the figures are from one of the WORST textboks ever written: Rhodney Rhodes Medical physiology, the other images are from www.targeting-mitochondria.com/alert-on-mitochondria/330-redox-signaling-pathways-modulation-and-mitochondria-hot-topic-to-be-discussed-during-targeting-mitochondria-2013 and this excellent review article www.researchgate.net/publication/221976729_Mitochondrial_redox_signaling_at_a_glance also in the description, lmk what you think
Thank you SO much for the comment! its always nice to have feedback, as always let me know if you have any questions, comments, or criticism good luck in your studies
Thank You for this piece of valuable info. I am trying to figure out what is the role of the microbiota in mothers birth channel regarding the baby's future ROS signaling capability. I understand that we inherit only half of our ROS signaling capability from the egg's mitochondria and the other half from carbon redox molecules made by microbiota living on the birth channel surfaces. Many with c-section history have autoimmune problems. Correlation, cause or effect? I am a semiconductor engineer with deep biohacking interest in natural solar radiation, earth magnetism, structured deuterium depleated aka metabolic celluar water and circadian changes regarding to our mitochondrial health.
man you are great .. i watched your immunology videos and am glad that i found your channel .. i hope you never stop and will be waiting for more of your great work 👍
Thank you SO much Ebrahim, it really means alot to hear that! let me know if you have any questions or criticism (im always looking for ways to improve) best of luck in your studies
Brilliant, thank you for sharing. So does exercising benefit us by increasing Mitochondrial output/ROS and Apoptosis so that they are in balance? My understanding is that too little ROS is bad as is too much.
eh basically depends on who you are talking with., its not all about apotosis though, endogenous ROS are involved in growth factor STPs and even play a role in protein folding so yes just one more reason we see a strong correlation between exercise and health.
@@medaphysicsrepository2639 Thank you. Is STP, Signal Transfer Point? Do you have any books- or offer consulting on health? I lost my gallbladder a few years back. I am doing mostly fine but I do not digest fats too well (not to be graphic but it floats- means there is still undigested fat in it.) Digestive enzymes did not really seem to change that. Is there anything I can eat or take that might help me digest better? Maybe Ox Bile or something? Otherwise, I am pretty healthy. I workout- eat healthy, mostly healthy fats like wild salmon, powerful things like garlic, onions, some low starchy veggies for some fiber (gut health) but not too much given the downsides. I drink mostly water. I have made nutrition and wellness my hobby. My recent physical and work-up was mostly good. My BP is very good- 98/65. I also focus on blood sugar control which is decent at 5.1. My BMI is 20. It is personally very low for me and I can't gain anything. Not even 1 lb. My doctor is clueless but says I am "in range." I have never been so thin and get comments about it which I don't like. I had tried a mild 18:6 fasting for a few weeks- lost weight and it never came back. I think I sped up my metabolism 14%. I did not do it to lose weight- just to be healthier. I have since even slowed down my running and eat more and still- not even 1/2 a lb. Not sure if this is related to my gallbladder or not. At my height, I was 215lbs. now I am 155lbs. 6'1". Any of your brilliant insights would be very much appreciated. Thanks!
Have you ever had a glass of kangen water? It's water that has been run over a live electrical current, specifically a series of electrically charged, platinum coated titanium plates. The water provides antioxidants at a level that would take barrels and barrels of blueberries to match.
Yes, I got into the perth group when I was an undergrad after I read peter duesberg's book. I have little to no doubt that oxidative stress can and does contribute significantly to many of the positive feedback loops associated with AIDS pathology. That being said, I dont endorse their ideas fully since the epidemiology of AIDS is more so that of an infectious agent than that of systematic immune disfunction. and the effectiveness of HAART in raising cd4 population.
I have what could be called a crazy alternative hypothesis on AIDS and viral activity as whole but while I acknowledge that there is an infectious dynamic to viral disease I don't entertain the existence of a viral agent. To me viral activity can more simply be explained by a combination of endogenous vesicles, toxic/stress perturbance and activation and cellular stress signaling. This last point seems to be something that Pasteurian theorists have never looked into but there is very much evidence that microbes, for instance, communicate electromagnetically. Cell-Cell stress signalling can be seen in plant life when herbivore predation is happening, you can also see fall leaves as something akin to this. For me I simply take Hans Selye's theories of general adaptive stress and extend them on to infection and contagion. This ends up being more simple as to the structural germ theory analysis leads to a whole lot of convoluted hypothesis on the evolutionary origins of viruses and the assumption that germs are primarily pathogenic which they are not. A toxicity/stress conception of infection and contagion ends up being more simple and relational in explanation. Germ agents can indeed be pathogenic factors and they play a consequential, not causative, role in infectious/contagious disease, but they are not causative agents onto themselves. There is still a place for Pasteur, but a modest place.
I've been studying hypochlorous acid and it's ability to kill pathogens. Am putting a website together and am trying to learn about all these related things like ROS, etc., so I can explain it to others. I'm so fascinated by neutrophils right now. Soo much I have to learn about all this so I appreciate videos like yours that break it down.
How it works specifically I am unsure. uncoupling proteins are not my expertise. On the fly id reason that uncoupler proteins work by increasing the amount of general ROS simply by driving up the need for electron transport. Great question though !
Evolution was dismissed as a scientific possibility over 100 years ago. When we developed powerful microscopes and began to discover the majestic complexity inside of living cells, showing beyond any reasonable doubt that there is no such thing as simple life. Therefore, life started complex from the beginning. The humble prokaryotic green algae cell has more complexity than all the machines mankind has ever invented.
I'll leave the gospel here:❤ How many lies have you told in your life? Have you ever taken anything that didn't belong to you? Have you ever used God's holy name to curse, would you do that with your mother's name? How many times have you held a grudge in your heart? Jusus said: Matthew 5:28 *_"but I say to you that everyone who looks at a woman to lust for her has already committed adultery with her in his heart."_* Have you ever done that? Only Jesus Christ lived a life worthy of Heaven. Substituting our sinful life for his is the only way to enter Heaven. 1. If we attempt to present our own righteousness to God the Father on the final day when we all stand before him. This will not work. *(We don't have any righteousness)* 2. Jesus has kindly offered to give us his righteousness as a free gift making us perfect and sinless in the sight of his Father. Ensuring a smooth transition to heaven on that final day. *(Choose this option.)* Romans 1:18-21 LSB - 18 For the wrath of God is revealed from heaven against all ungodliness and unrighteousness of men who suppress the truth in unrighteousness, 19 because that which is known about God is evident within them; for God made it evident to them. 20 For since the creation of the world His invisible attributes, both His eternal power and divine nature, have been clearly seen, being understood through what has been made, so that they are without excuse. 21 For even though they knew God, they did not glorify Him as God or give thanks, but they became futile in their thoughts, and their foolish heart was darkened.
Could you please site the graps and figures
the figures are from one of the WORST textboks ever written: Rhodney Rhodes Medical physiology,
the other images are from
www.targeting-mitochondria.com/alert-on-mitochondria/330-redox-signaling-pathways-modulation-and-mitochondria-hot-topic-to-be-discussed-during-targeting-mitochondria-2013
and this excellent review article
www.researchgate.net/publication/221976729_Mitochondrial_redox_signaling_at_a_glance
also in the description, lmk what you think
i honestly wish i had someone as enthusiastic as you as my professor, thank you for sharing
Thank you SO much for the comment! its always nice to have feedback,
as always let me know if you have any questions, comments, or criticism
good luck in your studies
I am just watched your video right now and I understood everything! Thank you! Congratulations!
Thanks alot Melina! you are very kind, be sure to let me know if a video doesnt explain something well enough or if you have questions
Thank You for this piece of valuable info.
I am trying to figure out what is the role of the microbiota in mothers birth channel regarding the baby's future ROS signaling capability. I understand that we inherit only half of our ROS signaling capability from the egg's mitochondria and the other half from carbon redox molecules made by microbiota living on the birth channel surfaces. Many with c-section history have autoimmune problems. Correlation, cause or effect?
I am a semiconductor engineer with deep biohacking interest in natural solar radiation, earth magnetism, structured deuterium depleated aka metabolic celluar water and circadian changes regarding to our mitochondrial health.
man you are great .. i watched your immunology videos and am glad that i found your channel .. i hope you never stop and will be waiting for more of your great work 👍
Thank you SO much Ebrahim, it really means alot to hear that!
let me know if you have any questions or criticism (im always looking for ways to improve)
best of luck in your studies
GREAT Explanation. Thank YOU SO MUCH.
thank you for being kind and leaving a comment
Such a good video
Hey thanks for being kind and leaving a comment!
Thanks for your videos man!
thanks for the feedback, let me know if you have any questions and stay tuned for more
Professor- not man. Show some respect please.
Brilliant, thank you for sharing. So does exercising benefit us by increasing Mitochondrial output/ROS and Apoptosis so that they are in balance? My understanding is that too little ROS is bad as is too much.
eh basically depends on who you are talking with., its not all about apotosis though, endogenous ROS are involved in growth factor STPs and even play a role in protein folding so yes just one more reason we see a strong correlation between exercise and health.
@@medaphysicsrepository2639 Thank you. Is STP, Signal Transfer Point? Do you have any books- or offer consulting on health? I lost my gallbladder a few years back. I am doing mostly fine but I do not digest fats too well (not to be graphic but it floats- means there is still undigested fat in it.) Digestive enzymes did not really seem to change that. Is there anything I can eat or take that might help me digest better? Maybe Ox Bile or something?
Otherwise, I am pretty healthy. I workout- eat healthy, mostly healthy fats like wild salmon, powerful things like garlic, onions, some low starchy veggies for some fiber (gut health) but not too much given the downsides. I drink mostly water. I have made nutrition and wellness my hobby.
My recent physical and work-up was mostly good. My BP is very good- 98/65. I also focus on blood sugar control which is decent at 5.1. My BMI is 20. It is personally very low for me and I can't gain anything. Not even 1 lb. My doctor is clueless but says I am "in range." I have never been so thin and get comments about it which I don't like. I had tried a mild 18:6 fasting for a few weeks- lost weight and it never came back. I think I sped up my metabolism 14%. I did not do it to lose weight- just to be healthier. I have since even slowed down my running and eat more and still- not even 1/2 a lb. Not sure if this is related to my gallbladder or not. At my height, I was 215lbs. now I am 155lbs. 6'1". Any of your brilliant insights would be very much appreciated.
Thanks!
Have you ever had a glass of kangen water? It's water that has been run over a live electrical current, specifically a series of electrically charged, platinum coated titanium plates. The water provides antioxidants at a level that would take barrels and barrels of blueberries to match.
Has anyone here looked into The Perth Group's theory of Oxidative Stress and Cellular Redox hypothesis regarding HIV/AIDS?
Yes, I got into the perth group when I was an undergrad after I read peter duesberg's book. I have little to no doubt that oxidative stress can and does contribute significantly to many of the positive feedback loops associated with AIDS pathology. That being said, I dont endorse their ideas fully since the epidemiology of AIDS is more so that of an infectious agent than that of systematic immune disfunction. and the effectiveness of HAART in raising cd4 population.
I have what could be called a crazy alternative hypothesis on AIDS and viral activity as whole but while I acknowledge that there is an infectious dynamic to viral disease I don't entertain the existence of a viral agent. To me viral activity can more simply be explained by a combination of endogenous vesicles, toxic/stress perturbance and activation and cellular stress signaling. This last point seems to be something that Pasteurian theorists have never looked into but there is very much evidence that microbes, for instance, communicate electromagnetically. Cell-Cell stress signalling can be seen in plant life when herbivore predation is happening, you can also see fall leaves as something akin to this.
For me I simply take Hans Selye's theories of general adaptive stress and extend them on to infection and contagion. This ends up being more simple as to the structural germ theory analysis leads to a whole lot of convoluted hypothesis on the evolutionary origins of viruses and the assumption that germs are primarily pathogenic which they are not. A toxicity/stress conception of infection and contagion ends up being more simple and relational in explanation. Germ agents can indeed be pathogenic factors and they play a consequential, not causative, role in infectious/contagious disease, but they are not causative agents onto themselves. There is still a place for Pasteur, but a modest place.
beautiful explanation!
thanks for the comment!
Is the video description from wikipedia? I want to look for the sources. Thanks!
I can neither confirm or deny that >_
This was great, thank you.
Thank s for the feedback
NP! Love the attention to detail!
Laura Ellen thanks ! I’m curious; what do you study ?
I've been studying hypochlorous acid and it's ability to kill pathogens. Am putting a website together and am trying to learn about all these related things like ROS, etc., so I can explain it to others. I'm so fascinated by neutrophils right now. Soo much I have to learn about all this so I appreciate videos like yours that break it down.
Thats awesome! Do you have a luanch date set ? I have some immunology stuff too if you are interested
sir how UCP2 protein is acting for ROS?
How it works specifically I am unsure. uncoupling proteins are not my expertise. On the fly id reason that uncoupler proteins work by increasing the amount of general ROS simply by driving up the need for electron transport. Great question though !
You look at this complex system and pretend it's an accident.
😂
Evolution was dismissed as a scientific possibility over 100 years ago.
When we developed powerful microscopes and began to discover the majestic complexity inside of living cells, showing beyond any reasonable doubt that there is no such thing as simple life.
Therefore, life started complex from the beginning.
The humble prokaryotic green algae cell has more complexity than all the machines mankind has ever invented.
I'll leave the gospel here:❤
How many lies have you told in your life?
Have you ever taken anything that didn't belong to you?
Have you ever used God's holy name to curse, would you do that with your mother's name?
How many times have you held a grudge in your heart?
Jusus said:
Matthew 5:28
*_"but I say to you that everyone who looks at a woman to lust for her has already committed adultery with her in his heart."_*
Have you ever done that?
Only Jesus Christ lived a life worthy of Heaven. Substituting our sinful life for his is the only way to enter Heaven.
1.
If we attempt to present our own righteousness to God the Father on the final day when we all stand before him. This will not work.
*(We don't have any righteousness)*
2.
Jesus has kindly offered to give us his righteousness as a free gift making us perfect and sinless in the sight of his Father. Ensuring a smooth transition to heaven on that final day.
*(Choose this option.)*
Romans 1:18-21 LSB -
18 For the wrath of God is revealed from heaven against all ungodliness and unrighteousness of men who suppress the truth in unrighteousness, 19 because that which is known about God is evident within them; for God made it evident to them. 20 For since the creation of the world His invisible attributes, both His eternal power and divine nature, have been clearly seen, being understood through what has been made, so that they are without excuse. 21 For even though they knew God, they did not glorify Him as God or give thanks, but they became futile in their thoughts, and their foolish heart was darkened.
Please don’t say the Lord’s name in vain. We are here to learn not for theatrics.
Used "G-- damn" in the video to express how upset you were? Disappointing.
For a textbook that cost hundreds of dollars you figured itd be the least they could do
Used passion to emphasize a teaching flaw? Inspiring :)
thanks for the comment kyle!
I appreciated the GD bomb.
I'm pretty sure that the "-" implies the electron. It doesn't have to be a lewis diagram, right?