This presentation discusses only synaptic pruning in the brain. The nervous system is distributed throughout the entire body. It would be nice to also hear a bit about how under-pruning can result in sensory processing difficulties in terms of heightened auditory and visual acuity in a loud, bright, fast-paced world... and more interestingly, vestibular and tactile/proprioceptive feedback.
I thought NMDA antagonists were associated with synapto/neurogenesis and agonists induce excitotoxicity and decay 🤔 Which is one the reasons they seem to be helpful in MH Trials for stuff like long-term resistant depression
Read that Neuronal pruning 2nd phase is approx from 10ys-to-20 yrs. 3rd phase approx. 20ys-to-30ys. During phase2, the limbic-(emotional) brain synapses are supposed to transition thought processing from limbic to pFC brain allowing complex cognitive executive function, e.g. delayed gratification & long term planning. Imo: Schizophrenia is a set of gene mutations that cause other physical abnormalities in those persons who eventually develop Schizophrenia, e.g. lengths of fingers digits 2-4 and a synapsis deletion program that goes into overdrive & maybe occurs subsequent to puberty and coincidental post height growth spurt. We need more research on the Pituitary gland and synaptic pruning.
Continuing to study and listening to classical music is an ideal way to keep synapses from pruning themselves as we continue to age. The older folks that are sharp and well read seem to be the ones that live longer
synaptic pruning may also be the cause of our brains physical dysfunction of flawed memory, i would say to prevent synaptic pruning from occurring could be going over theory you have absorbed, also keeping your mind active with reading thus by reflecting what your reading against acquired learned theory in your memory, also keeping your creative mind active also would help with the prevention of synaptic pruning based on what is portrayed in this clip.
'This is when the elimination of excess neuronal synapses, known as synaptic pruning, begins.' actually research shows that synaptic pruning is a process that already starts prenatal.
0:45 Can you give a source for this quote? "computational models suggest learning performance is optimal when synaptic connections are first over-generated then pruned"
As in, over-generation of synaptic connections and then pruning optimizes learning? Or did she mean synaptic connections being over-generated first, followed by the learning activity, and then pruning when learning performance ends, such as during rest, is most optimal route for performance? Sorry, this is very interesting but my adhd does it's best to confuse me! = (
@@Mike09legacy Pruning is something that happens as a part of learning process. Think about it as studying for an exam; there are only going to be a few questions but you don't know what's gonna be on it, so you gotta study for everything (or as much as possible). But then after the exam once you know what's on it, and you no longer need to know what was not on it (let's just assume here for the sake of analogy that the final exam later only includes questions that appeared on previous exams). Studying as many things as possible is like creating multiple synapses, and pruning is like forgetting those stuff that didn't come up on the test. Do note that this is an analogy -- I'm not saying that pruning is the basis of all forgetting, but you can think of it as lost possibilities of which you can think or behave. By pruning to a proper extent, you're limiting the way you can think or behave in such a way your actions and thoughts become stable and predictable, and this is what you call leaning.
@@iranjackheelson Now I understand. Thank you for explaining! Hopefully, being aware and learning about this helps me sort out the problems that interfered with my learning in the past.
Thanks for such a great video! Could you also please include references under the video? This might be much more helpful to read the original studies after learning the key points from here.
I have an exam test question that cant fin answer for! When does the selfdestruction of the neuronal synapsis begin? A) 5 weeks B )7weeks C) 2 months D) 3 months Thanks !!!
How does the excessive or too little synaptic pruning hypothesis with regards to schizophrenia and autism explain the fact that lots of people with autism have schizophrenia?
Also, what does this hypothesis say about adult neurogenesis? Adult neurogenesis is known to take place, at the very least, in the dentate gyrus part of the hippocampus of the brain, and new neurons surely imply new neural connections, i.e. synapses. Although I have heard that if you don't learn a new skill or expose yourself to new situations, those new neurons won't be incorporated as part of neural networks and will simply go to waste.
I mean AI and machine learning were developed on the basis of artificial neural networks (ANN) and you can probably guess where the inspiration of those came from... neural networks. Ever heard of biomimicry?
i'm Autistic Not Schizophrenic. We don't have Halucinations either auditory or visual. Some things might seem similar but trust me that I'm not schizophrenic.
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Best video I have seen on this topic, and information has been hard to find! Thank you!
This presentation discusses only synaptic pruning in the brain.
The nervous system is distributed throughout the entire body.
It would be nice to also hear a bit about how under-pruning can result in sensory processing difficulties in terms of heightened auditory and visual acuity in a loud, bright, fast-paced world... and more interestingly, vestibular and tactile/proprioceptive feedback.
I thought NMDA antagonists were associated with synapto/neurogenesis and agonists induce excitotoxicity and decay 🤔
Which is one the reasons they seem to be helpful in MH Trials for stuff like long-term resistant depression
Read that Neuronal pruning 2nd phase is approx from 10ys-to-20 yrs. 3rd phase approx. 20ys-to-30ys. During phase2, the limbic-(emotional) brain synapses are supposed to transition thought processing from limbic to pFC brain allowing complex cognitive executive function, e.g. delayed gratification & long term planning.
Imo: Schizophrenia is a set of gene mutations that cause other physical abnormalities in those persons who eventually develop Schizophrenia, e.g. lengths of fingers digits 2-4 and a synapsis deletion program that goes into overdrive & maybe occurs subsequent to puberty and coincidental post height growth spurt. We need more research on the Pituitary gland and synaptic pruning.
any meds that can increase synaptic pruning?
Continuing to study and listening to classical music is an ideal way to keep synapses from pruning themselves as we continue to age. The older folks that are sharp and well read seem to be the ones that live longer
Wow 😳🤩 Wow
I’m sending a huge 🤗 to whoever is behind sharing this amazing video!! ❤️ Thank you ! 🙏
Thank you for delivering such a smart way. Incredible ❤️
synaptic pruning may also be the cause of our brains physical dysfunction of flawed memory, i would say to prevent synaptic pruning from occurring could be going over theory you have absorbed, also keeping your mind active with reading thus by reflecting what your reading against acquired learned theory in your memory, also keeping your creative mind active also would help with the prevention of synaptic pruning based on what is portrayed in this clip.
or you can just say use it or lose it instead of your convoluted comment XD
'This is when the elimination of excess neuronal synapses, known as synaptic pruning, begins.' actually research shows that synaptic pruning is a process that already starts prenatal.
So you're saying prenatal babies have more synapses than adults? I thought the point was to bring it down
0:45 Can you give a source for this quote? "computational models suggest learning performance is optimal when synaptic connections are first over-generated then pruned"
As in, over-generation of synaptic connections and then pruning optimizes learning? Or did she mean synaptic connections being over-generated first, followed by the learning activity, and then pruning when learning performance ends, such as during rest, is most optimal route for performance?
Sorry, this is very interesting but my adhd does it's best to confuse me! = (
@@Mike09legacy Pruning is something that happens as a part of learning process.
Think about it as studying for an exam; there are only going to be a few questions but you don't know what's gonna be on it, so you gotta study for everything (or as much as possible). But then after the exam once you know what's on it, and you no longer need to know what was not on it (let's just assume here for the sake of analogy that the final exam later only includes questions that appeared on previous exams).
Studying as many things as possible is like creating multiple synapses, and pruning is like forgetting those stuff that didn't come up on the test.
Do note that this is an analogy -- I'm not saying that pruning is the basis of all forgetting, but you can think of it as lost possibilities of which you can think or behave. By pruning to a proper extent, you're limiting the way you can think or behave in such a way your actions and thoughts become stable and predictable, and this is what you call leaning.
@@iranjackheelson Now I understand. Thank you for explaining! Hopefully, being aware and learning about this helps me sort out the problems that interfered with my learning in the past.
@@iranjackheelson thank you so much for wonderfully explaining 🙏🙏
this is great. thanks
2:40 what does confusing and redundant refer to? Please elaborate
Thanks for such a great video! Could you also please include references under the video? This might be much more helpful to read the original studies after learning the key points from here.
I have an exam test question that cant fin answer for! When does the selfdestruction of the neuronal synapsis begin? A) 5 weeks B )7weeks C) 2 months D) 3 months
Thanks !!!
How does the excessive or too little synaptic pruning hypothesis with regards to schizophrenia and autism explain the fact that lots of people with autism have schizophrenia?
As a schizophrenic diagnosed with autism, I find abnormal pruning very interesting. I have cognitive deficits like memory and attention
thank you for sharing :)
Also, what does this hypothesis say about adult neurogenesis? Adult neurogenesis is known to take place, at the very least, in the dentate gyrus part of the hippocampus of the brain, and new neurons surely imply new neural connections, i.e. synapses.
Although I have heard that if you don't learn a new skill or expose yourself to new situations, those new neurons won't be incorporated as part of neural networks and will simply go to waste.
👏🏻👏🏻
I think of it like how AI works. First try everything, then weed out what doesn't help
I mean AI and machine learning were developed on the basis of artificial neural networks (ANN) and you can probably guess where the inspiration of those came from... neural networks.
Ever heard of biomimicry?
Ya
does that mean schizophrenics are never autistic? That can't be right
i'm Autistic Not Schizophrenic. We don't have Halucinations either auditory or visual. Some things might seem similar but trust me that I'm not schizophrenic.