Hi Dr Matthew’s. Thanks for this. Can you help my understanding on the below? Glycolysis produces ATP + Lactate + H ions . Lactate can cleared by the Liver, or it can be used by other organs in the body, or it could be cleared by the mitochondria in slow twitch muscles via the Lactate Shuttle. How are H ions cleared? Isn’t the H ions the cause of perceived pain and increased acidity? Thanks.
Hi @billc4833. My specialty is the cardiovascular system, and my understanding of bioenergetics is evolving in recent years. With that said, my current understanding is this. When we produce lactate from pyruvate it degrades an NADH into an NAD+ and also utilizes a from H+. So the production of lactate actually makes the glycolytic pathway H+ (acid) neutral. However, at the same time ATP is being hydrolyzed to provide energy to whatever process (like exercise) is consuming substantial amounts of energy quickly. ATP hydrolysis releases a H+ for each hydrolyzed (broken down) ATP molecule. Therefore, when glycolytic rates are high the muscle will become acidic due to the ATP usage, no glycolysis itself. The issue is the high rate of ATP usage that the electron transport chain/aerobic metabolism cannot keep up with. Source stating most acid is due to ATP hydrolysis not glycolysis and lactate: www.asep.org/asep/asep/TeachingByRobertRobergs.pdf A source giving information (see Table 3) about H+ production/consumption per pathway during an intense 3 minute bout of exercise. I am still trying to fully grasp this. So please respond with your thoughts if you can explain it simply.: www.sportsci.org/jour/0102/rar.htm Hopefully others will also respond to this comment chain with their thoughts and understanding. With all of the above stated, there are a number of buffering systems of the body to hand H+. These include the bicarbonate pathway, phosphate pathway, various blood proteins, and hemoglobin. Source: Exercise Physiology, Nutrition, Energy, and Human Performance, Seventh Edition. William D. McArdle Yes, I do believe the buildup of acid leads to discomfort and slowed bioenergetic pathways leading to fatigue. I don't have a direct citation readily available for that though.
Hi Dr. Evan, I was one of your student at Montclair state University couple years ago. I’m a first year Physical Therapy student now and I still refer back to your materials. Thank you so much!!
Evan your lectures are really helpful. thank you ❤
You are welcome!
these videos are awesome. Thank you so much for the free education. its great to get refreshers on this information a couple years out of school !
You are welcome!
Hi Dr Matthew’s. Thanks for this.
Can you help my understanding on the below?
Glycolysis produces ATP + Lactate + H ions .
Lactate can cleared by the Liver, or it can be used by other organs in the body, or it could be cleared by the mitochondria in slow twitch muscles via the Lactate Shuttle.
How are H ions cleared?
Isn’t the H ions the cause of perceived pain and increased acidity?
Thanks.
Hi @billc4833. My specialty is the cardiovascular system, and my understanding of bioenergetics is evolving in recent years. With that said, my current understanding is this. When we produce lactate from pyruvate it degrades an NADH into an NAD+ and also utilizes a from H+. So the production of lactate actually makes the glycolytic pathway H+ (acid) neutral. However, at the same time ATP is being hydrolyzed to provide energy to whatever process (like exercise) is consuming substantial amounts of energy quickly. ATP hydrolysis releases a H+ for each hydrolyzed (broken down) ATP molecule. Therefore, when glycolytic rates are high the muscle will become acidic due to the ATP usage, no glycolysis itself. The issue is the high rate of ATP usage that the electron transport chain/aerobic metabolism cannot keep up with.
Source stating most acid is due to ATP hydrolysis not glycolysis and lactate: www.asep.org/asep/asep/TeachingByRobertRobergs.pdf
A source giving information (see Table 3) about H+ production/consumption per pathway during an intense 3 minute bout of exercise. I am still trying to fully grasp this. So please respond with your thoughts if you can explain it simply.:
www.sportsci.org/jour/0102/rar.htm
Hopefully others will also respond to this comment chain with their thoughts and understanding.
With all of the above stated, there are a number of buffering systems of the body to hand H+. These include the bicarbonate pathway, phosphate pathway, various blood proteins, and hemoglobin.
Source: Exercise Physiology, Nutrition, Energy, and Human Performance, Seventh Edition. William D. McArdle
Yes, I do believe the buildup of acid leads to discomfort and slowed bioenergetic pathways leading to fatigue. I don't have a direct citation readily available for that though.
@@VivoPhys Thank you for this thoughtful and detailed response. I appreciate it.
Hi Dr. Evan, I was one of your student at Montclair state University couple years ago. I’m a first year Physical Therapy student now and I still refer back to your materials. Thank you so much!!
Awesome! Hope all is well.