Penicillin and Antibiotic Resistance (from PDB-101)

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  • เผยแพร่เมื่อ 14 ก.พ. 2019
  • Since its discovery in 1928, penicillin and penicillin-related antibiotics helped save countless lives from bacterial infections. However, in the face of overuse and misuse of antibiotics, bacteria evolved resistance mechanisms that allow them to proliferate even in the presence of the newest antibiotics. Watch this video to learn how penicillin and penicillin-related antibiotics disrupt the bacterial life cycle, and what molecular mechanisms bacteria employ to evade the action of these drugs.
    Learn more about antibiotic resistance from PDB-101 pdb101.rcsb.org/browse/antimic...
    Story by: Stephen K. Burley, David S. Goodsell, Maria Voigt
    Animation and Video Editing: Maria Voigt
    Narration: Brian Hudson

ความคิดเห็น • 88

  • @RCSBProteinDataBank
    @RCSBProteinDataBank  5 ปีที่แล้ว +11

    To contribute subtitles to this video in your language, use this link: th-cam.com/users/timedtext_video?v=m0V6DRJBBGY&ref=share

    • @ivanbombana9481
      @ivanbombana9481 5 ปีที่แล้ว

      Very beautiful video!! I amo a chemist 😊.... are You looking for a new chemist in your team? 😊

    • @RCSBProteinDataBank
      @RCSBProteinDataBank  5 ปีที่แล้ว +1

      We are looking for a Biocurator at Rutgers. Have a look:www.rcsb.org/news?year=2019&article=5ba8f79f6078e948d6421758

    • @RCSBProteinDataBank
      @RCSBProteinDataBank  5 ปีที่แล้ว +1

      Sorry, this link is better: www.rcsb.org/pages/jobs

  • @geoggernaut
    @geoggernaut 3 ปีที่แล้ว +43

    the squishy sounds really made me realize the importance of antibiotic resistance in a molecular level

  • @shihyonseo7314
    @shihyonseo7314 2 ปีที่แล้ว +18

    The video made so much sense. The graphics and the sound effects made it so much easier to understand how penicillin works. Thank you for a great video!

  • @desireemartin3303
    @desireemartin3303 3 ปีที่แล้ว +15

    I am so grateful to share the animation with my students, so they may see the mechanics of macromolecules in action through bonding.

  • @kummer45
    @kummer45 4 ปีที่แล้ว +11

    This work is of institutional proportions. From these new scientists will understand problems faster due to the detailed explanations with the animations.

  • @adabujiki
    @adabujiki 4 ปีที่แล้ว +7

    Seriously this is mind blowing .. i could watch 3 hours of this. How did they find out these details ??? This is bleeding edge bio chemistry.. and this guy and his voice drive this home!!! The detailed explanations, graphics OMG!! Imma fan

    • @raplopez4258
      @raplopez4258 2 ปีที่แล้ว

      I know, thank God for his American accent

  • @srgkzy1294
    @srgkzy1294 5 ปีที่แล้ว +20

    Underrated channel !

  • @jamesdean1074
    @jamesdean1074 5 ปีที่แล้ว +27

    Top-notch AV work. Thank you very much.

  • @ideoformsun5806
    @ideoformsun5806 5 ปีที่แล้ว +11

    I hope we can learn to use bacteriophage therapy more. It's targeted to a specific bacterium, and leaves the rest of the microbiome.
    I wonder if then we could cycle antibiotics in and out of use to retain their novelty.
    I wonder if antibiotics affect mitochondria.

  • @reneecardoso6400
    @reneecardoso6400 4 ปีที่แล้ว +1

    Esse canal é excelente.
    Parabéns!!!!!!!

  • @jamiek6471
    @jamiek6471 4 ปีที่แล้ว +2

    This channel is priceless

  • @sciencemomma100
    @sciencemomma100 4 ปีที่แล้ว

    Explained very well!

  • @muhtesemaksoy
    @muhtesemaksoy 5 ปีที่แล้ว +2

    A very good and educational video

  • @kseniaershova3818
    @kseniaershova3818 5 ปีที่แล้ว +2

    Thank you very much! Very cool video!!

  • @tilak231
    @tilak231 4 ปีที่แล้ว

    Awesome explanation!!!

  • @abeeraftab9410
    @abeeraftab9410 3 ปีที่แล้ว

    Such a helpful video.

  • @daniellujano5894
    @daniellujano5894 4 ปีที่แล้ว

    Wow, that was fantastic

  • @user-up6st1hx1t
    @user-up6st1hx1t 2 ปีที่แล้ว

    Thank you.. incredibly useful

  • @Kubra-fy7df
    @Kubra-fy7df 2 ปีที่แล้ว

    ga ik gebruiken tijdens mijn lessen, merci!

  • @williamdoherty4727
    @williamdoherty4727 3 ปีที่แล้ว

    This is really great

  • @augusto256
    @augusto256 5 ปีที่แล้ว

    Wonderful videos

  • @pharmaseraj
    @pharmaseraj 5 ปีที่แล้ว +3

    Very good

  • @rosesiano1173
    @rosesiano1173 ปีที่แล้ว

    Absolutely incredible fantastic and amazing.

  • @sharosepp8277
    @sharosepp8277 5 ปีที่แล้ว

    awesome..
    thanks a lot

  • @xpossed
    @xpossed 4 ปีที่แล้ว +4

    "oh.... That wasn't so bad"
    "That was penicillin"
    *_"BRUH"_*

  • @lintangkawuryan4587
    @lintangkawuryan4587 3 ปีที่แล้ว

    amazing video thankss!

  • @devendrakhandelwal5468
    @devendrakhandelwal5468 2 ปีที่แล้ว

    Thank you so much sir 🙏🙏🙏

  • @------country-boy-------
    @------country-boy------- 5 ปีที่แล้ว +1

    god i love these videos

  • @mcdonnell-douglasdc-1032
    @mcdonnell-douglasdc-1032 2 ปีที่แล้ว

    Excellent.

  • @ashleen6985
    @ashleen6985 4 ปีที่แล้ว +1

    Brilliant

  • @ShivaBioTechnical
    @ShivaBioTechnical 2 ปีที่แล้ว +1

    विख्यान बहुत अच्छा है धन्यवाद

  • @I_am_AmanSingh
    @I_am_AmanSingh ปีที่แล้ว

    So what is more effective penicillin G or penicillin V??

  • @PocketGlobalHealth
    @PocketGlobalHealth 5 ปีที่แล้ว +32

    The WHO recently listed antibiotic resistance as a leading threat to global health in 2019!

    • @lessalazar9068
      @lessalazar9068 3 ปีที่แล้ว +1

      Well... look at where we are now

    • @tucker2074
      @tucker2074 3 ปีที่แล้ว +4

      @@lessalazar9068 This is a "Plandemic" not a "Pandemic"

    • @Fallenangel_85
      @Fallenangel_85 3 ปีที่แล้ว +4

      @@lessalazar9068 A virus pandemic, unrelated to antibiotic resistance.

    • @DB-gl3jx
      @DB-gl3jx ปีที่แล้ว

      @@Fallenangel_85 Can be related if people take antibiotics for viral infections. One of the contributing factors to antibiotic resistance.

    • @DB-gl3jx
      @DB-gl3jx ปีที่แล้ว

      @@tucker2074 You live a sad, misinformed life.

  • @AcuarionAdenine
    @AcuarionAdenine 5 ปีที่แล้ว +4

    Ah Cat and mouse games , i love those

  • @jeewan1985
    @jeewan1985 5 ปีที่แล้ว

    Sir i understand completely and all world is know about drug Resistant Typhoid in Pakistan XDR typhoid Extremely drug Resistant also meropenim Sir here is my one question many Medicine companies selling there Antibiotics one just 05 rupees than other same are 50 rupees why ....If i am not wronge low power medicine or not completely distroy the Bacteria when the 3rd generation Antibiotics is powerful but patients are not treated...

  • @iliketurtles6777
    @iliketurtles6777 2 ปีที่แล้ว

    Could phage viruses be effective against these super bugs?

  • @brandonkelley6500
    @brandonkelley6500 5 ปีที่แล้ว +2

    Those sound effects tho

  • @Meleeman011
    @Meleeman011 4 ปีที่แล้ว

    Why not just let mold and mrsa battle it out?

  • @magellanaa
    @magellanaa 3 ปีที่แล้ว

    someone knows how to synthesize penicillin by chemical in vitro process? (No biochemical, no biotechnology)

    • @josoghurt5192
      @josoghurt5192 2 ปีที่แล้ว +1

      Yes! For years I have waited to share my scientific research. The only way to synthesize Penicillin in a lab is by [ redacted ]

    • @magellanaa
      @magellanaa 2 ปีที่แล้ว

      @@josoghurt5192 how funny

  • @jayashridoddamani7659
    @jayashridoddamani7659 4 ปีที่แล้ว

    Please let me know the difference between penicillin and antibiotics

    • @arqamzahid1821
      @arqamzahid1821 4 ปีที่แล้ว

      Penicillin is just a type of antibiotic. There are many other groups of antibiotics available.

    • @Weezechargedup
      @Weezechargedup 2 ปีที่แล้ว

      Does it work for sexual transmitted things ?

  • @nagendrarao3147
    @nagendrarao3147 4 ปีที่แล้ว

    👍👍👍

  • @bitchplease1519
    @bitchplease1519 3 ปีที่แล้ว

    niceee

  • @peakhead7087
    @peakhead7087 4 ปีที่แล้ว +1

    Wherever we go there is war.

  • @inesreardon3265
    @inesreardon3265 3 ปีที่แล้ว +2

    Please make sure to make it clear that "bacteria does NOT develop resistance in order to fight antibiotics" as implied in the video. Mutations are random, not driven by the organism's need! The mutation "pops" up which provides positive selection when the bacterium is in an environment with antibiotic present. This bacterium survives and reproduces.

  • @thug.shaker931
    @thug.shaker931 4 ปีที่แล้ว +1

    I am allergic to this medicine

  • @chrisp8168
    @chrisp8168 2 ปีที่แล้ว

    Marijuana killed my MRSA after months and months of failed antibiotics and if and when I ever get another infection that's exactly what I will use!

  • @poulomi__hari
    @poulomi__hari 4 ปีที่แล้ว

    Why is an enzyme named after New Delhi?

  • @jirayurchonmanat6887
    @jirayurchonmanat6887 ปีที่แล้ว

    Begine of the world

  • @malvinderkaur4187
    @malvinderkaur4187 3 ปีที่แล้ว

    why is bacteria named New Delhi? that is not fair.

  • @josepablolunasanchez1283
    @josepablolunasanchez1283 4 ปีที่แล้ว +1

    Alexander Fleming was not a pioneer and he did not invent penicilin. It was a Nicaraguan named Clodomiro Picado Twight.
    * 1923 Clodomiro "Clorito" Picado published a paper titled "Sobre la acción fitopatógena de los hongos a distancia" where he discovered penicilin effects on plants.
    * 1927 He published the paper "vacuna curativa no específica" described clinical data on how penicilin helped people with several infectious diseases.
    * 1929 Alexander Fleming published a paper on British Journal of Experimental Pathology on Penicilin.

    • @hwanglee3330
      @hwanglee3330 4 ปีที่แล้ว

      Do you have its paper in English? I am curious. Thanks

  • @dianetheone4059
    @dianetheone4059 ปีที่แล้ว

    *****

  • @Caktusdud.
    @Caktusdud. 4 ปีที่แล้ว +1

    Hhhmmmmm oo I know we one that penetrates the membrane and then explode

  • @Weezechargedup
    @Weezechargedup 2 ปีที่แล้ว

    Does it work for sexual transmitted things ?

  • @shianeharris1340
    @shianeharris1340 2 ปีที่แล้ว

    .🦁

  • @hwanglee3330
    @hwanglee3330 4 ปีที่แล้ว

    So greeny fungus lol

  • @bb-ig4kk
    @bb-ig4kk 3 ปีที่แล้ว

    💉

  • @jeepz669
    @jeepz669 2 ปีที่แล้ว

    Wow, how could these geniuses screw up so bad and allow super mutant bugs to potentially develop and destroy masses of people??

    • @shakehandsman
      @shakehandsman 2 ปีที่แล้ว

      Your assumptions are showing