Psilocybin mushrooms and psychedelics generally are very beneficial substances and can really help people with mental health issues. Psychedelics are just an exceptional mental health breakthrough. It’s quite fascinating how effective they are against depression and anxiety. Saved my life.
The difference between the final two papers you mentioned had to do primarily with the NEJM exerting unusually conservative and limiting editorial control over the interpretation of the findings, particularly the tools used to classify and interpret traditional SSRI findings. In the authors defence, he chooses to use far more meaningful outcome analyses, meaningful for sufferers of depression that is. All of this data is actually in the first study, but editors refused its admission in the main body of the paper, and it could only appear in an index. Another thing you might have mentioned that is a game-changer in terms of depression/psilocybin, is that effects are seen often after one single dose and are immediate, unlike SSRIs . Also psilocybin, when compared to literally any other pharmecutical, is as safe as can be measured or assessed. This alone makes it an appealing candidate for treatment, but always in combination with therapy.
Tricky stuff. Given that this is a science educational channel for the general public, I hardly think he could have gone into that kind of detail which would leave most viewers completely confused. The general point ... that the research is not yet conclusive ... is factually solid. Perhaps I would have preferred him to say that the research is also very promising, but that's for those researchers who are actually engaged in the research to debate. Given the way the public seems to be responding to the initial studies of psilocybin, I think it is right for a channel such as this to reinforce the message that it is NOT in fact settled science - far from it. We already have, in the United States, a cannabis industry that has no qualms cherry-picking very fuzzy and unclear medical science on the theraputic uses of CBD and THC. Some of them are absolutely shameless promoters of pseudoscience and even feed off the trend of distrust of pharmaceutical companies and the anti-psychiatry brigade. Others are thankfully a little more responsible, but prone to confirmation bias. I really don't think it would be good if psilocybin went the same way that cannabis has, as much as I really want to see all the promise turn out to be true. After all, we still aren't sure about just how often it triggers psychosis in people who are predisposed to psychotic illnesses - or what its effects might be on developing brains. We certainly aren't entirely clear on how to maximize positive outcomes and minimize "bad trips" in clinical settings and contexts. And what about how psilocybin might affect people with developmental disorders like autism or ADHD? Last I checked that is still completely unresearched. Making sure the public doesn't get too far ahead of the research is important, right?
@@ems7623 As an autistic physician with ADHD, I can at least provide minute anecdotal evidence that psychedelics have no negative effects on such conditions.
@@JC-yv1qj I also have ADHD, which is probably why I used that example. We do need research to move forward on psychedelics as treatments! You might be interested to hear ... I saw a reference to the first study on psilocybin and autism since writing that last comment. It is either still underway or the findings are recently published. The hypothesis seems to be that psychedelics might help ASD people learn what it feels like to be more socially connected and hopefully take those skills back with them into their lives. (I'm paraphrasing poorly, I imagine) But you know ... neither what I or you say, as people with a developmental differences in our brains, about our experiences with any of these substances is enough. They are just anecdotal. In my early 20s, I had an atypical reaction to a relatively small dose of psilocybin. Atypical reactions to certain psychoactive substances is common in ADHD. I imagine it would be in ASD too, but I don't know for certain. Was my reaction because of how my brain processes dopamine differently? Or was it something else - even something situational? Who knows.
@@ems7623 I think the first step would be to define "atypical reaction"; you most likely already know this, but set and setting are key defining parameters for a trip's outcome, thus consider that people with adhd/asd often are faced with a vast array of psychological, social, and even financial stressors, many of which could contribute to the "atypical-ness" of the psychedelic experience. That being said, while [traditional] psychedelics act through the heterodimerization of 5-HT2a receptors with mGlur2/3 receptors, there is a possibility that the altered dopaminergic receptors/pathways in adhd brains could contribute to an "atypical" psychedelic experience. Either way, more controlled research is certainly needed.
An important distinction that should be made is that these studies that were discussed only focus on depression and anxiety; traumatic stress is worthy of inclusion in mental health and not many treatments for depression work well for trauma. Psilocybin and other psychedelic medicines are an interest for treating trauma, so I'd be interested in that topic. In fact, it'd be great to get a healthcare triage specifically on trauma treatment.
Yeah, I'm interested on the treating of trauma and how it response to things like psilocybin. It's frustrating as someone with really bad PTSD and how all treatments I've gotten in the past didn't help at all (sometimes even making it worse)
Psilocybin containing mushrooms saved my life. The drastically reduced my benzodiazepine withdrawal allowing me to quite illicit pill addiction after three years of heavy daily use before it would had became medically dangerous to quit. It has also helped me survive depression.
The Trips I've been having really helped me a lot,I finally feel in control of my emotions and my future and things that used to be mundane to me now seem incredible and full of nuance on top of that I'm way less driven by my ego and I have alot more empathy as well.
Psilocybin containing mushrooms saved my life. The drastically reduced my benzodiazepine withdrawal allowing me to quite illicit pill addiction after three years of heavy daily use before it would had became medically dangerous to quit. It has also helped me survive depression.
Pure anecdote but back in my hippie days I preferred Psilocybin and Peyote to LSD. Both left me felling ‘mellower’ during and after. Since I’ve never had depressive symptoms and no one in my immediate family has either, it’s not even a helpful anecdote! 🥴
3:39 hold on, your report of the 2021 trial's "negative results" feels lacking. While the conclusion section of the trial states there was not statistically significant difference BETWEEN the psilocybin and escitalopram group when strictly looking at depression score reduction, BOTH groups still saw a decrease in their QIDS-SR-16 scores compared to baseline: "The mean scores on the QIDS-SR-16 at baseline were 14.5 in the psilocybin group and 16.4 in the escitalopram group. The mean (±SE) changes in the scores from baseline to week 6 were −8.0±1.0 points in the psilocybin group and −6.0±1.0 in the escitalopram group... A QIDS-SR-16 response occurred in 70% of the patients in the psilocybin group and in 48% of those in the escitalopram group...QIDS-SR-16 remission occurred in 57% and 28%, respectively... Other secondary outcomes generally favored psilocybin over escitalopram, but the analyses were not corrected for multiple comparisons. The incidence of adverse events was similar in the trial groups." To reiterate, the response rate in the psilocybin group was over *2/3* while escitalopram was just under *half*, plus remission in over *half* of psilocybin group vs just over *a quarter* of escitalopram. I feel that's saying a lot for an intervention administered once every 3 weeks to be comparable to a pill taken daily.
Love this. Would like a companion video about psilocybin's potential for other mental health diagnoses. I've heard (anecdotally but also from clinicians) it has far more potential for treatment for PTSD and addiction than it has for stuff like depression and bipolar. As someone who did psychedelic psychotherapy at a ketamine clinic, this kinda makes sense to me but I'm curious if there's data to support it.
Mehhh... I've been subbed since close to when this channel first started. This video is a perfect example of exactly why I stopped watching every video. Every time illegal drugs are the topic, he seems like he's forcing himself not to wave his hand and say, "Drugs are bad, m'kay."
@@rquaidpro I mean, yeah. The guy's a Dr. Basically any drug that wasn't vetted by "certified experts" will get his jimmies rustled. Also he's a token neoliberal so his views on anything outside the prevailing status quo is usually reactionary or dismissive. Except for the legal corporate heroin killing Muricans. He is fine with that shit existing. Since that neoliberal opium went through the "proper channels" before it was pushed on Muricans in mass.
@@r011ing_thunder6 Far more people die in cars both in absolute and per capita terms. Are we going to get rid of those? There are risks, of course, but so there are with everything humans get themselves up to.
This confirms my sentiment on this topic. Considering how difficult it is to study the effects of mainstream pharmacotherapy, attempting to study psychedelics in the same way seems like an unbelievably difficult task. Can you imagine all the paperwork you'd need from ethics committees, the DEA, grant funders etc... Hopefully one day it will be better studied but I doubt it will be in the near future, unfortunately.
Applying to the DEA, whose existence is reliant on the categorization of substances as illicit. They are still active this year in making new psychedelic compounds illegal, before any research whatsoever.
@@locochingadero Exactly.That institution exists to perniciously restrict access to drugs. Asking the DEA about anything regarding drugs is a fools errand. It's like asking the Mormon church to permit a study on the benefits of premarital sex.
On the other hand, there is a growing amount of scientific research being conducted in multiple countries, now. The DEA might remain an issue in the US a little longer, but at a certain point if psilocybin treatments are approved in other nations soon, it might become impossible for the US to keep psilocybin as a Schedule One drug any longer. That dam might finally be bust open by our friends in Europe, Canada and Israel.
Lex really needs to have Robin Carhartt-Harris on his show. He's the premier clinical researcher IMO and he's already rubbing up against the shenanigans of Pharm. If the public knew how little that passes for research actually contributes to health and wellbeing and how much is marketing and trying to get old drugs re-patented it would clearly demonstrate the failure of capitalism to effectively advance health science. I'm speaking here as an inside/outsider, with no stakes in any research but member of an REB.
There are barriers to research, absolutely. However, when an institution like Johns Hopkins Medical School leads the way on it in the US, all that "paperwork" isn't quite as challenging to deal with. They are, after all, a leading medical school and research institution. It is almost like putting a golden seal of approval on psilocybin research. There were others doing the work in Canada and a couple other nations prior to them, but the symbolism of Hopkins getting involved has been enough to lead to a flood of interest and the 50-year taboo around discussing psychedelics as potentially therapeutic is falling away. Hell, two psychotherapists I know (who don't even prescribe medications) talk about it frequently, even with their patients. They can't actually provide or promote psychedelic therapy without losing their licenses, but there's a buzz around the topic in the world of clinical psychology and psychiatry.
highly recommend michael pollan's book "how to change your mind" to anyone who wants to know more! there is much much more to know about this topic and pollan does an incredible job.
Lol "rich liberal tries drugs and (mostly) handles it okay" is a decent book. Trying the stuff in a safe controlled setting is definitely better. Though that is way more illegal for those of us that aren't rich and white.
I found the Netflix series interesting, what I would say about all the studies is that they mostly confirm what Deadheads, Phish Heads and DMB fans have known for a while without million dollar studies, it is the reset button on your brain.
I think that psilocybin will help people who suffer from depressed mood or a lack of emotion as it amplifies emotional response. Sadness and despair may be improved through feelings of unity and oneness but I don't think it will improve negative emotions otherwise.
The trial that has no significance mentioned at 4:02 was testing for difference between psicobylin 25 mg alone in two doses vs psicobylin 1 mg in two doses with escitalopram in between. No significance doesn’t mean the drug didn’t work, it may just have meant that the dosage is still no determined. I’m unsure why they added the escotalopram on the other group though as it would’ve been better to have it as a third separate group for control, although that would’ve been a phase 3 trial 🤔
I think it is worth mentioning that people who microdose typically use 10-30 mg 2-3x/week, for 4-8 weeks. If they are studying microdose amounts, they should adhere to a commonly used dosing schedule. It isn’t that surprising to find no significant effect if you are using a dosing schedule that no one has ever touted as effective.
Anecdotal I suppose, but, my partner was severely depressed and suicidal and psilocybin treatment at a clinic saved his life and gave him a positive outlook on life
I have bipolar 2, adhd, autism and anxiety and I did shrooms once. Had to do 4mg to feel anything and then took another 2mg later as it worked its way out of my system. My depression often manifests as not being satisfied or enjoying anything and needing to constantly bounce between activities to get any sort of stimulation... being on mushrooms made me satisfied with just very little. Honestly, I think there's some use for mushrooms in some people. Idk about microdosing but from my personal experience I think it would help me.
Thanks for sharing. Obviously anecdotal reports aren't the science we need, but your story caught my attention. I also have ADHD, recurring major depression and anxiety. Not exactly the same, but I can relate. I have been waiting for any news about studies into psilocybin and ADHD, because (as you know) our brains handle dopamine differently. So differently, that our reactions to psychotropic drugs can be atypical. That (plus the fact that it is still illegal) has prevented me from trying it. Interstingly ... I've seen more comments like yours from people with ASD than ADHD. And I saw one researcher say on camera that she hypothesized that psilocybin might be able to help ASD people feel more socially connected - and then take that experience back out of the trip into their lives. It was an interesting thought. That said, if I could shed the depression and anxiety with psilocybin, then only have to deal with the ADHD symptoms, my life would instantly improve tenfold or so. I might not end up waiting for the research to finally happen. Life is too short and depression/anxiety has already wasted too many of my years.
Thank you as always for sticking to the data, as well as noting some of these very studies may include publication bias. I'm tired of staunch advocates overhyping the health claims of psychedelics (the same thing happened with marijuana), so I'm all for more research. 💯
I do appreciate having the Data as well, but it hard to not be a staunch advocate when I started Ketamine during a time when I was debilitatingly depressed (only getting out of bed every 2-3 days to eat/drink/go to the bathroom as some of the milder symptoms, it was far worse) and it completely changed my life. Miracle is almost not strong enough a word to explain the difference it made for me. I have my life back and can function normally for the first time in a decade. I know (anecdotally) that it works, the question I hope can be answered soon is for how many more can it work and why it works for them.
Agreed. All these studies show is that the effects are not extremely detrimental, which is also good data to have. I'm an advocate of legalisation and of recreative use, while health benefits would not surprise me in the least, more research is needed before we can say anything with any certainty.
talking about bias, the so-called negative result mentioned at 4 minutes in determined psilocybin to be as effective as escitalopram. This sounds like a very positive result. The data can show what the data show, but the fact that this gets reported as a negative result just baffles me. Why would something that can be grown for nearly free performing as well as a first-line antidepressant be interpreted as a "negative" result? If Usain Bolt's speed were being compared to a race horse and they tied, sure, it would be null result. But it would be outstanding. It reminds me of something I saw on the Vibram toe-shoes many years back- the fact that someone did a study by transitioning a group of runners from regular running shoes to the toe-shoes all at once and not changing their running routine or technique or easing them into it caused the runners some injuries. And these injuries were used to show that the toe-shoes didn't improve their running ability. When what it actually showed is that those toe shoes are SIGNIFICANTLY different than regular shoes and that transitioning to them against ALL of the manufacturer's recommendations went as poorly as the manufacturer anticipated. Positive and negative results in a scientific paper still need to be looked at in terms of what it means in the real world as well as what it means for what questions should be asked next, and what it means for what questions were intentionally ommitted. Either positive or negative results can mean that something is effective or not effective or good or bad or similar or different.
Yes, that hype and potential bias is one of the most annoying biproducts of the DEA creating an artificial situation where real research on these substances was delayed for decades - all the while spreading misinformation about drug risks and failing miserably to stop consumers from using these substances. They created a situation where hundreds of thousands of people have experience with these substances (largely safe experiences), distrust authorities on drug policy and science and now no longer have any patience left to wait for the science to catch up. We often talk about the failed drug war and how it is probably responsible for creating drug cartels, violence in and around the black market, not to mention criminalizing addiction, but what you are pointing to is another nasty biproduct of those failed policies.
Couldn't it be considered a bit of a "harsh" conclusion to draw on the study mentioned at 4:00 as a negative? They are comparing it to the gold standard for depression and there was not a significant difference found between the two?
It's negative in the scientific sense, not the practical one. You design a study like this to look for a departure from an expected baseline. Finding the departure is a 'positive' result in that it lends evidence to whatever led you to investigate that hypothesis. A 'negative' result is just one that can't be differentiated from the chosen baseline strongly enough. The criticism of journals not publishing 'negative' results is not a criticism of only publishing 'good' results and ignoring 'bad' results, it's a criticism of publishing seemingly interesting results and ignoring those which may be less interesting/new/surprising but equally valuable to the scientific body of knowledge.
@@PlanckRelic I could probably have been more clear in what i meant. In the practical sense, then, does this negative result not warrant the interpretation "as effective as the gold standard" in this particular study
It's becoming fairly clear, little by little, that psilocybin can be used to treat depression at least in some people. It's just not clear yet how well, how lasting the effects, how safely (for the wide array of patients with depression and co-morbid mental illnesses.) We should have known this fifty years earlier. Thanks to Nixon's drug laws, we couldn't. How many people suffered from severe depression or are gone because of suicide as a result of his shallow thinking?
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I weigh 280Lbs or 127Kg, I took 2.7 grams of Psilocybin Cubensis and had a 3 hr strong introspective experience. Afterwards I can say that my Suicidal Ideation is no longer a symptom I live with :) , This is not the result of some single moment during my experience but is just something I noticed about myself. Depression down 50% Anxiety raised 30%. Although my experience mildly increased my anxiety I believe this to be a symptom of something disturbing I realized about myself that I wrestled with during the come down. I think I’m eventually going back to veganism which I abandoned last month because I was somewhat homeless but had access to fast food through EBT. I would rate Psilocybin as a 8/10. It helped and I’m a healthier person.
got a friend who doses and its made a noticable impact in his every day mood, guy suffered from depression that most medicines didn't help with, and the ones that did he grew a tolerence for. hoping that Psilocybin gets some more research behind it.
As a proud mushroom enthusiast, YES. WITHOUT QUESTION YES. When I can find mushrooms I am not just happy when I take them, they can greatly improve my mood for actual months at a time from only a single dose, non-micro of course. 2-3.5 grams can greatly help if not cure depression
its so frustating how for us that have been helped by this substance, because we feel as a objective truth that e does help. But honestly, microdose doesnt make sense... You should take a perceivable dose, its impossible for it to not show you beauty in life, meaning, conectedness which is all depressive people lack
I wonder if there is good research on adaptogenic mushrooms and herbs, these are legal and likely easier to get approval for Research studies e.g. reishi, chaga, lions Mmane, cordyceps
Before people get carried away dunking on the the anecdotal examples in the comments below, I just want to say this. While suffering from extreme anxiety and depression, I thought Escitalopram was going to kill me. I couldn't tolerate it for the amount of time it would require to start seeing results. I just couldn't do it. My point is this. If the study results for psilocybin and marijuana have results that are mixed, why wouldn't you still provide them as an option (so long as they're deemed to be safe). Drug safety and drug efficacy are two different things. Particularly in the realm of mental health, there is no such thing as a one size fits all solution. Even anti-anxiety and anti-depressants have mixed results. So again, pending safety, why wouldn't we just view psilocybin and marijuana as options, rather than a one size fits all second coming of Jesus? Whatever helps you feel like you don't want to die, should be a positive.
The only cannabinoids that can treat anxiety are CDB. THC actually increase anxiety. I've been using psilocybin for over 3 years and can attest to the claims that it is an effective treatment for anxiety and depression. That said, it is not a "magic bullet". It can only uncover the root causes of anxiety, depression, PTSD and substance use disorder (mine being AUD). You have to do something with the knowledge and new perspectives. That's called integration, and it's why pairing it with psychotherapy is so effective. And psychotherapy is more effective when you are in this state of "openness" caused by psilocybin.
Have you tried shrooms yet my dude? They are pretty great. Honestly the only thing better in life is WORKERS SEIZING CONTROL OVER THE MEANS OF PRODUCTION.
It sounds like you had an atypical reaction to Escitalopram. Sorry you went through that. Very unfortunate. Psychiatry is still not always a completely precise area of medicine and I join you entirely in hoping for some major advancements in our lifetime. There are other areas of medicine that need similar improvements in diagnosis and treatment, of course. Psychiatry gets its unfair share of criticism most likely because of how common mental illnesses (especially depression and anxiety) are. There are a few gaps in your thinking above. There's the simple fact that one of the reasons for careful (and, ugh, sometimes plodding) medical research is to maximize, if not ensure safety. For example, there's some evidence that psilocybin might induce psychotic episodes in people who are predisposed to schizophrenia or other psychotic illnesses. Wouldn't it be a good thing to know if that's true and if there are other kinds of people who really SHOULD avoid psilocybin? What if certain anxiety disorders lead to bad outcomes? We don't know for sure yet. That's one reason why we should ideally wait for the science. Another thing that is missing from your reasoning above: Another major reason for extensive medical research into a substance is to measure its effectivity rates across different population groups, at different doses across time. If someone has a depressive episode and is faced with a decision: "Do I try psilocybin? CBT? an SSRI? a SNRI?", it's obviously ideal to be able to have enough data to say that for that particular person with their psychological and medical history with these symptoms one or another treatment is more likely to provide the best results. It might still be a probability game in psychiatry for now, but that's surely preferable. As for making psilocybin available to patients before this research can be fully carried out, you're right that there could be a case made for that - at least after we have enough safety data. Our medical system is not designed to administer treatments that are not (yet) proven. That's very much the domain of so called "alternative" or "complementary" medicine which is flooded with all kinds of quackery and folklore, unfortunately. Ethically speaking, doctors could not recommend such unproven treatments. Maybe we need a profession of people who do handle complementary medicine who aren't quacks in the West. I'm not sure. But for now, psilocybin remains in that corner. The corner of crap-shoot remedies. All that said, none of this would necessarily prevent me from taking matters into my own hands, if I had a bout of suicidal depression and trying psychedelic therapy whether it was legal or not, particularly if it was clear that safety has been sufficiently proven for people like myself. I do think that mental illnesses can be severe enough to warrant more "experimental" treatments, at least in some cases - though those who are mentally ill aren't always the best judges of what is risky and what isn't.
Mushrooms are cool, but don't take them with high strung and annoying people like my uncle. Be with someone who's relaxed who you get along with or be alone and be in nature on a nice day. If you're around a lot of Karens who might be looking at and/or judging you you might be inclined towards paranoia. You don't see anything that's not there, so don't be expecting elves or dragons and crap like in the movies.
I'll do anything but I can't afford anything because I live in poverty. I would like to get electroconconvulsive therapy but I can't afford it. But no therapies have made any meaningful impact in years. I'm tired, bring on the mushrooms.
I found the benefits of psychedelics to be kinda short lasting, tbh. The perspective shifts were profound at the time, but wore off fairly quickly. In contrast, I found the benefits of intense meditation (Vipassana) to be MUCH longer lasting. It's been over 10 years since I practiced Vipassana regularly, but the techniques and perspectives I developed from learning it are still very helpful today. They've helped a lot with mental wellbeing over the years
Interesting anecdotes. You don't say whether or not you suffered from any mental illness when you self-administered psilocybin and if that dianosis was conferred by an MD or other clinician.
okay, so that study mentioned at 4 minutes in shows that psilocybin is as effective as escitalopram... and this is being reported as a NEGATIVE result? This sounds like a fairly strong bias to me. I mean, presumably excitalopram has become part of standard care because it is effective, right? And it grows on trees... or more properly, it can grow in cow poop. There are other comments describing the problems with how this study was required to be presented in the journal that published it due to heavy-handed editorial control, but even on this youtube show, calling "it's as effective as escitalopram" a NEGATIVE result seems like following the biased framing that the journal's editors wanted to convey.
Don't know about treating anything with psilocybin. My close relative got into a long psychotic episode after using them. Three years down the line he is still on antipsychotics and antidepressants. He was trying self medicate depression with mushrooms, all he got was psychosis to go with his depression.
That’s what we call an outlier. He was unlucky but on the flip side when my friend had to start taking anti-depression medicine he ended up committing suicide. Mushrooms on the other hand always helped his depression. The bottom line is that without ever trying it you have no authority to speak on it’s behalf at all. The person you spoke of was an extremely rare exception. We still sell baby aspirin even though 1-10,000,000 babies dies from an allergic reaction to it. Bottom line if we stopped doing things because it caused even death for a few people medicine would never improve or even continue. Try to think with your head and not just your heart
@@louismasar6147 You can't call something an outlier unless you actually have a data-set to demonstrate this mathematically. You anecdotes are no more or less valuable than anyone else's if we actually want to get to a point of understanding the real risks and theraputic uses of any substance. Psilocybin research is promising but inconclusive. That's as far as we can go for now.
So just two doses of psilocybin seems as effectice as the current gold standard, escitalopram - how on earth is this a negative finding? Furthermore, the author of said study recently commented on (super scientific and peer review) Medlifecrisis TH-cam video, that the study was not designed to show superiority.
I know, right? Listen to Robert Carhart-Harris' explanation of the study. He was only able to report the findings in a particular way because of the study design, but he wished he could report on the totality of the study's findings, which were in favor of psilocybin over the SSRI.
@@onsightitify do you have a video or podcast in mind for his thoughts? Or will a random Google search do the trick? Definitely interested in listening
That would be a really fucked up thing to do to people who actually are suffering from depression. It's already hard enough to get access to sufficient mental healthcare.
As someone who trips regularly, yes. Yes. Yes. Psilocybin has been a godsend for me. For 20 years, I took a variety of antidepressants (Lexapro, Celexa, Cymbalta, Zoloft, Wellbutrin, and so many others, in different combos and dosages), saw psychiatrists, and went through numerous therapists. Nothing helped me in the slightest. I was cripplingly, hopelessly depressed. I felt like garbage all the time, I had no energy, my life sucked. I was miserable for so, so long. Finally, I got clean off the antidepressants, and started tripping twice-yearly on magic mushrooms in very carefully planned trips (myself; not guided by anyone else). OMG my life has changed. I find so much more peace and joy in my life. I've become spiritual and regained happiness. I am more level-headed, less quick to anger, far few crying jags (still a few, linked to the hormonal swing of my period), and far, far, FAR happier in general. I never thought I'd get to this point. I didn't think it was possible. Psychiatry and the US medical establishment taught me that I was broken and I needed tons of (addictive) pills and constant therapy. All of which made certain people a ton of money. Mushrooms showed me reality: money is made up, psychiatry is made up, medicine is made up. You live, you die, you are reborn, you live again, you die again, an endless immortal cycle. So let go of your pain, let go of your fear, let go of your constructs. Let go and be reborn.
@@BlueCyann you need to analyze the concept drug and read more about the subject before commenting something so unbiased cause the truth is you’re saying that cause you know nothing about this
Psilocybin mushrooms and psychedelics generally are very beneficial substances and can really help people with mental health issues.
Psychedelics are just an exceptional mental health breakthrough. It’s quite fascinating how effective they are against depression and anxiety. Saved my life.
The difference between the final two papers you mentioned had to do primarily with the NEJM exerting unusually conservative and limiting editorial control over the interpretation of the findings, particularly the tools used to classify and interpret traditional SSRI findings. In the authors defence, he chooses to use far more meaningful outcome analyses, meaningful for sufferers of depression that is. All of this data is actually in the first study, but editors refused its admission in the main body of the paper, and it could only appear in an index.
Another thing you might have mentioned that is a game-changer in terms of depression/psilocybin, is that effects are seen often after one single dose and are immediate, unlike SSRIs . Also psilocybin, when compared to literally any other pharmecutical, is as safe as can be measured or assessed. This alone makes it an appealing candidate for treatment, but always in combination with therapy.
Fun fact, per LD50, caffeine is actually more toxic than psilocybin.
Tricky stuff. Given that this is a science educational channel for the general public, I hardly think he could have gone into that kind of detail which would leave most viewers completely confused.
The general point ... that the research is not yet conclusive ... is factually solid. Perhaps I would have preferred him to say that the research is also very promising, but that's for those researchers who are actually engaged in the research to debate. Given the way the public seems to be responding to the initial studies of psilocybin, I think it is right for a channel such as this to reinforce the message that it is NOT in fact settled science - far from it.
We already have, in the United States, a cannabis industry that has no qualms cherry-picking very fuzzy and unclear medical science on the theraputic uses of CBD and THC. Some of them are absolutely shameless promoters of pseudoscience and even feed off the trend of distrust of pharmaceutical companies and the anti-psychiatry brigade. Others are thankfully a little more responsible, but prone to confirmation bias.
I really don't think it would be good if psilocybin went the same way that cannabis has, as much as I really want to see all the promise turn out to be true. After all, we still aren't sure about just how often it triggers psychosis in people who are predisposed to psychotic illnesses - or what its effects might be on developing brains. We certainly aren't entirely clear on how to maximize positive outcomes and minimize "bad trips" in clinical settings and contexts. And what about how psilocybin might affect people with developmental disorders like autism or ADHD? Last I checked that is still completely unresearched.
Making sure the public doesn't get too far ahead of the research is important, right?
@@ems7623 As an autistic physician with ADHD, I can at least provide minute anecdotal evidence that psychedelics have no negative effects on such conditions.
@@JC-yv1qj I also have ADHD, which is probably why I used that example. We do need research to move forward on psychedelics as treatments! You might be interested to hear ... I saw a reference to the first study on psilocybin and autism since writing that last comment. It is either still underway or the findings are recently published. The hypothesis seems to be that psychedelics might help ASD people learn what it feels like to be more socially connected and hopefully take those skills back with them into their lives. (I'm paraphrasing poorly, I imagine)
But you know ... neither what I or you say, as people with a developmental differences in our brains, about our experiences with any of these substances is enough. They are just anecdotal. In my early 20s, I had an atypical reaction to a relatively small dose of psilocybin. Atypical reactions to certain psychoactive substances is common in ADHD. I imagine it would be in ASD too, but I don't know for certain. Was my reaction because of how my brain processes dopamine differently? Or was it something else - even something situational? Who knows.
@@ems7623 I think the first step would be to define "atypical reaction"; you most likely already know this, but set and setting are key defining parameters for a trip's outcome, thus consider that people with adhd/asd often are faced with a vast array of psychological, social, and even financial stressors, many of which could contribute to the "atypical-ness" of the psychedelic experience.
That being said, while [traditional] psychedelics act through the heterodimerization of 5-HT2a receptors with mGlur2/3 receptors, there is a possibility that the altered dopaminergic receptors/pathways in adhd brains could contribute to an "atypical" psychedelic experience.
Either way, more controlled research is certainly needed.
An important distinction that should be made is that these studies that were discussed only focus on depression and anxiety; traumatic stress is worthy of inclusion in mental health and not many treatments for depression work well for trauma. Psilocybin and other psychedelic medicines are an interest for treating trauma, so I'd be interested in that topic.
In fact, it'd be great to get a healthcare triage specifically on trauma treatment.
Yeah, I'm interested on the treating of trauma and how it response to things like psilocybin. It's frustrating as someone with really bad PTSD and how all treatments I've gotten in the past didn't help at all (sometimes even making it worse)
Psilocybin containing mushrooms saved my life. The drastically reduced my benzodiazepine withdrawal allowing me to quite illicit pill addiction after three years of heavy daily use before it would had became medically dangerous to quit. It has also helped me survive depression.
The Trips I've been having really helped me a lot,I finally feel in control of my emotions and my future and things that used to be mundane to me now seem incredible and full of nuance on top of that I'm way less driven by my ego and I have alot more empathy as well.
Psilocybin containing mushrooms saved my life. The drastically reduced my benzodiazepine withdrawal allowing me to quite illicit pill addiction after three years of heavy daily use before it would had became medically dangerous to quit. It has also helped me survive depression.
I bought some from a Drugstore online
FROM
TRIP_MYCOLOGIST
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instagram
Pure anecdote but back in my hippie days I preferred Psilocybin and Peyote to LSD. Both left me felling ‘mellower’ during and after. Since I’ve never had depressive symptoms and no one in my immediate family has either, it’s not even a helpful anecdote! 🥴
I but those mushrooms made you a fungi to hang out with.
😂😂😂
3:39 hold on, your report of the 2021 trial's "negative results" feels lacking. While the conclusion section of the trial states there was not statistically significant difference BETWEEN the psilocybin and escitalopram group when strictly looking at depression score reduction, BOTH groups still saw a decrease in their QIDS-SR-16 scores compared to baseline:
"The mean scores on the QIDS-SR-16 at baseline were 14.5 in the psilocybin group and 16.4 in the escitalopram group. The mean (±SE) changes in the scores from baseline to week 6 were −8.0±1.0 points in the psilocybin group and −6.0±1.0 in the escitalopram group... A QIDS-SR-16 response occurred in 70% of the patients in the psilocybin group and in 48% of those in the escitalopram group...QIDS-SR-16 remission occurred in 57% and 28%, respectively... Other secondary outcomes generally favored psilocybin over escitalopram, but the analyses were not corrected for multiple comparisons. The incidence of adverse events was similar in the trial groups."
To reiterate, the response rate in the psilocybin group was over *2/3* while escitalopram was just under *half*, plus remission in over *half* of psilocybin group vs just over *a quarter* of escitalopram.
I feel that's saying a lot for an intervention administered once every 3 weeks to be comparable to a pill taken daily.
Thank you.
Love this. Would like a companion video about psilocybin's potential for other mental health diagnoses. I've heard (anecdotally but also from clinicians) it has far more potential for treatment for PTSD and addiction than it has for stuff like depression and bipolar. As someone who did psychedelic psychotherapy at a ketamine clinic, this kinda makes sense to me but I'm curious if there's data to support it.
Great video info, love the content. Hope topics like this will be more discussed. Psychedelics are great..!
I may not always like what he's saying but I never doubt his sincerity
I doubt him a lot but not always
Mehhh... I've been subbed since close to when this channel first started. This video is a perfect example of exactly why I stopped watching every video. Every time illegal drugs are the topic, he seems like he's forcing himself not to wave his hand and say, "Drugs are bad, m'kay."
@@rquaidpro I mean, yeah. The guy's a Dr. Basically any drug that wasn't vetted by "certified experts" will get his jimmies rustled. Also he's a token neoliberal so his views on anything outside the prevailing status quo is usually reactionary or dismissive.
Except for the legal corporate heroin killing Muricans. He is fine with that shit existing. Since that neoliberal opium went through the "proper channels" before it was pushed on Muricans in mass.
@@rquaidpropeople have died on shrooms. Maybe that's why.
@@r011ing_thunder6 Far more people die in cars both in absolute and per capita terms. Are we going to get rid of those? There are risks, of course, but so there are with everything humans get themselves up to.
This confirms my sentiment on this topic. Considering how difficult it is to study the effects of mainstream pharmacotherapy, attempting to study psychedelics in the same way seems like an unbelievably difficult task.
Can you imagine all the paperwork you'd need from ethics committees, the DEA, grant funders etc...
Hopefully one day it will be better studied but I doubt it will be in the near future, unfortunately.
Applying to the DEA, whose existence is reliant on the categorization of substances as illicit. They are still active this year in making new psychedelic compounds illegal, before any research whatsoever.
@@locochingadero Exactly.That institution exists to perniciously restrict access to drugs. Asking the DEA about anything regarding drugs is a fools errand.
It's like asking the Mormon church to permit a study on the benefits of premarital sex.
On the other hand, there is a growing amount of scientific research being conducted in multiple countries, now. The DEA might remain an issue in the US a little longer, but at a certain point if psilocybin treatments are approved in other nations soon, it might become impossible for the US to keep psilocybin as a Schedule One drug any longer. That dam might finally be bust open by our friends in Europe, Canada and Israel.
Lex really needs to have Robin Carhartt-Harris on his show. He's the premier clinical researcher IMO and he's already rubbing up against the shenanigans of Pharm. If the public knew how little that passes for research actually contributes to health and wellbeing and how much is marketing and trying to get old drugs re-patented it would clearly demonstrate the failure of capitalism to effectively advance health science. I'm speaking here as an inside/outsider, with no stakes in any research but member of an REB.
There are barriers to research, absolutely. However, when an institution like Johns Hopkins Medical School leads the way on it in the US, all that "paperwork" isn't quite as challenging to deal with. They are, after all, a leading medical school and research institution. It is almost like putting a golden seal of approval on psilocybin research. There were others doing the work in Canada and a couple other nations prior to them, but the symbolism of Hopkins getting involved has been enough to lead to a flood of interest and the 50-year taboo around discussing psychedelics as potentially therapeutic is falling away.
Hell, two psychotherapists I know (who don't even prescribe medications) talk about it frequently, even with their patients. They can't actually provide or promote psychedelic therapy without losing their licenses, but there's a buzz around the topic in the world of clinical psychology and psychiatry.
highly recommend michael pollan's book "how to change your mind" to anyone who wants to know more! there is much much more to know about this topic and pollan does an incredible job.
Lol "rich liberal tries drugs and (mostly) handles it okay" is a decent book.
Trying the stuff in a safe controlled setting is definitely better. Though that is way more illegal for those of us that aren't rich and white.
Now it's a series on Netflix
I found the Netflix series interesting, what I would say about all the studies is that they mostly confirm what Deadheads, Phish Heads and DMB fans have known for a while without million dollar studies, it is the reset button on your brain.
I think that psilocybin will help people who suffer from depressed mood or a lack of emotion as it amplifies emotional response. Sadness and despair may be improved through feelings of unity and oneness but I don't think it will improve negative emotions otherwise.
The trial that has no significance mentioned at 4:02 was testing for difference between psicobylin 25 mg alone in two doses vs psicobylin 1 mg in two doses with escitalopram in between. No significance doesn’t mean the drug didn’t work, it may just have meant that the dosage is still no determined. I’m unsure why they added the escotalopram on the other group though as it would’ve been better to have it as a third separate group for control, although that would’ve been a phase 3 trial 🤔
I think it is worth mentioning that people who microdose typically use 10-30 mg 2-3x/week, for 4-8 weeks. If they are studying microdose amounts, they should adhere to a commonly used dosing schedule. It isn’t that surprising to find no significant effect if you are using a dosing schedule that no one has ever touted as effective.
A classmate of my in my Psych masters was doing this for her thesis. She sadly didn't find anything in her study, but she really hopes it can help ^€^
Anecdotal I suppose, but, my partner was severely depressed and suicidal and psilocybin treatment at a clinic saved his life and gave him a positive outlook on life
I have bipolar 2, adhd, autism and anxiety and I did shrooms once. Had to do 4mg to feel anything and then took another 2mg later as it worked its way out of my system. My depression often manifests as not being satisfied or enjoying anything and needing to constantly bounce between activities to get any sort of stimulation... being on mushrooms made me satisfied with just very little. Honestly, I think there's some use for mushrooms in some people. Idk about microdosing but from my personal experience I think it would help me.
Thanks for sharing. Obviously anecdotal reports aren't the science we need, but your story caught my attention. I also have ADHD, recurring major depression and anxiety. Not exactly the same, but I can relate. I have been waiting for any news about studies into psilocybin and ADHD, because (as you know) our brains handle dopamine differently. So differently, that our reactions to psychotropic drugs can be atypical. That (plus the fact that it is still illegal) has prevented me from trying it.
Interstingly ... I've seen more comments like yours from people with ASD than ADHD. And I saw one researcher say on camera that she hypothesized that psilocybin might be able to help ASD people feel more socially connected - and then take that experience back out of the trip into their lives. It was an interesting thought.
That said, if I could shed the depression and anxiety with psilocybin, then only have to deal with the ADHD symptoms, my life would instantly improve tenfold or so. I might not end up waiting for the research to finally happen. Life is too short and depression/anxiety has already wasted too many of my years.
As far as I know 100mg is a microdose where 1000mg is a standard one
Thank you as always for sticking to the data, as well as noting some of these very studies may include publication bias. I'm tired of staunch advocates overhyping the health claims of psychedelics (the same thing happened with marijuana), so I'm all for more research. 💯
I do appreciate having the Data as well, but it hard to not be a staunch advocate when I started Ketamine during a time when I was debilitatingly depressed (only getting out of bed every 2-3 days to eat/drink/go to the bathroom as some of the milder symptoms, it was far worse) and it completely changed my life. Miracle is almost not strong enough a word to explain the difference it made for me. I have my life back and can function normally for the first time in a decade.
I know (anecdotally) that it works, the question I hope can be answered soon is for how many more can it work and why it works for them.
Agreed. All these studies show is that the effects are not extremely detrimental, which is also good data to have.
I'm an advocate of legalisation and of recreative use, while health benefits would not surprise me in the least, more research is needed before we can say anything with any certainty.
talking about bias, the so-called negative result mentioned at 4 minutes in determined psilocybin to be as effective as escitalopram. This sounds like a very positive result. The data can show what the data show, but the fact that this gets reported as a negative result just baffles me. Why would something that can be grown for nearly free performing as well as a first-line antidepressant be interpreted as a "negative" result? If Usain Bolt's speed were being compared to a race horse and they tied, sure, it would be null result. But it would be outstanding.
It reminds me of something I saw on the Vibram toe-shoes many years back- the fact that someone did a study by transitioning a group of runners from regular running shoes to the toe-shoes all at once and not changing their running routine or technique or easing them into it caused the runners some injuries. And these injuries were used to show that the toe-shoes didn't improve their running ability. When what it actually showed is that those toe shoes are SIGNIFICANTLY different than regular shoes and that transitioning to them against ALL of the manufacturer's recommendations went as poorly as the manufacturer anticipated.
Positive and negative results in a scientific paper still need to be looked at in terms of what it means in the real world as well as what it means for what questions should be asked next, and what it means for what questions were intentionally ommitted. Either positive or negative results can mean that something is effective or not effective or good or bad or similar or different.
Yes, that hype and potential bias is one of the most annoying biproducts of the DEA creating an artificial situation where real research on these substances was delayed for decades - all the while spreading misinformation about drug risks and failing miserably to stop consumers from using these substances. They created a situation where hundreds of thousands of people have experience with these substances (largely safe experiences), distrust authorities on drug policy and science and now no longer have any patience left to wait for the science to catch up.
We often talk about the failed drug war and how it is probably responsible for creating drug cartels, violence in and around the black market, not to mention criminalizing addiction, but what you are pointing to is another nasty biproduct of those failed policies.
Couldn't it be considered a bit of a "harsh" conclusion to draw on the study mentioned at 4:00 as a negative? They are comparing it to the gold standard for depression and there was not a significant difference found between the two?
It's negative in the scientific sense, not the practical one. You design a study like this to look for a departure from an expected baseline. Finding the departure is a 'positive' result in that it lends evidence to whatever led you to investigate that hypothesis. A 'negative' result is just one that can't be differentiated from the chosen baseline strongly enough. The criticism of journals not publishing 'negative' results is not a criticism of only publishing 'good' results and ignoring 'bad' results, it's a criticism of publishing seemingly interesting results and ignoring those which may be less interesting/new/surprising but equally valuable to the scientific body of knowledge.
@@PlanckRelic I could probably have been more clear in what i meant. In the practical sense, then, does this negative result not warrant the interpretation "as effective as the gold standard" in this particular study
It's becoming fairly clear, little by little, that psilocybin can be used to treat depression at least in some people. It's just not clear yet how well, how lasting the effects, how safely (for the wide array of patients with depression and co-morbid mental illnesses.)
We should have known this fifty years earlier. Thanks to Nixon's drug laws, we couldn't. How many people suffered from severe depression or are gone because of suicide as a result of his shallow thinking?
Agreed, but corporate America can't profit from naturally grown medicines (mushrooms and cannabis), and therein lies the problem. Follow the money.
Absolutely love Healthcare triage. About as non-biased as you can get and he looks at tons of different studies so you don't have to.
I pray that you will find true peace in Jesus. Here is a story from my best friend that I would like to share with you. God bless you.
Precious Memories-By Sonya Lakey
Family Story
Little did our family of six know that Friday evening, September 24th, 2021, would be the last night our family would be complete. We laughed together, played games, sang, and enjoyed listening as our 16-year-old son, Ethan, played the piano for us. I packed a lunch for Ethan for a church mountain hike he was going on the following day.
My mother (who was visiting from out of state) and I woke early with Ethan on Saturday morning. He hugged me and smiled, never pulling away or rushing me. He got in the car, waved, said he'd see me later and he loved me. It was hard to watch my "new driver" heading out on his own that morning. As Ethan pulled out of the gate, I turned to my mother and said, "It's just so hard letting go." Little did I know how much "letting go" I was really doing. That was the last time I saw Ethan. He did not make it home that evening.
That afternoon, a friend tried to contact my husband, leaving an urgent message to call him back. He tried several times to return the call to no avail. As we were preparing supper, an overwhelming feeling of deep concern for Ethan filled my heart. I quietly blinked back tears. I glanced out the window, half expecting to see a police officer pull up to the house, but no one arrived. However, within a few minutes, a patrol car DID pull into the driveway. In my heart, I feared the worst. My husband and I went out to meet the officer, who confirmed our fears. Hesitantly, he told us our son had fallen off of
a bluff and had succumbed to his injuries. Our hearts were crushed; they still are.
Yet, in all of our brokenness, deep, continual grief and loneliness, our family has such a blessed Hope and assurance that we will see our dear son and brother again. You see, when Ethan was a young boy, he was saved; he put his faith in Jesus alone to forgive his sins and to take him to Heaven when he died. He realized some very important truths from the Bible that he would want to share with you.
His Story
Everyone is a sinner. Sin is any violation of God’s Law. God is holy, just and righteous, and He cannot allow sin in His presence. Ethan realized that he - like all of us - had sinned; and his sin separated Him from God.
“For all have sinned, and come short of the glory of God; ” (Romans 3:23)
“Wherefore, as by one man sin entered into the world, and death by sin; and so death passed upon all men, for that all have sinned:” (Romans 5:12)
He understood that, because of his sin, he deserved to spend eternity in Hell.
“For the wages of sin is death;” (Romans 6:23a) [Wages: price]
“But the fearful, and unbelieving, and the abominable, and murderers, and whoremongers, and sorcerers, and idolaters, and all liars, shall have their part in the lake which burneth with fire and brimstone: which is the second death.” (Revelation 21:8)
Ethan believed that Jesus, God’s Son, paid the price for all sin when He died on the cross - because His sinless sacrifice was the only thing that could satisfy the just demands of a righteous, holy God. Jesus was buried in a borrowed tomb, but He arose the third day, triumphant over sin, death, and Hell. Jesus is alive today!
“For God so loved the world, that he gave his only begotten Son, that whosoever believeth in him should not perish, but have everlasting life.” (John 3:16)
“For by grace are ye saved through faith; and that not of yourselves: it is the gift of God: Not of works, lest any man should boast.” (Ephesians 2:8-9)
Ethan was sorry for his sin, repented (turned), and received by faith the free gift that God offered to him.
“For whosoever shall call upon the name of the Lord shall be saved.” (Romans 10:13)
“...but the gift of God is eternal life through Jesus Christ our Lord.” (Romans 6:23b)
Because of this great salvation, Ethan lived his life serving Jesus. He worked hard to spread this Good News to the world. He is alive in Heaven with Jesus today; and because of this great HOPE in Christ, we know we will see him again soon - not because he was a great kid, but because of his faith in the great Saviour!
“And I give unto them eternal life; and they shall never perish, neither shall any man pluck them out of my hand.” (John 10:28)
Your Story
What about you? What if you had fallen to your death that day - What if you were to die today? Where will you spend eternity - Heaven or the Lake of Fire? There will not be any parties in the Lake of Fire. It is a place of eternal torment for those who reject God's Son.
The Word of God is very clear that there is only One Way to Heaven.
“Jesus saith unto him, I am the way, the truth, and the life: no man cometh unto the Father, but by me.” (John 14:6)
We did not know that Ethan would step into eternity that day; however, because he put his faith in Jesus alone for his salvation, Ethan was ready to go. Some day - perhaps today - you will take your last breath here on earth, and you will step into eternity. Where you spend eternity is determined by what you do with Jesus Christ. Will you accept Him or reject Him? You are not promised another day or another breath. Eternity begins soon - Are you ready?
“...Believe on the Lord Jesus Christ, and thou shalt be saved…” (Acts 16:31b)
“For whosoever shall call upon the name of the Lord shall be saved.” (Romans 10:13)
“(...behold, now is the day of salvation.)” (2 Corinthians 6:2c)
*********************************************************
If you need more help or if you would like to send a word of encouragement to the family, please go to:
facebook.com/GITM-Foundation-113997824650357/
If you don't have a church to attend, we would love for you to join us in person @ Liberty Faith Bible Church in Norwood, Mo. every Sunday morning central time 11:00 A.M., Sunday evening 7:00 P.M., and Wednesday evening 7:00. P.M. where you will hear sound, biblical preaching from God's Word as well as uplifting, godly music.
Or you can join our livestream family at:
libertyfaith.net
Facebook: Reg Kelly-Table In The Wilderness
Sermon audio: Liberty Faith Church Pastor Reg Kelly
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I weigh 280Lbs or 127Kg, I took 2.7 grams of Psilocybin Cubensis and had a 3 hr strong introspective experience. Afterwards I can say that my Suicidal Ideation is no longer a symptom I live with :) , This is not the result of some single moment during my experience but is just something I noticed about myself. Depression down 50% Anxiety raised 30%. Although my experience mildly increased my anxiety I believe this to be a symptom of something disturbing I realized about myself that I wrestled with during the come down. I think I’m eventually going back to veganism which I abandoned last month because I was somewhat homeless but had access to fast food through EBT. I would rate Psilocybin as a 8/10. It helped and I’m a healthier person.
Best psychedelics store
mushy_bible
On instagram
I am feeling the same way also I put too much on my plate and it definitely affect my stress and anxiety levels.
Best psychedelics store
mushy_bible
On instagram
sure
Can it help peoplewith BPD ?
got a friend who doses and its made a noticable impact in his every day mood, guy suffered from depression that most medicines didn't help with, and the ones that did he grew a tolerence for. hoping that Psilocybin gets some more research behind it.
Would you say that drug made him more of a fun-guy?
@@Praisethesunson Don't quit your day job and get new writers if you plan on staying in the laugh game.
I took mushrooms and they made me anticapitalist. Being anticapitalist cured my depression and gave me purpose in life.
So I give mushrooms an 8/10
Best psychedelics stuffs
mushy_bible
On instagram
That mushroom burger was good, but nooo
As a proud mushroom enthusiast, YES. WITHOUT QUESTION YES. When I can find mushrooms I am not just happy when I take them, they can greatly improve my mood for actual months at a time from only a single dose, non-micro of course. 2-3.5 grams can greatly help if not cure depression
Unfortunately, anecdotal reports are not scientific evidence. I wish they were. Life would be so much easier.
its so frustating how for us that have been helped by this substance, because we feel as a objective truth that e does help. But honestly, microdose doesnt make sense... You should take a perceivable dose, its impossible for it to not show you beauty in life, meaning, conectedness which is all depressive people lack
I wonder if there is good research on adaptogenic mushrooms and herbs, these are legal and likely easier to get approval for Research studies e.g. reishi, chaga, lions Mmane, cordyceps
@Bryson Martinez what is this please?
@Bryson Martinez do you have a recommended link or brand please?
Before people get carried away dunking on the the anecdotal examples in the comments below, I just want to say this. While suffering from extreme anxiety and depression, I thought Escitalopram was going to kill me. I couldn't tolerate it for the amount of time it would require to start seeing results. I just couldn't do it. My point is this. If the study results for psilocybin and marijuana have results that are mixed, why wouldn't you still provide them as an option (so long as they're deemed to be safe). Drug safety and drug efficacy are two different things. Particularly in the realm of mental health, there is no such thing as a one size fits all solution. Even anti-anxiety and anti-depressants have mixed results. So again, pending safety, why wouldn't we just view psilocybin and marijuana as options, rather than a one size fits all second coming of Jesus? Whatever helps you feel like you don't want to die, should be a positive.
The only cannabinoids that can treat anxiety are CDB. THC actually increase anxiety. I've been using psilocybin for over 3 years and can attest to the claims that it is an effective treatment for anxiety and depression. That said, it is not a "magic bullet". It can only uncover the root causes of anxiety, depression, PTSD and substance use disorder (mine being AUD). You have to do something with the knowledge and new perspectives. That's called integration, and it's why pairing it with psychotherapy is so effective. And psychotherapy is more effective when you are in this state of "openness" caused by psilocybin.
Have you tried shrooms yet my dude? They are pretty great. Honestly the only thing better in life is WORKERS SEIZING CONTROL OVER THE MEANS OF PRODUCTION.
It sounds like you had an atypical reaction to Escitalopram. Sorry you went through that. Very unfortunate. Psychiatry is still not always a completely precise area of medicine and I join you entirely in hoping for some major advancements in our lifetime. There are other areas of medicine that need similar improvements in diagnosis and treatment, of course. Psychiatry gets its unfair share of criticism most likely because of how common mental illnesses (especially depression and anxiety) are.
There are a few gaps in your thinking above. There's the simple fact that one of the reasons for careful (and, ugh, sometimes plodding) medical research is to maximize, if not ensure safety. For example, there's some evidence that psilocybin might induce psychotic episodes in people who are predisposed to schizophrenia or other psychotic illnesses. Wouldn't it be a good thing to know if that's true and if there are other kinds of people who really SHOULD avoid psilocybin? What if certain anxiety disorders lead to bad outcomes? We don't know for sure yet. That's one reason why we should ideally wait for the science.
Another thing that is missing from your reasoning above: Another major reason for extensive medical research into a substance is to measure its effectivity rates across different population groups, at different doses across time. If someone has a depressive episode and is faced with a decision: "Do I try psilocybin? CBT? an SSRI? a SNRI?", it's obviously ideal to be able to have enough data to say that for that particular person with their psychological and medical history with these symptoms one or another treatment is more likely to provide the best results. It might still be a probability game in psychiatry for now, but that's surely preferable.
As for making psilocybin available to patients before this research can be fully carried out, you're right that there could be a case made for that - at least after we have enough safety data. Our medical system is not designed to administer treatments that are not (yet) proven. That's very much the domain of so called "alternative" or "complementary" medicine which is flooded with all kinds of quackery and folklore, unfortunately. Ethically speaking, doctors could not recommend such unproven treatments. Maybe we need a profession of people who do handle complementary medicine who aren't quacks in the West. I'm not sure. But for now, psilocybin remains in that corner. The corner of crap-shoot remedies.
All that said, none of this would necessarily prevent me from taking matters into my own hands, if I had a bout of suicidal depression and trying psychedelic therapy whether it was legal or not, particularly if it was clear that safety has been sufficiently proven for people like myself. I do think that mental illnesses can be severe enough to warrant more "experimental" treatments, at least in some cases - though those who are mentally ill aren't always the best judges of what is risky and what isn't.
Lexapro is poison for the brain, agree 100%.
I felt like I could think clearly with the mushrooms and more in control of my emotions. As someone who have a mental health diagnosis
@Ricemilk-pr5yv yes
That's strange that's considered a high dose when street use 3.5 grams is standard dose
Mushrooms are cool, but don't take them with high strung and annoying people like my uncle. Be with someone who's relaxed who you get along with or be alone and be in nature on a nice day. If you're around a lot of Karens who might be looking at and/or judging you you might be inclined towards paranoia. You don't see anything that's not there, so don't be expecting elves or dragons and crap like in the movies.
I'll do anything but I can't afford anything because I live in poverty. I would like to get electroconconvulsive therapy but I can't afford it. But no therapies have made any meaningful impact in years. I'm tired, bring on the mushrooms.
Would you be willing to toil in the Amazon mines to access some basic bottom tier mental health?
@@Praisethesunson I'm in wheelchair jackass
I found the benefits of psychedelics to be kinda short lasting, tbh. The perspective shifts were profound at the time, but wore off fairly quickly. In contrast, I found the benefits of intense meditation (Vipassana) to be MUCH longer lasting. It's been over 10 years since I practiced Vipassana regularly, but the techniques and perspectives I developed from learning it are still very helpful today. They've helped a lot with mental wellbeing over the years
Interesting anecdotes.
You don't say whether or not you suffered from any mental illness when you self-administered psilocybin and if that dianosis was conferred by an MD or other clinician.
okay, so that study mentioned at 4 minutes in shows that psilocybin is as effective as escitalopram... and this is being reported as a NEGATIVE result? This sounds like a fairly strong bias to me. I mean, presumably excitalopram has become part of standard care because it is effective, right? And it grows on trees... or more properly, it can grow in cow poop. There are other comments describing the problems with how this study was required to be presented in the journal that published it due to heavy-handed editorial control, but even on this youtube show, calling "it's as effective as escitalopram" a NEGATIVE result seems like following the biased framing that the journal's editors wanted to convey.
I am absolutely sure that psilocybin mushrooms can treat anxiety and depression, as well as substance use disorder. They are absolutely magical. ;)
Sorry, but we should still wait for scientific validation of your claims if possible.
what a shocker, the "science" says that big-pharma SSRI/SNRIs are better. you pronounced escitalopram wrong also.
@Bobby46371 I don't buy it online but Ive been eating psilocybin every night for about a week so far
Hard to be sad when youre laughing!
@Chris_Bartlett what have I got myself into here? Peer pressure on TH-cam at 40.
So scammy. Also shrooms are easy to get in less scammy ways.@Eddie_flores
You've misread the results of that trial. Psilocybin kicked escitalopram's ass.
Don't know about treating anything with psilocybin. My close relative got into a long psychotic episode after using them. Three years down the line he is still on antipsychotics and antidepressants. He was trying self medicate depression with mushrooms, all he got was psychosis to go with his depression.
That’s what we call an outlier. He was unlucky but on the flip side when my friend had to start taking anti-depression medicine he ended up committing suicide. Mushrooms on the other hand always helped his depression. The bottom line is that without ever trying it you have no authority to speak on it’s behalf at all. The person you spoke of was an extremely rare exception. We still sell baby aspirin even though 1-10,000,000 babies dies from an allergic reaction to it. Bottom line if we stopped doing things because it caused even death for a few people medicine would never improve or even continue. Try to think with your head and not just your heart
@@louismasar6147 well, he might not be a rare exception. There is just not enough safety data.
@@louismasar6147 You can't call something an outlier unless you actually have a data-set to demonstrate this mathematically. You anecdotes are no more or less valuable than anyone else's if we actually want to get to a point of understanding the real risks and theraputic uses of any substance. Psilocybin research is promising but inconclusive. That's as far as we can go for now.
C'mon guys...it's pronounced "S"-"sittallopram"; not "eskitalopram". It is the 'S' enantiomer of citalopram.
Escitalopram = (S)-Citalopram
oh! never knew, thanks for the info! [:
That was what I thought too. I thought it was strange when he pronounced it with the k sound, and wondered if I'd gotten it wrong.
There are mushrooms where if you eat them once you'll never be angry, sad or happy ever again!
The green mushrooms. I believe that was in the documentary super mario
Yeah, they are the poisonous ones that will kill you.
So just two doses of psilocybin seems as effectice as the current gold standard, escitalopram - how on earth is this a negative finding?
Furthermore, the author of said study recently commented on (super scientific and peer review) Medlifecrisis TH-cam video, that the study was not designed to show superiority.
I know, right? Listen to Robert Carhart-Harris' explanation of the study. He was only able to report the findings in a particular way because of the study design, but he wished he could report on the totality of the study's findings, which were in favor of psilocybin over the SSRI.
@@onsightitify do you have a video or podcast in mind for his thoughts? Or will a random Google search do the trick? Definitely interested in listening
@@matthewblackwelder6487 I think it was this one from last Sept. th-cam.com/video/mdZcHYZJhws/w-d-xo.html
Anecdotally they work very well for me.
It's "ESS-suh-tal-o-pram", not "ESS-kit-al-o-pram". Escitalopram is the S-enantiomer of citalopram, which is a racemic mix of S- and R- enantiomers.
brb I'll go use NASA's radar dish to find who in the universe asked
@@ofallsadwords3207 While you're there, try to find out who asked for your opinion as well 👍😉
Oh boi, press F to all those brave volunteers who made it through MRI while on mushrooms! O7
Yo I can see the magnetic fields.
-MRI person on the shrooms.
Fake
One thing however is clear.
I'm much more likely to seek and obtain a diagnosis of depression if it means I get to try psilocybin.
That would be a really fucked up thing to do to people who actually are suffering from depression. It's already hard enough to get access to sufficient mental healthcare.
Guys long story short it works I’m living proof
Best psychedelics store
mushy_bible
On instagram
As someone who trips regularly, yes. Yes. Yes. Psilocybin has been a godsend for me. For 20 years, I took a variety of antidepressants (Lexapro, Celexa, Cymbalta, Zoloft, Wellbutrin, and so many others, in different combos and dosages), saw psychiatrists, and went through numerous therapists. Nothing helped me in the slightest. I was cripplingly, hopelessly depressed. I felt like garbage all the time, I had no energy, my life sucked. I was miserable for so, so long.
Finally, I got clean off the antidepressants, and started tripping twice-yearly on magic mushrooms in very carefully planned trips (myself; not guided by anyone else). OMG my life has changed. I find so much more peace and joy in my life. I've become spiritual and regained happiness. I am more level-headed, less quick to anger, far few crying jags (still a few, linked to the hormonal swing of my period), and far, far, FAR happier in general. I never thought I'd get to this point. I didn't think it was possible.
Psychiatry and the US medical establishment taught me that I was broken and I needed tons of (addictive) pills and constant therapy. All of which made certain people a ton of money. Mushrooms showed me reality: money is made up, psychiatry is made up, medicine is made up. You live, you die, you are reborn, you live again, you die again, an endless immortal cycle. So let go of your pain, let go of your fear, let go of your constructs. Let go and be reborn.
Of course they told you that how else would they get money?
Amen sister. Ego-death will save humanity.
As someone who's not willing to risk my family and my future for illegal drugs, where does that leave me with options?
@@BlueCyann you need to analyze the concept drug and read more about the subject before commenting something so unbiased cause the truth is you’re saying that cause you know nothing about this
@@eduardogamez2661 I have no idea what the fuck you are trying to communicate.