HPA Axis Dysfunction & Mood | Exploring the Mind Body Connection
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- เผยแพร่เมื่อ 30 พ.ค. 2024
- HPA Axis Dysfunction & Mood | Exploring the Mind Body Connection
#HPAAxis #dysregulation #cortisol #mentalhealthmatters #integrativehealth
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#HPAAxis #Dysregulation
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- Hypothalamic-Pituitary-Adrenal Axis
- Controls reactions to stress and regulates digestion, the immune system, mood and emotions, sexuality, and energy storage and expenditure
- The signs and symptoms of HPA-Axis dysfunction reflect a persistent, abnormal adaptation of neurobiological systems to trauma or chronic stress.
- In addition to trauma, multiple lifestyle factors have been associated with HPA-Axis dysregulation
Consequences of HPA-Axis Dysfunction
- More than 50% of Americans suffer from one or more chronic conditions associated with disturbances of the HPA-Axis with an estimated cost of $3.3 trillion annually including:
Overview of Healthy HPA-Axis Function
- When exposed to a physical, environmental or social stressor, the HPA-Axis is activated and prompts the “fight or flight” reaction.
- Glutamate and Norepinephrine are released
- The hypothalamus releases corticotropin releasing factor (CRF) and arginine vasopressin (AVP) to stimulate the anterior pituitary to produce and secrete adrenocorticotropic hormone (ACTH).
- ACTH causes glucocorticoid (cortisol) synthesis and release from the adrenal glands
- Cortisol’s primary function is to
- Increase blood glucose and modify fat and protein metabolism to fuel the fight or flight reaction
- Modulate immune and brain function to effectively manage stressors.
- Cortisol initially causes a potent anti-inflammatory response which allows the organism to react to the stressor without being pain or fatigue.
- Glucocorticoids interfere with the retrieval of traumatic memories
- As cues of the threat wane, the body increases inflammation by releasing proinflammatory cytokines to accelerate wound healing
Stress Response
- The response of an individual to stress depends not only on stressor characteristics, but also on factors specific to the individual
Emotional Valence
- The NEVER (Negative Emotional Valence Enhances Recapitulation ) model of emotional valence, asserts that the greater the number of stimuli related to the unpleasant event that are remembered, the greater the likelihood that the person will encounter reminders of the event leading to increased recapituation.
Physiological Changes Due to Hypocortisolism
- Sustained HPA-Axis activation causes persistently high levels of CRH which eventually causes a blunting of the ACTH response to CRH stimulation
- Disinhibition of corticotropin releasing hormone (CRH) and norepinephrine which lead to an exaggerated response to acute stressors and corresponding increase in cortisol.
- Exposure to additional stressors produces stronger trauma-related symptoms in part due to the exaggerated HPA-Axis response causing the stressor to have a stronger negative emotional valence
- Exaggerated elevation of cortisol during exposure to acute stressors increases the sensitivity of NMDA receptors, which makes the brain generally more vulnerable to excitoxic effects of stress
- The volume of the hippocampus which controls not only the HPA-Axis and stress responses, but also declarative memory is reduced due to the excitotoxic environment.
- Amygdala activity increases and promotes hypervigilance and impairs threat discrimination
- Reduced prefrontal cortex volume impairs executive functioning and impulse control
- Reduced anterior cingulate volume impairs the extinction of fear responses
- Thyroid hormones become imbalanced leading to abnormal T3:T4 ratio and increases in anxiety
- GABA (inhibitory) activity is decreased, and glutamate (excitatory) activity is increased
- GABA has profound anxiolytic effects in part by inhibiting the CRH/NE circuits
- Increased dopamine and norepinephrine levels increase arousal, startle response, fear memory encoding and increased HPA-Axis activation in response to recapitulation.
- Changes to the ratios of estrogen, testosterone and progesterone occur which impact the body’s ability to modulate cortisol levels
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I'm dealing with the noisy neighbors in an apartment that like to stomp around during the night hours. It is driving me insane, my HPA axis is out of wack.
I am sorry about that and I appreciate you watching the video. Other videos you might be interested in can be found at th-cam.com/users/DocSnipessearch?query=vagus
5:05 speaking about low-grade noise, there's high grade where I live too-- in the summer months, it is non-stop inner-city car racing every Friday and Sat night, so many that the cops can't stop them-not to mention the 3 drive-by SHOOTINGS at my neighbor's house. That will set your teeth on edge and contribute to your insomnia, guaranteed.
Daisy, I am so grateful for you and I am truly sorry you’ve experienced such awful and traumatic things and I appreciate you watching the video. What tips will you consider using first to start healing your HPA axis?
th-cam.com/users/DocSnipessearch?query=trauma
Thank you, Doctor Snipes for yet again another accessible and informative video which gives us hope that we can relay information about neuroscience to our clients without a master's in neuroscience! I am so grateful for your work as in just two days, your work as given me a degree of confidence in my knowledge to greatly impact the lives of the students I support with mental health challenges in my work. THANKYOU!
Thanks for watching. Wishing you peace, health, and happiness.
Any videos on treatments !?
Easy to talk about how things go wrong, but point is how to heal it. That is the hard part.
She released one today! I know this comment was a while ago but if you’re still out there…
Excellent educator, presentation and content! I am truly APPRECIATIVE. Pleasantly, intricate detail with exceptional simplification!
Just look at the Seratonin Receptors Box 37:36 - that is some serious information, and I like to know what is what with no holding back details.
Best help for me is when I understand - and this material is RICH with UNDERSTANDING, thank you!
Wow, thank you!
What a thorough talk-through of the HPA axis problems. Think I will have to listen again to get everything noted down. Thanks very much.
Thanks for watching.
As a nurse practitioner student, I find this lecture to be absolutely amazing. So well done and explained!
Thanks for watching.
You are brilliant
Thank you. Thank you so much for watching the video
I love watching/listening to your videos. Thank you from Utah for these invaluable explanations.
Brilliant presentation, thank you
Glad you enjoyed it!
I absolutely adore Dr. Snipes! I’ve been listening to her podcast for 2 years and now just discovering her TH-cam channel- yay!
Welcome aboard!
Absolutely grateful to learn. Thank you for making this easy to understand. Very helpful and super important to know. I shared it to friends.
For the first time i was actually able to get the clear picture of HPA axis .very grateful.
Wonderful! Thanks for being here.
Absolutely amazing. I just learned about HPA AXIS so I wanted to learn about it with lead me to your video.
The way you described the reactions to stimulation and the chemicals released into this feedback loop described me. I work with other veterans with severe Ptsd and see these same patterns in them.
I broke the cycle years ago and now I know the science which will helps me refine my techniques. Hope to hear from you.
“ people feel kore empowered when they understand …”
Wonderful. So glad my video was helpful to you, and hopefully the veterans you work with!
Excellent presentation. Thanks for sharing
Glad you liked it!
This is incredibly helpful! Thank you.
Welcome
Me too! SO happy I watched it. SO helpful. You are such a lovely lecturer !
Thank you so much!
Hi Doctor Donna, could you do a follow up on the effect of Caffeine and exogenous substances/stimulants on the HPA axis? Thank you for all your information and expertise, you are an incredible wellspring of knowledge! ❤️
th-cam.com/video/osHyB7ioj70/w-d-xo.html
Great video! This was very helpful in learning about what HPA Axis Dysfunction was from a general place. A very thorough explanation! As a personal trainer, I wanted to know about it generally from a mind point, before diving into it from a health and fitness place, which is my main focus. Thanks for this! :)
Thanks for watching. I used to be an aerobics instructor....back when we all still did high impact. :)
Amazing presentation. Really. Thank you so much 🥰
Thanks for this Doc! I am excited to dig in. 😀
Thanks for watching.
Do you treat or know anyone who treats hpa axis dysfunction? Mine is very severe I’m in my 20’s and I want my life back
Thank you 😊just found..timely synergy
Welcome
Excelente work and content 👏👏👏
Thanks for watching.
i went through some very traumatic personal experiences in my mid 20s and I've had chronic fatigue for the 15+ years since. I'm certain I've got an HPA issue. I sent in a home Testosterone test to Hone Health and my total Testo lvl was like 117! Hopefully that's a flawed test but the way I feel.. sounds about right. lol
Thanks for watching. Wishing you peace, health, and happiness.
This is me now in my 20’s with the same thing
51:30ish um..dosen't the liver provided enough glucose to? This ofcourse although I haven't check when a Chronically regenerating liver is being repaired the glucose production maybe? there for the lack of oxygen increases on the long term liver damage I mean glucose has 8 oxygen's a chemic it adds up regardless my original point is that the systems that you out line for early morning 3AM ish hast to do with the liver finishing the leftovers high sugar or alcohol glucose or ethanol throwing a chemical response back to the brain knocking you out of rem sleep? Uselessly it pairs with or is change in ADH Or DH ?
💚
Thanks for watching the video
My PA (can't get a Dr. around here) asked me to put steroids up my backside. I played ball for a week. After watching this... yeah, nope.
24:26
Im very sensitive to noise
My neighbors dogs , they have 4 bark at us in our own yard on our own property.
This really bothers me
When I spoke to my neighbor, her response was She wants Her dogs to bark.
I told her I dont want your dogs barking vicously at us when we are on our own property minding our business.
Her dogs need to mind theirs
She doesnt care obviously
Sigh
I hope she never has kids
I am sorry about that and I appreciate you watching the video
Next time you think somebody is stupid consider what stressors may have thrown their HPA axis off and what kind of bad advice they've been given.
Thanks for watching.
Thank you 😊just found..timely synergy
You are so welcome