Bacteriophage defend themselves with nucleus-like structure

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Mendoza SD et al. A Bacteriophage Nucleus-like Compartment Shields DNA from CRISPR Nucleases. Nature. December 9 2019. www.nature.com/articles/s4158...
• Savitskaya EE, Musharova OS, and Severinov KV. Diveristy of CRISPR-Cas-Mediated Mechanisms of Adaptive Immunity in Prokaryotes and Their Application in Biotechnology. Biochemistry (Moscow). 2016. www.protein.bio.msu.ru/biokhim...
• Nature report: Malone LM et al. A Jumbo Phage that Forms a Nucleus-like Structure Evades CRISPR-Cas DNA Targeting but is Vulnerable to Type III RNA-Based Immunity. Nature Microbiology. December 9 2019. www.nature.com/articles/s4156...
• The Atlantic: The Startling Secret of an Invincible Virus. www.theatlantic.com/science/a...
• Meet the Microbiologist podcast episode: CRISPR, anti-CRISPR, and anti-anti-CRISPR Systems with Joe Bondy-Denomy asm.org/Podcasts/MTM/Episodes...
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[@WmLatin]

Phage therapeutic use has been a LONG time coming. I've wondered about it since hearing of Soviet research decades ago. I guess we won't progress until we have to- as most antibiotics become increasingly useless.