Everything You Need to Know About Bupropion (Wellbutrin Review, Bupropion Side-Effects, Uses, MOA)
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- เผยแพร่เมื่อ 7 มิ.ย. 2024
- Everything you need to know about bupropion is covered comprehensively in our thorough Wellbutrin review, which delves into bupropion side-effects, MOA, and more).
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This video is a comprehensive Wellbutrin review covering its indications, mechanism of action, everything you need to know about bupropion side-effects, and more. The FDA approved indications for Wellbutrin (bupropion) include major depressive disorder treatment, seasonal affective disorder medication, smoking cessation aid (marketed as Zyban), and weight loss when combined with naltrexone (Contrave) or dextromethorphan (Aplenzin).
As a norepinephrine and dopamine reuptake inhibitor (NDRI), Wellbutrin's mechanism of action involves inhibiting the reuptake of these neurotransmitters. Common Wellbutrin side-effects include dry mouth, nausea, headache, insomnia, and tremor. More serious potential bupropion side-effects are seizure risk, sjs (Stevens-Johnson syndrome), hypomania/mania, blood pressure elevation, and increased suicidal thoughts/behaviors in youth.
Important Wellbutrin drug interactions to consider include CYP2D6 inhibition affecting codeine, beta blockers, and atomoxetine metabolism. Caution is advised with MAOI combinations due to hypertensive crisis risk from increased catecholamines. Wellbutrin's active metabolites like hydroxybupropion contribute to its therapeutic effects. Overall, this comprehensive Wellbutrin medication review covers key aspects for prescribers.
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#depression #psychopharmacology #adhd
Chapters:
00:00 Psychofarm is a Perfect Place for Shade
00:09 It's not Buproprion
01:23 Indications
03:40 Formulations and History
09:09 Mechanism of Action
14:53 Side-effects
18:35 Metabolism / Metabolites
19:25 Drug drug Interactions
22:12 Outro
Please just don't stop.
We (psychiatrists) really need your videos
Not stopping, just starting
Really good videos. Appreciate your service to our education!
🫡
My doctor said that, Wellbutrin inhibits more dopamine than noradrenaline. He said actually it's very week noradrenaline inhibitor. Instead of noradrenaline it works on dopamine. This is what my doctor said
man i also always thought it was buproprion i'm so glad i'm not alone
Thanks for the easy break down. ❤
Love your videos!! 😁🔥
Excellent content. Thank you
Thank you SO much for that info on vortioxetine + bupropion! I’ve been looking everywhere for data on combining them (given their interaction) and now I know the suggested max of vort is 10mg in combo. Can you PLEASE cover Vortioxetine in a stand-alone video? It hits so many receptors and it’s so interesting.
It will certainly be a while, but will hopefully eventually get to it
I love you already! Your great!
Thanks for this!
You are welcome!
Amazing video!!! And youre a stud muffin
i wish he could be my psychiatrist
Dig this video. Thank you!
Much appreciated!
Great video! Made me laugh a few times!
Thanks!
How common is balding as a side effect? I see it online but doctor and others never mentioned it.
In following on from the moa diatribe, if you look at the effect of antiseziure drugs as mood stablisers, is it then assuming wrong that an ndri with seziure risk is contraindicated for bipolar mania 🤔
Also I saw somewhere that Bupropion increases plasma levels of reboxetine multiple fold but it wasn't the best source and you won't find it in the literature. Make of that what you will but worth putting out there.
Ritalin isn't used as antidepressant anymore. I wondering if subjective mood scores would be equal for equal DAT blockade in ritalin vs Bupropion. More over I am wondering why ritalin doesn't have the same seziure risk as Bupropion?
Okay with the Jung deep end joke I had to log in and say:
good channel
good sense of humor
I loved psychopharm (basic, wikipedia) when I was in my late teens and doing drugs, and now I'm in my late 20's trying to find a way to not kms using a lot of the same knowledge and the help of my psychiatrist.
Thank you
Much appreciated! I’m almost there already…
You are the most precious psychiatrist.
(❁´◡`❁)
Is there a benefit in taking more than 300 mg in terms of dopamine and focus? Such as the max dose 450 mg
Nice; can you do a AED series, like you did with the antidepressants. I like your input on medicines; for example low dose quetiapine is basically a glorified antihistamine.
Maybe one day in the very far future but neurology is not my specialty so will probably stick to the psychiatric component of things
Thanks! Simply said..
Sorry for grammar errors, i am from Europe.
In my country we still do not have so many variations of the drug as bupoprion.., actualy we have only wellbutrin. For now ...
Thanks for all information and education.
Most important is what U say at the end of the video. For me, at least...
Thanx and b.ok
Howdy boss. Will I be blessed to hear you talk about Zuranolone in a future video? Cheers :)
Great.
I love your video's hehe
I thought it was 'bupropRion' too. New mandela effect!
Does Wellbutrin feel at all like adderall???
I just came off adderrall due to to horrible side effects…too much anxiety, sweating, sleeping, and physical tension I just couldn’t handle anymore….after taking for 10 years. My anxiety is so much better off adderrall but all other symptoms like lethargy and depression are back full force.
I’m worried that Wellbutrin will cause similar side effects and increased anxiety.
Should I be??
*Money tree playing* yep this is gonna be a good Psych video
That's just how I feel
Back 50 years ago, we just called these guy’s mamas boys. Now we have all these scientists involved and plenty of medications..
Since you didn't list spongiform degeneration as a side effect, you know it's bupropion and not "buproprion"! Thank you for another awesome vid!
source?
@@plockacherrys5765 It's a joke. Prion = causative agent of spongiform dementia
😂 this one took me a sec
@@PsychoFarm Can modafinil improve visual memory?
the guy that smells like cabbage on the subway told me its pronounced Buproprion..so we had it right all along
And now I smell like cabbage
you got a linkedin?
All I have on this drug is insomnia and anxiety. I hate it so far.
Non boring....u sound comatose!!!!! Tu for the info😮😮😮😮
New subbie here.
Much appreciated!
"con-tra-vay" lol is it intentional at this point
One never knows
I still say "Buproprion" to this day lol
I literally learned today propanolol is not propanolol; it's propranolol. Subtracting "r"s is just as bad as adding them.
@@kenhaze5230 Yeah I was calling it that for years. Also "sertaline".
And "Risperidal"
Me too Shane, me too
No offence but as someone with adhd this video was very difficult to watch. Too much side chatter just get to the point 😅
Don’t watch it then, smarty
Wow. Brutal. Just let the man enjoy himself.
Just watch it at 1.25 speed 😅
As someone with depression this video was actually enjoyable to watch lol
Sounds like you just couldn't understand it. Tik tok probably has shorter videos that might help you.
Your videos are great but you should get a better mic.
Still Love them though
Audio on next vid will be better I pinky promise
You look exactly like your voice
Interesting 🤓
Ur so funny😭
When they released the bupropion/DXM formulation it helped solidify my combination using another SERT compound with far less side effects, 450mg 24hr release + Chlorphenamine 4mg x 3/4 a day, also 13:37 did you screenshot wikipedia? Really hope you never used wikipedia as a source of information within your video, you would lose marks in the test (thumbs down).
youre not a dr? wiki has references. ive used it
This is actually the most boring…
☺️ Thanks for taking the time to comment
You sound very unsure about what you are talking about. Sorry. I had to say it.
Way too mumbled. Learn to pronounce the names. Very unreliable information if the presenter can’t even speak clearly.
Yeah. Leaving the video now, it’s been about 1.5 minutes. I already know I can’t finish listening to you, sorry. Way to click bait. Boring is an understatement.
I for some reason, thought this channel was mainly about drug pharmacokinetics, pharmacodynamics lol
Contrave, pronounced like the a in IPA