Thank you so much. I have been listening to my lectures, none of which made sense and you summed it all up in a way I understand in a couple of minutes. Not all professors should be lecturers!
Once I realized that physio would not make any improvement in the spasticity of the affected muscles and tendons below the waist, I gave up on it and chucked the useless and painful foot orthotics in the bin. The standard management of this disease wore me out, with very poor outcomes, although for a short time after multi level corrective surgery, of hip alignment and calf and rear knee tendon lengthening, I did gain some physical strength from an exercise program however, no improvement on the diplegia at all. I always found it odd why It was never suggested to me, the possibility of undergoing SDR (Selective Dorsal Rhysotomy) at age 12, instead my specialist took the alternative procedure. Oops! Tough cookies for me I guess. With the funny walk, has for me come a rather sedentary and somewhat; well can I say lonely lifestyle. In my 30s now, One might say I've accomplished A LOT in spite of CP, but from my personal standard of 'being a normal, healthy 'apparently good looking man' with all functions, and the same opportunities as others, not so much. And please, I don't need any medals for making it to my 30s, that's just lowering the standards of a very dog-eat dog world, and does nothing for character building. Although I paint a grim picture, it is however the cold truth of the situation. The only way one will truly benefit from an exercise program is to reduce spasticity with SDR, which I plan on looking into. Even with SDR's risk of incontinence among other unintended side effects, It sure does beat the assumption of deafness, intoxication, polio, intellectual disability, infertility, inability to perform well during intimacy or have any relationship at all, or worse! Being a total 'Champion' for accomplishing nothing other than putting up with this, with nothing to show for it, other than some charities, giving you free expensive stuff to raise your spirits, that's not to say I wasn't grateful. but, you know what I mean. No CP support groups either! thanks, it just bundles the problem all together in one room, where the privileged don't have to deal with it. It doesn't make it go away. and I've never personally gained psychological benefit from hanging out with other sufferers of the disease, it only compounded the reality of the situation. "Thanks for the reminder, I'm not normal, got it, now what?" Some might call me selfish, But, I cannot stand to be in the company of more suffering. As mentioned above, the ONLY true way you can exercise weak muscles is to turn off the constant fight against the high tone and stiffness, giving the weak and tired muscles a break, then perhaps rehabilitating them. and creating new pathways in the brain to take on the role of the once affected spinal cord and nerve pathways. bata-big-bata-boom CP. gone! or significantly reduced. If you end up with Spastic diaplegia, the only winners are physios, Occupational Therapists, foot orthotic manufacturers, assistive tech and wheel chair manufacturers and big Pharma. Oh and the fund-raisers and endless charities, who bring in BILLIONS of dollars! To date I've not seen a single dime spent on a cure, nor have I seen any medical approval for the free use of stem cell therapy pre or post injury to reverse the condition in children, teenagers or even the middle aged or elderly. Someone is lining someone else's pocket, I'm sure of it. The affected person and their family will always lose, unless the spasticity is taken away 100% or a cure for this cruel disease is found. Like they say; "The Squeaky wheel gets the oil" Well, I'd better get to work. If I may put it bluntly to again highlight the cruelty of society; If I can help it, No one with this rubbish deck of cards shall be deemed a 'spastic', retard or a cripple anymore! not on my watch. I was a pioneer in my school years copping those kind of taunts, and yet here we are, it continues to this day in some form, even with the curiosity of others, which in tern does nothing other than have me reliving the constant bullying, name calling and out-and-out exclusion from activities at school, along with less than adequate education due to poor teacher training. Time for a cure for ALL forms of Cerebral Palsy and associated medical problems! It's not funny anymore. And no child with the disease is a miracle baby, that's just condescending. From personal experience, like many terrible terrible diseases, its a fate worse than death.
Good but your explanation missed how the Globus Pallidus external is involved: From my understanding, the Basal Ganglia (Basal Nuclei) Indirect pathway is as follows: 1)Starting from the motor cortex, signal travels to Neostriatum (Caudate Nucleus and Putamen) then to Globus Pallidus EXTERNAL. 2)The signal continues traveling to the subthalamic nucleus and then to the Globus Pallidus INTERNAL. 3) Finally the signal goes to the Thalamus (Ventral Lateral [secondary: Ventral Anterior, Central Medial] Nucleus ) which will influence the motor cortex. Here I also believe Striatum is also known as Neostriatum.
Thank you so much. I have been listening to my lectures, none of which made sense and you summed it all up in a way I understand in a couple of minutes. Not all professors should be lecturers!
you are amazeballs, my brain works weirdly and your dog analogy helps so much. thank you so much
You just saved my neurobiology exam, thank you so much 🧡
This video has my 3 favorite things: soccer, puppies, and ice cream. Thank you!
Once I realized that physio would not make any improvement in the spasticity of the affected muscles and tendons below the waist, I gave up on it and chucked the useless and painful foot orthotics in the bin. The standard management of this disease wore me out, with very poor outcomes, although for a short time after multi level corrective surgery, of hip alignment and calf and rear knee tendon lengthening, I did gain some physical strength from an exercise program however, no improvement on the diplegia at all. I always found it odd why It was never suggested to me, the possibility of undergoing SDR (Selective Dorsal Rhysotomy) at age 12, instead my specialist took the alternative procedure. Oops! Tough cookies for me I guess.
With the funny walk, has for me come a rather sedentary and somewhat; well can I say lonely lifestyle. In my 30s now, One might say I've accomplished A LOT in spite of CP, but from my personal standard of 'being a normal, healthy 'apparently good looking man' with all functions, and the same opportunities as others, not so much.
And please, I don't need any medals for making it to my 30s, that's just lowering the standards of a very dog-eat dog world, and does nothing for character building.
Although I paint a grim picture, it is however the cold truth of the situation.
The only way one will truly benefit from an exercise program is to reduce spasticity with SDR, which I plan on looking into. Even with SDR's risk of incontinence among other unintended side effects, It sure does beat the assumption of deafness, intoxication, polio, intellectual disability, infertility, inability to perform well during intimacy or have any relationship at all, or worse! Being a total 'Champion' for accomplishing nothing other than putting up with this, with nothing to show for it, other than some charities, giving you free expensive stuff to raise your spirits, that's not to say I wasn't grateful. but, you know what I mean.
No CP support groups either! thanks, it just bundles the problem all together in one room, where the privileged don't have to deal with it. It doesn't make it go away. and I've never personally gained psychological benefit from hanging out with other sufferers of the disease, it only compounded the reality of the situation. "Thanks for the reminder, I'm not normal, got it, now what?" Some might call me selfish, But, I cannot stand to be in the company of more suffering.
As mentioned above, the ONLY true way you can exercise weak muscles is to turn off the constant fight against the high tone and stiffness, giving the weak and tired muscles a break, then perhaps rehabilitating them. and creating new pathways in the brain to take on the role of the once affected spinal cord and nerve pathways. bata-big-bata-boom CP. gone! or significantly reduced.
If you end up with Spastic diaplegia, the only winners are physios, Occupational Therapists, foot orthotic manufacturers, assistive tech and wheel chair manufacturers and big Pharma. Oh and the fund-raisers and endless charities, who bring in BILLIONS of dollars! To date I've not seen a single dime spent on a cure, nor have I seen any medical approval for the free use of stem cell therapy pre or post injury to reverse the condition in children, teenagers or even the middle aged or elderly. Someone is lining someone else's pocket, I'm sure of it.
The affected person and their family will always lose, unless the spasticity is taken away 100% or a cure for this cruel disease is found. Like they say; "The Squeaky wheel gets the oil"
Well, I'd better get to work. If I may put it bluntly to again highlight the cruelty of society; If I can help it, No one with this rubbish deck of cards shall be deemed a 'spastic', retard or a cripple anymore! not on my watch. I was a pioneer in my school years copping those kind of taunts, and yet here we are, it continues to this day in some form, even with the curiosity of others, which in tern does nothing other than have me reliving the constant bullying, name calling and out-and-out exclusion from activities at school, along with less than adequate education due to poor teacher training.
Time for a cure for ALL forms of Cerebral Palsy and associated medical problems! It's not funny anymore. And no child with the disease is a miracle baby, that's just condescending. From personal experience, like many terrible terrible diseases, its a fate worse than death.
Good but your explanation missed how the Globus Pallidus external is involved:
From my understanding, the Basal Ganglia (Basal Nuclei) Indirect pathway is as follows:
1)Starting from the motor cortex, signal travels to Neostriatum (Caudate Nucleus and Putamen) then to Globus Pallidus EXTERNAL.
2)The signal continues traveling to the subthalamic nucleus and then to the Globus Pallidus INTERNAL.
3) Finally the signal goes to the Thalamus (Ventral Lateral [secondary: Ventral Anterior, Central Medial] Nucleus ) which will influence the motor cortex.
Here I also believe Striatum is also known as Neostriatum.
agreed,amazing,the way of explanation is cool..thanks
Love the vids Emma.
Thank you
great video. thank you.
Agreed!!