Plasminogen and Plasmin (Fibrinolysis)

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►👨‍🏫💊Antibiotics Lectures: www.medicosisperfectionalis.c... ... Check out my brand new "Electrolytes" course at www.medicosisperfectionalis.c... and use the PROMO code: ELECTROLYTES50 to get a 50% discount. Tissue plasminogen activator (tPA) converts plasminogen into plasmin, then plasmin will dissolve the fibrin clot into degradation produts “i.e. fibrinolysis”.
This is known as thrombolytic therapy, useful for myocardial infarction and ischemic strokes, but contraindicated in hemorrhagic strokes (due to increased risk of bleeding).
There are absolute contraindications as well as relative contraindications to fibrinolytic therapy (tPA, alteplase, streptokinase,...etc). If you like my videos, please consider leaving a tip at www.paypal.me/perfectionalis/
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[@anniezaa1163]

I love this guy!! His lame humour is helping me through my degree😁

[@MedicosisPerfectionalis]

😁😁😁
Thanks 😊

[@katyabergstrom5742]

Simply brilliant and hilarious to the boot. Someday you should have a special podcast so that your fans could send questions to pick your brain. I think it would be immensely helpful for all of us to have a glimpse into your discipline, motivation and your generosity to teach. Mark my words, you are a legendary teacher.

[@katyabergstrom5742]

Oh also yes Shakespeare for life.

[@MedicosisPerfectionalis]

Dear, Katya...I don’t know what to say! I am truly speechless...Thank you:)

[@katyabergstrom5742]

Thank YOU and God bless.

[@Alexx-ke8be]

I feel like the genie from Aladdin is teaching me fibrinolysis... and I am not mad.

[@MedicosisPerfectionalis]

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[@candidranger9110]

you know, this is the one of the few channels that makes me pause the video to laugh

[@MedicosisPerfectionalis]

:)

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[@MedicosisPerfectionalis]

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Thanks a ton!

[@qaisdinho1999]

You actually explain better than my hematology course instructor, Thank you !

[@MedicosisPerfectionalis]

My pleasure 😇

[@filmonhaile3327]

The relativity joke was awesome man 😂😂😂

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@MegaCyber09]

AMAZING PRESENTATION! LOVE IT!

[@paulphelps7809]

Awesome! you actually make knowledge interesting;
...not to mention, also introducing the possibility of saving our lives.!

[@UristMcFarmer]

I really like the flow charts and color coding, they help me pick this stuff up. However, these videos were not designed to be binge watched. Have you made, or do you play on making, a version of these videos that are longer and where if you need to review you're expected to watch the previous videos?

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OMG I CAN'T THANK YOU ENOUGH I didn't skip the ad .... YOU ARE MY SUPER HERO

[@MedicosisPerfectionalis]

Thank you so much, friend!

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[@MedicosisPerfectionalis]

Thank you so much ☺️

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Very nicely explained...thank you

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I like the Einstein relative glasses joke!

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Thanks for these videos. I love that you explain thing like you are talking to little children..😉
You are AWESOME!

[@MedicosisPerfectionalis]

Haha 😂
Thank you so much 😊

[@Enpsychclopedia]

That's exactly right hunny

[@ianrjm969]

So if someone has Peyronie's Disease, they should take more proelytic enzymes to produce plasmin and then that plasmin can destroy the fibrin/plaque formation?

[@Floodland-bn3ol]

what can we do to trigger fibrinolysis?

[@laluhasan5165]

amazing, thousand thanks for you!!!!!!!

[@MedicosisPerfectionalis]

My pleasure...Thank you! Can you-please-share my videos with others? It really helps me.

[@laluhasan5165]

@@MedicosisPerfectionalis Done

[@MedicosisPerfectionalis]

Thanks a ton!

[@user-sc1dt4tq9o]

Your Channel the best 💐

[@MedicosisPerfectionalis]

Thank you so much 😊

[@fersonjames9793]

if Lp(a) is a homologus competitor of plasminogen how will high and low levels change coagulation as u see it?

[@Javabox04]

Thanks

[@vaishnavimannekunduri4090]

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[@krasivaqdevochka9680]

Thank you so much! It is a great and fun explanation ♥️♥️

[@MedicosisPerfectionalis]

Thank you 🙏

[@singh7282]

Best teacher i came across ever .. what u teach just fits in mind Nd i never forget...

[@MedicosisPerfectionalis]

Awesome 👏
Thanks a lot

[@ionictotalwar6389]

I am recommending you to all my classmates.

[@MedicosisPerfectionalis]

Thank you so much 😊

[@QassamAlaa]

Factor XII is amplified indirectly by plasmin too 🤔 I'm confused

[@danielj.6647]

awesome video, I didn't understand the importance of fibrinolysis in sepsis :)

[@MedicosisPerfectionalis]

It’s not an importance, it’s a statistical significance “i.e. correlation”

[@alexandranicolelazaro3873]

total life saver!!!!!!!!

[@MedicosisPerfectionalis]

Thank you so much, Alexandra!

[@sasasasa5806]

Pure genius..

[@MedicosisPerfectionalis]

Thanks 🙏

[@khyatichauhan5381]

Well explained 👏👏 thank you😊❤

[@MedicosisPerfectionalis]

You're welcome 😊

[@VDRO]

How can I get Plasmin to activate?

[@nguyentuananh18e11]

Thank you so much. Although I am not good at English , I feel this lecture be very great.

[@MedicosisPerfectionalis]

Thank you 🙏

[@alzeina8610]

I'm so in love with you❤️
Thank you so much for explening hema for me even better than my college professor❤️

[@MedicosisPerfectionalis]

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thank you💙

[@MedicosisPerfectionalis]

My pleasure!

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😂you are saving my life right now.

[@MedicosisPerfectionalis]

I am honored!

[@fdr.nazileguliyeva46]

great work ))

[@MedicosisPerfectionalis]

Thank you 😊

[@frailpel]

Sooooo what supplements should one take if they have blood clots, let’s say in their leg(s)?

[@MedicosisPerfectionalis]

They should dissolve the clots ASAP using anticoagulants.

[@frailpel]

@@MedicosisPerfectionalis thank u

[@maabfatah6160]

you are awesome 😭😭💕💕

[@noconintended]

QUESTION…in the hope you can answer… can I increase my fibrin from food? …cause I have big clots in portal vein and the polycythemia Vera mutation

[@MedicosisPerfectionalis]

I haven’t heard of a diet that was shown to help with polycythemia vera.

[@noconintended]

@@MedicosisPerfectionalis thank you for responding.

[@MedicosisPerfectionalis]

Anytime!

[@annaelizabeth3525]

I like the way you say plasmin

[@MedicosisPerfectionalis]

Is it pronounced differently? 😂

[@hanifabashir2002]

Perfectionist ❤

[@MedicosisPerfectionalis]

Thank you!

[@vaishnavimannekunduri4090]

Well said .... From india

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"Who is your daddy" got me weak

[@MedicosisPerfectionalis]

:)

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[@MedicosisPerfectionalis]

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That's Right, Too much of everything is bad... But your Lectures :P

[@MedicosisPerfectionalis]

Haha 😂
Thank you so much 😊

[@danbui4473]

After watching this video, I understand many things and one of them is that my prof doesn't understand hemostasis well enough ahaha

[@MedicosisPerfectionalis]

Haha 😂
I appreciate you so much, Dan!

[@eshepard682]

bahaahaah...because it's relative. You slay me sire

[@BaoTran2014]

love your sense of humor :)

[@paulhetherington3854]

Swedish-- words! PLASM--PSASMZ-- Personally Swedish, AYE! I'am this! MZ- Egypt as, well!

[@umernebiyat9105]

funny plus perfect

[@leteasilence8288]

pov youre a German high schooler just trying to make a powerpoint slide about plasmin--

[@MedicosisPerfectionalis]

Thank you for watching!

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Toooooo good🤩🤩

[@MedicosisPerfectionalis]

Thank you 🙏

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THAAAAAAANK YOOOUUU

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you're hilarious hahaha

[@MedicosisPerfectionalis]

Thanks 😂

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i would literally pay for your sessions

[@MedicosisPerfectionalis]

Thank you so much, dear :)
Your kind and encouraging words are infinitely more valuable than money.
Thanks 😊

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Its relative🤣🤣🤣

[@MedicosisPerfectionalis]

Haha 😂

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Don't stop teaching us in easy way.Those nerds who think that u r teaching in a way as teachers teach to children shall not visit this channel and fix their ischial tuberosities to their own books.😏

[@MedicosisPerfectionalis]

Haha 😂

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Elaborate

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[@MedicosisPerfectionalis]

??

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you are too fast though
but you are understandable

[@MedicosisPerfectionalis]

Thank you so much for your honest feedback

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some areas he's talking real fast bc they were already discussed on other videos, so he's just making a recap.

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Ur accent is little 🔥🔥

[@MedicosisPerfectionalis]

Is this a good thing or a bad thing 🧐🤔?

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Perfect ❤

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9:43-9:53 hahahahahaha

[@user-pe4lq8zg9i]

I am Egyptian I like uuu so much

[@MedicosisPerfectionalis]

Thanks a ton, dear!

[@paulhetherington3854]

No the, body breaks it, down alone! You cannot-- make, a drug for it! Illegal-- monopoly!

[@paulhetherington3854]

FIBAR-- Friendly, AYE! B-- past tense, I am-- AYE! Swedish! Funny he, used hemzo! Usually, means: Lots of hatred! Hawaii-- homosexuals.

[@paulhetherington3854]

Notice: they don't diagnose, what blocks, saturation? One word, Hawaii-- homosexuals!

[@amandaellsworth9254]

"If you haven't read Shakespeare, this is no hope for you. Keep reading your Kaplan medical."
#triggered

[@MedicosisPerfectionalis]

I am sorry 😭

[@amandaellsworth9254]

@@MedicosisPerfectionalis It's okay, I read plenty of Shakespeare in high school before I got old and went back to medical school in my almost 30s. 😂