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- เผยแพร่เมื่อ 21 ก.ย. 2024
- In this video I have explained how alcohol is metabolised in the liver. Alcohol or ethanol is metabolised predominantly in the liver into acetaldehyde. Alcohol is metabolised into acetaldehyde by alcohol dehydrogenase. Acetaldehyde is further metabolised into acetate by acetaldehyde dehydrogenase. Acetaldehyde is the toxic byproduct of alcohol. Most of the toxic metabolic effects of alcohol is because of acetaldehyde and increased levels of NADH+H. Alcohol causes changes in variety of metabolic pathways leading to various signs and symptoms.
You can watch my video on toxic effects of alcohol as in the link below.
• Alcohol - Its EFFECTS ...
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you are the best teacher i have ever meet and with a kind face
Sir what's your refrence? U explained all in easy way thank u so much sir love from nepal😊
This is very nice video sir...
But want to know about cyt p50 e1
Dr, I really appreciate what u are doing .. keep up the good work! This was so helpful
Thank you. I will.
Wow sir the explanation was wonderful
What is the reason why the percentage of alcohol decreases since the temperature of alcohol first comes during fermentation? Example 1 st liter abv 70 % Next 2 nd liter abv 30 % but why......?
Thank u,sir
from Bangladesh
Great explanation dr sir Tq somuch
You are most welcome.
Really helpful for my today's xm!thank you!
You are most welcome. I'm glad this video has helped you.
It is my humble understanding that most enzymes require one or more minerals to activate enzymes. Am I correct in remembering that in the pathway(s) you have described zinc and molybdenum are necessary for these reactions to proceed?
Many trace metals acts as a cofactor for enzymes and are some times required for enzyme activity (meaning necessary requirement), some acts as modulators of enzyme activity.
(Alcohol dehydrogenase) enzyme has ZINC as its cofactor , while (acetaldehyde dehydrogenase) enzyme has COPPER as its cofactor !
BTW ; I read in textbooks that an isozyme of (acetaldehyde dehydrogenase) enzyme utilizes FAD as its coenzyme to yield in the process FADH2 !
what are the pathways for a chronic alcoholic person
Superb work
You are the best doc
Thank you.
Are u a doctor or Msc
Dr.I Really Want You salute,Good Job, Sir Actually This days i m suffering from Asian flush syndrome when i taking little qty(30 ml) of any alcohol i have rashes and hives in body ,starting headache and fast heart breathing and eyes are like tomato and face is totally hot, so please any cure or medicine for this problem i want casual drink some time not like addict so please please please sir help me .
Dr. Mungli,is there a class of person that doesn't metabolize acetate normally?? And does high levels of acetate produce what is known in AA circles as the "phenomenon of craving"?
Good job sir
Love from pakistan
bestttttttt explanation
Thank you.
What are the risk factors of ALD
I did not quite get your question.
Thanks Dr Mungli. Does Metadoxine work in the case of EtOH value of 364?
Metadoxine has shown a benificial effect in both acute and chronic alcohol intake. 364 seems potentially fatal alcohol concentration.
Yes, I thought it was a sad case with EtOH=364. Some person sent it to me to review. The patient was presented with 20% of the body with 2nd degree burns but, with a COHB=4.1%, normal for a smoker. Initially the doctor reported acidosis with pH-7.24/PCO2-24/PO2-138. The doctor didn't give any medication, hemodialysis, only athe used a cynanokit that turned the urine etc... purple which I think is normal if combine with the old kit of methylene blue and the new kit, and intubated with respirator values of TV-450/AC-26/Peep-5/FIO2-50%. This changed the ABG to pH-7.40/PCO2-36/PO2-183/HCO3-20. Only pushing the PO2 high to 183. This value also seems dangerous high. What is a extremely dangerous level of PO2? I know the normal high limit is 100.
They say people who have strong aldh2
Enzymes have higher tolerance of alcohol
Than aldh2 deficit people (whi have high risk of getting cancer also )
So that means aldh2 people are safe to drink
Or they have great chances of getting fatty liver in future?!
How to prevent acetalddehyde
Wow
Explained it so well thank you
Glad it was helpful!
Good analysis
Sir
Thank you.
Sir please explain in hindi
Sir please explain in hindi