Estrobolome: How the gut affects hormones • Gut microbiome & estrogen levels

When I hear that someone’s experiencing hormone imbalance symptoms of painful period cramping, heavy periods, and/or menstrual clots, I get curious about what’s affecting their hormone levels.
Research shows that the gut microbiome regulates estrogen levels through a protein called beta-glucuronidase. Scientists suggest that this protein reactive estrogens, which enables the hormone to act on receptors to cause its physiological effects in the body
✅Watch this video to learn more about the estrobolome
This post does not constitute as medical advice; is not meant to diagnose, prevent, treat, or cure any conditions or disease; and is meant for educational purposes only. The information in this post does not replace the advice of your provider. Speak to your doctor before starting anything new.
References:
Baker JM, Al-Nakkash L, Herbst-Kralovetz MM. Estrogen-gut microbiome axis: Physiological and clinical implications. Maturitas. 2017 Sep;103:45-53. doi: 10.1016/j.maturitas.2017.06.025. Epub 2017 Jun 23. PMID: 28778332.
Elmassry MM, Kim S, Busby B. Predicting drug-metagenome interactions: Variation in the microbial β-glucuronidase level in the human gut metagenomes. PLoS One. 2021 Jan 7;16(1):e0244876. doi: 10.1371/journal.pone.0244876. PMID: 33411719; PMCID: PMC7790408.
Ervin SM, Li H, Lim L, Roberts LR, Liang X, Mani S, Redinbo MR. Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens. J Biol Chem. 2019 Dec 6;294(49):18586-18599. doi: 10.1074/jbc.RA119.010950. Epub 2019 Oct 21. PMID: 31636122; PMCID: PMC6901331.
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