Dear you are the common sense doctor I like and I wish I would know you more and share a lot.You said." medicine makes sense when you explain ." I liked you so much I like reading Guyton,medical physiology text book for it really make you sensible doctor.I call a bit out of fashion for I despise these question and answer type of study purly directed at passing an exam,I know some times it hurts but honestly medicine is so great that way.Thank you for your superflowing explanation with ease.
Hey there! Your videos are amazing, i would never be able to remember these details but you explain everything in such an easy manner i really am able to remember things!
hello dr. I hope you do answer questions here. I am having a bit of a problem in understanding why in obstructive lung diseases there is decreased ventilation. I know that it is very intuitive to understand why but I clearly recall that the problem in obstructive lung diseases was in expiration not in inspiration. Perhaps it is wrong to associate inspiration and ventilation together but for some reason I am associating them.
my professor asked the exact same question: "Is it worse to have high V/Q or low V/Q?" I know both are bad, but which one is worse if you had to choose one?
Thank you from the bottom of my heart! You are a savior!!! I have a question in 19:14 isn't that supposed to be BRONCOconstriction instead of VASOconstriction??? As you explain in the next sentence, the purpose is to narrow the BRONCHUS (not the VESSEL), when hypoperfussion takes place... Or am I wrong??? I dont know, thats why I ask my savior! Thaaaaaaanks again!
I am sorry as I didn't properly understand your question. But.. When the ventilation is decreased the body often tries to cut off blood supply to that region to prevent Ventilation perfusion mismatch, this happens through vasoconstriction - this explains why no blood flows into Fetal lungs during intra-uterine life, furthermore this vasoconstriction is responsible for right heart failure that is seen in COPD. Interestingly during sleep if someone has sleep apnea the lung overall recieve less oxygen, therefore there is vasoconstriction this applies stress on the right heart. You may know that in heart failure we give diuretics - so the heart secretes it' s own diuretic or ANP, this causes nocturia in patients of sleep apnea.
Hi thankyou❤ Lower lobe infarction common due to more diffusion or more purfusion In your notes written diffusion while in your video speaking perfusion? Please explain
Yes, you are right. At the apex of the lung both perfusion (Q) and ventilation (V) are decreased, but the decrease in Q exceeds the decrease in V, making the V/Q ratio relatively high. Otherwise, it is really a perfect video.
Lollll you are so silly, yet so entertaining at the same time.... thanks for making learning a fun environment. You did an amazing job at explaining 👍🏼
Hi sir, Hope you can answer me back!, if we have dead space, so no gas exchange, why pO2 is nearly 100 mmHg like normal situation? I was expecting like "shunting".
Hi medicosis! i had a question about 10:48 when you mentioned emphysema leads to decreased V/Q ratio. What you say makes sense; however, everywhere online Ive seen that emphysema is an example of increased V/Q mismatch. Currently watching Dr. John B. West's resp phys lectures and he states that emphysema leads to higher V/Q inequality due to some ventilation but little perfusion in the destroyed lung tissue. Again, id like to say that both your reasoning and his makes sense to me, so its a bit difficult to piece things together lmao. Love your videos man, hope you can help! -a young M1
The V/Q mismatch will always be mismatched, the closest that we will be to attaining 100% is in the middle of the lung? @ the apex we will have a higher ratio, and @ the base a lower, ratio? So when does this become a problem if it is always mismatched?
What happens to alveolar ventillation in theses cases 1- testrictive lung disease 2 -obstructive lung disease 3- airway collapse 4 increasing compliance ?!! Can you give me the answer as Unfortunately I cannot answer that
I believe it is quite complex... Both emphysema and chronic bronchitis are part of COPD therefore obstructive lung disorder. In emphysema the inflammation is quite close to the blood vessels, so blood vessels get destroyed, this leads to VQ mismatch. In Pulmonary embolism blood flow stops so there is VQ mismatch. The topic is very vast I think. But let me give you a Mnemonic. In type I respiratory failure there deranged level of one gas and in type II there is deranged levels of two gases. How is it possible to have deranged level of only gas shouldn't the levels of two gases always be affected. If there is fluid CO2 being somewhat polar(although theoritically it has zero net dipole) is soluble in water than O2 that is non polar as it is made up of two similar atoms - the low solubility of O2 means oxygenated drinks are not popular like carbonated drinks because CO2 solubility is high. Okay let me try to tell you why V/Q mismatch causes type 1 respiratory failure. Carbon dioxide theoretically doesn't have a dipole, but it does contain polar units. This makes carbon dioxide more soluble in water, which is polar-like dissolves like. On the other hand, oxygen is made up of similar atoms and, therefore, is nonpolar. Because of its solubility, carbon dioxide doesn't need a specialized transporter such as hemoglobin. Furthermore, the presence of carbon dioxide in water means that it can be converted into bicarbonate and act as a buffer molecule to maintain a stable pH. Carbon dioxide can freely travel in the blood, but oxygen needs a specialized protein molecule called hemoglobin. Proteins, by nature, are very complex, and the oxygen dissociation curve follows cooperative binding. You can think of ventilation-perfusion mismatch as a form of faulty division of labor. Ideally, you would want the areas where ventilation is high to have high perfusion to load the right amounts of oxygen. Therefore, ventilation-perfusion mismatch is a form of faulty division of labor and is more likely to affect the oxygen dissociation curve, as it follows cooperative binding. Type II respiratory failure is a lot more intuitive I believe. All the best. 🙌🙌🙌🙌🙌 One more thing.... Why does in obstructive lung diseases expiration is more difficult?? This is because during inspiration lungs expand so the obstruction is somewhat relieved.
i have a question; i always see the equation written like this: Co2 + H2O H2co3 Hco3 + H ... y does it say co2 + water if CA is removing the water to form carbonic acid? another question; in decreased ventilation shouldn't the PaCO2 go up? or is normal because its corrected by increased respiratory rate?
I think on the contrary CA adds water to CO2. I remember once I was in something like a ferry at the end when I was leaving I saw that the CO2 that was coming out from the ferry was mixing with water to form this white colour Carbonic acid - if my observation is correct.
Let me try to answer your second question - Low Ventilation is not the same as low Ventilation perfusion ratio. Carbon dioxide theoretically doesn't have a dipole, but it does contain polar units. This makes carbon dioxide more soluble in water, which is polar-like dissolves like. On the other hand, oxygen is made up of similar atoms and, therefore, is nonpolar. Because of its solubility, carbon dioxide doesn't need a specialized transporter such as hemoglobin. Furthermore, the presence of carbon dioxide in water means that it can be converted into bicarbonate and act as a buffer molecule to maintain a stable pH. Carbon dioxide can freely travel in the blood, but oxygen needs a specialized protein molecule called hemoglobin. Proteins, by nature, are very complex, and the oxygen dissociation curve follows cooperative binding. You can think of ventilation-perfusion mismatch as a form of faulty division of labor. Ideally, you would want the areas where ventilation is high to have high perfusion to load the right amounts of oxygen. Therefore, ventilation-perfusion mismatch is a form of faulty division of labor and is more likely to affect the oxygen dissociation curve, as it follows cooperative binding.
I think your analogy, where you said that the base is more likely to suffer from infarction because it is more dependent on the blood supply, is inaccurate. The base has a higher blood supply and, therefore, is less likely to suffer if you apply the logic of higher perfusion. It is like saying a loss of $50 is a bigger issue for a rich man than for a poor man. In my opinion, the real reason the base is more likely to suffer from infarction is because it has higher perfusion. Coupled with the fact that, due to gravity, the weight of everything above it leads to more turbulence, higher turbulence is more likely to damage the endothelium. Therefore, there is a higher chance of clot formation, which can even embolize. This is my understanding; I may be wrong, but in any case, your lectures are a boon.
🧠 Autonomic Pharmacology Lectures: www.medicosisperfectionalis.com/
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Dear you are the common sense doctor I like and I wish I would know you more and share a lot.You said." medicine makes sense when you explain ." I liked you so much I like reading Guyton,medical physiology text book for it really make you sensible doctor.I call a bit out of fashion for I despise these question and answer type of study purly directed at passing an exam,I know some times it hurts but honestly medicine is so great that way.Thank you for your superflowing explanation with ease.
You’re welcome 😇
Good luck! 👍
This statement ‘medicine makes perfect sense IF explained properly’ is so underrated tbh
Thank you so much!
I agree!
Thank you so much! Your videos are helping me get through nursing school! Thank you, Thank you, Thank you!!!!
It’s my pleasure 😇
Good luck to you 🍀
The world need more people like you!
Can you please help me by sharing?
You deserve million views sir
Thanks a million!
Your explanation is amazing and simultaneously funny! After that i will remember v/q mismatch for a decade!
Thank you!
Your friends must be lucky to have you, guess you make them laugh alot lol
Haha 😂
Hey there! Your videos are amazing, i would never be able to remember these details but you explain everything in such an easy manner i really am able to remember things!
Awesome 👏
Thank you so much for watching!
I dn know why you have few likes.. You deserve million of likes man❤
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You are genius..all doubts thoughts solved
Thank you so much!
@@MedicosisPerfectionalis waiting for more videos
hello dr. I hope you do answer questions here. I am having a bit of a problem in understanding why in obstructive lung diseases there is decreased ventilation. I know that it is very intuitive to understand why but I clearly recall that the problem in obstructive lung diseases was in expiration not in inspiration. Perhaps it is wrong to associate inspiration and ventilation together but for some reason I am associating them.
I really should've started with your videos earlier in my studies
Thank you 😊
Extraordinary.. full content thoroughly touched with clear explanation…
Thanks a ton!
Well explained. Thankyou so much. 🤩
My pleasure!
Can you provide a few references for this information? Not saying your incorrect but would help me tremendously for my essay
See Guyton’s, Ganong’s and Boron’s Physiology textbooks. They have a lot of citations.
my professor asked the exact same question: "Is it worse to have high V/Q or low V/Q?" I know both are bad, but which one is worse if you had to choose one?
Please add refrences and further reading if possible .. thanks🔥
Your teaching is marvelous...also your jokes in between gives a good laugh
Thank you 😊
Thank you from the bottom of my heart!
You are a savior!!!
I have a question in 19:14 isn't that supposed to be BRONCOconstriction instead of VASOconstriction???
As you explain in the next sentence, the purpose is to narrow the BRONCHUS (not the VESSEL), when hypoperfussion takes place...
Or am I wrong??? I dont know, thats why I ask my savior!
Thaaaaaaanks again!
I am sorry as I didn't properly understand your question.
But..
When the ventilation is decreased the body often tries to cut off blood supply to that region to prevent Ventilation perfusion mismatch, this happens through vasoconstriction - this explains why no blood flows into Fetal lungs during intra-uterine life, furthermore this vasoconstriction is responsible for right heart failure that is seen in COPD.
Interestingly during sleep if someone has sleep apnea the lung overall recieve less oxygen, therefore there is vasoconstriction this applies stress on the right heart. You may know that in heart failure we give diuretics - so the heart secretes it' s own diuretic or ANP, this causes nocturia in patients of sleep apnea.
@worldaround6520 thanks!!!!
@@kipkipour4507 🙌🙌🙌🙌
Thank you so much for the on point video. Very well illustrated to suit all level.
Thank you 🙏
You are such a gem sir
Thank you so much 😊
Fav physio channel
Thank you so much!
Hi thankyou❤
Lower lobe infarction common due to more diffusion or more purfusion
In your notes written diffusion while in your video speaking perfusion? Please explain
I really needed this. Thank you
My pleasure 😇
Can you please help me by sharing?
you made a very hard subject into freaking 😆easy 😘thank you very much doc
My pleasure!
It's a humble request pls make some videos on immunology as well... Please... Thank you
Ok 👍
These videos are AMAZING!!! Thank you so much!!
My pleasure 😇
Emphysema has low V/Q right? Damaged Alveoli causes loss in ventilation with same perfusion which will result in low V/Q.
Excellent
You saved me twice in a day
I didn’t do anything!
Thank you so much 😊
Very easy to understand. Thanks a lot.
My pleasure 😇
3:25 - I think there is an error in "in the base" line. Shouldn't it be: "increased V, but Q increased even more"?
Yeah thought same
Same with you, he confused us also at 9:29 , there he said there is increased ventilation in apex. Should be decreased ventilation in apex
Thank you so much for the great explanation. You're the best!!!
My pleasure!
I adore this channel wallahi❤
Thank you!
Hi, hello my dear friend medicosis perfectionalis, simply u are just awesome. Nothing to say more. Thanks for ur sharing knowledge.
You’re very welcome 😊
5:34 there is maybe a mistake. Part where “normal apex”. If I’m not right, explain pls
Yes, you are right. At the apex of the lung both perfusion (Q) and ventilation (V) are decreased, but the decrease in Q exceeds the decrease in V, making the V/Q ratio relatively high. Otherwise, it is really a perfect video.
Lollll you are so silly, yet so entertaining at the same time.... thanks for making learning a fun environment. You did an amazing job at explaining 👍🏼
Thanks 😊
I am honored!
Can you please help me by sharing?
Hi sir, Hope you can answer me back!, if we have dead space, so no gas exchange, why pO2 is nearly 100 mmHg like normal situation? I was expecting like "shunting".
"dont just go 1,2,3,4 show me your me your back like an idiot, auscultate above the clavicle'', I cant stop laughing :D
Haha 😂
Superb explanation
Thank you!
Hi medicosis! i had a question about 10:48 when you mentioned emphysema leads to decreased V/Q ratio. What you say makes sense; however, everywhere online Ive seen that emphysema is an example of increased V/Q mismatch. Currently watching Dr. John B. West's resp phys lectures and he states that emphysema leads to higher V/Q inequality due to some ventilation but little perfusion in the destroyed lung tissue. Again, id like to say that both your reasoning and his makes sense to me, so its a bit difficult to piece things together lmao. Love your videos man, hope you can help!
-a young M1
Why does Wikipedia say emphysema is high vq
The V/Q mismatch will always be mismatched, the closest that we will be to attaining 100% is in the middle of the lung? @ the apex we will have a higher ratio, and @ the base a lower, ratio? So when does this become a problem if it is always mismatched?
To a certain degree we can tolerate VQ mismatch.
How to get these video form pateron these videos are free ?
What happens to alveolar ventillation in theses cases
1- testrictive lung disease
2 -obstructive lung disease
3- airway collapse
4 increasing compliance
?!!
Can you give me the answer as Unfortunately I cannot answer that
I believe it is quite complex... Both emphysema and chronic bronchitis are part of COPD therefore obstructive lung disorder. In emphysema the inflammation is quite close to the blood vessels, so blood vessels get destroyed, this leads to VQ mismatch. In Pulmonary embolism blood flow stops so there is VQ mismatch.
The topic is very vast I think. But let me give you a Mnemonic.
In type I respiratory failure there deranged level of one gas and in type II there is deranged levels of two gases.
How is it possible to have deranged level of only gas shouldn't the levels of two gases always be affected. If there is fluid CO2 being somewhat polar(although theoritically it has zero net dipole) is soluble in water than O2 that is non polar as it is made up of two similar atoms - the low solubility of O2 means oxygenated drinks are not popular like carbonated drinks because CO2 solubility is high.
Okay let me try to tell you why V/Q mismatch causes type 1 respiratory failure.
Carbon dioxide theoretically doesn't have a dipole, but it does contain polar units. This makes carbon dioxide more soluble in water, which is polar-like dissolves like. On the other hand, oxygen is made up of similar atoms and, therefore, is nonpolar. Because of its solubility, carbon dioxide doesn't need a specialized transporter such as hemoglobin. Furthermore, the presence of carbon dioxide in water means that it can be converted into bicarbonate and act as a buffer molecule to maintain a stable pH.
Carbon dioxide can freely travel in the blood, but oxygen needs a specialized protein molecule called hemoglobin. Proteins, by nature, are very complex, and the oxygen dissociation curve follows cooperative binding.
You can think of ventilation-perfusion mismatch as a form of faulty division of labor. Ideally, you would want the areas where ventilation is high to have high perfusion to load the right amounts of oxygen. Therefore, ventilation-perfusion mismatch is a form of faulty division of labor and is more likely to affect the oxygen dissociation curve, as it follows cooperative binding.
Type II respiratory failure is a lot more intuitive I believe. All the best. 🙌🙌🙌🙌🙌
One more thing....
Why does in obstructive lung diseases expiration is more difficult??
This is because during inspiration lungs expand so the obstruction is somewhat relieved.
Good done, thank you
I appreciate you!
your a genius
Thank you!
هههه ربنا يحفظك و تبقى 100 سنة يارب❤
Thank you 🙏
thanks for ur effort,but in obstructive lung disease with low v/q ratio,i think u should have hypercapnea not normocapnea,what do u think?
Give me an example.
@@MedicosisPerfectionalis Thanks for answering me,i mean all type 2 respiratory faliure is hypoxic hypercapnic or at least thats how they teach us.
@@MedicosisPerfectionalis In COPD problem is in expiration so CO2 is retained leading to hypercapnia
Thanks ❤❤
My pleasure!
can ventilation defect cause hypercapnia? less o2 is in the alveoli so i thought Paco2 would be higher
Hypoventilation can cause hypercapnia.
Also, hyperoxia can cause hypercapnia.
Yes, no doubt this is the amazing creation of Allah
i have a question; i always see the equation written like this: Co2 + H2O H2co3 Hco3 + H ... y does it say co2 + water if CA is removing the water to form carbonic acid?
another question; in decreased ventilation shouldn't the PaCO2 go up? or is normal because its corrected by increased respiratory rate?
I think on the contrary CA adds water to CO2.
I remember once I was in something like a ferry at the end when I was leaving I saw that the CO2 that was coming out from the ferry was mixing with water to form this white colour Carbonic acid - if my observation is correct.
Let me try to answer your second question -
Low Ventilation is not the same as low Ventilation perfusion ratio.
Carbon dioxide theoretically doesn't have a dipole, but it does contain polar units. This makes carbon dioxide more soluble in water, which is polar-like dissolves like. On the other hand, oxygen is made up of similar atoms and, therefore, is nonpolar. Because of its solubility, carbon dioxide doesn't need a specialized transporter such as hemoglobin. Furthermore, the presence of carbon dioxide in water means that it can be converted into bicarbonate and act as a buffer molecule to maintain a stable pH.
Carbon dioxide can freely travel in the blood, but oxygen needs a specialized protein molecule called hemoglobin. Proteins, by nature, are very complex, and the oxygen dissociation curve follows cooperative binding.
You can think of ventilation-perfusion mismatch as a form of faulty division of labor. Ideally, you would want the areas where ventilation is high to have high perfusion to load the right amounts of oxygen. Therefore, ventilation-perfusion mismatch is a form of faulty division of labor and is more likely to affect the oxygen dissociation curve, as it follows cooperative binding.
@@worldaround6520 bruh my comment is from 3 yrs ago btw lmao. I already graduated 😂😂
@@Mikesco10 hahahaah congratulations. ✨✨✨✨✨✨
All the best. ✨🙌🙌🙌🙌
@@worldaround6520 thank you, all the best to you as well 🙏🙏
I like you videos so much. This one was hilarious xD. Great job!! ♥️
Thank you!
10:46 shouldnt emphysema have a high v q ratio ??
When the vessel is closed, close the bronchus...
Does that happen? There is bronchoconstriction?
I am sorry, I don’t understand your question
@@MedicosisPerfectionalis The last statement of the video
Decreased perfusion. Does it cause closing of bronchus?
I love you , you’re my hero
Thank you 🙏
15:28 why is it 40? Can't it be any number less than 105?
Great explanation ❤️
Thanks 😊
At 4:22, you said there is decreased Ventilation in apex;
At 9:29, you said there is more ventilation in apex.
Which statement is correct?
The apex has less ventilation than the base. However, the apex has a higher ventilation-to-perfusion ratio than the base.
Thanks for clarification
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You’re the GOAT
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thanks for that perfect video
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Can you please help me by sharing my videos with your friends?
I think your analogy, where you said that the base is more likely to suffer from infarction because it is more dependent on the blood supply, is inaccurate. The base has a higher blood supply and, therefore, is less likely to suffer if you apply the logic of higher perfusion. It is like saying a loss of $50 is a bigger issue for a rich man than for a poor man.
In my opinion, the real reason the base is more likely to suffer from infarction is because it has higher perfusion. Coupled with the fact that, due to gravity, the weight of everything above it leads to more turbulence, higher turbulence is more likely to damage the endothelium. Therefore, there is a higher chance of clot formation, which can even embolize.
This is my understanding; I may be wrong, but in any case, your lectures are a boon.
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We're on Earth, Nothing is a 100% 🤦♂️
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awesome!
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Amazing ❤️❤️❤️😍
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Did you just make a reference to Tamannah as in the Indian actress Tamannah? :O
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Dead space for fools 🤦♂️
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He talk a lot, at last can't remember anything 😢😢
I bet u can't pin my comment 😌🤧
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