Thank you for this - I am a biology high school teacher learning more during my summer holidays to further answer questions from my bright students. Never stop learning - thank you for being my teacher on this journey!
Goodness, this is a tremendous resource from one of the country's national treasures, V. Racaniello. This information is stuff you would normally pay hundreds of dollars per credit hour to get! I listen to this while working and putzing around the house, because it is so interesting. Thanks Vincent.
Dr. Racaniello, I have been listening to you throughout the past year on COVID and just found these lectures for 2021. Thank you so much for posting them on TH-cam. Excellent! Look forward to each one.
as phytovirologist we never stop learning even repeating & repeating or may be discovering something because there is always something there....thanks my teacher
I know this is only the 3rd lecture, but I am really enjoying them so far and needed to say I love your sense of humor throughout! Thank you for uploading these and making them free for everyone!
Thank you for being a healthcare worker who spends the time and effort at refining and/or deepening their understanding of biology. Maybe I'm wrong, but I get the impression that many in the field learn what they think they HAVE to know, first to get the accreditation/licensing and then to 'get by' or maybe be reasonably competent each shift. And I'm not just picking on the nurses and technicians -- many of us surely have encountered physicians who don't inspire confidence either due to archaic ideas or models of physiology/disease, or who APPEAR to be going through the motions (come on doc, the nurses and PA already do most of the work for you! ..j.k ; ) (also in the interest of fairness, many of us in all fields/sectors do not make enough of a voluntary, concerted effort to truly UNDERSTAND what it is that we do)
Retired engineer. Fascinating to me. It's like the whole world's gone digital. In fact already was. I am fascinated by the 'what works' anarchy, ie never mind any grand ideas, just see what stuff is able to get away with doing, and don't make assumptions that will colour your interpretation of the reality.
In your discussion on RNA and DNA, and specifically the what came first and why DNA is more dominant. I think another reason, which wasn't mentioned, is the stability of RNA vs DNA, where DNA is much more stable than RNA. I think this would have been an important point to make.
“If you do these experiments carefully, they *can* be done safely.” (Emphasis mine.) So, it’s possible. With that, no disagreement. But is it likely? Is it expedient? What exactly is the rate of accident given “carefully” done experiments? And what are the likely or *possible* costs of such accidents? What are the likely gains from doing such experiments? Seems to me that there’s a more careful analysis needed.
Hi Vincent, I don't quite understand whether there are only 7 virus genomes or 7 types of genome? I was slightly confused how the SARS-CoV-2 variants are different in that case? Is it that it's a variation within one of the same types of genome, or are they different from each other in another respect than the genome? Actually never mind, you answer this question later on :)
Hey! I have a question. As you said it's wrong to say that there's a mutation in the spike protein but instead we could say there's a mutation in the gene that encodes the spike protein, right?
I am Ph.D., cell biologist and I don't agree with presented opinion. One can learn and advance the knowledge without bringing back dangerous stuff. There no100% certainty, in experimental design. Neither in conditions of experiment. That is why the statistics is for. The statistician can evaluate the risk of dangerous experiments and safety. It never will be 0 or 100%.
Does anyone in the comment section know if Vincent Racaniello has ever done an episode on the role of the immune system on viruses with people who have varying HLA alleles? For example folks with the HLA B57 allele seem to mount an impressive immune response to certain viruses such as HIV and have been associated with long term non progressors.
32:25 to 32:31 mention of bacteria that has to live inside another bacteria - does this give a clue that the transition to eukaryotic cells was not an unlikely event ie not a Great Filter?
I teach chemistry at a college level. Yoy are much better than I'll ever be. Anthropomorphizing systems helps students remember and relate. Besides you are not antheopimorpgizing what is actually occurring, you are always antheopimorpgizing the latest model that we have for what we observe. If you always tell students up front that the current models we use will surely change and the stories we share about them are just to better understand the models, but...gasp...are not true, then you don't leave behind a useful tool simply because you are afraid of leading students astray in one specific way. Models are allways charging as we get closer to an understanding of what is actually driving the local energy mimimization of a particular system. It becomes distracting to hear you constantly try to correct your words over something so relatively trivial. The students know. I know you don't agree but if you truly want to remove it all you are still doing it quite a few times, which doesn't really matter other than to hear you direct yourself in some instances and not in others. Again you are far better than ill every be as a teacher and I'm loving your course and would appreciate your feedback on this matter if you have time.
I couldn't (respectfully) disagree with you more, Ms. Scott. I LOVE that he does this. Dr. Racaniello does what is done too rarely, teaching and reinforcing the epistemological component of his subject (and science in general.) His reminders to himself are distracting in the BEST way, and hopefully drive home to these new students the importance of having the right intellectual models when approaching or furthering our understanding of a given topic. I believe it also speaks to his character (self-improvement, conscientiousness) and credibility/leadership (practicing what he preaches!)
Hi. This is really informative. I've been trying to find for TH-cam vid similar to yours that informs the stuff in this vid. 👏 🥼Your explanation actually is like the videos of this awesome health enthusiast Dr Ethan! Ethan's tips are actually informative and I really learned a lot for my practice. He is the most knowledgable Doctor in Nottingham and he talks about medical school. I suggest you check his page out and give Dr Ethan a like over here! ➡️ #DrEthanAdvice
Thank you for this - I am a biology high school teacher learning more during my summer holidays to further answer questions from my bright students.
Never stop learning - thank you for being my teacher on this journey!
Goodness, this is a tremendous resource from one of the country's national treasures, V. Racaniello. This information is stuff you would normally pay hundreds of dollars per credit hour to get! I listen to this while working and putzing around the house, because it is so interesting. Thanks Vincent.
Dr. Racaniello, I have been listening to you throughout the past year on COVID and just found these lectures for 2021. Thank you so much for posting them on TH-cam. Excellent! Look forward to each one.
as phytovirologist we never stop learning even repeating & repeating or may be discovering something because there is always something there....thanks my teacher
I know this is only the 3rd lecture, but I am really enjoying them so far and needed to say I love your sense of humor throughout!
Thank you for uploading these and making them free for everyone!
Thank you, Professor Racaniello. When I am hip-deep in patients, it’s easy to get mentally exhausted. Your videos help stimulate my old brain.
Thank you for being a healthcare worker who spends the time and effort at refining and/or deepening their understanding of biology.
Maybe I'm wrong, but I get the impression that many in the field learn what they think they HAVE to know, first to get the accreditation/licensing and then to 'get by' or maybe be reasonably competent each shift.
And I'm not just picking on the nurses and technicians -- many of us surely have encountered physicians who don't inspire confidence either due to archaic ideas or models of physiology/disease, or who APPEAR to be going through the motions (come on doc, the nurses and PA already do most of the work for you! ..j.k ; )
(also in the interest of fairness, many of us in all fields/sectors do not make enough of a voluntary, concerted effort to truly UNDERSTAND what it is that we do)
Does it make me weird that I watch this as entertainment during breaks from my actual genetics coursework?
I find it not weird! Great use of break time, indeed!
Cheers & mabuhay, from tropical Philippines!
Retired engineer. Fascinating to me. It's like the whole world's gone digital. In fact already was. I am fascinated by the 'what works' anarchy, ie never mind any grand ideas, just see what stuff is able to get away with doing, and don't make assumptions that will colour your interpretation of the reality.
Thanks for putting online. Good faith suggestion - 15:25 would make easier to read if bullet points on left were numbers that lined up to diagram.
19:30 his humor right there.... Love you Prof.
finally we are getting into the gain of function
In your discussion on RNA and DNA, and specifically the what came first and why DNA is more dominant. I think another reason, which wasn't mentioned, is the stability of RNA vs DNA, where DNA is much more stable than RNA. I think this would have been an important point to make.
Really love these lectures! Thanks for putting them on youtube.
YOU ARE A LIFE SAVER !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
This should be a mandatory course for doctors
Please God no.
surely, it is?
(Am I wrong in assuming that a basic virology course is required to get through medical school?!)
I heard that reassortment might have been the origin of the omicron variant but I also heard that recombination might be more plausible.
Thank you so much for letting us follow along ❤️
The viruses are the mythology it medical sciences.neurologist.
“If you do these experiments carefully, they *can* be done safely.” (Emphasis mine.) So, it’s possible. With that, no disagreement. But is it likely? Is it expedient? What exactly is the rate of accident given “carefully” done experiments? And what are the likely or *possible* costs of such accidents? What are the likely gains from doing such experiments? Seems to me that there’s a more careful analysis needed.
what is an example of a non-RNA dependent RNA Replicase? Something in mitochondria?
This is good stuff 😃🦠
Corporations independently develop weapons and governments develop weapons. Whether either are capable of restricting themselves IS quite a dilemma.
Thank you for the amazing lectures.
Hi Vincent, I don't quite understand whether there are only 7 virus genomes or 7 types of genome? I was slightly confused how the SARS-CoV-2 variants are different in that case? Is it that it's a variation within one of the same types of genome, or are they different from each other in another respect than the genome?
Actually never mind, you answer this question later on :)
Hey! I have a question. As you said it's wrong to say that there's a mutation in the spike protein but instead we could say there's a mutation in the gene that encodes the spike protein, right?
I am Ph.D., cell biologist and I don't agree with presented opinion. One can learn and advance the knowledge without bringing back dangerous stuff. There no100% certainty, in experimental design. Neither in conditions of experiment. That is why the statistics is for. The statistician can evaluate the risk of dangerous experiments and safety. It never will be 0 or 100%.
What do the pandoravirus, the mimivirus etc infect? Do they infect humans?
No they don't infect humans. Giant viruses like mimivirus are usually cultured and found in amoeba.
I have to leave to watch grandchildren but...great class!
Does anyone in the comment section know if Vincent Racaniello has ever done an episode on the role of the immune system on viruses with people who have varying HLA alleles? For example folks with the HLA B57 allele seem to mount an impressive immune response to certain viruses such as HIV and have been associated with long term non progressors.
how is this stuff free? thank you Vincent!
Propaganda is bought and paid for, that's how lol
32:25 to 32:31 mention of bacteria that has to live inside another bacteria - does this give a clue that the transition to eukaryotic cells was not an unlikely event ie not a Great Filter?
It still took some 2 billion years.
This is my breakfast.
I teach chemistry at a college level. Yoy are much better than I'll ever be. Anthropomorphizing systems helps students remember and relate. Besides you are not antheopimorpgizing what is actually occurring, you are always antheopimorpgizing the latest model that we have for what we observe. If you always tell students up front that the current models we use will surely change and the stories we share about them are just to better understand the models, but...gasp...are not true, then you don't leave behind a useful tool simply because you are afraid of leading students astray in one specific way. Models are allways charging as we get closer to an understanding of what is actually driving the local energy mimimization of a particular system. It becomes distracting to hear you constantly try to correct your words over something so relatively trivial. The students know. I know you don't agree but if you truly want to remove it all you are still doing it quite a few times, which doesn't really matter other than to hear you direct yourself in some instances and not in others. Again you are far better than ill every be as a teacher and I'm loving your course and would appreciate your feedback on this matter if you have time.
I couldn't (respectfully) disagree with you more, Ms. Scott.
I LOVE that he does this. Dr. Racaniello does what is done too rarely, teaching and reinforcing the epistemological component of his subject (and science in general.)
His reminders to himself are distracting in the BEST way, and hopefully drive home to these new students the importance of having the right intellectual models when approaching or furthering our understanding of a given topic.
I believe it also speaks to his character (self-improvement, conscientiousness) and credibility/leadership (practicing what he preaches!)
LOVE IT...
Hi. This is really informative. I've been trying to find for TH-cam vid similar to yours that informs the stuff in this vid. 👏 🥼Your explanation actually is like the videos of this awesome health enthusiast Dr Ethan! Ethan's tips are actually informative and I really learned a lot for my practice. He is the most knowledgable Doctor in Nottingham and he talks about medical school.
I suggest you check his page out and give Dr Ethan a like over here! ➡️ #DrEthanAdvice