@@miloradmilutinovic7691 today we can study what works and what doesn't by applying methods that proved effective because they show consistency with cause and effect.
As an Exercise Physiologist I applaud how accurate the exercise based information was! I did a little cheer when he said ‘no one type of exercise is the best’, because people are constantly saying there is a secret special exercise that fixes it all.
OOOO MY GOD... I've been doing this for YEAR.. giving my stomach a break. Intermitted fasting for the past 24 year.. Im 53 in June and still in great shape. Thanks Dr. Sinclair.. Also im preparing for my MCAT, will be a Dr. soon myself..
I'm 73 years old and have engaged in resistance training for over thirty years. My current exercise activity and nutrition focus on slowing the process of sarcopenia and the decline in other physiological functions. I have used supplements to augment my food diet. Currently, my supplements concentrate on the mitochondria. Your "Lifespan with Dr. David Sinclair" TH-cam series is excellent.
I’ve loved and learned from every single one of these so far ! I am so grateful to you both. I really feel there should be a Dr. Sinclair health class taught at every level of education! Starting now.
Get off your ass!🔥❤️🔥🔥 62 and loving life. I gave up driving in 1998 and choose to live within 2 miles from where I work. I ride my beach cruiser bike and walk everywhere. I am always amazed how people tell me those are strange choices, yet clearly they are healthy choices. I look far younger than most my age, but more importantly, I feel younger. Your health is your wealth. We must take accountability for our own health and happiness. Love this podcast. I did a lot of intermittent fasting in my youth, not understanding how healthy it was for me, I only knew I felt better while doing it. Thanks for explaining it all here.
-Have Low Levels Of Iron -Get Off Your Butt -Walk After Eating -Low Impact Excercise For 50 Minutes A Day 4000 Thousand Steps A Day (Walking, Running, Cycling) -Have A Hypoxic For Atleast 10 Min A Day; Recommendation: Do HIIT Or Vigorous Excercise 75 Min A Week -Bio-Tracking -Weight Training Maintain Muscle Mass Focus On Big Muscles -Hyperbaric Oxygen Therapy 90 Min A Day; Helps In Mimicking Excercise -Cold Exposure: Cold Shower Or Cryotherapy, Leave a Window Open While You Sleep, Put Fewer Clothes On And Move Out Specially In Winter, Etc. -Heat Exposure - Sauna Bathing Recommendation: Heat-Cold Contrast Shower Or Bath; 5 Or More Cycles
I devotedly started listening to this podcast ... i learned the right things... i am presently implementing low glycemic food, exercise, fasting in my daily regime. i dont feel tired or stressed .... i exercise daily for half an hour and vigrous exercise around e times a week... my focus increases... my brain fog gone...my memory enhanced...my organizational skill increases. this is what happens when you learn from right people. We genuinely thank you for sharing this valueble knowledge for free ..i am sure i will not get such knowledge even by sharing thousand of dollars anywhere in the world. Really thanks !!
Dr. Sinclair and other scientist in his field that are tying to solve aging are literally doing the most important work in modern times. We'll have to solve our short life spans if we ever want to explore the cosmos and visit other worlds.
Premium quality content. Thank you so much Dr. Sinclair. Reading your book and listening to these podcasts has fundamentally changed the way I view human life and it's duration.
Dr. Sinclair you are awesome! Thank you for the insights, very pleasant to listen to. I've been learning a lot from you. Thank you for the free information!
I am reading your book 'Lifespan'. Your written style is pleasing, funny, you go to the point, it's knowledge rich, and you are a very lively person. I feel lucky to be alive right now witnessing the development of this longevity research. What a gift you're building, David, among others. My most meaningful thank you. Really!
Another great podcast ! It would be amazing though, if Dr. Sinclair and Mr. Matthew LaPlante could take some questions and dedicate 2-5min segment to them, either from comment section or submitted upfront. Good job 👌!
I would be remiss Not to Mention: “I have been ‘practicing’ Aerial Silks & Lyra (Hoop) & Flexibility for 1 year to this day…6-8 hrs. per week. Literally, this Full Body ‘Workout’ has changed my life❣️Ladies, You Can Do It..Give it a shot⭐️⭐️⭐️⭐️⭐️
This was another great episode! Learning so much. Just sharing my notes here. Too much iron is dangerous for longevity. Drives the accumulation of zombie cells. Survival sensors: - Mtor: senses amino acids. Lower levels of BCAAs are good - Ampk: senses energy (glucose). - Sirtuins: sense NAD (goes up and down with food and exercise) Insulin tells the body that's there sugar to use. -Exercise prevents diseases. Reduces mortality. -Walking after a meal stimulates the production of new blood vessels and turns on ampk (registers energy -atp-). -Vigorous exercise. Low levels of oxygen (Hypoxia) are good (though doesn't feel good). -As we get older, our muscles become less sensitive to the insulin that the pancreas is putting out. This is due to aging. -glucose in the bloodstream damages blood vessels. -Exercise impacts epigenome (regulator of DNA). -80% of future health is manipulable and modifiable (epigenome) Weight training: - Maintain hormone levels, ability to walk well and have good posture, makes look better - Is hard to get muscle as you get older. - Breaking your hips is equivalent to have stage 4 cancer. Mortality rates are that bad after hip injury. ○ How to avoid breaking hips? Build muscle and work on flexibility. - Senescent cells: when the epigenome becomes deregulated, cells can either die or they can be shut down, so they are zombie cells. Slowing the formation of zombie cells or killing them is important. Exercise kills these cells. Hyperbaric Oxygen Therapy (HBOT) - Hyperbaric chamber where pressured is increased. - Can reverse aging. - It's similar to hypoxia. So it's similar to exercise. Cold Therapy - Production of brown fat (burns white fat and enhances metabolism). - Cryotherapy, cold showers, sleep with few blankets. Heat - Saunas reduce 20% in cardiovascular disease. Let me know if you want me to keep posting these notes, I am on Twitter @juampiaranovich
These are amazing. I get too anxious about watching the whole video when all I want is the actionable info. Would rather just know key points. Thank you for these notes.
Thank you very much for your notes! The only problem with your notes is that now I'm always going to wait to read your notes first before watching the video. Because your notes really help to absorb the important information while he talks.
Are you acquainted with or have read a book published by Durk Pearson & Sandy Shaw in the 1980s called The Life Extension Companion? We read that book when it was published. We were impressed. But I don't think it has extended our life. There are so many things that makes a lot of people live longer and many others that will make our lives shorter. If you do have a way for us to reverse genetic and environmental damage it would be amazing. We are in our 70s and our chances of success are limited. Thanks for the series. Good luck!
My local spa has a sauna and cold pool (60 degrees F). I LOVE to cycle between them. At first, the time in the cold pool is brief, maybe 30 seconds. But as I keep doing it, I can eventually stay in long enough to do some stretches and use their waterfall (it cascades out of the wall) on my shoulders. For me, I do it because it helps with muscle soreness. But also, I do come out of it feeling very exhilarated yet very relaxed. Now I understand why.
Thank you Dr Sinclair ! You don’t have idea how much I appreciated and love you for all great things that you are doing. ! I follow you and check up your need. Thanks again for makes the science for us , the regular people👍👏🏼👏🏼
Great podcast!!! ❤️ In case you could do Q&A in a future episode I'd love to know how pregnancy and breastfeeding affect ageing and whether the suggested protocols have been studied on pregnant and/or breastfeeding women.
I have listened to it breathlessly. Many thanks for making this channel available for us. I feel myself privileged for discovering Prof.Dr. David Sinclair years ago in TH-cam. I have been amazed with the information he has been giving out since then. I try my best to follow his recommendations and yes they do work🥰. I have been always wishing that he would have his own channel. And here He is. I appreciate all the efforts being invested here. Wish you all in 2022 all the best.
So many thought provoking tidbits but the hyperbaric chamber information...I've been screaming how beneficial it has to be for more than just wound therapy. Tried to get Medicare to pay for treating both my parents with it after strokes which seemed to be a no brainer but wasn't covered and I didn't have the funds at the time to cover it myself. Bringing hope to so many with all of this thought provoking data:) Thank you both.
I have a request: future research on aged folks like 60s,70s to 80+, my reasoning is that we ate living with some pathology and refuse meds offered since I just exercise the best I can. Thank you terrific video and more and more clarity from the lab and life styles.This is not the first video I have listened to with Dr S's research yet the added information here is so hopeful.
I really LOVE this series. What would make the take-aways even better is talking about how many years each suggestion would likely add to your life IF that information is available (even if you have to infer that from the rat studies). Great job again on the podcast! Love the format and info.
My Dad was still running marathons in his late 70's ... He ran everyday ... had two hip replacements ( he wore them out).... His was the fittest person I know.... Sadly at 88 he now has Dementia and is very frail ... It all happened in just over a year !!!
Great episode, couple of follow up questions: How much iron is too much? If I can afford the blood test, what numbers should I be looking for as a male? What should the timing of the heat/cold exposure be in relation to exercise? Distanced from it or immediately around it?
Wow, I'm awesomely pleased to see Dr Sinclair with a podcast of his own! I've followed many podcasts he's spoken on. I'm glad to hear him say he skips breakfast AND lunch; just hope I'm doing the best for myself by typically doing so although sometimes I eat a package of seaweed in the early hours of the day or make myself a beetroot and chlorella powder simple smoothie to keep my body calmed.
Absolutely love this channel. Reading the book, been listening to every podcast and you tube video since last May. Taking some of the supplements and at 46, I have noticed a difference. Thank you! This is the best thing to listen to while you walk you dog, folks.
What a relief. About 10 years ago, I was told I could not donate blood because my level was about 2.5 points too low. I tried to raise my level for a month and the iron made me so sick. I"m fine without it!
I have been doing all this for years without knowing :) I ride my motorcycle in winter in the uk (cold) to the gym (exercise) then have a shower (heat) then back on the motorbike (cold). The motorbike also gets my heart pumping
Here we go.. after listening to the entire episode3 on Spotify 2 hours ago..waited for this here..One more time.. Cheers to taking another step towards a better future for humans evolution
I use to run track and then 5k and 10k road races a lot when I was younger in the 1970s and 80s, My last 5k was 2015 at age 54. I remember reading somewhere about distance runners actually having more blood volume, but less red blood cells and more white blood cells than average, because a runners red cells, lungs and circulatory system was much more efficient.
I bet life insurance companies would love to get their hands on the death prediction data for people. Very thought provoking podcast, and I love learning the science behind it all. Thanks!
This really really outstanding. Naturally with David Sinclair. Covering so much ground in a little over an hour is so useful. I think the 1 hour podcast will become the new standard.
Dr. David, would it be possible to measure Biological Age from Europe? Please please make it happen. And if there is a chance for Inside tracker to provide full service for European market, would be amazing. Or any chance to cooperate with Inside tracker to open the European lab / center?
Thank you both for the excellent podcast!! Dr. Sinclair is brilliant but thankfully understandable, and Mr. LaPlante is the perfect interviewer to ask the questions we would like to ask, Greatness incarnate!!
You guys got one important thing wrong. Back in time when humans lived in the nature we were mostly less stressed. Today with all this media, loans, divorces and so on keeps us stressed constantly. That is what makes your body lose the balance together with process foods and no outdoor exercise. Keep up the good job in analyzing our genes and our inner game.
Dr. Sinclair, What do you think about high calorie, high protein diets like the ones that are recommended for muscle building (hypertrophy) programs? For what I understand, you can't have that much calories overall in a single meal, but it's been proven to be effective on building muscle. Is it worth it to go that path if slowing down aging is your goal or it's actually not beneficial?
Thank you so much for the free education! And it's really not so hard to understand either for a layman like me. Right now I'm getting the key ideas and translating them and explaining them in details in Chinese, putting them in my blog hoping to convince more people cognitively to get more exercise including my parents. Now I seem to have very strong arguments to back me up! Exercise is so important. Thank you both, please keep up more updates.
I like it when you do the advertising - business regarding the sponsors of your podcast, and your eyes lock into the wording as you read the data and the stare forward and the eyes look all serious and locked into each letter. As you talk about getting younger as you take trips around the sun! My mindset too 👍👍
Thank you so much to both of you. I'm 41 years old, originally from Philadelphia now living in Finland. Im playing music here with legondary rock and roller Andy McCoy but recently times have been tuff due to Covid and I have not been taking advantage of doing the things I should to to maintain my health. Nothing bad, just mostly sitting around and not getting proper exercise and not using the Sauna's that are available here in Finland. Because I have been watching these pod cast episode's, I have been motivated to learn and start to implement the simple strategies you discuss. I'm looking forward on the next pod cast and if there is any way I could chat with either of you about my health and what I can do to not only better myself but also help people around me and spread the knowledge I would love to. Thank you, Kiitos...Matthew.
Great podcast. Amazing scientific information. A lots of the information in this podcast regarding diets and lifestyles are spot on. I am currently living in Italy and I see a lots of people in their 90s looking like they are 60, full of energy riding bikes or walking everywhere. I see that most Italians dont usually eat breakfast, they just drink a coffee (espresso) and when they have lunch or dinner is not too much food, small portions and lots of vegetables. The Italians eat food in order (primi and secondo piatti) and then they have a digestive drink at the end. Eating in Italy or in the Mediterranean is an experience because the way is cooked (pasta cooked only a few minutes) and the way you eat and how is almost sacred because if you dont follow it people will look at you weird hahaha. And of course, every meal comes with the wine! I ordered Athletic Greens, I hope it taste good!🤣
Thank you a lot for all these interesting informations. I have began to assume Reveratrol, I practise sport at home for 20/30 minutes three times a week in the afternoon; sometimes I go out for walking, not all days, but I never stop moving at home. I wait for the next post.😍😍😍🇮🇪
This discussion is so satisfying. This science is insanely interesting 🚀I want to turn on all the good turn off all the bad. I’m getting my lab work with inside tracker in the morning! Thank you for sharing
Thank you for this amazing information! I was wondering if you had any information regarding using Breathwork such as the Wim Hof method or Buteyko breathing to induce hypoxia. Is the hyperventilation / hypoventilation we see in Wim Hof doing the same thing as the Hyperbaric chamber you mentioned, due to the large differential created during the practice? Thanks again!
Dr David, Do you have any advise/opinion/evidence on the effect of aromatase estrogen blockers when given as a 5 year post preventative treatment after mastectomy/breast cancer? .is there any protocols to offset this deficiency in women(as read women suffer huge age acceleration due to this)? Thank you…
Ooof, I lost over half my hair 3 months after having Delta. It’s finally starting to grow back but I lost so much. So overwhelming. They are calling 2021 The Year Americas Hair Fell Out. Maybe do a cast on the Covid hair loss? There’s a yoububer who is losing hair 17 months after just losing her smell and taste a few days. It’s insane. Feels like radiation sickness. My Thyroid test came back normal but I am always iron and D deficient no matter what I do it seems. There are articles all over the internet about Covid hair loss. I’m not on Fb but a lot of my friends and family are coming to me telling me more and more they are seeing people sharing about their Covid hair loss experience. It’s becoming a sort of an epidemic of its own. 😣 not fun at all. I went from my hair very thick and long to filling the toilet every day for almost two months. I’ve heard of plumbers posting about pulling wads of hair out of the septic lines from Covid hair loss. It’s no joke. Bless.
I was taking Donotage NMN and resveratrol every day and wasn't feeling well so I stopped and felt better. I take Vital Proteins, two scoops and I exercise 60 minutes 6 days a week which consists of doing X3 with bands which takes 20 minutes, a 20-minute abb work out, and walk at 3.2 MPH at a 2% grade for 20 minutes with a 15Lb weight vest which is really strengthens my legs to where walking for 4 miles without the vest is nothing and I feel great. I think clearly and at 74 and my reaction time is very good when driving and still can run around with younger adults. I'm losing weight and gaining mass which is really nice. Some people don't believe my age when I tell them.
Can you comment further about iron consumption? I did an inside tracker test and mine was slowly below optimal so I’ve been looking for ways and have increased consumption a bit through my plant based diet but want to be sure I’m not overdoing it. Any recommended daily amounts based on body weight or more specific guidance you can give?
Regarding sauna bathing, Dr Rhonda Patrick has cited a study that says the optimal temp/duration is at least 176°F for 20 mins, 3 times a week. Thanks for these great talks! I've really enjoyed Lifespan as well! Thanks to you, I have joined Inside Tracker, which has been very helpful, and I'm also taking NMN and rsveratrol (500mg/day each to start). Keep up the great work, and thank you! 🙂
I'm so happy for my grandkids that they will probably see the cure of aging happen in their lifetimes (maybe when they are my age). It's a huge system engineered with many odds and ends to kill us in the long term. A truely sad state of affairs. For my wife and I, it will come too late. It's all falling apart under our feet. Allowed to see the promised land, but we shall not enter it. It's alright though when you know that others continue.
Does "cold" have to be actually cold or just relative? For example if you live in the Middle East with no air conditioning even a 20degC bath would seem very cold, where as a resident of Alaska would thing the same 20degC bath to be quite warm I'd think.....
I love this podcast and everything about staying young as long as possible , but I thought of something recently , I would NEVER want to live as long and outlive everyone I love , nope , especially my wife and daughter , mortality has many wisdoms , and "everything that has a beginning has an end" As Agent Smith Said in the Matrix lol , Watch the green mile , tom hanks in that movie his character lived to 108 and was still going he outlived everyone he loved , and it was sad , BUT all being said the way I live is not to die, the way I live is dying to live
I’d be interested to know if there are benefits to starting this at a younger age say before 30 or if you still get the same benefits starting after 30?
Yeah I’m quite young and do intermittent fasting and other things like this but I sometimes question is there benefits for our age or is it only beneficial at an older age
@@Ghhhhhjjccvv do it all now!! Yes I’m 59. People think I’m my granddaughter’s mother!! Wish I’d done cold and hot therapy sooner tho! And meditation! Profound epigenetic impact!
@@lizmallen3461 thanks for the response, would you say you get the most benefits of hot and cold therapy by swimming in the sea for roughly 20 minutes then into a sauna for 1 hour?
I have been following Dr. Sinclair since I was 25.
I am 22 now.
What an exciting era to be alive thank you professor Sinclair!
That's kind of you.
Well, 2000 years ago it was written already that people are living around 1000 years. No body made it. Why should it be different this time?
@@miloradmilutinovic7691 today we can study what works and what doesn't by applying methods that proved effective because they show consistency with cause and effect.
Really??
@@miloradmilutinovic7691 I guess the podcast targets 130 years (maximum)
This is the only series of podcast which I watch from starting to ending without skipping.
Thank you David sir for all the knowledge 🙏🏻
Series ?
You watch the sponsors ;)?
@@JkBee nope but ya sometime i watch with curiosity
100%
@@Junaid_x01 I believe there are 8 videos in this series...and a number of other videos by Dr. Sinclair.
As an Exercise Physiologist I applaud how accurate the exercise based information was!
I did a little cheer when he said ‘no one type of exercise is the best’, because people are constantly saying there is a secret special exercise that fixes it all.
for what ?
Yeah but bench press is still king
Gina... 65 with torn meniscus in both knees... Any suggestions as to what exercise I can do, please??
What? This guy's in his fifties, dyes his hair and he's built like a child.
@@Sunnysue31 yoga
OOOO MY GOD... I've been doing this for YEAR.. giving my stomach a break. Intermitted fasting for the past 24 year.. Im 53 in June and still in great shape. Thanks Dr. Sinclair.. Also im preparing for my MCAT, will be a Dr. soon myself..
I'm 73 years old and have engaged in resistance training for over thirty years. My current exercise activity and nutrition focus on slowing the process of sarcopenia and the decline in other physiological functions. I have used supplements to augment my food diet. Currently, my supplements concentrate on the mitochondria. Your "Lifespan with Dr. David Sinclair" TH-cam series is excellent.
I’ve loved and learned from every single one of these so far ! I am so grateful to you both. I really feel there should be a Dr. Sinclair health class taught at every level of education! Starting now.
Get off your ass!🔥❤️🔥🔥
62 and loving life. I gave up driving in 1998 and choose to live within 2 miles from where I work. I ride my beach cruiser bike and walk everywhere. I am always amazed how people tell me those are strange choices, yet clearly they are healthy choices. I look far younger than most my age, but more importantly, I feel younger. Your health is your wealth. We must take accountability for our own health and happiness. Love this podcast. I did a lot of intermittent fasting in my youth, not understanding how healthy it was for me, I only knew I felt better while doing it. Thanks for explaining it all here.
-Have Low Levels Of Iron
-Get Off Your Butt
-Walk After Eating
-Low Impact Excercise For 50 Minutes A Day
4000 Thousand Steps A Day
(Walking, Running, Cycling)
-Have A Hypoxic For Atleast 10 Min A Day; Recommendation: Do HIIT
Or Vigorous Excercise 75 Min A Week
-Bio-Tracking
-Weight Training
Maintain Muscle Mass
Focus On Big Muscles
-Hyperbaric Oxygen Therapy 90 Min A Day; Helps In Mimicking Excercise
-Cold Exposure: Cold Shower Or Cryotherapy, Leave a Window Open While You Sleep,
Put Fewer Clothes On And Move Out Specially In Winter, Etc.
-Heat Exposure - Sauna Bathing
Recommendation: Heat-Cold Contrast Shower Or Bath; 5 Or More Cycles
Thank you for summarizing it.
thanks for summery man. these health videos can be so complicated
Thank you for the summary...the clip is way too long.
Thank You Mr. Singh! Awesome summary and Podcast! "live long and prosper"
Thank you kind sir. 🙏
I devotedly started listening to this podcast ... i learned the right things... i am presently implementing low glycemic food, exercise, fasting in my daily regime. i dont feel tired or stressed .... i exercise daily for half an hour and vigrous exercise around e times a week... my focus increases... my brain fog gone...my memory enhanced...my organizational skill increases. this is what happens when you learn from right people. We genuinely thank you for sharing this valueble knowledge for free ..i am sure i will not get such knowledge even by sharing thousand of dollars anywhere in the world. Really thanks !!
I just spent 4 hours learning how the mitochondria works because of this amazing episode ... Life is bazar. Thank you David & Matthew!
Hi. Did you find a good book or just by googling? Thanks!
Obsessed with this podcast! Recommending all my clients follow along too so we can all learn together and have discussions
Dr. Sinclair and other scientist in his field that are tying to solve aging are literally doing the most important work in modern times.
We'll have to solve our short life spans if we ever want to explore the cosmos and visit other worlds.
Premium quality content. Thank you so much Dr. Sinclair. Reading your book and listening to these podcasts has fundamentally changed the way I view human life and it's duration.
I appreciate
do you take metformin
I’m so glad I discovered his podcast. This is my first episode and I’m already in love.
Dr. Sinclair you are awesome! Thank you for the insights, very pleasant to listen to. I've been learning a lot from you. Thank you for the free information!
Can't get enough DR! THANK YOU! YOU ARE CHANGIN LIVES !
One of the few channels/podcasts I am eagerly waiting for the next episode!
Same here😃👍
Watched this video while on my elliptical. The podcast sure kept me motivated!!
I am reading your book 'Lifespan'. Your written style is pleasing, funny, you go to the point, it's knowledge rich, and you are a very lively person. I feel lucky to be alive right now witnessing the development of this longevity research. What a gift you're building, David, among others. My most meaningful thank you. Really!
Dr. Sinclair is always interesting. One hour goes so fast 💨 and the topics are so amazing 🤩
Swim a mile every day, 50 minutes in a sauna, then five minutes in an ice cold shower. My energy levels and feeling of wellness go through the roof.
Another great podcast ! It would be amazing though, if Dr. Sinclair and Mr. Matthew LaPlante could take some questions and dedicate 2-5min segment to them, either from comment section or submitted upfront. Good job 👌!
I love love love David Sinclair and the information he provides. Perhaps another ‘co-host’ would be a better fit.
These episodes were pre taped some time ago.
@@melimevivzla is co
Zz. P c
At 57 & 1/2…I am making progress❣️Blessings to you, Dr. Sinclair..Staying close to your podcast, Here, Lake Tahoe, NV🏔
I would be remiss Not to Mention: “I have been ‘practicing’ Aerial Silks & Lyra (Hoop) & Flexibility for 1 year to this day…6-8 hrs. per week. Literally, this Full Body ‘Workout’ has changed my life❣️Ladies, You Can Do It..Give it a shot⭐️⭐️⭐️⭐️⭐️
@@lisafalanga8457 you go girl !
Hey thank you both for this PodCast! I am trying to make a new life long routine starting at 26. Can't wait to track myself.
I just turned 24 also looking to start a new great routine for the rest of my life. I wish you success with it fellow human :)
26 is a good age to start.
Dr Sinclair, Thank you for the time and dedication to share this valuable information. I appreciate it.
It is crazy anyone can come and get this information for free!!!! Thanks so much for putting these together.
Information like this should be spread to the masses. Thank you for your hard work & research!
Folks, get ready. David is soon becoming a rock star! Thanks for sharing your expertise!
Becoming? He already is. The world is just now realizing it. 😁
WOW!
This was another great episode! Learning so much. Just sharing my notes here.
Too much iron is dangerous for longevity. Drives the accumulation of zombie cells.
Survival sensors:
- Mtor: senses amino acids. Lower levels of BCAAs are good
- Ampk: senses energy (glucose).
- Sirtuins: sense NAD (goes up and down with food and exercise)
Insulin tells the body that's there sugar to use.
-Exercise prevents diseases. Reduces mortality.
-Walking after a meal stimulates the production of new blood vessels and turns on ampk (registers energy -atp-).
-Vigorous exercise. Low levels of oxygen (Hypoxia) are good (though doesn't feel good).
-As we get older, our muscles become less sensitive to the insulin that the pancreas is putting out. This is due to aging.
-glucose in the bloodstream damages blood vessels.
-Exercise impacts epigenome (regulator of DNA).
-80% of future health is manipulable and modifiable (epigenome)
Weight training:
- Maintain hormone levels, ability to walk well and have good posture, makes look better
- Is hard to get muscle as you get older.
- Breaking your hips is equivalent to have stage 4 cancer. Mortality rates are that bad after hip injury.
○ How to avoid breaking hips? Build muscle and work on flexibility.
- Senescent cells: when the epigenome becomes deregulated, cells can either die or they can be shut down, so they are zombie cells. Slowing the formation of zombie cells or killing them is important. Exercise kills these cells.
Hyperbaric Oxygen Therapy (HBOT)
- Hyperbaric chamber where pressured is increased.
- Can reverse aging.
- It's similar to hypoxia. So it's similar to exercise.
Cold Therapy
- Production of brown fat (burns white fat and enhances metabolism).
- Cryotherapy, cold showers, sleep with few blankets.
Heat
- Saunas reduce 20% in cardiovascular disease.
Let me know if you want me to keep posting these notes, I am on Twitter @juampiaranovich
hi Juan, you are a great guy to share your key notes from this David Sinclair's video lessons on our longevity and health span.
Thanks for sharing!
Thanks
These are amazing. I get too anxious about watching the whole video when all I want is the actionable info. Would rather just know key points. Thank you for these notes.
Thank you very much for your notes!
The only problem with your notes is that now I'm always going to wait to read your notes first before watching the video. Because your notes really help to absorb the important information while he talks.
Are you acquainted with or have read a book published by Durk Pearson & Sandy Shaw in the 1980s called The Life Extension Companion? We read that book when it was published. We were impressed. But I don't think it has extended our life. There are so many things that makes a lot of people live longer and many others that will make our lives shorter. If you do have a way for us to reverse genetic and environmental damage it would be amazing. We are in our 70s and our chances of success are limited. Thanks for the series. Good luck!
My local spa has a sauna and cold pool (60 degrees F). I LOVE to cycle between them. At first, the time in the cold pool is brief, maybe 30 seconds. But as I keep doing it, I can eventually stay in long enough to do some stretches and use their waterfall (it cascades out of the wall) on my shoulders. For me, I do it because it helps with muscle soreness. But also, I do come out of it feeling very exhilarated yet very relaxed. Now I understand why.
@19Jetta - Check out the Wim Hof breathing technique that incorporates cold showers too.
Excelent podcast, two intelligent brains, fantastic educative and pleasant discussion of very important health issues! Thank you!!
This is such an important podcast . Health longevity good healthspan is the key to living better. Get off your seat so true sitting is the new smoking
I'm in a wheelchair.
Thank you Dr Sinclair ! You don’t have idea how much I appreciated and love you for all great things that you are doing. ! I follow you and check up your need. Thanks again for makes the science for us , the regular people👍👏🏼👏🏼
( correction): Check up your great work!
Great podcast!!! ❤️
In case you could do Q&A in a future episode I'd love to know how pregnancy and breastfeeding affect ageing and whether the suggested protocols have been studied on pregnant and/or breastfeeding women.
I have listened to it breathlessly. Many thanks for making this channel available for us. I feel myself privileged for discovering Prof.Dr. David Sinclair years ago in TH-cam. I have been amazed with the information he has been giving out since then. I try my best to follow his recommendations and yes they do work🥰. I have been always wishing that he would have his own channel. And here He is. I appreciate all the efforts being invested here. Wish you all in 2022 all the best.
Dr. Sinclair thank you for your information. Loving the podcast too.
So many thought provoking tidbits but the hyperbaric chamber information...I've been screaming how beneficial it has to be for more than just wound therapy. Tried to get Medicare to pay for treating both my parents with it after strokes which seemed to be a no brainer but wasn't covered and I didn't have the funds at the time to cover it myself. Bringing hope to so many with all of this thought provoking data:) Thank you both.
I feel younger when I watch this interview, awesome people keep it up good work 👍🏼
Lol
I have a request: future research on aged folks like 60s,70s to 80+, my reasoning is that we ate living with some pathology and refuse meds offered since I just exercise the best I can. Thank you terrific video and more and more clarity from the lab and life styles.This is not the first video I have listened to with Dr S's research yet the added information here is so hopeful.
I really LOVE this series. What would make the take-aways even better is talking about how many years each suggestion would likely add to your life IF that information is available (even if you have to infer that from the rat studies). Great job again on the podcast! Love the format and info.
My Dad was still running marathons in his late 70's ... He ran everyday ... had two hip replacements ( he wore them out).... His was the fittest person I know.... Sadly at 88 he now has Dementia and is very frail ... It all happened in just over a year !!!
Great episode, couple of follow up questions:
How much iron is too much? If I can afford the blood test, what numbers should I be looking for as a male?
What should the timing of the heat/cold exposure be in relation to exercise? Distanced from it or immediately around it?
Wow, I'm awesomely pleased to see Dr Sinclair with a podcast of his own! I've followed many podcasts he's spoken on. I'm glad to hear him say he skips breakfast AND lunch; just hope I'm doing the best for myself by typically doing so although sometimes I eat a package of seaweed in the early hours of the day or make myself a beetroot and chlorella powder simple smoothie to keep my body calmed.
Absolutely love this channel. Reading the book, been listening to every podcast and you tube video since last May. Taking some of the supplements and at 46, I have noticed a difference. Thank you! This is the best thing to listen to while you walk you dog, folks.
What a relief. About 10 years ago, I was told I could not donate blood because my level was about 2.5 points too low. I tried to raise my level for a month and the iron made me so sick. I"m fine without it!
I have been doing all this for years without knowing :) I ride my motorcycle in winter in the uk (cold) to the gym (exercise) then have a shower (heat) then back on the motorbike (cold). The motorbike also gets my heart pumping
Awesome Shit 👍🏽
Why do you get your heart pumping when riding a motorcycle?
@@leandrog2785 cold weather after hot shower
Last Friday I hit ten gallons of blood donated since 1993. I was doing it to help others. Nice to learn it helps me too. Thanks for all you do.
Here we go.. after listening to the entire episode3 on Spotify 2 hours ago..waited for this here..One more time.. Cheers to taking another step towards a better future for humans evolution
That intro is just so beautiful *chef's kiss*
Great podcast. Would love to hear some commentary on how protocols and methodology changes for those that haven't started "getting old" yet
I use to run track and then 5k and 10k road races a lot when I was younger in the 1970s and 80s, My last 5k was 2015 at age 54. I remember reading somewhere about distance runners actually having more blood volume, but less red blood cells and more white blood cells than average, because a runners red cells, lungs and circulatory system was much more efficient.
I bet life insurance companies would love to get their hands on the death prediction data for people. Very thought provoking podcast, and I love learning the science behind it all. Thanks!
This really really outstanding. Naturally with David Sinclair. Covering so much ground in a little over an hour is so useful. I think the 1 hour podcast will become the new standard.
Started with cold water at the end of the shower... will get there, comfort is such a trap!
Very thankful for this video from Korea. I also would like to know more on relationship between sleep and longevity through the view of Dr. Singlair !
Amazing series. Can't wait for the next episode
Subscribed before 1.2 seconds in to the Ad.
This is a shot with fully loaded information. Can we say body building and longevity are two different goal of life ? Or can we achieve both ?
I have the same question how can i fast without losing my gains 😭😭
@@azesal8922 which episode if i may ask ?
Amazing to learn about the science behind Wim Hof's entire practice!
Dr. David, would it be possible to measure Biological Age from Europe? Please please make it happen. And if there is a chance for Inside tracker to provide full service for European market, would be amazing. Or any chance to cooperate with Inside tracker to open the European lab / center?
Thank you both for the excellent podcast!! Dr. Sinclair is brilliant but thankfully understandable, and Mr. LaPlante is the perfect interviewer to ask the questions we would like to ask, Greatness incarnate!!
Love all of your episodes. Thank you so much 😊
Do we do the same things if you are over 60 or 70? Love your work.
How amazing it is to have all this info direct from the fount and for free. Thanks a lot
How much iron is too much? What is the maximum level for Hemoglobin [g/dl] and Ferritin [ng/ml]?
Which values are optimal (for an adult)?
Im watching this and shivering from the cold.
You guys got one important thing wrong. Back in time when humans lived in the nature we were mostly less stressed. Today with all this media, loans, divorces and so on keeps us stressed constantly. That is what makes your body lose the balance together with process foods and no outdoor exercise. Keep up the good job in analyzing our genes and our inner game.
Dr. Sinclair, What do you think about high calorie, high protein diets like the ones that are recommended for muscle building (hypertrophy) programs? For what I understand, you can't have that much calories overall in a single meal, but it's been proven to be effective on building muscle. Is it worth it to go that path if slowing down aging is your goal or it's actually not beneficial?
Thank you so much for the free education! And it's really not so hard to understand either for a layman like me. Right now I'm getting the key ideas and translating them and explaining them in details in Chinese, putting them in my blog hoping to convince more people cognitively to get more exercise including my parents. Now I seem to have very strong arguments to back me up! Exercise is so important. Thank you both, please keep up more updates.
Great, clear information! Thank you, as always! So many questions was answered!
I like it when you do the advertising - business regarding the sponsors of your podcast, and your eyes lock into the wording as you read the data and the stare forward and the eyes look all serious and locked into each letter. As you talk about getting younger as you take trips around the sun! My mindset too 👍👍
Thank you so much 👍🏻❤️
Please podcast with Leo and Longevity
Thank you so much to both of you. I'm 41 years old, originally from Philadelphia now living in Finland. Im playing music here with legondary rock and roller Andy McCoy but recently times have been tuff due to Covid and I have not been taking advantage of doing the things I should to to maintain my health. Nothing bad, just mostly sitting around and not getting proper exercise and not using the Sauna's that are available here in Finland. Because I have been watching these pod cast episode's, I have been motivated to learn and start to implement the simple strategies you discuss. I'm looking forward on the next pod cast and if there is any way I could chat with either of you about my health and what I can do to not only better myself but also help people around me and spread the knowledge I would love to. Thank you, Kiitos...Matthew.
Great podcast. Amazing scientific information. A lots of the information in this podcast regarding diets and lifestyles are spot on. I am currently living in Italy and I see a lots of people in their 90s looking like they are 60, full of energy riding bikes or walking everywhere. I see that most Italians dont usually eat breakfast, they just drink a coffee (espresso) and when they have lunch or dinner is not too much food, small portions and lots of vegetables. The Italians eat food in order (primi and secondo piatti) and then they have a digestive drink at the end. Eating in Italy or in the Mediterranean is an experience because the way is cooked (pasta cooked only a few minutes) and the way you eat and how is almost sacred because if you dont follow it people will look at you weird hahaha. And of course, every meal comes with the wine!
I ordered Athletic Greens, I hope it taste good!🤣
What do they eat first and second in Italy?
That moment between them at 44:11 really got me
Thank you a lot for all these interesting informations.
I have began to assume Reveratrol, I practise sport at home for 20/30 minutes three times a week in the afternoon; sometimes I go out for walking, not all days, but I never stop moving at home.
I wait for the next post.😍😍😍🇮🇪
Thanks fot the video! These podcasts are so great! I love the content!
Question, do these things change (eating less, taking cold showers etc etc...) if you live somewhere that is already damp and cold?
I was so tired and took iron supplement, and helped tremendously. I’m vegetarian.
This discussion is so satisfying. This science is insanely interesting 🚀I want to turn on all the good turn off all the bad. I’m getting my lab work with inside tracker in the morning! Thank you for sharing
Thank you for this amazing information! I was wondering if you had any information regarding using Breathwork such as the Wim Hof method or Buteyko breathing to induce hypoxia. Is the hyperventilation / hypoventilation we see in Wim Hof doing the same thing as the Hyperbaric chamber you mentioned, due to the large differential created during the practice? Thanks again!
Extremely informative and very actionable ⭐⭐⭐⭐⭐
Dr David, Do you have any advise/opinion/evidence on the effect of aromatase estrogen blockers when given as a 5 year post preventative treatment after mastectomy/breast cancer?
.is there any protocols to offset this deficiency in women(as read women suffer huge age acceleration due to this)?
Thank you…
Thank you sir for these amazing podcasts !!!! :)
Incredible. Thanks for sharing your knowledge.
Ooof, I lost over half my hair 3 months after having Delta. It’s finally starting to grow back but I lost so much. So overwhelming. They are calling 2021 The Year Americas Hair Fell Out. Maybe do a cast on the Covid hair loss? There’s a yoububer who is losing hair 17 months after just losing her smell and taste a few days. It’s insane. Feels like radiation sickness. My Thyroid test came back normal but I am always iron and D deficient no matter what I do it seems. There are articles all over the internet about Covid hair loss. I’m not on Fb but a lot of my friends and family are coming to me telling me more and more they are seeing people sharing about their Covid hair loss experience. It’s becoming a sort of an epidemic of its own. 😣 not fun at all. I went from my hair very thick and long to filling the toilet every day for almost two months. I’ve heard of plumbers posting about pulling wads of hair out of the septic lines from Covid hair loss. It’s no joke.
Bless.
I was taking Donotage NMN and resveratrol every day and wasn't feeling well so I stopped and felt better. I take Vital Proteins, two scoops and I exercise 60 minutes 6 days a week which consists of doing X3 with bands which takes 20 minutes, a 20-minute abb work out, and walk at 3.2 MPH at a 2% grade for 20 minutes with a 15Lb weight vest which is really strengthens my legs to where walking for 4 miles without the vest is nothing and I feel great. I think clearly and at 74 and my reaction time is very good when driving and still can run around with younger adults. I'm losing weight and gaining mass which is really nice. Some people don't believe my age when I tell them.
Dan - I hope I can get to where you are in your exercise routine by the time my 70 years catches up to your 74...but I've got a LONG way to go!
Can you comment further about iron consumption? I did an inside tracker test and mine was slowly below optimal so I’ve been looking for ways and have increased consumption a bit through my plant based diet but want to be sure I’m not overdoing it. Any recommended daily amounts based on body weight or more specific guidance you can give?
Regarding sauna bathing, Dr Rhonda Patrick has cited a study that says the optimal temp/duration is at least 176°F for 20 mins, 3 times a week. Thanks for these great talks! I've really enjoyed Lifespan as well! Thanks to you, I have joined Inside Tracker, which has been very helpful, and I'm also taking NMN and rsveratrol (500mg/day each to start). Keep up the great work, and thank you! 🙂
Damn that’s hot! Mine only goes 160, infa red
I'm so happy for my grandkids that they will probably see the cure of aging happen in their lifetimes (maybe when they are my age). It's a huge system engineered with many odds and ends to kill us in the long term. A truely sad state of affairs. For my wife and I, it will come too late. It's all falling apart under our feet. Allowed to see the promised land, but we shall not enter it. It's alright though when you know that others continue.
Hello :)
I like to tweak the saying "what doesn't kill you makes you stronger" by saying "what doesn't handicap you makes you stronger"
Does "cold" have to be actually cold or just relative?
For example if you live in the Middle East with no air conditioning even a 20degC bath would seem very cold, where as a resident of Alaska would thing the same 20degC bath to be quite warm I'd think.....
Been following you since your episode in Tom Bilyue's show. The way you explain things in awesome. Thank you for sharing your knowledge.
I love this podcast and everything about staying young as long as possible , but I thought of something recently , I would NEVER want to live as long and outlive everyone I love , nope , especially my wife and daughter , mortality has many wisdoms , and "everything that has a beginning has an end" As Agent Smith Said in the Matrix lol , Watch the green mile , tom hanks in that movie his character lived to 108 and was still going he outlived everyone he loved , and it was sad , BUT all being said the way I live is not to die, the way I live is dying to live
So introduce your family to the process and live longer with ALL the ones you love!
Thank you! So much!
I really want to know what your thoughts are on ghrelin suppressants would you recommend people take them?
Thank you so much for this great information. You are brilliant 👏
Thanku thanku both people
I’d be interested to know if there are benefits to starting this at a younger age say before 30 or if you still get the same benefits starting after 30?
Yeah I’m quite young and do intermittent fasting and other things like this but I sometimes question is there benefits for our age or is it only beneficial at an older age
@@Ghhhhhjjccvv do it all now!! Yes I’m 59. People think I’m my granddaughter’s mother!! Wish I’d done cold and hot therapy sooner tho! And meditation! Profound epigenetic impact!
@@lizmallen3461 thanks for the response, would you say you get the most benefits of hot and cold therapy by swimming in the sea for roughly 20 minutes then into a sauna for 1 hour?