and are satiated with real food they hopefully will be able to keep the weight off, and more importantly keep metabolically healthy (without any drugs)
As I already have delayed gastric emptying, I am afraid to take any of these medications, regardless of their many reported benefits. Hopefully, they'll be able to come up with something that doesn't have that effect. (Currently ketovore but still obese)
You have to make the best decision for you. I hope you find something that works and/or that your ketovore journey is going well
Well said: a healthy lifestyle causes weight loss, and not vice versa. Hence, it sounds to me more like Carbohydrate-Insulin Model of obesity (CIM) hypothesis is the one to take seriously.
The CIM is incomplete but a useful model that makes biological predictions that have generally held true at population scale. The "CICO" model isn't even a model of obesity. It's a post-hoc description and simple statement of physics that doesn't tell us about physiology.
There is bacteria in gut which is called akkermansia. It increases glp1 naturally and is known to regulation glucose metabolism which helps reduce type 2 diebetes. That should be safer option.
Any data showing a probiotic or food X that changes akk levels in a stable way with clinical benefits?
I watched the video and perhaps I missed it, but if blocking GLP-1 receptors in the brain attenuates the anti-inflammatory response, could you not just as easily attribute the anti-inflammatory outcome to a decrease in calories? As opposed to some sort of mechanistic action? Was a decrease in calories consumed observed by the regular mice compared to the GLP knockout in the brain mice?
I'M with you, Nick
Cheers
This is interesting re metabolic health and inflammation.
In my experience buying food from a proper small farm with good farming practices reduced my inflammation so much compared to the same foods but from the supermarket.
And binging cereal one time made me cry in pain as my joints did not approve 🤔
This is interesting as my doctor has asked me to take a GLP-1 Agonist due to the fact insurance doesn't want to cover it... I decided not to due to multiple factors, the largest being cost, which I find interesting as they will cover TRT because that is off the charts low. But I'm obese, and have metabolic dysfunction, however I'm not sick enough for a corrective tool for that. I'm not sure if Id be more willing to try it or not at that point based off of what I've found out about it so far...
cant remember but wasnt there a sugar replacement which containes/triggers GLP-1?
Allulose. It is a natural sugar But it is rare.
Allulose can stimulate endogenous GLP-1 production, but not to the supra-physiologic levels of these medications.
Thank you!🎉
Interesting video as always. Thank you.
Note: The total food supply available for consumption has increased. This is most certainly also a contributing factor.
Personally, I still think calories are a great tool for people with specific goals and determining baseline. If we assumed only whole food like meat, fruit and vegetables existed and day to day diet and lifestyle was exactly the same then calories could be used as a tool to measure baseline to make adjustments as needed for specific goals, in the same way we adjust macros to meet specific goals.
The food environment is certainly a factor.
I believe either ketovoir or carnivore are the best way to go,no drugs needed!!!🥩
🥩👌
Hi Dr Norwitz
I know this is such a random comment, but was wondering about your thoughts on keto and AGEs. Often animal derived products are demonised for their higher AGE levels and deemed "unhealthy".
Thanks so much!
I hated Ozempic. It didn’t curb my appetite, it caused intestinal distress, and didn’t lower my A1C. I’ve been off it for ten months and have been on a Keto diet with intermittent fasting. I’ve lost sixty pounds, lowered my A1C to normal, and feel immensely better. I also quit my statin snd blood pressure medications. Medications, in most cases, aren’t the answer. It’s a proper human diet.
But if people start eating healthily and getting good exercise and sleep, how will drug companies pay their dividends?
Not my problem
What do you think of orexinsystem is like the head of metabolic health?
100% agree with your points!
Cheers
Can you comment on the current information about hydroxytyrosol and polyphenols in olive oil being a key to weight loss in triggering GLP1? Thanks!
It is sort of too much to ask, since you'll never get the very long term data before a medication is rolled out. It's not really feasible. But once it's present in a population one can monitor the population for risks that take longer to manifest.
What's your view of Ozempic versus a straight Semaglutide peptide? I've been delving into peptides and I'm wondering if some of the problems with Ozempic is that it may need to be cycled. Possibly the preservatives versus the peptide? I know most wouldn't want to mess with the straight peptide because it takes some learning to do correctly.
This is what I'm saying- GLP-1 has been a very important subject on the front lines of health and fitness for the better part of the last 4 years (at least in my business). Succinct, intelligent, and true. I appreciate your demeanor and content around a hot-button topic.
Thank you. I'm glad you appreciate the balanced perspective. It's an important topic, with too many hyper-extreme positions.
Nick didn’t you say that Allulose also acts on GLP-1 similar to these drugs
Allulose can increase endogenous GLP-1 production via actions on the Vagus nerve, it's true. But the degree of increase is far lesser than via pharmacotherapy. That's not a judgement, it's just a fact.
What is that chart or map behind you?
A metabolic pathway chart,I guess
It's a serious of metabolism pathways that my dad drew back int he 80s during his PhD at Oxford.
The meaning of "lifestyle" has been diluted for being used in void contexts. Thank you for trying to revive it!
It's needs a defibrillator, stat
Inflammation can manifest in so many ways. I went low carb and pretty much cured the arthritis pain in my fingers. Eat properly and you don't need to take drugs.
What kind of patient profile do you see as potentially a good candidate for these medications?
What are your thoughts on akkermansia?
With respect to the topic of this video? Can you be more specific about your question?
@@nicknorwitzPhD I have seen information stating the utilization of akkermasia could naturally raise levels of glp-1 to a more healthy level in those people who's microbiome is out of balance or lacking. Also, thank you for being a clear source of science rather than a drugged up blow hard.
Take a pill or change your life.....hmmmmm I wonder what people will do.
Doesn't this tie into the good effects of keto diet (the antiinflammatory properties)? And I am wondering, since there's been good outcomes for some alzheimers pati3nts put on a ketogenic diet (improvement in cognition) - and we are beginning 5o understand that some cognitive decline is inflammation driven, are there any studies of GLP-1 agonists on dementia patients??
We have been over fed and under nourished for decades thanks to the food industry.
I loved this video, but the main question is: what is a healthy diet? Vegan? Animal-based? Mediterranean? ...
I think you are ketogenic, but, did you hear about less meat for longer life?
I am on a ketogenic diet, yes. I am not at all convinced reducing meat intake extends lifespan. Also see: th-cam.com/video/JmEQESj1zNU/w-d-xo.html
I wonder about the paper and money trail in this publication. GLP was already found to have side and detrimental effects in the long run.
Elaborate … what effects are you referring to?
There hasn't been a "long run" yet, though. Isn't that part of the problem? As Ken Berry says, "understand that you're part of the experiment."
@@nicknorwitzPhD It's my wife who reads many things and I remember her saying not good things about GLP and Ozempic.
Here is one of the essays she recommended reading. Google, midwesterndoctor the-great-ozempic-hustle
For those who don't want to read the entire essay mentioned above, just search for "side effects".
Seems clear that reducing inflammation by way of lifestyle changes is superior to an expensive drug. That said, it took investigating how the drug works that we find that it reduces inflammation. It’s obvious that inflammation reduction is key to meany diseases, and lifestyle changes are effective in preventing inflammation/ disease. However, marketing strategies seem to be a major issue, sell the cause, then sell the cure. Unfortunately it has become the business model for many of our problems. Just saying.
Hi Nick, I want that world too. No more junk foods. I know that won’t happen in my lifetime. But, people are waking up now. Junk foods are addicting and should come with a warning to eat at your own risk, may cause addictions & poor health out comes. Plus, you are literally paying for shitty health when you it them. Put that money towards something good instead.
Yes - personally I put it towards grass-fed beef 👍🙂
I agree... people are waking up. I'm hopeful!
So the GLP-1 drugs act in unexpected ways. That could be beneficial, which of course is emphasized by the researchers. What about unknown detrimental effects? Is it too much to ask for medicins to have all the effects catalogued BEFORE it is used in a large number of humans?
I lived a healthy lifestyle for four years and slowly increased my weight every year. The problem, for me, was/is SATIETY!!!! GLP1 cured that part. I am interested to see what my blood markers are at my next annual appointment. I would say the only downside is my RHR has increased by about 8 to 10. I have only seen this talked about sparingly. I am slowly reducing my dosage and watching my weight carefully.
Did your 4year healthy lifestyle include at least .8-1.2g of animal based protein per lb of body weight and high saturated animal fats as well as low carb? When my carb intake is above 30g total per day I can lose the satiety signaling.
@@noyebalmer8112 Yes on the protein. I use Cronometer to track diet and Whoop exercise/sleep/heart etc. Sat fat did help but also did mess up some biomarkers. tx, jt
Also averaged 79.9 minutes of exercise a day over the four years.
Overtly not healthy diet
U gained wgt
@@YeshuaKingMessiah yes i was eating too many calories...albeit from healthy sources...I had a lack of satiety as I stated. Thanks for the feedback. jt
does this something to do with the famous Ozempic?
Exactly - that
@6:24 - We could use a pill for /that/.
/s
So "calories in, calories out" is always true, but it is the result, not the cause of the problem.
This can be your next video to watch: How to Fix a Broken Metabolism
th-cam.com/video/t2zqSzDJp1s/w-d-xo.html ;)
@ thank you sir! I’m really enjoying your content.
@@az10sbum1 Cheers :)
There is a crowd that says it's just calories and hormones don't play a major role in weight loss. There is also another crowd that says the only benefit of GLP-1 is weight loss and people that take them are just lazy. I guess both these sides are going to be wrong. Time will tell but I fully support the proper use of these medications.
They both are wrong. Period. And I agree... although "proper use" is a term to unpack...
You can place me firmly in the hyper skeptical group (of injectable glp-1 agonists that is).
Can I use one of those crane machines?
@@nicknorwitzPhD you can try but I am skinnier than you, so grabbing me would be "state fair arcade" hard :-)
But if these drugs reduce inflammation, why shouldn’t we take them?
I didn’t say should/shouldn’t.