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This is possibly the ONLY reason I'd take Prozac after reading the trials that got it approved. I occasionally infuriate doctors by refusing "off label" prescribing. I'd much rather have a medication for it's intended purpose than for it's interesting side effects. Mostly excited to discover a new energetic here!
@@chemistryofquestionablequa6252 why do you refuse them? do the off-label medications just not work as well or do they work but the side effects aren't tolerable?
I saw this paper and thought it was super interesting. I think we will see lots more examples of this, especially with the machine learning and "AI" methods being developed.
16:10 I wonder what happened to the sertindole results. Most of the drugs on the ass end of this spectrum had relatively weak activity, but sertindole appears to have some sort of subgroup-selective conflicting effect. On a few patient samples and all three cell lines, it is as effective as VORT, but it makes things worse often and badly enough to be the second worst drug on the list, on average. I wonder if this is just noise, or there is some difference in gene expression that decides if sertindole harms or helps the cancer cells.
0:40 "We've only recently realised it's explosive" Jesus, really!? That much nitrogen in one place automatically puts this in the "probably explody" category for me!
Antidepressants increase BDNF signalling and through that excert neuroprotective effects towards glia cells and neurons. Inflammation gets downregulated, the capability to buffer and withstand oxidative stress increases. BDNF is closely related to actual nerve growth factors/hormones, which could prove as a double edged sword, since it could actually promote the growth of an existing tumor, make it more resilient against treatment and improve its capability of immune system evasion.
The neurotoxicity of flourine should be enough to make anyone stop taking SSRIs. Yet here we are trying to repurpose that toxicity. What a time to be alive.
Hey there - thanks for watching! Let me know how you liked the video and if you have any questions or suggestions.
Thanks to all my channel supporters! www.patreon.com/totalsynthesis | instagram.com/totalsynthesis_official/
So Temozolomide is gone be the next Explosion & Fire vid? i guess
Call it "Fighting cancer with explosives" or something like that.
This is possibly the ONLY reason I'd take Prozac after reading the trials that got it approved. I occasionally infuriate doctors by refusing "off label" prescribing. I'd much rather have a medication for it's intended purpose than for it's interesting side effects.
Mostly excited to discover a new energetic here!
you're missing out.
@@pocpic nah, I've tried a lot of the common "off label" Rx meds and antidepressants.
@@chemistryofquestionablequa6252 why do you refuse them? do the off-label medications just not work as well or do they work but the side effects aren't tolerable?
Off label is made up tbh. It does the same stuff for everyone.
@@chemistryofquestionablequa6252 SSRIs are neurotoxic. End of story
Chlorpromazin and trifluoperazin has shown promise in various brain infections
Might be worth makng a video on?
I saw this paper and thought it was super interesting. I think we will see lots more examples of this, especially with the machine learning and "AI" methods being developed.
Excellent content
Thanks Giga Chad!
Love the coverage of the biology aspects, great
Glad you liked it!
Great video. Super interesting papers and underlying mechanism. Thank you for the great video. ☺
Why mixed up?
16:10 I wonder what happened to the sertindole results. Most of the drugs on the ass end of this spectrum had relatively weak activity, but sertindole appears to have some sort of subgroup-selective conflicting effect. On a few patient samples and all three cell lines, it is as effective as VORT, but it makes things worse often and badly enough to be the second worst drug on the list, on average. I wonder if this is just noise, or there is some difference in gene expression that decides if sertindole harms or helps the cancer cells.
I actually got this one on time!
Yasss
It seems Methadon ist very effectful in case of brain tumors..😊
0:40 "We've only recently realised it's explosive"
Jesus, really!? That much nitrogen in one place automatically puts this in the "probably explody" category for me!
1000%
Antidepressants increase BDNF signalling and through that excert neuroprotective effects towards glia cells and neurons. Inflammation gets downregulated, the capability to buffer and withstand oxidative stress increases. BDNF is closely related to actual nerve growth factors/hormones, which could prove as a double edged sword, since it could actually promote the growth of an existing tumor, make it more resilient against treatment and improve its capability of immune system evasion.
A missed opportunity to highlight the pivotal role of thalidomide in the discovery and development of PROTACs.
I go into degraders at the end of my thalidomide video!
There’s a problem with with the mechanism at 7:38 ain’t it?
Why?
I don’t know how chemist doesn’t realise that is an explosive just by looking at it
Never feel too safe around that many nitrogens
The neurotoxicity of flourine should be enough to make anyone stop taking SSRIs. Yet here we are trying to repurpose that toxicity. What a time to be alive.
what are you talking about?