Beautiful explanation! I am preparing for my pulmonary boards and there was a question on pleural effusions and multi-system toxicity after getting treated for APML. It asked what was the patient treated with and the answer was arsenic trioxide. Thanks for explaining it so clearly!
I was diagnosed with APL in November 2018 and experienced DS 3 weeks after beginning ATRA/ATO. My symptoms were minor at first- rash and low grade fevers so I was given vancomycin, which only seemed to complicate matters as I got worse and ended up with acute renal failure (now a chronic kidney disease). I was moved to NTCC where I was sedated and dialysis was started. DS almost cost me my life. I wonder if the choice of steroid matters.
Would you ever be in a position where you would need to differentiate between differentiation syndrome and febrile neutropenia in a patient with acute promyelocytic leukemia?
Neutropenia is not likely after treating aPML as vit A doesn't cause marrow suppression also differentiation syndrome develops only after the treatment of aPML
@@aimbotff2860 I know this comment is old, so I'm just adding some perspective from a (well-educated) patient in 2024. Nowadays the standard protocol is ATRA + arsenic trioxide (ATO) concurrently for new cases of APL. ATO certainly causes immunosuppression so, yes, you could have both DS and febrile neutropenia. I had DS and was neutropenic during the 2nd-3rd week of my treatment. Thankfully did not develop any fever!
so we have promyelocyte malignant cells which give rise after maturation to basophils , eosinophils and neutrophils .. why we only focused on neutrophils ?
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U make everything simple to understand. Trait of an excellent teacher. Vice versa also holds true. Some ppl make simple things way more complicated..
Thank you so much 😊
Beautiful explanation! I am preparing for my pulmonary boards and there was a question on pleural effusions and multi-system toxicity after getting treated for APML. It asked what was the patient treated with and the answer was arsenic trioxide. Thanks for explaining it so clearly!
My pleasure 😇
Good luck 🍀
I like how the videos are short and to the point. Thank you for making them
Wow! I am so glad you liked them...Thanks for taking time to share this...I appreciate that :)
Binge watching your hema playlist!!! I learned so much in one day wow.............
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Awesome! You just nail down every topic like cheese! Respect from an internal medicine resident.
Thanks for watching!
Can you please help me by sharing?
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Thanks, dear!
Awesome dude🌹
Keep it up, i wish u started making these videos 6 years back, to help me get knowledges during my university time 😂
Appreciate it! Thanks a million! I will keep it up!
I was diagnosed with APL in November 2018 and experienced DS 3 weeks after beginning ATRA/ATO. My symptoms were minor at first- rash and low grade fevers so I was given vancomycin, which only seemed to complicate matters as I got worse and ended up with acute renal failure (now a chronic kidney disease). I was moved to NTCC where I was sedated and dialysis was started. DS almost cost me my life. I wonder if the choice of steroid matters.
Clear explainations. Good job!
Thank you so much!
Thank you you are making medicine easy we are self studying at home and your videos are explaining everything with ease may Allah bless you
You too!
Thank you 🙏
Thanks a lot for this beautiful explanation.
My pleasure, brother!
Thankyou V much Sir ..... Watching it in quarantine .... CRAZY !! Isn't it 😂😂♥️♥️🇵🇰🇵🇰
why is the blasts < 9% if the leukemia is acute (if blasts in ALL is >20%)
i agree, normally blasts less than 9 % must be chronic myeloid leukemia
Would you ever be in a position where you would need to differentiate between differentiation syndrome and febrile neutropenia in a patient with acute promyelocytic leukemia?
Neutropenia is not likely after treating aPML as vit A doesn't cause marrow suppression also differentiation syndrome develops only after the treatment of aPML
@@aimbotff2860 I know this comment is old, so I'm just adding some perspective from a (well-educated) patient in 2024. Nowadays the standard protocol is ATRA + arsenic trioxide (ATO) concurrently for new cases of APL. ATO certainly causes immunosuppression so, yes, you could have both DS and febrile neutropenia. I had DS and was neutropenic during the 2nd-3rd week of my treatment. Thankfully did not develop any fever!
Yesterday I started using tretinoin cream my chest pain why
so we have promyelocyte malignant cells which give rise after maturation to basophils , eosinophils and neutrophils ..
why we only focused on neutrophils ?
1:30azotemia
U r so awesome
???? ELI5
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I think are u sleepy
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