Great Great and simply great. So fortunate are your offline classroom students who are blessed to attend your live lectures. Stay safe and stay blessed madam amidst good health happiness and success forever. My prayers and good wishes are always with you
Thank you Samanta. I feel your blessings are real and not virtual. They push me when I am down, they validate I am on right path. And I think everyone needs that kind of blessings. Thank you so much
Mam you clearly define ,what i wanted to know 😊 thankyou ,can you explain efficiency of all vaccine ,why some are 90% other are 80% effective ,why there is such difference?
Superb explanation. Can you also throw some light on spike protein testing 20 days after 2nd dose of covishield - like what range is considered good for spike protein test value
Great Great and simply great...such a beautiful way of teaching and explaining..such a wise teacher....stay safe and stay blessed madam amidst good health happiness and success forever...I wish you and all your family members a very happy and wonderful new year..tc
Nicely explained.... But if the antibody lasts for only 1month or more then how many booster doses required? & is the genome @ mRNA of adeno viruses are same as different varients of corona virus🦠😷? According to your explanation after the first doses the antibodies rises up to peak level in 1/2months then what is justification for making the gap of 84days....& after the second dose how long the antibody titre will remain high?
2 months is what generally happens, but the response may vary from antigen to antigen...the gap also decided by vaccine availability, vaccine types.. booster doses will definitely be required but again ‘when’ depends on the vaccine
Dr. Kindly tell us that what is the difference between the first dose and the second dose of Covishield vaccine, in terms of composition or potency. Kindly answer.
thank you for explaining in such details!!( I just got vaccinated by covishield been 12 days am doing perfectly fine) but !! I have a query!! that if spike proteins are produced by our own cells post delivery of spike specific genes doesn't our own immune system attack our own cells and harm us!! 2: Are spike only produced at the site of injection and no where else in the body...i mean i know that 0.5ml of vac is a minute amount to get all across the body but even then isnt there chances of vac getting absorbed and getting transmitted to heart or lungs etc and damaging those areas post spike protein expression!! just curious!!
If virus doesn’t multiply...protein itself doesn’t do damage...this protein helps virus move into cells and multiply. In vaccine virus is not there, only spike protein
Mam in already covid infected person those antibodies are affecting the same protein structure present in our lungs which are causing clots for that we are taking steroids along with anticoagulant after taking covidsheild or any other vaccine same antibodies will affect our blood vessels structure and cause clots? ?
Thanks for wonderful explanation Mam. Mam coronavirus already has RNA genome. My question is when it is integrates with adenovirus vector, whether reverse transcription is done to convert in to DNA? This question arise because u said after entering immune cells, through transcription process DNA is transcripted to mRNA. My another question. is there any particular area of our body where all these immune responses occur? Is there connection between our body pain , headache and this?
DNA with sequence from which spike proteins can be synthesized is manufactured in labs (since we know viral genome) and is itself integrated with adenovirus
Hello Madam, That was a great explanation. Wonder why TH-cam didn't recommend your channel all these days. Keep these kind of videos coming. People are still hesitating to get vaccinated, this video will clearly let them know it's impact. I have a couple of questions. 1. These vaccines (all vaccines as of today) are built basing on the research they have done on the covid 19 virus and have created the vaccines basing on the results which were carried from the analysis of Covid 19. But as we don't know the origin of this virus we are not able to create the proper vaccine/drug which will give a 100 percent confidence that if a vaccine/drug is taken then covid will die inside the body. Am i right? 2. I am a software engineer who knows a bit of machine learning. After the first dose/second dose gets injected into the person basing on the graph you have shown it shows a log normal distribution (towards the right side in the graph it keeps going and never ends). So if the scientists were correct then the antibodies will keep developing according to that graph. Am i right?. 3. Does this work against all mutations which evolved and which may evolve later?? Please let me know about my questions . Thanks.
Thanks for the appreciation According to me these are the explanations for your questions 1. No we need not know about the origin of virus for development of the vaccine. We know its whole genetic material and the way it acts on body, that’s sufficient to create the vaccine. However, the desperate times required that we develop the vaccine fast ( normally this process takes years)...so the need of vaccine led to the vaccines of even lower efficacy being approved...details in my upcoming video
Q2. Yes, there are memory cells...and they will keep producing antibodies...however without the stimulus, the concentration of antibodies goes down because of routine protein turnover in body. However when the body will be exposed to the virus, memory cells will produce antibodies P.S ...you are absolutely right about log distribution...many functions in body follow that pattern
3. This question is tricky...nobody can predict that...however data suggests vaccine efficacy is much lower to some of the mutants...if virus mutates (like HIV) , it’s difficult to develop avaccine against such virus...in covid case...vaccines do show some efficacy...so something is better than nothing
@@PhysiologyOpen So these memory cells recognise the pattern and they produce anti bodies and never stop producing them. If we keep having protein rich good then will this count keep ticking?. Or my perception is wrong - only when virus comes in these memory cells react quickly and produce antivirus cells and they go and attack the virus cells?.
@@PhysiologyOpen There was a news which I saw yesterday a women with HIV had 32 mutations inside her. Wonder this wave 2 came out from such kind of situations. Also say if a person has sugar problem or HIV or any problem and gets covid, their body will be in a position to generate new mutations inside their body given that they are already less immune?.
OK only if the secondary dose of vaccine is taken than this covishield works u didn't said about first dose of this vaccine that means v hv to wait for second dose in between there r chances of getting infected to corona virus Kindly reply
Chances of getting infected are there in between the two doses and even after two days. After two doses, however there are very less chances of severe disease and hospitalisation
As per new research the spike protein generated by covishield is breaking down and mixing with blood which is causing clot and cardiac arrest in few. Is astrazenika going to do anything on this?
Please share the source with me. I will also go through. Yes there was some concern, and it was banned also in few countries. But then after looking at the data I think the ban was lifted. Secondly in case of any issue (for this data collection by government agencies and scientists), that data has to be shared with WHO and government which can/will put a stop. As far as company is concerned, if they change the formula depending on the data, they will have to do the research all over again.
@@PhysiologyOpen attaching the link www.ft.com/content/f76eb802-ec05-4461-9956-b250115d0577 As per scientist a small tweak in the vaccine is sufficient to change its function but as you say I am not sure whether the trial has to go through again. Along with astrazenika even j&j are in touch with these German scientist for further changes. Since it's a very rare incident WHO and most of the top heads are silent on this.
@@PhysiologyOpen and thanks for the reply even though I am not sure of your profession I was not getting proper response from doctors probably they did not want to comment on anything related to covid.
Most probably yes it will be required. Current data suggests may be after an year. But currently we can’t say...may change depending on the ongoing research
it looks so easy, cytokine stoms are scary & could they happen after taking the vaccine, also coul yo explain covaxin & other types of vaccine mechanisms.
Hi Mam..very nice explanation..thanks much for sharing this video. If the effect of the whole mechanism starts from only after 1 st week, then why its said that its common to expect people to fall bit sick like fever, body pain , head ache..etc as soon we take vaccine may be in the first week usually..How cautitious one should be during the 'after vaccination period' before the second dose as well after the second dose..Awaiting kind response
Side effects are due to other components in vaccine something known as adjuvant...next video on factors affecting vaccine efficacy will talk about adjuvants
You have to be as cautious as before vaccination...there is something known as viral load I.e the amount of virus we are exposed to...if that is too much..vaccine will have less effect...also mutant viruses are circulating, against which vaccines are less effective (though something is better than nothing)
B cells themselves act as APCs ie antigen presenting cells which are then read by helper T cells. There's clonal selection ie multiplication of T and B cells specific to the antigen ie spike protein. Antibodies will destroy the spike proteins in the primary immune response. There may be some antibodies left. At the end of primary immune response memory T and B cells are produced. So formation of memory cells takes more time with the primary immune response. The same gets accelerated with the 2nd dose of vaccine. Also the main antibody in primary immune response is IgM & it's IgG in secondary immune response ie 2nd dose of vaccine. IgG has more affinity than IgM and is a better quality antibody than IgM. This is apart from the quantum of IgG and IgM antibodies produced in 1st and 2nd doses. Adenovirus used has the part of its genome that allows it to replicate, removed making it non replicating
In an ideal world of healthy immune systems this vaccine could be best but science is aware that many humans do activities that weakens the immune system therefore there will be consequences? Theories dont come from ignorance but some vaccines have been harmful in the past and people become skeptical? Now, why variants are happening in population who are 80% vaccinated? Is this virus a product of errors in a lab which created a multi variant virus and somehow escaped? How about the WHO agency closing all labs that are not transparent on experiments or that are manipulating viruses ? Thank you?
@@PhysiologyOpen but if we see the proteins of this virus are highly immune suppresser and if covishield uses these proteins then is there possibility of suppression
It may be minimally effective but second dose is recommended. If it’s not available increasing the time duration from 8 to 12 weeks after the first dose is also ok...rather it’s recommended
@@PhysiologyOpen , Nice explanation , but what will be the effect of not taking 2nd dose in 6-8 weeks timeframe as now the recommended time is 12 week ?
@@pawandixit5575 actually if you take the dose after 12 weeks , it’s much better as shown by antibody response...can’t say that about 16 weeks...I couldn’t find any scientific evidence for that
Thank you for sharing knowledge, spreading awareness among people and taking pains of responding to queries. I have one question though. Does it mean that after Covishield vaccinations there is greater chances of cytokine storms in body through increased response from killer T cells? Something like autoimmune disorder!
Cytokine storm occurs due to inappropriate response of body to kill the virus when it is unable to win over it. Vaccine doesn’t has virus. Moreover it prepares the body for an adequate response when it actually meets the virus
No recommendation against alcohol as such but if you don’t eat properly then it may interfere with protein synthesis required for an adequate immune response
For some vaccines , it has been found that alcohol interferes with response...for other vaccines it has no effect No recommendation for covid vaccines as such... Sleep good, eat good, no stress is what Research shows improves immune response
![[Live] : ONE 169 วันนี้!! "อนาโตลี vs อูมาร์"](http://i.ytimg.com/vi/IK3YZVWuFJg/mqdefault.jpg)
Who all are here after taking covishield vaccine?😇 i am one among 🙏
Even I am one
just today 21/06/2021.😜
me .frm odisha ..😊
i am not felling well after vaccination guys.... having lil fever , and also having lot bodyache at night.
@@soildevil8972 ya, me too had that for the second day after Vaccination. Dont worry. it was only for one day for me.
just got the 2nd dose and watched this video thank you for explaining ma'am... revision bhi ho gaya immunity ka
Yeah....same mechanism
Great Great and simply great. So fortunate are your offline classroom students who are blessed to attend your live lectures. Stay safe and stay blessed madam amidst good health happiness and success forever. My prayers and good wishes are always with you
Thank you Samanta. I feel your blessings are real and not virtual. They push me when I am down, they validate I am on right path. And I think everyone needs that kind of blessings. Thank you so much
Perfect explanation!!! You explain like you are teaching a baby,,,I listened like a baby👏🔥
🙃..so nice of you
Mam you clearly define ,what i wanted to know 😊 thankyou ,can you explain efficiency of all vaccine ,why some are 90% other are
80% effective ,why there is such difference?
Glad you liked the video. Thanks for the topic...will have fun in researching that...next video on covid will be this
Superb explanation. Can you also throw some light on spike protein testing 20 days after 2nd dose of covishield - like what range is considered good for spike protein test value
Thank you. Will do for sure as soon as possible. Thanks for the topic
Great Great and simply great...such a beautiful way of teaching and explaining..such a wise teacher....stay safe and stay blessed madam amidst good health happiness and success forever...I wish you and all your family members a very happy and wonderful new year..tc
Thanks for all the wishes
Are antibodies generated after those vaccines we got at childhood still in our blood or only memory T cells ?
Memory cells are there
Nicely explained.... But if the antibody lasts for only 1month or more then how many booster doses required? & is the genome @ mRNA of adeno viruses are same as different varients of corona virus🦠😷?
According to your explanation after the first doses the antibodies rises up to peak level in 1/2months then what is justification for making the gap of 84days....& after the second dose how long the antibody titre will remain high?
2 months is what generally happens, but the response may vary from antigen to antigen...the gap also decided by vaccine availability, vaccine types.. booster doses will definitely be required but again ‘when’ depends on the vaccine
Dr, thank you for all COVID related videos. If possible, please add a video on why blood cloth happens so that vaccine hesitancy goes down.
Will definitely try...
One more question, how do you make these presentation. Can you share your method?
Automation in VBA
A digital tablet is required. Then you can write on software’s like ppt too..
Need this type of explanation for Covaxin also. Please make a video on this 🙏
Will surely do soon
wonderful explanation ,how are immune system get activated and keeps in memory via vaccination
Thankyou. So glad
Thanks madam. Hope many more who understand Human Physiology watch it. i was waiting for this kinda video. Just took my Vaccine on 20th.
Hopefully 😊
Very clear explanation. Shortest it can be explained. Good work. Thank you.
Most welcome. Glad you liked it.
Dr. Kindly tell us that what is the difference between the first dose and the second dose of Covishield vaccine, in terms of composition or potency.
Kindly answer.
No difference
Thanks.
Welcome
Please read anjana warrier comment 👀
Hi Madam, what if not take 2nd dose and will be there any side effects or something could u plz tell me on the same
No side effects, but even if you missed the dose kindly take it as early as possible.
I am watching after 1 day of vaccination! 😀
Hope it helped
Mam.. Now lancet study says that covishield dose duration should be narrowing for protecting DELTA varient... What is your opinion
Thanks for the update. Will check and get back..
Wonderful presentation
Thank you 😊
thank you for explaining in such details!!( I just got vaccinated by covishield been 12 days am doing perfectly fine) but !! I have a query!! that if spike proteins are produced by our own cells post delivery of spike specific genes doesn't our own immune system attack our own cells and harm us!! 2: Are spike only produced at the site of injection and no where else in the body...i mean i know that 0.5ml of vac is a minute amount to get all across the body but even then isnt there chances of vac getting absorbed and getting transmitted to heart or lungs etc and damaging those areas post spike protein expression!! just curious!!
If virus doesn’t multiply...protein itself doesn’t do damage...this protein helps virus move into cells and multiply. In vaccine virus is not there, only spike protein
Beautifully explained mam
It's my pleasure
Should I take my daily anxiety medication after taking vaccine...???
Sir kindly consult your physician
Nice explanation
Hello Sir...Thanks..Hope you remember me from L.N .Medical College
Mam in already covid infected person those antibodies are affecting the same protein structure present in our lungs which are causing clots for that we are taking steroids along with anticoagulant after taking covidsheild or any other vaccine same antibodies will affect our blood vessels structure and cause clots? ?
But the virus is not there which multiplied and causes pathology
@@PhysiologyOpen thanks for the explanation mam
You are welcome
Thank you for throwing more lights on the subject.👏👏👏
Pleasure is all mine
Very clear explanation.
Thank you
No word in your phrase mam ❤️🔥 Thanku for this beautiful explanation ❤️
Glad you liked it
Ma'am why blood clots happens and why there are cases of blood colts in AstraZeneca vaccine. Please make a video.
Will try
Thanks for wonderful explanation Mam.
Mam coronavirus already has RNA genome. My question is when it is integrates with adenovirus vector, whether reverse transcription is done to convert in to DNA? This question arise because u said after entering immune cells, through transcription process DNA is transcripted to mRNA.
My another question. is there any particular area of our body where all these immune responses occur? Is there connection between our body pain , headache and this?
DNA with sequence from which spike proteins can be synthesized is manufactured in labs (since we know viral genome) and is itself integrated with adenovirus
@@PhysiologyOpen
Thanks mam😊
Most welcome
Now Delta plus variant which mutated spike protein will this vaccine work or not?
different vaccines are showing different efficacy against mutants
You are great madam. You explained it very lucidly
Thanks. Glad you liked it
Thanks Madam. Perfect Scientific Explanation 👌👍
Thanks and welcome
Hello Madam,
That was a great explanation. Wonder why TH-cam didn't recommend your channel all these days. Keep these kind of videos coming. People are still hesitating to get vaccinated, this video will clearly let them know it's impact.
I have a couple of questions.
1. These vaccines (all vaccines as of today) are built basing on the research they have done on the covid 19 virus and have created the vaccines basing on the results which were carried from the analysis of Covid 19.
But as we don't know the origin of this virus we are not able to create the proper vaccine/drug which will give a 100 percent confidence that if a vaccine/drug is taken then covid will die inside the body. Am i right?
2. I am a software engineer who knows a bit of machine learning. After the first dose/second dose gets injected into the person basing on the graph you have shown it shows a log normal distribution (towards the right side in the graph it keeps going and never ends). So if the scientists were correct then the antibodies will keep developing according to that graph. Am i right?.
3. Does this work against all mutations which evolved and which may evolve later??
Please let me know about my questions . Thanks.
Thanks for the appreciation
According to me these are the explanations for your questions
1. No we need not know about the origin of virus for development of the vaccine. We know its whole genetic material and the way it acts on body, that’s sufficient to create the vaccine. However, the desperate times required that we develop the vaccine fast ( normally this process takes years)...so the need of vaccine led to the vaccines of even lower efficacy being approved...details in my upcoming video
Q2. Yes, there are memory cells...and they will keep producing antibodies...however without the stimulus, the concentration of antibodies goes down because of routine protein turnover in body. However when the body will be exposed to the virus, memory cells will produce antibodies
P.S ...you are absolutely right about log distribution...many functions in body follow that pattern
3. This question is tricky...nobody can predict that...however data suggests vaccine efficacy is much lower to some of the mutants...if virus mutates (like HIV) , it’s difficult to develop avaccine against such virus...in covid case...vaccines do show some efficacy...so something is better than nothing
@@PhysiologyOpen So these memory cells recognise the pattern and they produce anti bodies and never stop producing them. If we keep having protein rich good then will this count keep ticking?. Or my perception is wrong - only when virus comes in these memory cells react quickly and produce antivirus cells and they go and attack the virus cells?.
@@PhysiologyOpen There was a news which I saw yesterday a women with HIV had 32 mutations inside her. Wonder this wave 2 came out from such kind of situations. Also say if a person has sugar problem or HIV or any problem and gets covid, their body will be in a position to generate new mutations inside their body given that they are already less immune?.
Very informative doc🙏
Thanks
Plz mam , yehi video hindi me aur ek banaenge toh samajhne me asaan ho jaega. Thank u 🙏
Ok will do that
Thank you so much for the lucid explanation
Glad it was helpful!
Thankyou so so so much ji for perfect illustration of working mechanism of covishield vaccine
Glad that you liked it
Did you have fatigue post covisheild vaccination 1st dose if yes then how many days did it last.
Yes it was there. Lasted 2 days
@@PhysiologyOpen ok thanks for the reply
You are most welcome
Beautifully explained
Thanks for liking 😊
OK only if the secondary dose of vaccine is taken than this covishield works u didn't said about first dose of this vaccine that means v hv to wait for second dose in between there r chances of getting infected to corona virus
Kindly reply
Chances of getting infected are there in between the two doses and even after two days. After two doses, however there are very less chances of severe disease and hospitalisation
Mam ,which cell produces spike proteins
Is type 2 pneumocytes?
All cells which take up the genome..can convert genome into proteins
Which is better covaxin or covisheld
Can’t say. Covishield approves by WHO, covaxin not yet
As per new research the spike protein generated by covishield is breaking down and mixing with blood which is causing clot and cardiac arrest in few. Is astrazenika going to do anything on this?
Please reply
Please share the source with me. I will also go through.
Yes there was some concern, and it was banned also in few countries. But then after looking at the data I think the ban was lifted.
Secondly in case of any issue (for this data collection by government agencies and scientists), that data has to be shared with WHO and government which can/will put a stop.
As far as company is concerned, if they change the formula depending on the data, they will have to do the research all over again.
@@PhysiologyOpen attaching the link
www.ft.com/content/f76eb802-ec05-4461-9956-b250115d0577
As per scientist a small tweak in the vaccine is sufficient to change its function but as you say I am not sure whether the trial has to go through again. Along with astrazenika even j&j are in touch with these German scientist for further changes.
Since it's a very rare incident WHO and most of the top heads are silent on this.
@@PhysiologyOpen and thanks for the reply even though I am not sure of your profession I was not getting proper response from doctors probably they did not want to comment on anything related to covid.
I am MBBS, MD Physiology. Thanks for sharing the resource. Will go through
Great madam... Thanks
Most welcome 😊
Is a third dose required.
Most probably yes it will be required. Current data suggests may be after an year. But currently we can’t say...may change depending on the ongoing research
it looks so easy, cytokine stoms are scary & could they happen after taking the vaccine, also coul yo explain covaxin & other types of vaccine mechanisms.
Cytokine storm happens in an attempt of body to eliminate the virus. Vaccine doesn’t has virus
Yes will try to explain. However fundamentally immune mechanisms are activated in similar ways
How Sputnik v is given only single dose ??
Depends on the immune response after vaccination . The vector used is different which may engage immune system better.
More on this that why different vaccines have different efficacy in upcoming video this Sunday
Hi mama I am goted booster does after 4days my RTPCR test positive how any days after booster does give positive
Hi Mam..very nice explanation..thanks much for sharing this video. If the effect of the whole mechanism starts from only after 1 st week, then why its said that its common to expect people to fall bit sick like fever, body pain , head ache..etc as soon we take vaccine may be in the first week usually..How cautitious one should be during the 'after vaccination period' before the second dose as well after the second dose..Awaiting kind response
Side effects are due to other components in vaccine something known as adjuvant...next video on factors affecting vaccine efficacy will talk about adjuvants
You have to be as cautious as before vaccination...there is something known as viral load I.e the amount of virus we are exposed to...if that is too much..vaccine will have less effect...also mutant viruses are circulating, against which vaccines are less effective (though something is better than nothing)
Thanks for this useful information 🙌
It’s my pleasure, duty as well
B cells themselves act as APCs ie antigen presenting cells which are then read by helper T cells. There's clonal selection ie multiplication of T and B cells specific to the antigen ie spike protein. Antibodies will destroy the spike proteins in the primary immune response. There may be some antibodies left. At the end of primary immune response memory T and B cells are produced. So formation of memory cells takes more time with the primary immune response. The same gets accelerated with the 2nd dose of vaccine. Also the main antibody in primary immune response is IgM & it's IgG in secondary immune response ie 2nd dose of vaccine. IgG has more affinity than IgM and is a better quality antibody than IgM. This is apart from the quantum of IgG and IgM antibodies produced in 1st and 2nd doses.
Adenovirus used has the part of its genome that allows it to replicate, removed making it non replicating
Thanks for elaborating...will be beneficial for the viewers. Sharing knowledge always helps
nice explanation
Thanks. Happy you liked it 😊
Thank you much ,, very well explained
You are welcome!
Excellent - keep them coming -would like a video on nsp12 rna dependent rna polymerase mechanisms of action
Will definitely try
covishield vaccine is fake I have proof call me on you channel
Very nicely explained Madam👌🙏Thank you😊🌹
You are most welcome 😊
Wonderful explanation 👍
Glad you think so!
Explained pretty wel.thank yu
My pleasure
Best video in youtube ❤️❤️❤️ thank you mam
Thanks
Perfect explanation 👍
Good to know you liked it. Thanks
very well explained
Thanks. Happy that you liked it
Mam, Stunning video I am your new viewer💙✌️
Thanks for liking. Keep watching
Thank you for the explanation. 🙏 Helps us better understand about vaccination and stop believing in conspiracy theories.
Yup. You got the point 😊
In an ideal world of healthy immune systems this vaccine could be best but science is aware that many humans do activities that weakens the immune system therefore there will be consequences?
Theories dont come from ignorance but some vaccines have been harmful in the past and people become skeptical?
Now, why variants are happening in population who are 80% vaccinated?
Is this virus a product of errors in a lab which created a multi variant virus and somehow escaped?
How about the WHO agency closing all labs that are not transparent on experiments or that are manipulating viruses ?
Thank you?
Good explanation
Thanks
Excellent mam. Thank you so much.🙏🏻🤗👌🏻👌🏻
My pleasure
Good
thanks 😊
Very nicely explained ma'am cheerz !
Thanks
Ma'am you made it a piece of cake.
Thanks 😊
You should have also explained COVAXIN mechanism Bharat Biotech
Will do a video on that
@@PhysiologyOpen Still waiting for your video on Covaxin how it works inside our immunity plz make it one video.
Yeah...looking for some genuine content
Very well explained... Keep up the good work!
Thanks
Glad you liked it
Thank you🙏
You’re welcome 😊
does covishield can suppress immunity
No
@@PhysiologyOpen but if we see the proteins of this virus are highly immune suppresser and if covishield uses these proteins then is there possibility of suppression
i have recovered in sep now today i have taken vaccine can i go out after 2 days with mask
Actually no...it does not suppress immune system...on the contrary...it is excessive immune reaction which is causing most damage
Yes...taking all precautions though...soon will release video on coronavirus variants which are circulating..
Good explanation 👍
Thanks
Much needed information!!Ty🥰
You are welcome
Brilliant
Thanks
Thank you. Well explained 👍
Thanks 😊
Will taking just one dose(bcs 2nd dose isnt available)help combat the virus?
It may be minimally effective but second dose is recommended. If it’s not available increasing the time duration from 8 to 12 weeks after the first dose is also ok...rather it’s recommended
@@PhysiologyOpen , Nice explanation , but what will be the effect of not taking 2nd dose in 6-8 weeks timeframe as now the recommended time is 12 week ?
@@pawandixit5575 actually if you take the dose after 12 weeks , it’s much better as shown by antibody response...can’t say that about 16 weeks...I couldn’t find any scientific evidence for that
Thank you for such wonderful explaination
Pleasure is all mine
Mam please do a video on injury current in ecg
Will surely do...your exam? Postponed?
@@PhysiologyOpen over mam...
Ohh great
Then we can try 3rd booster
We don’t know yet when to take the third booster
Very informative madam 🙏
Glad you found it helpful
But why in India 2nd dose is after 12 week???
Experimental evidence suggests for this vaccine 12 weeks is most effective
So different countries have different experimental evidence Uk which make the vaccine 8 week apart while India 12 week.. Hmmm very confusing..
Covishiekd WHO recommends 8-12 weeks..then policy matters of each country decide when to give
Thank you madam for the amazing explanation!
Pleasure is all mine
now i know why i got flu after taking covishield
Thanks madam.. very well explained.
My pleasure
maam is covaxin good for us?....
WHO not yet approved. Govt and the company say
Recently phase 3 data says it has 77% efficacy
but maam crores of people already taken jab? what about them..maam....
Some of my colleagues have also taken covaxin. I didn’t say it doesn’t work. Efficacy as shown in recent data is 77%
Thank u 🙂
You are welcome
Who were taken jab will face future cause pls dont take jab govt is fooling
Consequences like what ?
Thank you for sharing knowledge, spreading awareness among people and taking pains of responding to queries.
I have one question though.
Does it mean that after Covishield vaccinations there is greater chances of cytokine storms in body through increased response from killer T cells? Something like autoimmune disorder!
Cytokine storm occurs due to inappropriate response of body to kill the virus when it is unable to win over it. Vaccine doesn’t has virus. Moreover it prepares the body for an adequate response when it actually meets the virus
@@PhysiologyOpen thanks for your response. Appreciate it
madam could please share the literature foe covishield for my future references
WHO site gives all the information
after getting vaccinated covishield after how many days can someone consume alcohol? will alcohol have any impact etc?
No recommendation against alcohol as such but if you don’t eat properly then it may interfere with protein synthesis required for an adequate immune response
For some vaccines , it has been found that alcohol interferes with response...for other vaccines it has no effect
No recommendation for covid vaccines as such...
Sleep good, eat good, no stress is what Research shows improves immune response
Covaxin only
Even i took
But ,covid shield didn't protected my Amma.she left us 25 days before.after 36th day vacinated she get infected by covid😭😭😭😭
😥
May be a person taking AstraZeneca May need more shots in future to help himself from covid19
Yeah true
But now second dose 12-16 weeks....it it works
Different researches showing different time interval between doses is effective
🙂
😊
*I am here after recovery from Covid*
Glad to know
Looks all Greek
Sorry, couldn’t make you get the point of it