The Most Feared Side Effect of Antipsychotic Medications
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- เผยแพร่เมื่อ 4 มิ.ย. 2024
- I get a lot of questions about the risks and side effects associated with antipsychotic medications. These medications are no longer used exclusively in schizophrenia, and they are now widely accepted as treatment for bipolar disorder, adjunctive therapy for depression, and even severe anxiety disorders resistant to other medications.
Time stamps:
Introduction: 00:00 to 01:35
What is the most feared side effect: 01:36 to 02:11
Dopamine and EPS: 02:12 to 04:54
Myths About TD: 04:55 to 08:01
Risk factors for developing TD: 08:02 to 10:13
Risk of TD with second Gen Antipsychotics: 10:14 to 13:15
Treatment for TD: 13:16 to 16:23
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Permanent loss of emotions, anhedonia and sexual dysfunction and many others are far more terryfing. too bad they don't mention these in the leaflets and shrinks don't know about the reality of taking these drugs, so if you complain to them abiut these they just say "its your illness, not the drug"
My doctor prescribed Risperidone for my Bipolar mania phase, but I saw that it is an antipsychotic, now I have doubts
Thanks for this great video!
Do antipsychotics destroy the dopamine receptors forever?
I want to know this too. I feel like my dopamine is lost.
I've heard that it takes months, a year or in some people maybe two to recover.
Do psychiatrists even care ? Do coroners cover up suicides ?
Same here it destroyed my dopamine 😮
Me too
I was prescribed 2mg of Abilify in addition to an anti-depressant. It did help me quite a bit but within a few weeks I started having facial twitches and shaky hands. I stopped taking it and within 3 days those issues resolved themselves completely. Bummer, as it actually worked for depression, but I was not willing to continue taking it due to concern about TD.
We are thankful for you.🎉
My daughter has Tourettes. In 2020 she was put on Pimozide. We know the possible side effects. Her tics were so bad that they were convulsive. She couldn't eat, or sleep or walk. She tried to end her life. Pimozide has saved her life. She now has no tics and is living a good life.
Great to know about this 😊😊
Love your videos, very informational!!!!!
not to sound stupid but what really is the difference between akathisia and TD?
Well I have seriously considered it and would wish everything else would be tried before administration of antipsychotics, with appropriate periods to try them. I think antipsychotics need to also be a restricted substance, only antidepressants should be able to be prescribed as they seem safer aside from sexual dysfunction but I would gladly trade all cognitive impairment and the loss of mental ability, emotional depth, just everything I currently experience for just having sexual dysfunction as I never used that system anyway.
What should a care giver of a person with schizophrenia look for specifically to identify the beginning stages of tardive dyskinesia?
Trembling of the hands, eyes, lips. Rolling of the eyes (oculargyric crisis) is a sudden onset type of dystonic reaction, same with the jaw and tongue. In my case anyway
Shrink in sneakers sounds like a weight loss channel for runners.
What supplements help with antipsychotic withdrawal
AKATHISIA is far more deadly
Neurological damage manifesting from neurotoxins declared safe and effective.
I hate antipsychotics
@@xxbeccabrutalityxx7873Wow you're so unique. People usually want to quit because of side effects not worth the benefits anymore.
@@cuekinaja I quit them a while after making that comment bc of the side effects ngl. Never thought I would, but I did. Last night, hallucinated having everything I ever wanted.. I'm in such a dark place now, after quitting them. But if this delusion can sometimes give me everything I everwanted, rather than the delusion of being less than miserable on meds, maybe it isn't so bad after all.. idk... I'll probably end up back in the nut house very soon tbh... but wow it felt so good to pet my deceased cat and to hold my baby brothers again... I just wish it had been real and not a hallucination
Maybe it's better if I never stop my meds again
I'm so sad all the time now, worse than before. But I finally got to hold them all one more time. Even if it wasn't real. Even if I quit my good job and now make part time minimum wage. Even if I cry all the time and developed alcoholism since quitting my meds this year
At least I got to hold them
I'm not being sarcastic or funny or a dick. I'm just so conflicted and confused now. Like, what really is better? Being emotionless, or being miserable yet occasionally (even if it was a hallucination) getting to love the ones I love most one last time?
Is a better job really worth never seeing their beautiful faces again? I'm not so sure anymore.
Is it better to be easy to understand and empty, than to be difficult and sad yet at least true and real? No clue now
I'm sure I'll go back on them soon. But god damn... it felt so good to be able to hold them one more time. It felt so fuckin real. Damn
Ditto
What is the range of dosage that would cause TD ? I take 10.5 mg every 2 days. I take Caplyta. I have BiPolar Depression type II
Once in a while, you could add an answer to a question
Hey, this is kind of off topic for this video but I have a question. I know that atypical antipsychotics are commonly used for augmentation with SSRIs, but is there a reason for this beyond the obvious "they both work as antidepressants, so using both is sometimes better than only using one". Do they work synergistically together or does it really just come down to what I wrote in the quotes. Sorry if this is too deep of a question for a youtube comment. It's okay if you can't answer this fully here. Thanks for the videos!
Many of the atypical medications have mechanism that result in antidepressant effects. For example abilify will increase dopamine levels and act as an agonist in low dopamine states at 5-10 mg/day. Seroquel will stimulate serotonin receptors at 150-300 mg doses, same goes for ziprasidone. So it's not the dopamine D2 blocking effects that help with depression it's these other minor mechanisms that can be leveraged for the antidepressant effects. Hope this makes some sense
@@ShrinksInSneakers My doctor prescribed Risperidone for my Bipolar mania phase, but I saw that it is an antipsychotic, now I have doubts
@@ShrinksInSneakers there use to be drofmindmd psych doc on youtube who you really resemble because he as you really liked play with every psych substances and dosages. Just like you, he desappeared and you will probably follow his way sooner or later.
@@ShrinksInSneakersFrom where I stand; the manner in how many psych meds work (especially RE: antidepressants, antipsychotics/neuroleptics, & benzodiazapines), I'm so much better off DRINKING BEER!!!!! Alcohol (the primary ingredient in beer) has the same effect as psych meds but leaves ur system much quicker than psych meds do.
I take resperidone because of this i face erectile dysfunction please tell solution
Liked your video.
Hey I am on olanzapine 5mg.
Does olanzapine also gives TD ?
Every antipsychotic carries the risk of TD.
There is always risk it's significantly lower in the newer medications as explained in the video.
@@ShrinksInSneakers ok
what about Abilify which caused my TD or Seroquile?
Can you do a video on propranolol?
Thats a good one we haven't covered
I take propranolol everyday. I too would like to know more about it.
how common is it for people with TD to switch to clozapine? i remember reading somewhere that it is the drug of choice for when TD is present but stopping antipsychotic treatment is not feasible
It's a good option in that cases and has the lowest risk. That would be one strategy the other option would be to use the new FDA approved treatments VMAT-2 inhibitors.
Keep going
I don't think I'm stopping
Eat more protein. Your blood sugar will level & so will your moods
Seroquel saved my brain from ocd, but gosh i got paralysis, face ticks..i have small dose 12mg, like nothing, but to stop it it is even worse..😢 but eating keto do the magic
What did you experience when trying to stop seroquel? I just started on 25mg for C-PTSD and BPD
@@xujznajit not good, alot of ticks, huge insomnia...so i Rather take the small dose 🙏
I'm on 700mg of Invega Trinza (two 350mg shots) every three months and 2.5mg of olanzapine every night. What are the chances that I will develop tardive dyskinesia?
Ps. I've had a lot of acute EPS on Haldol 1mg, olanzapine 15mg and Invega Sustenna 100mg + clozapine 25mg.
This is beyond the scope of what I can answer here but the The cumulative incidence is about 4% to 5% annually; the prevalence rate is 20% to 30%. It's significantly lower in those taking second generation medications, and much lower in younger adults than older adults. Clozapine has virtually no risk. Schizophrenia itself is known to cause movement disorders in the absence of antipsychotic treatment which is a fact few are aware of
Thanks.
I'm 27 and I started taking them a few years ago, so I guess the risk is low.
When I took Invega Sustenna along with a really low dose of clozapine (25-50mg), I had a lot of akathisia and also acute dystonia of the neck. And also postural hypotension.
Furthermore, when I took about 200-300mg of clozapine alone, I felt extremely sedated and had sialorrhea. So I guess clozapine is not a good drug for me.
@@kauebotsman2676 clozapine sialorrhea can be treated effectively. You can also follow blood levels which have a clearly defined range. There is virtually no risk for TD and EPS risk. I'm still a fan and sometime dosing it all at night helps with sedation.
But I used to take it all at night, and still was sleeping all day long. And the few hours I was awake, I actually felt like I was in sort of a dream-like state.
Also, the weekly blood tests were kinda annoying.
But I know it's a good drug for many people. Just didn't work well in my case
@@kauebotsman2676 thats fair, there just aren't a whole lot of places to go from there with said evidence from a pharmacology perspective. People don't always think about it but CBT has been shown to help with positive symptoms
The Most Feared Side Effect is Neuroleptic induced deficite syndrome.
Exactly
Side note: they're now prescribing anti-psychotics for autism. Seriously.
As the famous psychiatrist, Peter Brians would say, psychotropic drugs, or neuro toxic
I knew it!
You get the prize
My husband was killed by his antipsychotic med.
Olanzapine
My Mom just died from it cause her heart to stop!😢
qT prolongation sudden death
Experimental chemicals. Tested on humans. Nobody knows the long term effects.
there is a new anti comming called KarXT
I talked about this in another video, it stimulates M4 and M1 cholinergic receptors. This is a way of modulating dopamine and glutamate transmission without directly blocking dopamine receptors. I believe they hope to have this medication approved by the second half of 2024
Nope. Akathisia is the worst.
The biggest fear is Drs prescribing without warnings of possible side effects thus there is no informed consent.There is the chance of neck and trunk seizures(not just TorticolIis) and the torture of akathesia.For some men it is the loss of sexual function.(yes spare us the bullshxt that it very rare)
why do antisphychotics cause sexual dysfunction ?
Cuz its poison🧠🧪
They can affect your hormones and dopamine receptors
There’s no magic pill
Should call this video The side effects of going to a psychiatrist the most feared person to go too
lol, I like this it just hasn't been my experience that seeing a psychiatrist is scary or dangerous unless the goal is to create more stigma surrounding the evidence based treatment of mental health disorders. Cool part is I treat people every day with severe mental illness and it's hard to appreciate if you never treated anyone who is grossly psychotic or manic
I was in a hell of a lot more fear when I was too manic and delusional to be able to ask a psychiatrist for help. After going to my psychiatrist and a mental hospital, I can finally live within reality again. I can eat, sleep, think, and heal now. I'm more afraid of the stigma attached to getting the necessary help for disorders like mine than I am of my doctor
@@xxbeccabrutalityxx7873 everyone is different, some people don’t experience side effects but those who do experience pain
Stay away from psychiatrists.
The only way you can conquer happiness and tranquility is by living your life with out drugs… legal, illegal.. fact !
why are u screaming? pls man this sounds bad