Dr. Cywes, your way of explaining complicated biological/medical/scientific terms and processes is so clear and to the point without fluff. I always wanted to study medicine witht the goal to become a brain surgeon. However I was not smart enough to enter medical school. Life has its way. Nevertheless, my interest in medical subjects has never waned. You, as an accomplished medical professional offering these free lectures, provides us lay people with invaluable access to knowledge. You spent years to acquire this knowledge, and all we have to do is listening for a short time to start grasping complicated concepts. I consider you a master teacher. thank you for your effort.
Dr. Cywes' explanation here, of a pretty complex topic - the Randal Cycle - is a great example of how to simplify something so as to make it comprehensible to a layperson. Dr. Cywes is not just teaching us about the Randal Cycle, but he is teaching a masterclass on how to distill the esoteric nuances of a scientific concept into something that is more accessible. Thank you Dr. Cywes! I am sure you are a busy man, but given how much attention the Randal Cycle has been getting, if time permits, maybe you can do a presentation on this with slides. Visual aids, especially when dealing with the such a intricate topic, helps describe things more clearly - especially for those who are more visual learners. Given how much the Randal Cycle is being used or misused to argue for a particular point, and just the sheer amount of misunderstanding there is around the concept, warrants taking the time and effort to do a deep dive into this topic.
I see a lot of people suggesting this video discredits Bart Kay's understanding of the Randle Cycle, but it doesn't seem to do that at all. Both Dr. Cywes and Bart Kay seem to be saying that cells prefer fat, and in the presence of fat it doesn't utilize glucose. The mitochondria, once satisfied, will block further energy absorption. As I understand it Dr. Cywes is merely pointing out some nuance about how Randle incorrectly assigned causality to the presence of fat blocking glucose pointing out that Glut4 would facilitate the transport of glucose into the cell. However ultimately the effect is still the same, that the cell prefers fat and once energy requirements are satisfied it will block the glucose even with the facilitation of GLUT4 which would then cause the glucose to enter adipose cells. They are both saying the same thing about the effect of the Randle Cycle, Dr. Cywes is just providing more scientific clarification that Randle's assumptions weren't entirely correct because he assigned causality to the presence of fat instead of to the satisfying of energy requirements.
Cell arguably prefer burning glucose as they increase the nad to nadh ratio which speed metabolism of the cell, creating more atp and co2 production with less reductive stress and ROS. With a high metabolism from glucose burning that energy systems won’t be “satisfied” for long compared to fats. The brain, red blood cells, CNS, and kidneys for example need a constant supply of glucose
Great video! You are the first have seen that brings up the role of glucagon with relation to the Randle cycle! I have severe type 2 diabetes. Even after a full year of strict carnivore diet and cutting out all meds, including insulin, my average blood sugar was in the 270 range. I finally twisted my docs arm and got both a fasting insulin and fasting glucagon test. My insulin was 12, so high, as expected. But my gucagon was only at 18, so severely depressed. So then the depressed glucagon no longer restricts the insulin production, which again makes my liver produce as much glucose as possible, to get rid of the excess insulin. Then Ben Bikman explained the role of glucagon in detail and the fact that eating healthy saturated fat actually boosts glucagon production, thereby LOWERING the insulin production. So if you wanted to conspire to get as many people as possible to die from the effects of insulin resistance, the obvious first thing to do is to completely demonize or ban eating saturated fats... Something to think about... With all this information I have devised a strategy for curing my diabetes. I do periods of 9-10 days of waterfasting combined with daily exercise. This will after a few days completely normalize my blood sugar. Then when I start eating, I ONLY eat fat, as in lard, for the first few days. After completeing two such cycles, my avarage blood sugar is now reduced to around 130 when eating a normal carnivore diet. I believe that with a couple more of these cycles, my diabetes will be cured. So get tested for both blood glucose, A1C, fasting insulin and fasting glucagon. That gives you a complete picture of what is going on.
i've fasted several times, even dry fasting, and I have to say the health benefits are exaggerated. there's less stressful methods for achieving equal or greater results. it may be necessary in your case, idk. but I would attempt less severe protocols first. the rule should always be: if you're hungry, eat. the only exception is carbs, since our instincts are evolved for an environment where carbs are rare and seasonal, nothing like our current environment.
Please debate Bart Kay on this as there seems to be disagreement here and we need an actual consensus to make a decision. Please. This would help a lot.
I don't think there is disagreement. They both seem to agree that cells don't use both fat and sugar at the same time. It's one or the other. Unless I'm misunderstanding this video.
Take away practicality : separate carbs from fats if not on carnivore diet and never exceed proteins if on carnivore diet . That's listening to your metabolic needs through taste buds Lions and cats just stop eating , when their saliva either stops or changes !
I agree. Terrance. Although this video was a bit over my level of understanding.... I will do more research so that I understand. The little bit of digging that I've done today.... it appears that Bart Kay disagrees with what Dr. CYWES just discussed. A conversation between Bart Kay and the good doctor would be enlightening!
@@oyvind6838Dr Cywes is saying that the Randle paper was great for its time but Randle didn't know about a lot of mechanisms that have been discovered in the 50 years since, particularly the hormonal influence of glucagon in the process. Bart Kay is stuck in the past and has not kept up with new discoveries. Dr Cywes is definitely keeping up better with the new discoveries. I really recommend the lectures of Dr Richard Johnson on the metabolism of fructose to get the most recent discoveries from a biochemical and physiological perspective. If the Randle process was correct those children doing extreme ketogenic diets to treat epilepsy (fat making up more than 90% of their calories) would have developed diabetes and that is not the case
If I am understanding correctly, we won't lose fat in our fat cells until the glucose and fats in our circulating blood is used up first? I have high triglycerides and cholesterol, prob genetic. Initially in 1995 had chest pain hypertensive episode and found a Chol >800 triglycerides >1600. Turned out I had esophogitis. I was a normal weight gal. A doctor once told me, abt 30 yrs ago that I was a hyperproducer of chol. Put me on 2 statins and fenobrate, vegan diet. Many diff diets later, and change in statin names gained upwards 70 lbs Im an overweight, diabetic nurse who.... Stopped taking fenofibrate and statin 18 mo ago. went low carb, then transition to carnivorish..a1c 5.5. Trigly 149. Ldl is 284. Hdl 58 vldl
Bravo. Very good and very respectfull (with regards to Randle) explanation of this complex subject. This is why enjoy watching your videos so much. Thanks for enlightening us by providing us with this valuable information!
Hey Dr Cywes As this video is three months old, I don’t know if you’ll see this post . The issue with some very loud influences regarding the Randle cycle is that they use it to deny insulin resistance. I think they read Randle’s paper as showing that once the cell is full of energy, the cell itself down regulates the insulin receptors to block more energy coming into the cell, because that would be deleterious for it. They say because trying to put too much energy into a cell is toxic for it, the cells actively down regulate and force the excess fats and sugars to remain in the blood where they are also dangerous, but it’s the lesser of two evils. So insulin resistance is wrong as a concept. Thoughts?
Most of what you said is true though, and Dr. Cywes's video does not debunk it. Also, who are these people saying insulin resistance is wrong? No one is disputing the existence of insulin resistance, but some are disputing it as a condition. And frankly from what I've seen of Dr. Cywes, he doesn't necessarily argue against that either. He himself is saying insulin resistance is a result of too much carbs and sugars. Even in this video he is suggesting too much glucose causes a disregulation of glucagon hormonal system. Why would you have too much sugar? Because your cells don't need energy either due to fat or having too much sugar to satisfy its needs.
@@yann664 nice explanation my understanding is like yours but a particular professor influencer who is dismissively dogmatic say's insulin resistance through hyperinsulinaemia is wrong
@@davegriffin9083We are unable to absorb two fuel types at one time. Two fuel types attempting to enter a cell at one time creates an inflammatory response. Repeated inflammatory responses cause cell damage, & eventually cell dysfunction that disables a cells ability to stop healing. This causes cells to multiply out of control & grow into cancerous tumors. Anything in our environment & especially consumed that we did not evolve with, & adapt to, will be recognized as foreign material by our body, & cause an inflammatory response leading to damaged dysfunctional cells, autoimmune disease, cancer, & eventually death.
Ancestrally Appropriate Diet! (Short) Our evolved ancestrally appropriate diet consists primarily of Ruminant animals fed a clean diet of grass & weeds that reach deep into the soil & suck up nutrients unavailable near the surface, or from nutrient void GMO corn, wheat, & soy sprayed with carcinogenic glyphosate weed killer, & estrogenic pesticides. Some examples of ruminant animals are lamb, goat, deer, elk, bison, & cattle. Yeshua Hamashiach, (Jesus) said, "Eat split hooved animals that chew the cud." (Leviticus 11) These are ruminant animals with long four chambered stomachs biologically designed to be capable of breaking down plant matter, filtering out plant defense chemicals, plant toxins, anti-nutrients, & even many environmental pollutants, while also providing more essential nutrients than any other food, also making those nutrients more bioavailable or absorbable for us. The anti-nutrients & inflammation caused by plant defense chemicals puts us in a state of brain fog we can't tell we're in, until we find our way out. Benjamin Franklin said, “Life’s tragedy is that we get old too soon and wise too late.” We don't have long multi chambered digestive tracts like cattle & other ruminants, capable of breaking down plant matter, filtering out plant defense chemicals, & anti-nutrients. Botany teaches us that all plants, fruits, & vegetables have thousands of plant defense chemicals & anti-nutrients to protect themselves, because they are stationary. Anti-nutrients prevent us from breaking down, & absorbing our proteins, nutrients, & essential fatty acids. We've evolved to have varying degrees of tolerances determined by our ancestors' diets, & environmental factors such as weather, & religion, or dictatorships controlling diets for lengthy periods of time, which has altered our genetics at a molecular level, but that does not make them viable, or optimal nutritional sources. We're not biologically designed with long digestive tracts to break down plant matter or fiber, which are indigestible carbohydrates that feed bad bacteria! That's why we have to take pre/probiotics to break it down. This creates a science experiment, & balancing act in our stomach. Plant fermentation produces methane gas build up that expands our stomachs, stretching the walls of our gut lining, creating tears through which we lose Vitamin C, back into our blood, contributing to free radicals, & metabolic waste our bodies struggle to clean up, along with more nutrient loss, because we need Vitamin C to direct nutrients where to go. Inappropriate diets lead us to needing supplementation, but 90% of the supplements on the market are fake. Ascorbic acid is a molecularly incomplete synthetic form of Vitamin C that competes for the absorption of real Vitamin C. Cyanocobalamin is synthetic B12 that breaks down as cyanide in our blood. Cyanide was used by the Nazis to commit suicide when caught during espionage. Our bodies have not evolved to recognize these lab synthesized compounds made over the last hundred years, because it typically takes evolutionary adaptations hundreds of thousands of years or more to occur... Usually out of necessity for survival. They say small amounts won't hurt us, but I would argue that creating chronic inflammation that prevents us from being able to use mitosis, & autophagy to heal, definitely hurts us. These synthetic vitamins are added to many processed foods. Everything has a "root cause." Cause & effect are fundamental concepts in science that describe how "every action has an equal & opposite reaction." (Newton's third law) Mixing sugar & protein, like what's in a sandwich with bread & meat, creates sticky proteins or glycation, that sticks to the walls of our arteries, & solidifies or hardens, clogging them faster. Many vegetables have a glycemic index high enough to spike insulin levels, induce unhealthy glycogen fat storage, kick us out of ketosis, & out of fat burning, & into burning glucose. Glucose burns rapidly, & volatile, like rocket fuel, but fat burns slow, steady, & efficient. Evident by the deaths of many carb loading bodybuilders. We need to be burning fat in order to use our "fat soluble" vitamins. There's no such thing as an essential carbohydrate! Two fuel types trying to enter a cell at the same time, causes cell damage. Repeatedly damaging the cell eventually leads to cell dysfunction, overgrowth, & cancerous tumors. Glucose speeds up the growth of cancer cells. Sugar & high glycemic complex carbohydrates create the same damaging inflammatory response to our cells, & levels of dopamine response or addictive instant gratification signaling in our brain, as meth & cocaine! We burn glucose first as a defense mechanism to prevent it from causing problems. We can derive the 4 grams of glucose we need from fat, & that's all we can tolerate before being kicked out of fat burning & ketosis, & into unhealthy glucose burning, & glycogen storage. We are unable to properly regulate our blood sugar levels when we are creating insulin spikes with sugar & carbs, which signals our bodies to create more insulin signaling the storage of more glycogen fat. This glycogen storage is that which makes up the subcutaneous fat beneath our skin, visceral fat smothering our organs, & eventually clogging our arteries, causing heart attacks & strokes! Bad bacteria cannot survive on fat or ketones, but we thrive. We can starve out viruses like the Coronavirus, or bad bacteria such as Candida & yeast by avoiding sugar, fructose, & carbs our bodies turn into glucose, which feed bad bacteria. The dawn of agriculture brought with it mind fog, malnutrition, disease, pestilence, a reduction in overall health, lifespan, reduced size, reduced jawlines... evident by crooked teeth, & our wisdom teeth no longer fitting in our head, as well as reduced cranial cavity & brain size, & the optimal neurological function that running on ketones provides. Siddhartha Gautama (Buddha) said, "To keep the body in good health is a duty... otherwise we shall not be able to keep our mind strong and clear." Agriculture regressed our evolution, & made us smaller, weaker, dumber, docile, more manipulatable, & easier to control. George Orwell said, "The most effective way to destroy people, is to deny and obliterate their own understanding of their history." "Knowledge is power and it can command obedience." (Imam Ali Bin Abi Taleb) We can convert fat into glucose, or ketones. Ketones are our brain's preferred fuel type. Cognitive & regenerative brain functions increase tremendously while burning ketones. This means we have adequate power, the correct fuel, & the building blocks needed to make repairs, along with the cognitive & regenerative abilities granted running on ketones to achieve miraculous recovery. We're able to make connections on another level with increased intuition granting us a level of validity like that which our eyes & ears provide... Who wants to be a human lie detector, & so much more! Carnivore is a fasting mimicking diet that allows us to maintain a low inflammatory state capable of using our body's natural healing processes. Our bodies use mitosis, & autophagy to clean out, repair, & replace old damaged mitochondria, creating new healthy cells. Inflammation or chronic stress prevents us from using autophagy to heal! Appropriately fed clean ruminant animals are our only source of nutrition that contain every essential nutrient in "clean" non-inflammatory bioavailable forms. Every other diet creates chronic stressors that cause inflammation preventing us from healing! Dr. Anthony Chaffee, & Dr. Ken Berry are two extraordinary TH-cam producers of amazing, & trustworthy dietary, & medical advice videos that I highly recommend. They talk about everything you need to know to keep you happy & healthy. They explain in detail our evolved diet, how plants are trying to kill us, & expose corruption in the food, & medical industries... Also discussing other typically health-related topics. Please support the TH-cam channel "HomeSteadHow" that's working on a non-profit documentary called "Healing Humanity." There are amazing success stories of people curing blindness, finding their way out of a wheelchair, recovering from autoimmune diseases, & so many other seemingly miraculous recoveries from what are actually dietary nutritional deficiencies! In other words real nutrition heals us from the inside out. There's before & after pictures of physical proof that will astonish you! Steak & Butter Gal has a great support network, especially for women. Between them, there are hundreds of thousands, if not millions of success stories. These wonderful people are doing a great job spreading the truth about a proper human diet. They have channels on TH-cam, or Rumble, covering everything we need to know to be healthy! We all know how difficult it can be switching from the addictive dopamine spiking standard American diet (SAD) to a healthy ruminant animal based diet. We all have inspiring personal stories about how we got our health back, & you can too! The recommended dietary guidelines are as they are to profit from us by greedy corporations, & by religious shell companies, to keep us foggy-minded, & under their control. With support from a corrupt government under the same mind debilitating conditions, & influences or brainwashing tactics that keep us all from finding proper diet, World sanity, Heaven on Earth, & God! Unhealthy, unsustainable, environmentally destructive Industrial agriculture is killing off our bee population needed for the cycle of life. Bees pollinate plants that feed our ruminant animals providing adequate nutritional profiles to keep us healthy! Please support healthy, sustainable, environmentally friendly Regenerative farming! Good luck on your journeys my friends. "We Are One!" My TH-cam playlist titled "Corruption Shorts" is enlightening! www.youtube.com/@VanDamn911
Finally the pieces of the puzzle. To make a long story (2.5 years)short; fat, lost weight, lost bladder, found adenoma (flunked suppression test) and now I know why I can do a three day fast with high blood glucose and normal A1C. Thanks so much for the information.
Has anyone updated the Randle Cycle with our current knowledge? I wish there would be more discussion at keto and carnivore events regarding this. Having the input of Ben Bikman, Eric Westman, Tim Noakes, Zoe Harcombe etc would enrich our understanding.
THANKS FOR THIS VIDEO. IMHO: MOST PEOPLE DON'T WANT TO, OR NEED TO, MASTER THE "SCIENCE" OF ALL THESE COMPLEX VARIABLES. WE JUST NEED SOLID DIETARY ADVICE, AND RECOMMENDATIONS ABOUT WHAT WE SHOULD, AND SHOULD NOT BE EATING, DAILY.
So, if following a carnivore diet, should i include a small amount of carbs with my fatty meat, or not? I'm so confused! Dr Bart Kay says to eat no carbs ever. But I've recently discovered that another role of insulin is to allow immune acids to ever a cell and stimulating protein synthesis. Which is good🎉, right! So that would suggest that *some* insulin production is a positive thing. Not excessive production, but some? I don't know what to do now. I'm so confused 😵💫😵💫😵💫😵💫😵💫
protein stimulates insulin production, while avoiding the nasty spikes carbs create. this is why most keto diets are low-protein, because protein will 'kick you out of ketosis'. but the benefit of low-carb isn't ketosis, it's alleviating the Randle Cycle.
Love this, but barely hanging on. I want more of this, please. However ... can you please suggest a book/books to read and study about biology - especially of the cell - and and "Microbiology for Dummies"? I need to repair and rebuild a foundation begun long ago. Thanks!
For what I have understood it is a two phases process: by a ketogenic or fat adaptation process you get back to insulin sensitivity in most cases and when fat adapted you avoid the insulin suppression by reintroducing carbs one or two times a day (dairy for me is optimal and I do some days but have still cycles of pure ketogenic).
@@lucia_cossu_voiceteacher That's what I'm thinking. I've recently taken to having carbs after exercise, and I'm considering being more judicious about how much protein I eat in one meal, to limit gluconeogenesis.
I would say, "essential" in order to make it easier to comprehend. In the British National Library, a book written by Leonardo Da Vinci had illustrations, captions, and explanatory paragraphs, it was a good example. In contrast in an adjacent room, a copy of the Magna Carta showed that the tremendously important content was made difficult to comprehend because of the poor writing style.
It’s not the fat causing. Is the combination of fat and carbs. They block each other. Fat comes naturally with protein. So what is the unnatural part here. Carbohydrates.
Yeah, Bart Kay may have the correct facts, but his contempt with which he expresses himself just hurts my soul. Don’t need that kind of negativity in my life.
I can’t listen to Bart .. his know it all delivery and dismissive attitude of others makes him a bad communicator. On top of that his assertion that everybody is wrong about the metabolic bio chemistry and only he is right re Randle’s Paper, seems likely to be wrong as Randal was unaware of other important mechanisms undiscovered at the time the paper was written.
eating fats doesn't make fat in the blood (triglycerides) go up. Eating carbs do. This is 100% caused by carb overconsumption. You should always eat fat with each meal, whether it has carbs or not. And there is no natural healthy food that you would want to eat that has only carbs in it anyway. So the people who characterize this as saying not to eat carbs and fat together are wrong. This is a pathogenic state caused by eating too many carbs.
Hoping the good doctor reads my question. My wife is on a Jak inhibitor , ruxolitinib, for myelofibrosis. She is on a strict low carb diet, attempt to keep daily carbs below 20g . For some reason she seldom if ever goes into ketosis. Could the drug be somehow interfering with this cycle?
Because they are both clever people that are trying to do what they do to help as many people as they can. If you can make a point that is correct he sees that point. Bart isn’t arrogant, he is just confident of what he knows
@@Damudean not arrogant .. I think we’re watching different videos. I would go as far as to say that he is rather narcissistic. He is always completely right and everybody else is wrong. I just went back to look at his list of videos, which rubbish literally everybody. And now it appears that he’s wrong about the Randle cycle, as the paper in question missed a lot of important but at the time undiscovered information.
Wow, totally loved this breakdown! Made it so easy to follow and understand! Always questioned the theory of fat causing diabetes and now it is super clear.
There is a crucial point that needs to be highlighted here which is where all of the excessive free fatty acids come from in the first place. Dr Ben Bikman explained that adipocytes start leaking FFAs when they become hypertrophic, up to 4 times their normal size, as the fat droplet within the fat cells gets larger, perilipin can no longer protect the stored fat from the effect of lipases. Again, it is Insulin that activates lipogenesis and it is carbohydrates that spike insulin.
Many thanks Dr. Cywes - it took me a cup of tea, notes and replays but at last I feel I understand what's going on. I've been carnivore for a while but looking at Ketovore. My take away is - add a few carbs to give my insulin a work out but continue with intermittent fasting.
I wonder what it is about one's lifestyle that is influencing this hormonal imbalance, looking more holistically, is there a primary imbalance somewhere else?
What's your thought on being metobolically flexible while endurance trail running? I am animal based during my normal day, I mix in carbs /fruits for a little extra energy but only about 25-30g hr.
Dr. Cywes, I understand some of this, but too fast and detailed for me to synthesize and retain. Would like a simpler more concise explanation. Also would love a video with recommendations for labs to check for insulin resistance, glucagon excess, etc. I try to eat a lot of fat with meals and limit protein, but am not satisfied with less protein. This is on pure carnivore with nothing plant based or sweetness of any kind. Could glucose produced from higher protein be driving overconsumption? I think I'm a fatty with no shortage of insulin, not diabetic. Thanks for your great videos.
Hi Doc great video. Question: Does the Randle cycle debunk the concept of insulin resistance? Others explain the Randle cycle thus: “When a cell is full of fat it will lock the door to both fat and carbohydrate because there is heaps of energy stored in that cell ready for use, we don't need it right now and actually sugar inside your cells is incredibly toxic. So to protect the inside workings of the important cells like muscle cells, organ cells etc the ‘door is locked’ no more fat can come in.… We don't need any more sugar so we are locking the door to that sugar too, so it then sits in the blood and starts to pool in the blood which is detectable as an increase in your fasting blood glucose level…. They then diagnose it as ‘insulin resistance’, no, it's nothing of the sort, it's a mechanism by which the body protects itself from damage. The sacrificial lamb in this case is the red blood cells which become damaged by the glucose in a high blood sugar situation.” Is the above what the Randle cycle describes?
Insulin resistance is not a thing in and of itself. It doesnt exist in the way that its there, and can be measured directly. The Bart Kay says it best. “Its a concept”. But its a valid concept, in that we can see results of it physiologically or pathologically.
@@Technichian462 this isn’t my area of expertise, though I have been carnivore for five years mostly finding my own way. Only recently have very knowledgeable people got into the space. So in general, I’m not arguing the rights of wrongs but I’m finding the infighting confusing. For me, it doesn’t really matter whether the Randle cycle locks the door to more energy coming in as Bart says. Or if the cell becomes resistant to normal levels of insulin and needs more to push energy into it. In the end like most animals if we eat the diet we are supposed to we will be healthy. Understanding the biochemistry is just interesting. For example, another Bartism is that evolution just hasn’t bothered to turn off our digestive enzymes that digest starches. I think that is just wrong. I don’t think we are obligate carnivore and many people can eat a mixed diet including starchy veg my whole extended family have done so in the past and without those starchy vegetables would’ve starved to death. Most people during the Second World War in the UK would have starved without our ability to make use of plant starches. And although it is only my experience, my mum has just turned 90 and just about everyone in my family from poverty in the Welsh valleys have lived to their very late 80s and 90s none of them were on a carnivore diet. Yet they were all healthy and died of old age. And another example, I turned carnivore as I say about five years ago, I’m 58, so I until about the age of 52 I ate a western diet, though I didn’t indulge greatly in processed food. However, I have drunk copious amounts of alcohol and suffered hangovers, and yet when I had my CAC score measured, my coronary calcium was zero. That’s 52 years on a standard diet.
Question: Does this mean "Don't eat carbs with your fat because the fat burning will be blocked and result in insulin resistance and cause metabolic syndrome."?
Very interesting video! I am curious: why in case of insulin resistance, the cell does not just switch to fat use, since not enough glucose enters them, instead of causing diabetes and other metabolic ilnesses? Another video about this would be very welcomed! Much love for your work, doc!
Why poison the cells further with carbs? Fat adaption takes time and excess sugar damages the circulatory system. One must accept lower energy while the mitochondria translates into fat burning mode.
Eat meat and fats ,which in return we become fat adapted , and our body will reduce fatty heart and liver, after we get the fats back to optimum, we begin to repair damaged insulin sensitivity
Thank you for this information. However, how does one fix the problem of not being able to lose weight or bring their glucose down and stop being insulin resistant? I'm not a scientist (or a doctor) so I am at a loss of what to do and I cannot find anyone in my area to help me. Where do I go to find the information I need to fix myself?
Very interesting video! Do we know the mechanism(s) how insulin resistance actually happens? E.g. how does the Randle Cycle (or inflammation?) cause GLUT4-receptors to stop working or perhaps the insulin receptors stop working? I keep hearing about how inflammation causes insulin resistance but to me it is a big, important puzzle piece to have a somewhat complete understanding, as a layman.
My understanding of IR is the more insulin you produce the more resistant you'll become over time. I think more importantly than that simple concept is what we eat and the consequences of that. Take seed oils as an example, they cause a compound called 4HNE which damages the cells ability to respond to insulin it causes fat cells to grow instead of divide until they can't grow anymore and cause disease. A good book for this is "why we get sick" by Dr. Ben Bikman PhD. And zero acre farms has good info on their website under "white papers"
Dr Cywes, I live to explore, explore explore. I continue doing the research And I so appreciate these types of videos. 2 weeks ago it dawned on me that my A1C went from 4.9 as a 10-month low carb eater to a 5.4 as a mostly omad carnivore (for just 6 months). This makes perfect sense to me. My question is, what if in my next A1C blood reading my numbers are higher? Is it problematic? I literally eat meat, eggs and occasionally cheese.
No. A1C measures the life cycle of red blood cells and they live longer with a Carnivore diet which raises the A1C. If it raised under a SAD then you have worries. This is why a fasting insulin or HomaIR is a much better measure of metabolic health, especially for us carnivores. Under 5 is good. Dr. Paul Mason discusses this quite often.
Thanks Dr. Cywes!!!!! Kind of complicated for me!!! To make it simple: Can we combine fat and carbs in the diet without being detrimental for health??? Have been doing that for all my life and am in my 70´s, proper weight, work out 3 p/week, strong all my bloodwork very good, HDL 59, Triglycerides 44, glucose 78 ??????? I feel so confuse????? thanks for all your help! Of course, never use seed oils nor processed foods or sugar by itself.
This is why I am not concerned when a carnivore's body produces more glucose on demand via gluconeogenesis and the individual may have a slightly higher fasting glucose reading of course it will be higher!!! the on-demand process in the liver is happening DURING fasting in the person who consumes no carbohydrates
Very good. I love getting into the science of things. Now, consider this. Heart disease. Plaque build up. Calcium build up. The CAC score is a measurement of built up calcium, under the plaque. But what is causing the calcium build up? Is the calcium somehow attracted to the damage done to the arterial wall? But what about oxolates? Oxolates build up in the body. Oxolate crystals build up, get caught is these damaged areas. Oxolates love to bind with calcium. Could it be then, that the plaque build up is caused by oxolates? If so, there is a larger commonality in heart disease with Plants than with animal products? Many plants contain oxolates, so ergo... The root cause of heart disease is plants?
Interesting! In a review of coronary arteries from 80 patients, we found 4 cases in which there were prominent oxalate deposits within the atherosclerotic plaques in coronary arteries. Oxalate deposits were also present in the media of arteries, the thyroid gland, and other organs, but not the kidneys, and the patients surprisingly did not have renal failure. (Fishbein and Fishbein 2009, p. 1315)
I'd say oxalates could be a contributing factor but it's my understanding that heart disease is caused by excessive, inappropriate carbohydrate consumption.
Enjoyed this video. Can I suggest a video on lactate metabolism? Trying to comprehend Xiaolu Li et al Lactate metabolism in human health and disease and also George Brooks Role of the heart in lactate shuttling. You mentioned lactate at about time stamp 15:00. Lactate seems to be a potentially greater source as a fuel than previously given credit, but only if one is adapted to using it? I’m 61 and have been doing low carb for about 5 years. Been seriously exercising the last 3. Did a fitness test at UT in May and I have a pretty high VO2 max and and a really good ability to clear lactate (as measured by aerobic fit w/ lactate test). I’m wondering if the ability to clear lactate is a surrogate of metabolic health?
So interesting. You don't even need to understand the Randle cycle to recognize that competitive athletes (and their coaches and trainers) don't actually need to replace every calorie they burn during a competitive event. Yet they continue to force sugary gels and other crap into their systems at a rate of 100-200 calories per hour, often puking and bonking in the effort. It's hilarious to me. I spent the last dozen years as a recreational (not competitive) endurance runner who learned this from a book written by Phil Maffetone (a pioneer in this area) years ago, and I even had my fat-burning capacity measured in a sports medicine lab at a university. If a weekend warrior like myself can burn fat at very high levels during hard efforts, imagine what a highly trained, professional runner or cyclist could do if their coaches understood what you're describing. (A small number of them do know this, but they are considered a bit kooky in that world.) In my less-trained state, a marathon or a long trail race is very hard for me, and it takes me much longer to finish than a competitive athlete -- and yet, I can do it without ingesting a single calorie for hours. No gastric distress, no bonking. But competitive athletes are brainwashed into thinking it is not possible to generate your own energy during hard efforts. Their coaches calculate how many calories they're going to burn at a certain power output and make their athletes set timers to guzzle down an equivalent amount of sugar every twenty minutes to prevent... sudden death? (ha). Sure, some supplemental fuel might be needed or helpful at times for top-level performance, but the belief that you have to replace every calorie burned in real time is nonsense. This is why some marathoners and triathletes can have visible fat around their midsection despite training for 30 or 40 hours per week.
This kind of training makes me think of the stories I've heard of ancient message deliverers that could run for up to days on end without stopping. Maybe a little overblown, but an interesting connection.
Ben Bikman has done a few videos on the Randle cycle since this video was first published. He just very recently did one with Ken Berry which included a short discussion of the Randle cycle. Bikman made a very compelling condition on using an untreated Type 1 diabetic as a perfect example. The untreated T1D will have sky high glucose and will also have sky high fatty acids. Yet because NO(or very little) insulin is present the body will ALWAYS choose the fatty acids for energy even though there are tons of glucose available for use. As soon as you treat with insulin the body will shift to burning glucose. Which brings us back to the Hormone insulin. Which is where/how insulin resistance can effect things. "Construct" or not.
insulin's job is to shuttle glucose out of the blood and into cells. the Randle Cycle's job is to protect the cell from glycation and mitochondrial burnout. it is by design that the Randle Cycle overrides the role of insulin, because it is more important to protect organ and muscle cells from glycation than it is the more easily replaceable red blood cells.
So, when you hear people say fat causes insulin resistance, they're referring to Randle's incorrect assertion, and thus, they're wrong. Additionally, excess protein may not seem to be problematic, but it does indeed cause high blood sugar in someone who already has chronically high insulin. This tells me that it's very important to consume an appropriate amount of protein, of an optimal (animal) type, and even more important to make that protein source fatty or accompany it with fat, to avoid overproducing glucose. What I find interesting about this is that many carnivore advocates claim that gluconeogenesis is on-demand. This seems to indicate that is not true. I started my diabetes-reversal journey by extended fasting and eating a moderate-protein ketogenic diet, which many would say is appropriate, in context. However, I believe I did not get enough protein (I developed a hip issue) and went the other direction-to a "ketovore" diet, with (truly) intermittent 36-72 hour fasting on some weekends. I believe I've corrected protein issues, but my blood sugar isn't ideal (it's still below "pre-diabetic.") Now I'm trying to figure out how to best adjust. I'm doing more weight training now, so I presume that will help. I suppose I should be eating 3MAD with more level amounts of animal protein, and including fiber, to throttle gluconeogenesis. My preferred way to do that would be to accompany meat with cruciferous vegetables (which is more or less what I do, but I don't alway eat the veg.)
Dr Cywes, What's your response to the myth that high fat intake is the cause of heart/cardiac disease, especially in light of the recent discovery that high blood pressure in diabetes may be linked to the effect of GLP-1 on the carotid body? Thanks!
So in your understanding, carnivore poses problems when there is an excess of protein? If there’s not an excess of protein and there is plenty of fat, does it cause any problems?
Extended fasting with only water. Work up to three, four and five day fasting once a month. Look at Butter Bob Briggs' video on the 50% insulin problem.
This was just beutiful. Please, do not hesitate to do more ninja nerd hardcore stuff. I Just loved this one. As a layman I have wondered how the heck researchers could empirically identify the electron transport chain, the compartments and all that jazz. If someone could explain how thing like thas was identified it would be a real treat.
So in plain terms, what does that mean? Keto and carnivore are the way to go? According to the study, Bart Kay says that we should never ever ever ever eat carbs. At all. None. No vegetables, no fruit.
Dr cywes can you please make a video and clear up what a fella called Georgi Dinkov is claiming about how excessive lipolysis from fasting and keto diets can cause inflammation in our bodies because the stored fat is mostly PUFA fats. He has scared the shit out of me about keto.
Can you consider please doing a supplement to this video that explains it all in even more layman-language? I know you have significantly dumbed it down here, but if it cld be on the level of "insulin knocks on the cell's door" etc but for each of these chemical actions? It cld be both fascinating and motivating to think about the entire chain/sequence of events that happens both when we eat right and especially when we don't. Thank you for this video!
I think the word "cycle" is a bit of a misnomer which tends to lead people to a wrong understanding. It's not like, say, the Krebs cycle where we see a circular chain of reactions. It's more to be thought of as explaining an either/or function where cells will either (almost) exclusively use fat for energy or (almost) exclusively glucose, but not both at the same time, except in exceptional circumstances.
I heard muscle also has insulin independent glucose receptor which is recently 🤔 verified. This is very complicated..... If you read Dr. Jorge Watson 's Nutrition and your Mind book which is written 1970's maybe he verified carb and fat should be simultaneously existed by every meal consumption because they work coordinatedly for normal ATP production. Otherwise they became mad because oxalo-acetate from glucose pathway and acetate from fat are not combining enough each other. What is the conclusion between Dr. Randle and Dr. Watson ?
I didn't know that Randle blamed fat for Diabetes, I thought he blamed carbs. If you mean he thought being fat caused obesity I think all the skinny diabetics would have showed him otherwise. I've always been thin but can easily shift my blood glucose, cholesterol and triglycerides with diet changes, have to swap one for another though, can't get them all low simultaneously.
I cant believe how long winded this is to explain a very well known aspect of type 1 diabetes called 'glucagon dominance' many things are examined once you simply learn that phrase. People on keto or carnivore have low levels of insulin and when eating protein you see a small bump in blood glucose due to glucagon (not the protein) and seems Robert does not know this either. It is common knowledge but he presents it like he has discovered something
As a type2 listening on these fascinating topics and also having for decades experience with ADA explaining it. And you and Bart K my own anecdotal experience doesn’t see fault with either gentleman. Rather that there are levels to this disease that disrupts chemical physiology. In my case it Non alcoholic stetoses or NASH. The communication between liver and pancreas were muted due to excessive fat on the liver and pancreas making them hard of hearing towards each other if you will. The insulin resistance is a body’s way of protecting the muscles and mitochondria from the excess supply of energy regardless of where it is coming from. Be ketones from fats that the liver also supply in and exogenous glucose from carbohydrates. And that glcogenous hit job called dawn. effect. The latter will be using the stored fat already turned into glucose that is trapped on the liver’s surface and glycated red blood cells. Even fasting 24 hours for a Gastrointestinal exam didn’t bring my blood sugar down 5 points. As my levels were 684 the start of the fast and by the time I was checked again it had only dropped 679. It was years to clear the liver issue up and get those enzymes under control before even insulin would bring my levels below 400. Insulin resistance was doing double duty damage control but the odd thing about that was my insulin levels in fasting was .08 and after a OTT they only gotten to 1.26. My triglycerides. 90. . Figured I was not a type 2 but a late adult type1 running out grace. But 3 years later I am satisfied that with limited insulin reserves I do eat strict carnivore and limit my bolus to 800 calories in a single meal per day. Now my A1c is 4.6. And I am still producing some insulin. I just don’t eat out of my production limit because I don’t want to start insulin and have that thing quit on me. Is it more to find a balance what amounts the body absolutely needs to restore balance. It will do the rest.
Fantastic insight! The takeaway message for me here is that we don’t want our blood sugar level to get so low that the body begins to continuously rely on glucagon to maintain a normal blood sugar level. This is because persistent excessive glucose production from constantly elevated glucagon levels can cause insulin resistance. The solution to this potential problem would therefore be to consume enough cabs with each meal that would support a normal blood glucose level while minimising the impact on insulin levels. This in practise would mean consuming low to medium glycemic index fruits as part of a keto/carnivore diet that have a low glycemic load - e.g. blueberries, strawberries, rock melon etc. This approach would essentially turn a carnivore diet into a meat based diet.
@@erharddinges8855 I think it is more a concern associated with the carnivore diet where there is virtually no carbs ingested. probably not so much a concern with the keto diet where there are some carbs incorporated into the diet.
You've got it completely backwards. You're body makes all of the glucose it needs. Glucagon activation is the preferred method and insulin activation needs to be kept at bare minimum. It sounds like you are saying glucagon resistance is a big problem and the solution is to tax the pancreas more with sugar to stimulate more insulin progression because diabetes is not a thing.
@@adriansrfr Glucagon and insulin work in balanced opposition and are regulated in a negative feedback loop. It is indicated in the video that type 2 diabetes can develop when this negative feedback loop is broken by persistently elevated glucagon levels. Did you watch the full video? If not see video at time 26:45.
@mjoh090 , yes, that is why sugar and fat taken together are contraindicated. It confuses the cell's, and they reject both. The result is visceral fat. The confusion doesn't last for a few hours, it can last days. This explains why vegetarians can be lean (low fat). Keto can be lean (low carb). But those who choose to confuse the Randle cycle will end up overweight if not obese.
Because most people in this space heard about the R. Cycle via Bart Kay. And Bart in his very ‘know all’ way rubbishes the idea of insulin resistance as a concept and uses this paper mistakenly to assert ‘the science is settled’ when Randal was unaware of other key components like glucagon. In other words Kay has muddied the waters and given us wrong conclusions.
@@ChappySinclair What you said in my opinion fits with reality. Our bodies have complex enzymatic machinery to break plant starch into glucose. Kay says this is an evolutionary over site. There in you see his biased reasoning, denying reality to ‘prove’ we are obligate carnivore. Our ancestors if they had had a successful animal, kill and plenty of fatty meat and by coincidence came across starchy tubers, or sugary fruits. They would most certainly have eaten them together. One of the missing keys that I used to heal myself was fasting. Fortunately, Jason Fung was one of the first in the low-carb space, but focused on fasting. And fasting is ancestrally relevant because there would not have been an absolute guaranteed access to food at all times. I think one of the big mistakes, when thinking about the best diet for human beings, is not taking into account the not eating part of the process and it’s benefits e.g autophagy.
@@GoldenBlaisdaleI disagree. Both Dr. Cywes and Bart Kay agree the Randle Cycle is true. They may or may not agree on some of the nuance of why, but ultimately that's less important.
So …. I am type 2 diabetic , using insulin , and have been on carnivore for a yr … I am still getting high glucose spikes …. I still have to take insulin every 2-4 days to get my levels down to a good range as my readings gradually creep up …. I am however using about 20-25% of the slow acting insulin I hade to use before I started on this diet Is there any supplement or protocol I should try to fix what is going on , or should I just keep doing what I’m doing and eventually it will heal?
@@danielbarr9795I'm 64 , I still need insulin on Carnivore too but much less, the dawn effect, our liver dumps glucose at pre dawn, around 4 am, then it slowly falls if fasting, I use a little slow release before bed, fast till 6 pm, eat meat fats, and often need little to no rapid insulin again, I believe time to get our weight normal is only thing that will stop this, good luck
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Dr. Cywes, your way of explaining complicated biological/medical/scientific terms and processes is so clear and to the point without fluff. I always wanted to study medicine witht the goal to become a brain surgeon. However I was not smart enough to enter medical school. Life has its way. Nevertheless, my interest in medical subjects has never waned. You, as an accomplished medical professional offering these free lectures, provides us lay people with invaluable access to knowledge. You spent years to acquire this knowledge, and all we have to do is listening for a short time to start grasping complicated concepts. I consider you a master teacher. thank you for your effort.
@biancagadi I echo your story and comments
Love the discussion. Will puzzle me for weeks until I can sort out the concepts and practical applications. Never ending challenge and never boring.
Dr. Cywes' explanation here, of a pretty complex topic - the Randal Cycle - is a great example of how to simplify something so as to make it comprehensible to a layperson. Dr. Cywes is not just teaching us about the Randal Cycle, but he is teaching a masterclass on how to distill the esoteric nuances of a scientific concept into something that is more accessible. Thank you Dr. Cywes! I am sure you are a busy man, but given how much attention the Randal Cycle has been getting, if time permits, maybe you can do a presentation on this with slides. Visual aids, especially when dealing with the such a intricate topic, helps describe things more clearly - especially for those who are more visual learners. Given how much the Randal Cycle is being used or misused to argue for a particular point, and just the sheer amount of misunderstanding there is around the concept, warrants taking the time and effort to do a deep dive into this topic.
Prof Bart Kay was on the Nutrition with Judy channel and showed charts of the Randal Cycle
I see a lot of people suggesting this video discredits Bart Kay's understanding of the Randle Cycle, but it doesn't seem to do that at all. Both Dr. Cywes and Bart Kay seem to be saying that cells prefer fat, and in the presence of fat it doesn't utilize glucose. The mitochondria, once satisfied, will block further energy absorption. As I understand it Dr. Cywes is merely pointing out some nuance about how Randle incorrectly assigned causality to the presence of fat blocking glucose pointing out that Glut4 would facilitate the transport of glucose into the cell. However ultimately the effect is still the same, that the cell prefers fat and once energy requirements are satisfied it will block the glucose even with the facilitation of GLUT4 which would then cause the glucose to enter adipose cells. They are both saying the same thing about the effect of the Randle Cycle, Dr. Cywes is just providing more scientific clarification that Randle's assumptions weren't entirely correct because he assigned causality to the presence of fat instead of to the satisfying of energy requirements.
Beautifully stated
Cell arguably prefer burning glucose as they increase the nad to nadh ratio which speed metabolism of the cell, creating more atp and co2 production with less reductive stress and ROS. With a high metabolism from glucose burning that energy systems won’t be “satisfied” for long compared to fats.
The brain, red blood cells, CNS, and kidneys for example need a constant supply of glucose
@@aspiresk8boarding which the body makes for itself, so that's irrelevant.
Now you should see Dr Bikman explanation.
@@aspiresk8boardingthumb down
Great video! You are the first have seen that brings up the role of glucagon with relation to the Randle cycle!
I have severe type 2 diabetes. Even after a full year of strict carnivore diet and cutting out all meds, including insulin, my average blood sugar was in the 270 range.
I finally twisted my docs arm and got both a fasting insulin and fasting glucagon test. My insulin was 12, so high, as expected. But my gucagon was only at 18, so severely depressed. So then the depressed glucagon no longer restricts the insulin production, which again makes my liver produce as much glucose as possible, to get rid of the excess insulin.
Then Ben Bikman explained the role of glucagon in detail and the fact that eating healthy saturated fat actually boosts glucagon production, thereby LOWERING the insulin production.
So if you wanted to conspire to get as many people as possible to die from the effects of insulin resistance, the obvious first thing to do is to completely demonize or ban eating saturated fats... Something to think about...
With all this information I have devised a strategy for curing my diabetes. I do periods of 9-10 days of waterfasting combined with daily exercise. This will after a few days completely normalize my blood sugar. Then when I start eating, I ONLY eat fat, as in lard, for the first few days.
After completeing two such cycles, my avarage blood sugar is now reduced to around 130 when eating a normal carnivore diet. I believe that with a couple more of these cycles, my diabetes will be cured.
So get tested for both blood glucose, A1C, fasting insulin and fasting glucagon. That gives you a complete picture of what is going on.
i've fasted several times, even dry fasting, and I have to say the health benefits are exaggerated. there's less stressful methods for achieving equal or greater results.
it may be necessary in your case, idk. but I would attempt less severe protocols first. the rule should always be: if you're hungry, eat. the only exception is carbs, since our instincts are evolved for an environment where carbs are rare and seasonal, nothing like our current environment.
Please debate Bart Kay on this as there seems to be disagreement here and we need an actual consensus to make a decision. Please. This would help a lot.
Whats his disagreement?
I don't think there is disagreement. They both seem to agree that cells don't use both fat and sugar at the same time. It's one or the other. Unless I'm misunderstanding this video.
Dr. Cywes literally says "The Randle Cycle is absolutely true".
He said "true but..."@@xmenotux
Take away practicality : separate carbs from fats if not on carnivore diet
and never exceed proteins if on carnivore diet . That's listening to your metabolic needs through taste buds
Lions and cats just stop eating , when their saliva either stops or changes !
I love the way you explain concepts. I put this talk on repeat and get more out of it every time I listen. Thank you.
Thanks, Dr.. You are the first one to explain the Randle cycle in a way I can easily understand it (and explain it to others).
CAN YOU PLEASE DO A VIDEO WITH BART KAY!!
I agree. Terrance. Although this video was a bit over my level of understanding.... I will do more research so that I understand. The little bit of digging that I've done today.... it appears that Bart Kay disagrees with what Dr. CYWES just discussed. A conversation between Bart Kay and the good doctor would be enlightening!
@@BarbaraJ1111 These two guys know ALOT and are also huge advocates for the carnivore woe. So it would interesting to hear both sides.
@@BarbaraJ1111 I do not see disagreement on the issues in this video
@@oyvind6838Dr Cywes is saying that the Randle paper was great for its time but Randle didn't know about a lot of mechanisms that have been discovered in the 50 years since, particularly the hormonal influence of glucagon in the process. Bart Kay is stuck in the past and has not kept up with new discoveries. Dr Cywes is definitely keeping up better with the new discoveries. I really recommend the lectures of Dr Richard Johnson on the metabolism of fructose to get the most recent discoveries from a biochemical and physiological perspective. If the Randle process was correct those children doing extreme ketogenic diets to treat epilepsy (fat making up more than 90% of their calories) would have developed diabetes and that is not the case
@@BarbaraJ1111 I don't see a disagreement fundamentally.
If I am understanding correctly, we won't lose fat in our fat cells until the glucose and fats in our circulating blood is used up first? I have high triglycerides and cholesterol, prob genetic. Initially in 1995 had chest pain hypertensive episode and found a Chol >800 triglycerides >1600. Turned out I had esophogitis. I was a normal weight gal. A doctor once told me, abt 30 yrs ago that I was a hyperproducer of chol. Put me on 2 statins and fenobrate, vegan diet. Many diff diets later, and change in statin names gained upwards 70 lbs Im an overweight, diabetic nurse who.... Stopped taking fenofibrate and statin 18 mo ago. went low carb, then transition to carnivorish..a1c 5.5. Trigly 149. Ldl is 284. Hdl 58 vldl
You found your own way, and it never begins with statins,I think.
Bravo. Very good and very respectfull (with regards to Randle) explanation of this complex subject. This is why enjoy watching your videos so much. Thanks for enlightening us by providing us with this valuable information!
Dankie.
Hey Dr Cywes
As this video is three months old, I don’t know if you’ll see this post .
The issue with some very loud influences regarding the Randle cycle is that they use it to deny insulin resistance.
I think they read Randle’s paper as showing that once the cell is full of energy, the cell itself down regulates the insulin receptors to block more energy coming into the cell, because that would be deleterious for it.
They say because trying to put too much energy into a cell is toxic for it, the cells actively down regulate and force the excess fats and sugars to remain in the blood where they are also dangerous, but it’s the lesser of two evils.
So insulin resistance is wrong as a concept.
Thoughts?
Most of what you said is true though, and Dr. Cywes's video does not debunk it. Also, who are these people saying insulin resistance is wrong? No one is disputing the existence of insulin resistance, but some are disputing it as a condition. And frankly from what I've seen of Dr. Cywes, he doesn't necessarily argue against that either. He himself is saying insulin resistance is a result of too much carbs and sugars. Even in this video he is suggesting too much glucose causes a disregulation of glucagon hormonal system. Why would you have too much sugar? Because your cells don't need energy either due to fat or having too much sugar to satisfy its needs.
@@yann664 nice explanation my understanding is like yours but a particular professor influencer who is dismissively dogmatic say's insulin resistance through hyperinsulinaemia is wrong
Don't eat sugar. Eat fat. Sadly, that's all I understood, I'm not real sciency, but at least I understood that. And that's a start...
I wish someone would put this in layman's terms I'm no Einstein either.
@@davegriffin9083 Cells prefer fat for energy, not sugar. Stop eating sugar. It causes hormonal dysfunction. Was that layman enough? 😅
@@davegriffin9083We are unable to absorb two fuel types at one time. Two fuel types attempting to enter a cell at one time creates an inflammatory response. Repeated inflammatory responses cause cell damage, & eventually cell dysfunction that disables a cells ability to stop healing. This causes cells to multiply out of control & grow into cancerous tumors. Anything in our environment & especially consumed that we did not evolve with, & adapt to, will be recognized as foreign material by our body, & cause an inflammatory response leading to damaged dysfunctional cells, autoimmune disease, cancer, & eventually death.
Ancestrally Appropriate Diet! (Short)
Our evolved ancestrally appropriate diet consists primarily of Ruminant animals fed a clean diet of grass & weeds that reach deep into the soil & suck up nutrients unavailable near the surface, or from nutrient void GMO corn, wheat, & soy sprayed with carcinogenic glyphosate weed killer, & estrogenic pesticides. Some examples of ruminant animals are lamb, goat, deer, elk, bison, & cattle. Yeshua Hamashiach, (Jesus) said, "Eat split hooved animals that chew the cud." (Leviticus 11) These are ruminant animals with long four chambered stomachs biologically designed to be capable of breaking down plant matter, filtering out plant defense chemicals, plant toxins, anti-nutrients, & even many environmental pollutants, while also providing more essential nutrients than any other food, also making those nutrients more bioavailable or absorbable for us. The anti-nutrients & inflammation caused by plant defense chemicals puts us in a state of brain fog we can't tell we're in, until we find our way out. Benjamin Franklin said, “Life’s tragedy is that we get old too soon and wise too late.”
We don't have long multi chambered digestive tracts like cattle & other ruminants, capable of breaking down plant matter, filtering out plant defense chemicals, & anti-nutrients. Botany teaches us that all plants, fruits, & vegetables have thousands of plant defense chemicals & anti-nutrients to protect themselves, because they are stationary. Anti-nutrients prevent us from breaking down, & absorbing our proteins, nutrients, & essential fatty acids. We've evolved to have varying degrees of tolerances determined by our ancestors' diets, & environmental factors such as weather, & religion, or dictatorships controlling diets for lengthy periods of time, which has altered our genetics at a molecular level, but that does not make them viable, or optimal nutritional sources. We're not biologically designed with long digestive tracts to break down plant matter or fiber, which are indigestible carbohydrates that feed bad bacteria! That's why we have to take pre/probiotics to break it down. This creates a science experiment, & balancing act in our stomach. Plant fermentation produces methane gas build up that expands our stomachs, stretching the walls of our gut lining, creating tears through which we lose Vitamin C, back into our blood, contributing to free radicals, & metabolic waste our bodies struggle to clean up, along with more nutrient loss, because we need Vitamin C to direct nutrients where to go. Inappropriate diets lead us to needing supplementation, but 90% of the supplements on the market are fake. Ascorbic acid is a molecularly incomplete synthetic form of Vitamin C that competes for the absorption of real Vitamin C. Cyanocobalamin is synthetic B12 that breaks down as cyanide in our blood. Cyanide was used by the Nazis to commit suicide when caught during espionage. Our bodies have not evolved to recognize these lab synthesized compounds made over the last hundred years, because it typically takes evolutionary adaptations hundreds of thousands of years or more to occur... Usually out of necessity for survival. They say small amounts won't hurt us, but I would argue that creating chronic inflammation that prevents us from being able to use mitosis, & autophagy to heal, definitely hurts us. These synthetic vitamins are added to many processed foods. Everything has a "root cause." Cause & effect are fundamental concepts in science that describe how "every action has an equal & opposite reaction." (Newton's third law)
Mixing sugar & protein, like what's in a sandwich with bread & meat, creates sticky proteins or glycation, that sticks to the walls of our arteries, & solidifies or hardens, clogging them faster. Many vegetables have a glycemic index high enough to spike insulin levels, induce unhealthy glycogen fat storage, kick us out of ketosis, & out of fat burning, & into burning glucose. Glucose burns rapidly, & volatile, like rocket fuel, but fat burns slow, steady, & efficient. Evident by the deaths of many carb loading bodybuilders. We need to be burning fat in order to use our "fat soluble" vitamins. There's no such thing as an essential carbohydrate! Two fuel types trying to enter a cell at the same time, causes cell damage. Repeatedly damaging the cell eventually leads to cell dysfunction, overgrowth, & cancerous tumors. Glucose speeds up the growth of cancer cells. Sugar & high glycemic complex carbohydrates create the same damaging inflammatory response to our cells, & levels of dopamine response or addictive instant gratification signaling in our brain, as meth & cocaine! We burn glucose first as a defense mechanism to prevent it from causing problems. We can derive the 4 grams of glucose we need from fat, & that's all we can tolerate before being kicked out of fat burning & ketosis, & into unhealthy glucose burning, & glycogen storage. We are unable to properly regulate our blood sugar levels when we are creating insulin spikes with sugar & carbs, which signals our bodies to create more insulin signaling the storage of more glycogen fat. This glycogen storage is that which makes up the subcutaneous fat beneath our skin, visceral fat smothering our organs, & eventually clogging our arteries, causing heart attacks & strokes!
Bad bacteria cannot survive on fat or ketones, but we thrive. We can starve out viruses like the Coronavirus, or bad bacteria such as Candida & yeast by avoiding sugar, fructose, & carbs our bodies turn into glucose, which feed bad bacteria. The dawn of agriculture brought with it mind fog, malnutrition, disease, pestilence, a reduction in overall health, lifespan, reduced size, reduced jawlines... evident by crooked teeth, & our wisdom teeth no longer fitting in our head, as well as reduced cranial cavity & brain size, & the optimal neurological function that running on ketones provides. Siddhartha Gautama (Buddha) said, "To keep the body in good health is a duty... otherwise we shall not be able to keep our mind strong and clear." Agriculture regressed our evolution, & made us smaller, weaker, dumber, docile, more manipulatable, & easier to control. George Orwell said, "The most effective way to destroy people, is to deny and obliterate their own understanding of their history." "Knowledge is power and it can command obedience." (Imam Ali Bin Abi Taleb)
We can convert fat into glucose, or ketones. Ketones are our brain's preferred fuel type. Cognitive & regenerative brain functions increase tremendously while burning ketones. This means we have adequate power, the correct fuel, & the building blocks needed to make repairs, along with the cognitive & regenerative abilities granted running on ketones to achieve miraculous recovery. We're able to make connections on another level with increased intuition granting us a level of validity like that which our eyes & ears provide... Who wants to be a human lie detector, & so much more! Carnivore is a fasting mimicking diet that allows us to maintain a low inflammatory state capable of using our body's natural healing processes. Our bodies use mitosis, & autophagy to clean out, repair, & replace old damaged mitochondria, creating new healthy cells. Inflammation or chronic stress prevents us from using autophagy to heal! Appropriately fed clean ruminant animals are our only source of nutrition that contain every essential nutrient in "clean" non-inflammatory bioavailable forms. Every other diet creates chronic stressors that cause inflammation preventing us from healing!
Dr. Anthony Chaffee, & Dr. Ken Berry are two extraordinary TH-cam producers of amazing, & trustworthy dietary, & medical advice videos that I highly recommend. They talk about everything you need to know to keep you happy & healthy. They explain in detail our evolved diet, how plants are trying to kill us, & expose corruption in the food, & medical industries... Also discussing other typically health-related topics. Please support the TH-cam channel "HomeSteadHow" that's working on a non-profit documentary called "Healing Humanity." There are amazing success stories of people curing blindness, finding their way out of a wheelchair, recovering from autoimmune diseases, & so many other seemingly miraculous recoveries from what are actually dietary nutritional deficiencies! In other words real nutrition heals us from the inside out. There's before & after pictures of physical proof that will astonish you! Steak & Butter Gal has a great support network, especially for women. Between them, there are hundreds of thousands, if not millions of success stories. These wonderful people are doing a great job spreading the truth about a proper human diet. They have channels on TH-cam, or Rumble, covering everything we need to know to be healthy! We all know how difficult it can be switching from the addictive dopamine spiking standard American diet (SAD) to a healthy ruminant animal based diet. We all have inspiring personal stories about how we got our health back, & you can too! The recommended dietary guidelines are as they are to profit from us by greedy corporations, & by religious shell companies, to keep us foggy-minded, & under their control. With support from a corrupt government under the same mind debilitating conditions, & influences or brainwashing tactics that keep us all from finding proper diet, World sanity, Heaven on Earth, & God! Unhealthy, unsustainable, environmentally destructive Industrial agriculture is killing off our bee population needed for the cycle of life. Bees pollinate plants that feed our ruminant animals providing adequate nutritional profiles to keep us healthy! Please support healthy, sustainable, environmentally friendly Regenerative farming! Good luck on your journeys my friends. "We Are One!" My TH-cam playlist titled "Corruption Shorts" is enlightening! www.youtube.com/@VanDamn911
Finally the pieces of the puzzle. To make a long story (2.5 years)short; fat, lost weight, lost bladder, found adenoma (flunked suppression test) and now I know why I can do a three day fast with high blood glucose and normal A1C.
Thanks so much for the information.
Fasting and controlling overall healthy behaviour seems to leed to success.
Has anyone updated the Randle Cycle with our current knowledge? I wish there would be more discussion at keto and carnivore events regarding this. Having the input of Ben Bikman, Eric Westman, Tim Noakes, Zoe Harcombe etc would enrich our understanding.
Yes there is. doi: 10.1152/ajpendo.00093.2009 published Jun 16. 2009
Bart Kay has addressed this topic many times.
Yes. See second reference in show notes. Great question
@@robertcywes2966 Thank you!
bikman talking about brain preferring ketones to sugar by about 2.5 to 1
th-cam.com/video/b0tLE0bwmc4/w-d-xo.html
THANKS FOR THIS VIDEO. IMHO: MOST PEOPLE DON'T WANT TO, OR NEED TO, MASTER THE "SCIENCE" OF ALL THESE COMPLEX VARIABLES.
WE JUST NEED SOLID DIETARY ADVICE, AND RECOMMENDATIONS ABOUT WHAT WE SHOULD, AND SHOULD NOT BE EATING, DAILY.
So, if following a carnivore diet, should i include a small amount of carbs with my fatty meat, or not?
I'm so confused! Dr Bart Kay says to eat no carbs ever.
But I've recently discovered that another role of insulin is to allow immune acids to ever a cell and stimulating protein synthesis. Which is good🎉, right! So that would suggest that *some* insulin production is a positive thing. Not excessive production, but some?
I don't know what to do now. I'm so confused 😵💫😵💫😵💫😵💫😵💫
protein stimulates insulin production, while avoiding the nasty spikes carbs create.
this is why most keto diets are low-protein, because protein will 'kick you out of ketosis'. but the benefit of low-carb isn't ketosis, it's alleviating the Randle Cycle.
Love this, but barely hanging on. I want more of this, please. However ... can you please suggest a book/books to read and study about biology - especially of the cell - and and "Microbiology for Dummies"? I need to repair and rebuild a foundation begun long ago. Thanks!
Brilliant! I'm so glad this is still available, I learned a lot. Thank you.
So how do we increase insulin sensitivity vs insulin suppression? Great video btw.
I did it by lowering my carb intake to as close to zero as possible; eating two meals per day. Best regards.
For what I have understood it is a two phases process: by a ketogenic or fat adaptation process you get back to insulin sensitivity in most cases and when fat adapted you avoid the insulin suppression by reintroducing carbs one or two times a day (dairy for me is optimal and I do some days but have still cycles of pure ketogenic).
@@lucia_cossu_voiceteacher That's what I'm thinking. I've recently taken to having carbs after exercise, and I'm considering being more judicious about how much protein I eat in one meal, to limit gluconeogenesis.
is this the key?
You are a masterful teacher. So pleased to have a better understanding.
A chart or diagram would have been very helpful. It was hard to follow you.
I would say, "essential" in order to make it easier to comprehend. In the British National Library, a book written by Leonardo Da Vinci had illustrations, captions, and explanatory paragraphs, it was a good example. In contrast in an adjacent room, a copy of the Magna Carta showed that the tremendously important content was made difficult to comprehend because of the poor writing style.
It's called pen and paper. It's used to take notes.
Yeah… Bart Kay has a few videos about RC with charts…. Worth a look…
@@brucemckay6615 Yes, thx... much better 👍
Prof Bart Kay was on the Nutrition with Judy channel and showed charts explaining the Randal Cycle.
It’s not the fat causing. Is the combination of fat and carbs. They block each other. Fat comes naturally with protein. So what is the unnatural part here. Carbohydrates.
Milk is exactly a prof. Milk does the same and they gain weight in a critical phase in their life when it is critical.
Wow! Amazing masterclass...after struggling to undertand the Randal cycle I finally understand it plus some!
So true . I'm about 3 yers on a carnivore . I feel way better if I add lots of fat to my diet like pork shoulder , pork belly , butter , makrel etc .
@alba:you should stimulate your bile by eating bitter things 😉
@@muchasalud2011 don’t tolerate how?
GI upset?
Scale back. Eat a little more every week. Take bitters as suggested above.
He is not only saying eat fat. He is saying become insulin-insensitive but don't suppress insulin. So we need some sugar just not excessive
@@ketontrack Any sugar you eat is excessive, toxic and not required. That's why the body wants to get rid of it first.
That´s an everyday question to make life and meals more comfortable. Meat and fat without any bread or potatoes is not funny.
A great explanation. Thank you for clarifying this.
Beautiful explanation of the Randle Cycle; presented without the arrogance and sarcasm of, say, a Bart Kay. Lol. Much love & respect.
Yeah, Bart Kay may have the correct facts, but his contempt with which he expresses himself just hurts my soul. Don’t need that kind of negativity in my life.
@@bonnieo8 disagree
Bart Kay seems completely nuts.
Thanks. No hyperbole necessary
I can’t listen to Bart .. his know it all delivery and dismissive attitude of others makes him a bad communicator.
On top of that his assertion that everybody is wrong about the metabolic bio chemistry and only he is right re Randle’s Paper, seems likely to be wrong as Randal was unaware of other important mechanisms undiscovered at the time the paper was written.
eating fats doesn't make fat in the blood (triglycerides) go up. Eating carbs do. This is 100% caused by carb overconsumption. You should always eat fat with each meal, whether it has carbs or not. And there is no natural healthy food that you would want to eat that has only carbs in it anyway. So the people who characterize this as saying not to eat carbs and fat together are wrong. This is a pathogenic state caused by eating too many carbs.
merry christmas, happy new years, & thank u sir for all uve done for us. god bless
Hoping the good doctor reads my question. My wife is on a Jak inhibitor , ruxolitinib, for myelofibrosis. She is on a strict low carb diet, attempt to keep daily carbs below 20g . For some reason she seldom if ever goes into ketosis. Could the drug be somehow interfering with this cycle?
Have you tried to talk to Prof. Bart Kay it would be nice if you two had a conversation about this cycle
Why?
The guy is extremely rude and arrogant, I wouldn’t want to see a rational person discussing anything with Kay.
Because they are both clever people that are trying to do what they do to help as many people as they can. If you can make a point that is correct he sees that point. Bart isn’t arrogant, he is just confident of what he knows
@@Damudean not arrogant .. I think we’re watching different videos. I would go as far as to say that he is rather narcissistic. He is always completely right and everybody else is wrong.
I just went back to look at his list of videos, which rubbish literally everybody.
And now it appears that he’s wrong about the Randle cycle, as the paper in question missed a lot of important but at the time undiscovered information.
@@Damudean you’re right. More obnoxious than anything else
Wow, totally loved this breakdown! Made it so easy to follow and understand! Always questioned the theory of fat causing diabetes and now it is super clear.
There is a crucial point that needs to be highlighted here which is where all of the excessive free fatty acids come from in the first place. Dr Ben Bikman explained that adipocytes start leaking FFAs when they become hypertrophic, up to 4 times their normal size, as the fat droplet within the fat cells gets larger, perilipin can no longer protect the stored fat from the effect of lipases. Again, it is Insulin that activates lipogenesis and it is carbohydrates that spike insulin.
Don't mix fats with carbs, since carbs shut down lipolysis leading to fat storage.
As the vegan dumps fatty dressing,seed and avocado to his salad
Many thanks Dr. Cywes - it took me a cup of tea, notes and replays but at last I feel I understand what's going on. I've been carnivore for a while but looking at Ketovore. My take away is - add a few carbs to give my insulin a work out but continue with intermittent fasting.
I wonder what it is about one's lifestyle that is influencing this hormonal imbalance, looking more holistically, is there a primary imbalance somewhere else?
Yes. Carbophilia and lipophobia
@@robertcywes2966 But I love both!
What's your thought on being metobolically flexible while endurance trail running? I am animal based during my normal day, I mix in carbs /fruits for a little extra energy but only about 25-30g hr.
Dr. Cywes, I understand some of this, but too fast and detailed for me to synthesize and retain. Would like a simpler more concise explanation. Also would love a video with recommendations for labs to check for insulin resistance, glucagon excess, etc. I try to eat a lot of fat with meals and limit protein, but am not satisfied with less protein. This is on pure carnivore with nothing plant based or sweetness of any kind. Could glucose produced from higher protein be driving overconsumption? I think I'm a fatty with no shortage of insulin, not diabetic. Thanks for your great videos.
At the end everyone needs practical advice what to eat and to do and what to avoid!
Dr. Cywes, you are 💯 brilliant man. Thank you so much for your blunt explanation‼👏🏻
Hi Doc great video.
Question:
Does the Randle cycle debunk the concept of insulin resistance?
Others explain the Randle cycle thus:
“When a cell is full of fat it will lock the door to both fat and carbohydrate because there is heaps of energy stored in that cell ready for use, we don't need it right now and actually sugar inside your cells is incredibly toxic.
So to protect the inside workings of the important cells like muscle cells, organ cells etc the ‘door is locked’ no more fat can come in.…
We don't need any more sugar so we are locking the door to that sugar too, so it then sits in the blood and starts to pool in the blood which is detectable as an increase in your fasting blood glucose level….
They then diagnose it as ‘insulin resistance’, no, it's nothing of the sort, it's a mechanism by which the body protects itself from damage.
The sacrificial lamb in this case is the red blood cells which become damaged by the glucose in a high blood sugar situation.”
Is the above what the Randle cycle describes?
Insulin resistance is not a thing in and of itself. It doesnt exist in the way that its there, and can be measured directly. The Bart Kay says it best. “Its a concept”. But its a valid concept, in that we can see results of it physiologically or pathologically.
@@Technichian462 this isn’t my area of expertise, though I have been carnivore for five years mostly finding my own way. Only recently have very knowledgeable people got into the space.
So in general, I’m not arguing the rights of wrongs but I’m finding the infighting confusing.
For me, it doesn’t really matter whether the Randle cycle locks the door to more energy coming in as Bart says.
Or if the cell becomes resistant to normal levels of insulin and needs more to push energy into it.
In the end like most animals if we eat the diet we are supposed to we will be healthy. Understanding the biochemistry is just interesting.
For example, another Bartism is that evolution just hasn’t bothered to turn off our digestive enzymes that digest starches.
I think that is just wrong. I don’t think we are obligate carnivore and many people can eat a mixed diet including starchy veg my whole extended family have done so in the past and without those starchy vegetables would’ve starved to death. Most people during the Second World War in the UK would have starved without our ability to make use of plant starches.
And although it is only my experience, my mum has just turned 90 and just about everyone in my family from poverty in the Welsh valleys have lived to their very late 80s and 90s none of them were on a carnivore diet. Yet they were all healthy and died of old age.
And another example, I turned carnivore as I say about five years ago, I’m 58, so I until about the age of 52 I ate a western diet, though I didn’t indulge greatly in processed food. However, I have drunk copious amounts of alcohol and suffered hangovers, and yet when I had my CAC score measured, my coronary calcium was zero. That’s 52 years on a standard diet.
Randle cd not consider insulin resistance bc did not know about GLUT4 receptors
You're going to get a review from Bart kay
😂 I wish I had a euro for every time Bart's mentioned in TH-cam comments.
@@TerriblePerfection I think that the Dr have made a good point, let's see what will come in the future
@@ConanFC I would bring the popcorn but...
👍🏻👍🏻
Dr Cywes, should we be careful of eating too much protein? Thank you!
No, but seldom lean
Super important video! Thank you for all your work, Dr. Cywes, we need to understand in order to do the right thing. Eat fat, not carbs!
Which part if the Randel Cycle say this?
Question: Does this mean "Don't eat carbs with your fat because the fat burning will be blocked and result in insulin resistance and cause metabolic syndrome."?
Good explanation. Thank you.
I went to nerd heaven with this video! Thanks Dr. Cywes.
You hav a brilliant way of explaining
Wow, what a beautiful rabbit-hole... Very interesting!
How do we modify the carnivore diet to control sugar from glucagon?
What do you mean?
@@adriansrfr It's been a while since I heard this Adrian. I no longer remember the context.
very well explained! thank you
Very interesting video! I am curious: why in case of insulin resistance, the cell does not just switch to fat use, since not enough glucose enters them, instead of causing diabetes and other metabolic ilnesses? Another video about this would be very welcomed! Much love for your work, doc!
Why poison the cells further with carbs? Fat adaption takes time and excess sugar damages the circulatory system. One must accept lower energy while the mitochondria translates into fat burning mode.
So how do we increase insulin sensitivity?
Eat meat and fats ,which in return we become fat adapted , and our body will reduce fatty heart and liver, after we get the fats back to optimum, we begin to repair damaged insulin sensitivity
Thank you for this information. However, how does one fix the problem of not being able to lose weight or bring their glucose down and stop being insulin resistant? I'm not a scientist (or a doctor) so I am at a loss of what to do and I cannot find anyone in my area to help me. Where do I go to find the information I need to fix myself?
e.g. go to doctor Robert Lustig on you tube! Reduce carbohydrates strictly!
Very interesting video!
Do we know the mechanism(s) how insulin resistance actually happens? E.g. how does the Randle Cycle (or inflammation?) cause GLUT4-receptors to stop working or perhaps the insulin receptors stop working?
I keep hearing about how inflammation causes insulin resistance but to me it is a big, important puzzle piece to have a somewhat complete understanding, as a layman.
Yes we know some but not all regarding IR
May be it is only a question of quantity in ovarall intake
My understanding of IR is the more insulin you produce the more resistant you'll become over time. I think more importantly than that simple concept is what we eat and the consequences of that. Take seed oils as an example, they cause a compound called 4HNE which damages the cells ability to respond to insulin it causes fat cells to grow instead of divide until they can't grow anymore and cause disease. A good book for this is "why we get sick" by Dr. Ben Bikman PhD. And zero acre farms has good info on their website under "white papers"
Wow this explanation is gold 👌 thanks
Love how you explain this, thank you Dr Cywes 🙏
Thank you so much, i always wondered why my sugar levels were high even when i would fast.
It takes up to 96 hrs before we spend the livers glocogon,
Dr Cywes, I live to explore, explore explore. I continue doing the research And I so appreciate these types of videos. 2 weeks ago it dawned on me that my A1C went from 4.9 as a 10-month low carb eater to a 5.4 as a mostly omad carnivore (for just 6 months). This makes perfect sense to me. My question is, what if in my next A1C blood reading my numbers are higher? Is it problematic? I literally eat meat, eggs and occasionally cheese.
Yes. U need insulin release. Wd be a good idea to check ur bloodwork
Maybe a keto diet a la long is not the golden way?! Change to a low carb diet?
@@erharddinges8855 Thank you for the suggestion.. I found my way! th-cam.com/video/54uG1syV5YQ/w-d-xo.html
No. A1C measures the life cycle of red blood cells and they live longer with a Carnivore diet which raises the A1C. If it raised under a SAD then you have worries. This is why a fasting insulin or HomaIR is a much better measure of metabolic health, especially for us carnivores. Under 5 is good. Dr. Paul Mason discusses this quite often.
@@YourLifeRedefined Thank you! I have since learned all of this and am doing great! A1C of 5.1 and thriving!!
Thanks Dr. Cywes!!!!! Kind of complicated for me!!! To make it simple: Can we combine fat and carbs in the diet without being detrimental for health??? Have been doing that for all my life and am in my 70´s, proper weight, work out 3 p/week, strong all my bloodwork very good, HDL 59, Triglycerides 44, glucose 78 ??????? I feel so confuse????? thanks for all your help! Of course, never use seed oils nor processed foods or sugar by itself.
Your way seems to be the best! Trigl/HDL under 1!!
@@erharddinges8855 Thanks Erhard!!
This is why I am not concerned when a carnivore's body produces more glucose on demand via gluconeogenesis and the individual may have a slightly higher fasting glucose reading
of course it will be higher!!!
the on-demand process in the liver is happening DURING fasting in the person who consumes no carbohydrates
Very good. I love getting into the science of things.
Now, consider this.
Heart disease. Plaque build up. Calcium build up. The CAC score is a measurement of built up calcium, under the plaque. But what is causing the calcium build up? Is the calcium somehow attracted to the damage done to the arterial wall? But what about oxolates? Oxolates build up in the body. Oxolate crystals build up, get caught is these damaged areas. Oxolates love to bind with calcium. Could it be then, that the plaque build up is caused by oxolates? If so, there is a larger commonality in heart disease with Plants than with animal products? Many plants contain oxolates, so ergo... The root cause of heart disease is plants?
Interesting!
In a review of coronary arteries from 80 patients, we found 4 cases in which there were prominent oxalate deposits within the atherosclerotic plaques in coronary arteries. Oxalate deposits were also present in the media of arteries, the thyroid gland, and other organs, but not the kidneys, and the patients surprisingly did not have renal failure. (Fishbein and Fishbein 2009, p. 1315)
Yes ! Dr. Robert Kiltz explains that beautifully on TH-cam .
I'd say oxalates could be a contributing factor but it's my understanding that heart disease is caused by excessive, inappropriate carbohydrate consumption.
Our bodies can make oxylates on its own
And what would cause the body's inability to properly dispose of oxalates before they are deposited in arterial plaque?
Enjoyed this video. Can I suggest a video on lactate metabolism? Trying to comprehend Xiaolu Li et al Lactate metabolism in human health and disease and also George Brooks Role of the heart in lactate shuttling. You mentioned lactate at about time stamp 15:00. Lactate seems to be a potentially greater source as a fuel than previously given credit, but only if one is adapted to using it? I’m 61 and have been doing low carb for about 5 years. Been seriously exercising the last 3. Did a fitness test at UT in May and I have a pretty high VO2 max and and a really good ability to clear lactate (as measured by aerobic fit w/ lactate test). I’m wondering if the ability to clear lactate is a surrogate of metabolic health?
Isi t?
So interesting. You don't even need to understand the Randle cycle to recognize that competitive athletes (and their coaches and trainers) don't actually need to replace every calorie they burn during a competitive event. Yet they continue to force sugary gels and other crap into their systems at a rate of 100-200 calories per hour, often puking and bonking in the effort. It's hilarious to me. I spent the last dozen years as a recreational (not competitive) endurance runner who learned this from a book written by Phil Maffetone (a pioneer in this area) years ago, and I even had my fat-burning capacity measured in a sports medicine lab at a university. If a weekend warrior like myself can burn fat at very high levels during hard efforts, imagine what a highly trained, professional runner or cyclist could do if their coaches understood what you're describing. (A small number of them do know this, but they are considered a bit kooky in that world.) In my less-trained state, a marathon or a long trail race is very hard for me, and it takes me much longer to finish than a competitive athlete -- and yet, I can do it without ingesting a single calorie for hours. No gastric distress, no bonking. But competitive athletes are brainwashed into thinking it is not possible to generate your own energy during hard efforts. Their coaches calculate how many calories they're going to burn at a certain power output and make their athletes set timers to guzzle down an equivalent amount of sugar every twenty minutes to prevent... sudden death? (ha). Sure, some supplemental fuel might be needed or helpful at times for top-level performance, but the belief that you have to replace every calorie burned in real time is nonsense. This is why some marathoners and triathletes can have visible fat around their midsection despite training for 30 or 40 hours per week.
This kind of training makes me think of the stories I've heard of ancient message deliverers that could run for up to days on end without stopping. Maybe a little overblown, but an interesting connection.
barts data is more updated. showing that the glucose is blocked at the glut 4. meaning not reaching pyruvate etc. also sliding scale
Ben Bikman has done a few videos on the Randle cycle since this video was first published. He just very recently did one with Ken Berry which included a short discussion of the Randle cycle. Bikman made a very compelling condition on using an untreated Type 1 diabetic as a perfect example. The untreated T1D will have sky high glucose and will also have sky high fatty acids. Yet because NO(or very little) insulin is present the body will ALWAYS choose the fatty acids for energy even though there are tons of glucose available for use. As soon as you treat with insulin the body will shift to burning glucose. Which brings us back to the Hormone insulin. Which is where/how insulin resistance can effect things. "Construct" or not.
insulin's job is to shuttle glucose out of the blood and into cells. the Randle Cycle's job is to protect the cell from glycation and mitochondrial burnout.
it is by design that the Randle Cycle overrides the role of insulin, because it is more important to protect organ and muscle cells from glycation than it is the more easily replaceable red blood cells.
So, when you hear people say fat causes insulin resistance, they're referring to Randle's incorrect assertion, and thus, they're wrong. Additionally, excess protein may not seem to be problematic, but it does indeed cause high blood sugar in someone who already has chronically high insulin.
This tells me that it's very important to consume an appropriate amount of protein, of an optimal (animal) type, and even more important to make that protein source fatty or accompany it with fat, to avoid overproducing glucose. What I find interesting about this is that many carnivore advocates claim that gluconeogenesis is on-demand. This seems to indicate that is not true.
I started my diabetes-reversal journey by extended fasting and eating a moderate-protein ketogenic diet, which many would say is appropriate, in context. However, I believe I did not get enough protein (I developed a hip issue) and went the other direction-to a "ketovore" diet, with (truly) intermittent 36-72 hour fasting on some weekends. I believe I've corrected protein issues, but my blood sugar isn't ideal (it's still below "pre-diabetic.")
Now I'm trying to figure out how to best adjust. I'm doing more weight training now, so I presume that will help. I suppose I should be eating 3MAD with more level amounts of animal protein, and including fiber, to throttle gluconeogenesis. My preferred way to do that would be to accompany meat with cruciferous vegetables (which is more or less what I do, but I don't alway eat the veg.)
Dr Cywes,
What's your response to the myth that high fat intake is the cause of heart/cardiac disease, especially in light of the recent discovery that high blood pressure in diabetes may be linked to the effect of GLP-1 on the carotid body?
Thanks!
We blamed fat for what nicotine did. Now they blame fat for what carbophilia is doing
What a great educator……. !
Do you think it's this Randle Cycle what gave me two heart attacks on the carnivore diet?
Nope. Likely ur precarnivore lifestyle and sudden plaque rupture
So in your understanding, carnivore poses problems when there is an excess of protein? If there’s not an excess of protein and there is plenty of fat, does it cause any problems?
For the same total calories, is there a certain combination of carbs and fats the maximizes the storage as fat?
Reference charts to understand this better would have helped.
So what do I do on the carnivore diet to apply everything correctly
Check ur bloodwork
This is supposed to demystify but I think I couldn’t follow this at all. Need some graphics or something.
I was keto for 2 years now I've turned Carnivore and I am experiencing still elevated BS. I am insulin resistant. How do I become insulin sensitive?
Try with fasting
Extended fasting with only water. Work up to three, four and five day fasting once a month. Look at Butter Bob Briggs' video on the 50% insulin problem.
The only thing I understood was, "Don't eat sugar, eat fat." That, I can do!
This was just beutiful. Please, do not hesitate to do more ninja nerd hardcore stuff. I Just loved this one.
As a layman I have wondered how the heck researchers could empirically identify the electron transport chain, the compartments and all that jazz. If someone could explain how thing like thas was identified it would be a real treat.
Professor Bart Kay explained this 3 years ago, I notice a lot of the other influencers have suddenly remembered to run a blog on it.
You should see Dr Bikman's explanation, it looks like Bart telling only half truth about RC
So in plain terms, what does that mean? Keto and carnivore are the way to go? According to the study, Bart Kay says that we should never ever ever ever eat carbs. At all. None. No vegetables, no fruit.
Dr cywes can you please make a video and clear up what a fella called Georgi Dinkov is claiming about how excessive lipolysis from fasting and keto diets can cause inflammation in our bodies because the stored fat is mostly PUFA fats. He has scared the shit out of me about keto.
Bart Kay has some videos on this that you may find helpful.
I would like yo see that video from Dr Cywes as well.
@@erinmariebaker712 What is the name of that Bart Kay video? I tried to see if Bart responded specifically to Georgi, but did not find one.
Gotta burn through those Pufas anyway… no other choice.
Ignore the noise. It will always buzz in the background
Can you consider please doing a supplement to this video that explains it all in even more layman-language? I know you have significantly dumbed it down here, but if it cld be on the level of "insulin knocks on the cell's door" etc but for each of these chemical actions? It cld be both fascinating and motivating to think about the entire chain/sequence of events that happens both when we eat right and especially when we don't. Thank you for this video!
Excellent video, thank you.
I think the word "cycle" is a bit of a misnomer which tends to lead people to a wrong understanding. It's not like, say, the Krebs cycle where we see a circular chain of reactions. It's more to be thought of as explaining an either/or function where cells will either (almost) exclusively use fat for energy or (almost) exclusively glucose, but not both at the same time, except in exceptional circumstances.
Really interesting but it certainly went over my 😕
Is it pkf or hexokinase? Because hexokinase converts glucose to G6P which can't leave the cell
What’s your opinion of Apo b and it’s significance on healthy people ?
Nope, still not clear. Too much technical talk in the beginning to understand and agree with later summations
Warned ya!🙂
I heard muscle also has insulin independent glucose receptor which is recently 🤔 verified.
This is very complicated.....
If you read Dr. Jorge Watson
's Nutrition and your Mind book which is written 1970's maybe he verified carb and fat should be simultaneously existed by every meal consumption because they work coordinatedly for normal ATP production.
Otherwise they became mad because oxalo-acetate from glucose pathway and acetate from fat are not combining enough each other.
What is the conclusion between Dr. Randle and Dr. Watson ?
I didn't know that Randle blamed fat for Diabetes, I thought he blamed carbs. If you mean he thought being fat caused obesity I think all the skinny diabetics would have showed him otherwise. I've always been thin but can easily shift my blood glucose, cholesterol and triglycerides with diet changes, have to swap one for another though, can't get them all low simultaneously.
I cant believe how long winded this is to explain a very well known aspect of type 1 diabetes called 'glucagon dominance' many things are examined once you simply learn that phrase. People on keto or carnivore have low levels of insulin and when eating protein you see a small bump in blood glucose due to glucagon (not the protein) and seems Robert does not know this either. It is common knowledge but he presents it like he has discovered something
As a type2 listening on these fascinating topics and also having for decades experience with ADA explaining it. And you and Bart K my own anecdotal experience doesn’t see fault with either gentleman. Rather that there are levels to this disease that disrupts chemical physiology. In my case it Non alcoholic stetoses or NASH. The communication between liver and pancreas were muted due to excessive fat on the liver and pancreas making them hard of hearing towards each other if you will. The insulin resistance is a body’s way of protecting the muscles and mitochondria from the excess supply of energy regardless of where it is coming from. Be ketones from fats that the liver also supply in and exogenous glucose from carbohydrates. And that glcogenous hit job called dawn. effect. The latter will be using the stored fat already turned into glucose that is trapped on the liver’s surface and glycated red blood cells. Even fasting 24 hours for a Gastrointestinal exam didn’t bring my blood sugar down 5 points. As my levels were 684 the start of the fast and by the time I was checked again it had only dropped 679.
It was years to clear the liver issue up and get those enzymes under control before even insulin would bring my levels below 400. Insulin resistance was doing double duty damage control but the odd thing about that was my insulin levels in fasting was .08 and after a OTT they only gotten to 1.26. My triglycerides. 90. . Figured I was not a type 2 but a late adult type1 running out grace. But 3 years later I am satisfied that with limited insulin reserves I do eat strict carnivore and limit my bolus to 800 calories in a single meal per day. Now my A1c is 4.6. And I am still producing some insulin. I just don’t eat out of my production limit because I don’t want to start insulin and have that thing quit on me. Is it more to find a balance what amounts the body absolutely needs to restore balance. It will do the rest.
Im a farmer and get it thanks
Fantastic insight!
The takeaway message for me here is that we don’t want our blood sugar level to get so low that the body begins to continuously rely on glucagon to maintain a normal blood sugar level. This is because persistent excessive glucose production from constantly elevated glucagon levels can cause insulin resistance.
The solution to this potential problem would therefore be to consume enough cabs with each meal that would support a normal blood glucose level while minimising the impact on insulin levels.
This in practise would mean consuming low to medium glycemic index fruits as part of a keto/carnivore diet that have a low glycemic load - e.g. blueberries, strawberries, rock melon etc.
This approach would essentially turn a carnivore diet into a meat based diet.
What kind of insulin resistance could this be? a secondary, due to keto diet? I have enough with my primary resistance!
@@erharddinges8855 I think it is more a concern associated with the carnivore diet where there is virtually no carbs ingested. probably not so much a concern with the keto diet where there are some carbs incorporated into the diet.
You've got it completely backwards. You're body makes all of the glucose it needs.
Glucagon activation is the preferred method and insulin activation needs to be kept at bare minimum.
It sounds like you are saying glucagon resistance is a big problem and the solution is to tax the pancreas more with sugar to stimulate more insulin progression because diabetes is not a thing.
@@adriansrfr Glucagon and insulin work in balanced opposition and are regulated in a negative feedback loop. It is indicated in the video that type 2 diabetes can develop when this negative feedback loop is broken by persistently elevated glucagon levels. Did you watch the full video? If not see video at time 26:45.
@mjoh090 , yes, that is why sugar and fat taken together are contraindicated. It confuses the cell's, and they reject both. The result is visceral fat. The confusion doesn't last for a few hours, it can last days. This explains why vegetarians can be lean (low fat). Keto can be lean (low carb). But those who choose to confuse the Randle cycle will end up overweight if not obese.
I didn’t think the Randle cycle said fat causes I thought it explained too much sugar causes the problem when we have fat as well
Because most people in this space heard about the R. Cycle via Bart Kay.
And Bart in his very ‘know all’ way rubbishes the idea of insulin resistance as a concept and uses this paper mistakenly to assert ‘the science is settled’ when Randal was unaware of other key components like glucagon.
In other words Kay has muddied the waters and given us wrong conclusions.
Would Cywes read Randall’s paper if Bart Kay didn’t bring them.
Nope. He blamed fat
@@ChappySinclair What you said in my opinion fits with reality.
Our bodies have complex enzymatic machinery to break plant starch into glucose.
Kay says this is an evolutionary over site. There in you see his biased reasoning, denying reality to ‘prove’ we are obligate carnivore.
Our ancestors if they had had a successful animal, kill and plenty of fatty meat and by coincidence came across starchy tubers, or sugary fruits. They would most certainly have eaten them together.
One of the missing keys that I used to heal myself was fasting. Fortunately, Jason Fung was one of the first in the low-carb space, but focused on fasting.
And fasting is ancestrally relevant because there would not have been an absolute guaranteed access to food at all times.
I think one of the big mistakes, when thinking about the best diet for human beings, is not taking into account the not eating part of the process and it’s benefits e.g autophagy.
@@GoldenBlaisdaleI disagree. Both Dr. Cywes and Bart Kay agree the Randle Cycle is true. They may or may not agree on some of the nuance of why, but ultimately that's less important.
So at what point do we get apoptosis from glucose ? doe the randle cycle induce it ?
Thank you. I think I understood most of it.
Ha, wish I could say the same 😊. Nar, more or less. But I would have appreciated a more succinct summary
Makes sense.
So …. I am type 2 diabetic , using insulin , and have been on carnivore for a yr … I am still getting high glucose spikes …. I still have to take insulin every 2-4 days to get my levels down to a good range as my readings gradually creep up …. I am however using about 20-25% of the slow acting insulin I hade to use before I started on this diet
Is there any supplement or protocol I should try to fix what is going on , or should I just keep doing what I’m doing and eventually it will heal?
Love to know how to move forward with this issue …. So many of my other issues have healed up but not this …. I’m 62 btw
@@danielbarr9795I'm 64 , I still need insulin on Carnivore too but much less, the dawn effect, our liver dumps glucose at pre dawn, around 4 am, then it slowly falls if fasting, I use a little slow release before bed, fast till 6 pm, eat meat fats, and often need little to no rapid insulin again, I believe time to get our weight normal is only thing that will stop this, good luck
Increase fat and lessen protein?
Sort of...depends
Does Kay Bart know it?
Clearly.