I'm sorry I still don't get it. So the antibodies target and attack the phospholipids, which are fat acids that bind on the the coagulant factors (on the cell membranes). Due to these attacks the patient's physiological ability to perform a normal haemostasis is interrupted, disturbed. So how does a thrombosis occur? Is it because the cell membrane is attacked, which leads to cell lysis whereafter an accumulation of the cell materials? Update: after a little digging; so the thrombosis occurs because the antibodies do attack but also promote the epithelial cells, thrombocytes and WBC to form a clot. Correct? So they damage but promote?
Patient with lupus has a higher chance of developing APS, you should suggest a mixing study ie dRVVT assay prolong drvvt + normal plasma if corrrected -factor deficiency and if not corrected then suggest a presence of lupus. Confirmatory test followup adding excess phopholipd clotting should normalize.
I always test positive for lupus anticoagulant and anti-cardioleptin antibodies. I had 4 miscarriages, a twin pregnancy with a placental pathology very consistent with APS, a blood clot in my right upper arm. I am not on any therapy.
spellbound! very nice. I think you can add about other treatment modalities such as eculizumab in refractory case/ aPL nephropathy, immunomodulator in autoimmune hemolytic anaemia/ thrombocytopenia.
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I was diagnosed with lupus anticoagulant im a 28 year old male i dont have lupus this came out of nowhere i had dvt and pe and idk wat to do i feel lost and defeated at times
coagulation can happen spontaneously, but triggers like infection or inflammation, trauma, immobilisation,... are the most common findings in trombosis events.
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I have APS, suffered these "treatments" for 34 years, and finally learned it was all coming from food! 5 months ago I went to a 100% organic diet, and am seeing more progress in that time, than I have in my entire life! I'm talking all around health people! It's all improving.....It's diet! Diet!!!! I tell you!!!!!!
I'm sorry I still don't get it.
So the antibodies target and attack the phospholipids, which are fat acids that bind on the the coagulant factors (on the cell membranes).
Due to these attacks the patient's physiological ability to perform a normal haemostasis is interrupted, disturbed.
So how does a thrombosis occur? Is it because the cell membrane is attacked, which leads to cell lysis whereafter an accumulation of the cell materials?
Update: after a little digging; so the thrombosis occurs because the antibodies do attack but also promote the epithelial cells, thrombocytes and WBC to form a clot. Correct?
So they damage but promote?
Now u got it?
Patient with lupus has a higher chance of developing APS, you should suggest a mixing study ie dRVVT assay prolong drvvt + normal plasma if corrrected -factor deficiency and if not corrected then suggest a presence of lupus. Confirmatory test followup adding excess phopholipd clotting should normalize.
I always test positive for lupus anticoagulant and anti-cardioleptin antibodies. I had 4 miscarriages, a twin pregnancy with a placental pathology very consistent with APS, a blood clot in my right upper arm. I am not on any therapy.
how likley would it be when tested the 2nd time ,when the first test was high
spellbound! very nice. I think you can add about other treatment modalities such as eculizumab in refractory case/ aPL nephropathy, immunomodulator in autoimmune hemolytic anaemia/ thrombocytopenia.
thank you very much. it was very helpful to me.
It's our pleasure, we're glad you liked it!
Subscribe to us to keep in touch and
visit www.learningin10.com to know more about us!
Best regards,
Learning in 10
Why does thrombosis occur if there is a defect in anti coagulation (anti phospholipid)?
Anti coagulation factors are the prinple of measuring how much the blood coagulate
Just like gas in the car without it wont move
Thank you
I was diagnosed with lupus anticoagulant im a 28 year old male i dont have lupus this came out of nowhere i had dvt and pe and idk wat to do i feel lost and defeated at times
Have you seen a hematologist or a rheumatologist? Best place to start. God bless.
Nice presentation
Beta-2 Glycoprotein I Ab, IgG
Not much honestly. You need other labs to correlate
What causes coagulation disorders in the presence of the antiphospholipid antibody syndrome?
Johnson and Johnson vaccine
@@jenniferfrances8793 F. Lol
coagulation can happen spontaneously, but triggers like infection or inflammation, trauma, immobilisation,... are the most common findings in trombosis events.
@@jenniferfrances8793as someone with APS, I find that offensive.
Crystal clear 👌
Nice video
To the point!
Thank You. So helpful.
Thanks a lot
It's our pleasure, we're glad you liked it!
Subscribe to us to keep in touch and
visit www.learningin10.com to know more about us!
Best regards,
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Thank U
Thx
Thanks alot mam!
Is there any way to cure APS?
I have APS, suffered these "treatments" for 34 years, and finally learned it was all coming from food! 5 months ago I went to a 100% organic diet, and am seeing more progress in that time, than I have in my entire life! I'm talking all around health people! It's all improving.....It's diet! Diet!!!! I tell you!!!!!!
Let us know after a year how you feel.
I have started Mediterranean diet. I am hoping this will help
"It's made from people!"
How you getting on?
@@chestnutmair1 Is that pizza?
@@jonathanstempleton7864 not sure your asking me but I'm getting along great! Diet has completely changed my life in every way!
❤❤
Boring 🪴