I'm studying for board exams for Oriental Medicine. Bio-science and pharmacology were two of my favorite courses, but the information isn't easily recalled when I need it. Your videos are a great help. Thanks! :)
both the insulin and glucagon video have made my life easy. thank you so much for your content. It is so easy to understand and makes so much sense. Thank you, you are a hero.
just something I've thought. Please do correct me if I'm wrong. Glycogen is converted to glucose through a process call glycogenolysis and not gluconeogenesis since it is carbohydrate-based.
+btingang Glycogen is converted firstly to glucose-1-phosphate and then glucose-6-phosphate so ur right, that process is what is known as Glycogenolysis. (splitting of glycogen) The step after where G-6-P is converted to Glucose is Gluconeogenesis. (The term is loosely used though to describe the entire process of glucose creation despite the stages)
What is the effect of Cardarine in this process? Cardarine is supposed to use fat cells absorption vs glycogen for energy. Can you apply that process to this demonstration?
Your video is great. However, I should indicate one correction. Acetyl-CoA derived from fatty acids or other sources is not used in the synthesis of glucose. During the fasting state, the acetyl group from acetyl-CoA can be used as a substrate in the synthesis of ketone bodies, as you indicated, and in the Citric acid cicle.
Hello Armando this was really interesting video information. But I am bit confused about a thing. please try to solve it soon. I want to lose fat. I workout regularly in gym. before gym I usually take L-Argininebefore 15 minutes of starting my workout, as intra workout I take 5g BCAA (with 2:1:1 L:I:V ratio) after workout I take L-glutamine and whey protein isolate. so the confusion is all of these supplements increases insulin according to webmd and pubmed. but insulin is a fat increasing hormone, how I am losing weight. no doubt I keep myself about 200 calories deficient for 5 days a week and consuming 100 calories more than my BMR for 2 days. according to examine.com all of these supplements have fat burning effects. and one more thing I need to know is, if I am following keto diet, can I still add these supplements?
In high protein and low carb diets I heard they push insulin down, but starting to increase glucagon, which increases levels of cortisol. Is this true? Is this bad for your body?
Acetyl Coa is obligate activator of Pyruvate carboxylase which forms Oxaloacetate which helps to form PEP and gluconeogenesis is carried out from there. It's crucial in gluconegenesis.
Also Acetyl Coa is not a substrate. It's an obligate activator of an enzyme called Pyruvate carboxylase. The three substrates for Gluconeogenesis is Glycerol, alanine or any other glucogenic amino acid and Lactate.
why do you want to decrease glycolysis? is it because you dont want glucose to break down? so is the focus "not providing energy to krebs cycle" but more to " increasing glucose levels?
Yes, the purpose of maintaining a high blood sugar level is to provide sugar to the tissues (e.g. Brain, CNS, etc.) That really require or primarily run on glucose. By inhibiting glycolysis we are preserving sugar from being broken down in tissues that could run on fatty acids and ketones and giving it to the brain and other organs that require glucose (The brain and other organs can technically run on ketones if they have to, but they do not like it).
yes, the caloric deficit is necessary for the body to store less fat in adipose tissue, and minimizing carbs would minimize the need for the body to store excess energy in adipose tissue which ultimately causes weight loss.
hello there, do you make videos on pathophysiology of the endocrine glands ? if you do please provide me the links. thanks ! and if you dont, i think it would be better if you also make videos on pathophysiology of endocrine glands :)
Glucagon promotes Glucogenolysis (the degradation of Glucogen into glucose). It doesn't go through gluconeogenesis because gluconeogenesis is the synthesis of glucose from non-carbohydrates molecules such as TAG.Anyway, perfect video ..
Hi All respect for you ,but remember one thing you are the only one saying such things here, we all do like his video and thump up Armando because he is doing all this effort for us because you know why !!he cares to help others and we care for him too . stop saying such things ok next time say something good or better to be silent . thank you for listening :)
That was some crazy shit. I thought I was pretty good with anatomy and physiology. Thank god I don't have to memorise that much detail for my uni course
You're misinterpreting what I said. Other precursors can be used to synthesize glucose like amino acids, glycogen, lactate etc. Glucose can be converted to fatty acids however this reaction is irreversible because acetyl coA cannot be converted back to pyruvate.
Thing you are doing is excellent. Keep improving. You can do chapters like 1 hour lessons, in endocrinology. Like Chapter 1 "Tyroid gland" which includes all aspects briefly - phisiology-phatogenesis- Disease state- Treatment- Pharmachological approach. I expect this from you later on.
These videos are so helpful and so well done! Thank you for clearly and simply explaining everthing with great illustrations too!!
Please do not stop of doing these great entertaining informative lectures.
You are the best lecturer ever.
Mannnnn, your videos are absolutely awesome. I am in an RN program and really enjoy your videos, thanks so much for all your hard work!!!!!!
I'm studying for board exams for Oriental Medicine. Bio-science and pharmacology were two of my favorite courses, but the information isn't easily recalled when I need it. Your videos are a great help. Thanks! :)
I have an endocrinology exam tomorrow and this is absolute gold!! Seriously wishing I had thought about watching youtube videos earlier...
both the insulin and glucagon video have made my life easy. thank you so much for your content. It is so easy to understand and makes so much sense. Thank you, you are a hero.
1The 😊 p.m.
totally agree!
One of the best descriptions - THANKS
You totally make my life SOOOOO much easier when studying for Patho! What an incredible talent you have!
The videos are honestly incredible. I'm astonished you are only on the 3000 views range.
Your videos are always excellent Armando....seriously keep up the excellent work bro! Im a huge fan of your videos.
You don't get to complain about gifts... this video is awesome and everyone here is grateful that Armando made it.
Many thanks Armando Hasudungan
mind:blown
everything in my mind has connected after watching a handful of your vids, my brain appreciates your teaching style.
nice drawing man !!! and also good way of teaching...very clear
You're the best. Please don't stop :)
Thank you so much!
Really in love the way u explain 😍😍
just something I've thought. Please do correct me if I'm wrong. Glycogen is converted to glucose through a process call glycogenolysis and not gluconeogenesis since it is carbohydrate-based.
+btingang Glycogen is converted firstly to glucose-1-phosphate and then glucose-6-phosphate so ur right, that process is what is known as Glycogenolysis. (splitting of glycogen) The step after where G-6-P is converted to Glucose is Gluconeogenesis. (The term is loosely used though to describe the entire process of glucose creation despite the stages)
@@mickkd6462 Might be a little late, but gluconeogenesis is used form bot making glucose out of G6P AND out of acetyl-CoA?
You’re wrong
Thank you so much for this informative video. Making med school easier for me.
you are amazing !! I really really appreciate your videos!! thank you~~
Thank you 💖
U dont have an idea upto what extend u have helped me ... Thankyou
Very helpful, thank you so much
Your videos are amazing!
Thank you!
you are GREAT.
Thank you.
Thank u so much
What is the effect of Cardarine in this process? Cardarine is supposed to use fat cells absorption vs glycogen for energy. Can you apply that process to this demonstration?
Thank you
hey could you tell me your refrences please
Your video is great. However, I should indicate one correction. Acetyl-CoA derived from fatty acids or other sources is not used in the synthesis of glucose. During the fasting state, the acetyl group from acetyl-CoA can be used as a substrate in the synthesis of ketone bodies, as you indicated, and in the Citric acid cicle.
Sir greatjob
fantastic videos. I think you wanted to say Oxyntomodulin , which suppresses appetite. Keep up the AMAZING job. You have helped me immensely.
GReat videos!! amazing pics!! thank you!!
Heloo :) Thank you for this by the way. I was wondering if you could do one for Cortisol? Thank you so much
Very helpful 👍
Armando u are amazing😍😍😍
Activated pka does glucagon job.. So why it decrease glycogenlysis
Hello Armando this was really interesting video information. But I am bit confused about a thing. please try to solve it soon. I want to lose fat. I workout regularly in gym. before gym I usually take L-Argininebefore 15 minutes of starting my workout, as intra workout I take 5g BCAA (with 2:1:1 L:I:V ratio) after workout I take L-glutamine and whey protein isolate.
so the confusion is all of these supplements increases insulin according to webmd and pubmed. but insulin is a fat increasing hormone, how I am losing weight. no doubt I keep myself about 200 calories deficient for 5 days a week and consuming 100 calories more than my BMR for 2 days.
according to examine.com all of these supplements have fat burning effects.
and one more thing I need to know is, if I am following keto diet, can I still add these supplements?
Great video. However acetyl-CoA does not feed glyconeogenesis. Oxaloacetate, glycerol, lactate, and glicogenic aminoacids do.
exactly
thank you 😊
thanks for thisvideo...i love it...plz do it about other mekanism....thank you
Awesome explained
Great video.
In high protein and low carb diets I heard they push insulin down, but starting to increase glucagon, which increases levels of cortisol. Is this true? Is this bad for your body?
i love these videos so much. However, Armando seems sleepless, distracted, and rattled in this one.
What happens if glucagon is not produced by the liver? What is the treatment
great teaching
can I borrow your brain for my exams please !
How cortisol regulates insulin secretion ???
thank u
hi, great information overall. However, I must point out one minor mistake - acetyl-coA are not gluconeogenic 10:31
its only stimulating it
That's what I learned, I think. Acetyl-CoA can never return to become glucose, right?
Acetyl Coa is obligate activator of Pyruvate carboxylase which forms Oxaloacetate which helps to form PEP and gluconeogenesis is carried out from there. It's crucial in gluconegenesis.
Also Acetyl Coa is not a substrate. It's an obligate activator of an enzyme called Pyruvate carboxylase. The three substrates for Gluconeogenesis is Glycerol, alanine or any other glucogenic amino acid and Lactate.
It is amazing!
Why does it inhibit PFK-1 and not Hexokinase? I know it pertains to Gluconeogenesis.
Thank u a lot
Superb!
Great vids, thanx
thanks a lot
thank you............
What does it mean to be in a fasted state?
good work
Is there a test to monitor Glucagon?
why do you want to decrease glycolysis? is it because you dont want glucose to break down? so is the focus "not providing energy to krebs cycle" but more to " increasing glucose levels?
Yes, the purpose of maintaining a high blood sugar level is to provide sugar to the tissues (e.g. Brain, CNS, etc.) That really require or primarily run on glucose. By inhibiting glycolysis we are preserving sugar from being broken down in tissues that could run on fatty acids and ketones and giving it to the brain and other organs that require glucose (The brain and other organs can technically run on ketones if they have to, but they do not like it).
Not enough details on the mechanism of each activations at different levels
Just one question. So of im trying to lose weight being in a caloric deficit and minimizing carbs is the way to go ?
yes, the caloric deficit is necessary for the body to store less fat in adipose tissue, and minimizing carbs would minimize the need for the body to store excess energy in adipose tissue which ultimately causes weight loss.
very helpful
How do we know that glucagon is released?
mindblowing..// love and respect from pakistan
hello there, do you make videos on pathophysiology of the endocrine glands ? if you do please provide me the links. thanks ! and if you dont, i think it would be better if you also make videos on pathophysiology of endocrine glands :)
very helpful thank you a lot :)
I love you man!!!! :D
i like this
Glucagon promotes Glucogenolysis (the degradation of Glucogen into glucose). It doesn't go through gluconeogenesis because gluconeogenesis is the synthesis of glucose from non-carbohydrates molecules such as TAG.Anyway, perfect video ..
again, better than my professor.
Amazing work!!!
I don't know it it's well proved, but we've just seen that GLP-1 may potentialize the effect of insulin
That was good
2:23 Glycogen has nothing to do with gluco-NEO-genesis; but rather glycogenolysis.
1. Gluconeogenesis uses: Pyruvate
great
can you tell me how to make my body produce more glucagon? thank you
Drop insulin
This is helping me so much right now before my finals ..thank you kind sir :') :D
bro youtube should have already verified you.
There is one little mistake in video , glucose cant be made from fatty acids , only from gyicerol, otherwise , keep doing your work ! :D
very helpful,,,, thank uuuu (Y)
Long life man.......
Last schematic should have Glucagon (rather than Glycogen) at the top.
Love from Afghanistan
Hi All respect for you ,but remember one thing you are the only one saying such things here, we all do like his video and thump up Armando because he is doing all this effort for us because you know why !!he cares to help others and we care for him too . stop saying such things ok next time say something good or better to be silent . thank you for listening :)
That was some crazy shit. I thought I was pretty good with anatomy and physiology. Thank god I don't have to memorise that much detail for my uni course
i have to memorize all this shit for my uni course in biochem :/ fml >.>
I have to memorize all thşs shit and loads of other even more detailed shit for my uni course in Medicine.
the synthesis lacks details... (encime names, what actualy happends - tipe of reactions...) sorry for criticising, and bad spelling :)
You made a mistake, fatty acids cannot be converted back to glucose due to the irreversible link reaction.
You're misinterpreting what I said. Other precursors can be used to synthesize glucose like amino acids, glycogen, lactate etc. Glucose can be converted to fatty acids however this reaction is irreversible because acetyl coA cannot be converted back to pyruvate.
Thing you are doing is excellent. Keep improving. You can do chapters like 1 hour lessons, in endocrinology. Like Chapter 1 "Tyroid gland" which includes all aspects briefly - phisiology-phatogenesis- Disease state- Treatment- Pharmachological approach. I expect this from you later on.
AHH too fast
ftw,,
Very helpful , thank you so much