I recorded this twice saying NCC2215 the whole way through... 🖖 Use code 50DRBENMILES to get 50% OFF plus free shipping on your first Factor box at bit.ly/3OqNXuh!
Ethically questionable ad-read considering it's a service only provided in the US and you do not live in the US, so how could you possibly be a customer?
@@ryanbentley6147 The delivery of this ad was pretty nice and although I try to block all forced ads, I tend to watch those incorporated into the clip by a maker. I live in Poland and just as you noticed - I will not be able to get this product even if I wanted. But, there are other companies starting to provide such services. And this is where such ad comes with good results - you have the idea, topic and basic data for search. In my country, they call it "the box diet" and I was able to find services like that in my town too 😊
Thank you for the work you and your team made. This is really wonderful to see, when universities get funded and their research is used. Combining all that Feynman spirit of having fun with science and imagination and creating something amazing for humanity well being 👍 Great thumbs up and more such positive news please! Live long and prosper 🖖
It's been almost two decades since a doctor explained insulin to me, and it still baffles me that my cells need a signal to remind them to not die but instead eat the ample food in the environment around them.
Yeah it sucks. Now I don't have diabetes, but I do have liver and kidney failure. Kidneys failed due to liver failing. It is called hepatorenal syndrome. Man I remember the days they failed too. Could have given me a cup as big as the ocean full of liquid, and it wouldn't have satiated my thirst. I was already on a liquid restriction. I remember burning through two liters of frozen juice just munching on it. I actually went into the ER, because I wasn't going to the bathroom at all. I just got out of a two week stint, and from a coma. I did not want to go to the ER within 48 hours. So the third day I went where they went onto do horrible test. Like shoving a straight cath in my penis fishing for urine with No pain killers or muscle relaxers. Only stopped due to my vitals being dangerous! Anyway just posting because I think the Egyptians weren't kidding with the thirst thing. My insulin scares me honestly. Always sitting at 120 which I hear is pre diabetic, but no doc is taking it seriously since I have organ failure.
I do NOT know biology that well. But I do know a bit more about fail safes...and that sounds like a failsafe. Sounds like a way to prevent cells from going berzerk outside the body's support system. create a system that requires a specific and hard to get otherwise resource and make them dependent on it? That, to me, sounds a way to prevent cancer. It's a feature not a bug.
My girlfriend was a type 1 diabetic. She also had kidney and heart disease. She looked healthy 5' 5" 120lbs. Less than a year into dating her she had a stroke. She told me she wouldn't live past 50 years old. She died when she was 37. Her name was Heather and she had two daughters.
As a type 1 diabetic since I was 5, I do appreciate the rare reminders that people are actually working to cure this disease. On the other hand I really wish we'd stop preemptively and wrongly labeling everything a cure. It gets very disheartening.
My wife and daughter are T1. It is nice to know work is being done around the world. I think most people this close to it understand that a proper cure is very complicated. With any luck something like this can become the standard insulin and eliminate dangerous lows. That would be a big win in my books. Heck 36 years ago my wife was doing litmus tests to check blood glucose and not counting carbs. We've come far enough that i have hopes this thing becomes a minor nuisance. Stay strong!
Actually, I doubt this guy is a proper MD. Modern Western doctors would never claim a treatment as a cure. you have to be so careful on TH-cam. the content creators care more about views than any other thing. pure greed driven. they tell themselves all kinds of things to help them not worry and sleep at night, but in the end, they are greedy and if they are not outright liars then they are bending the truth within millimeters of being a lie. im getting so frustrated with the direction TH-cam is taking. there was a time when YT was sprinkled with Bullshit, now it's almost everywhere. Clickbait was fairly common, but now its almost everywhere.
@@k-mac9798 yeah, just consider how much money the pharmaceutical manufacturer and intellectual rights holders will make!!! This is a gimmick and a money grab. Think critically.
Sorry, the people on this video aren't working to cure diabetes type 1, or 2. This is another treatment. The Chinese are working on a cure. Check "Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient" published last September on Cell magazine.
@@acmhfmggru Yep, and one I'm ready to pay for because after 35 years of type 1, my body is failing and I'm tiring. I hate the diabetes industry but my kids and wife are without a father and husband, without it. I would have been dead at 15, I've already tripled that and at 50 it's clear even with insulin, it's hard.
@@Dosbomber neither do you. And neither do the doctors. I am sure you have never tried fasting since you seem to have a lazy mindset of dismissing. Goodluck finding a pill that fixes everything
As a bioinformatician and someone who has Diabetes Type 1, I must say that if Novo Nordisk is able to push this through clinical trials successfully (which... realistically speaking is another 10 years or so) this can indeed really help people with diabetes. There is a huge catch however, while yes this feed is undeniably amazing, it does not cure the disease. Yes, administering insulin won't become as much of an accuracy art, but we'd still need to inject the new compound while monitoring glucose levels (as a really simple example; exercise for example can still cause hypoglycemia). This is by no means a dig at the amazing achievement, but it is still a very long ways away from actually curing diabetes.
I couldn't have said it better. Thank you. If you really want to follow someone seriously trying to actually "cure" Type1 diabetes, follow Dr. Denise Faustman, MD, Ph.D
While I agree it's not a cure, if I haven't I misunderstood you could have a big dose once a day and it would effectively self regulate. No need to measure blood sugar, or even to be careful with sugar intake, just a daily jab. Possibly even some sort of slow release implant? A cure would be better, but this sounds like a huge step in the right direction. This is probably completely ridiculous, but if you could create an implant with GM cells in it which manufactured the drug, it would effectively be a cure? I'm not in the biology field, so that's probably closer to scifi, but a nice idea.
The title is misleading. They haven't created a cure for diabetes, but a new form of insulin. A cure for diabetes would be a proper functioning pancreas. But great research indeed.
This is overhyped. It isn't a cure. Compared to a well run closed loop this will provide marginally tighter controls (and still require the loop). I wouldnt say no to it. But it's not a miracle drug.
@@lunakoala5053 It's the headline to the discovery/creation of insulin, a drug that literally saves the lives of millions of people daily. It's as far from excessive hype as one can get. Similarly, an improvement on this drug that helps prevent the much less numerous but still very much present lethal over/underdoses of insulin when people/pumps fail to monitor and administer it correctly still wouldn't qualify as "overhyped".
Even if it's a cure it will cost you 30 million USD out of pocket to afford, and no matter what provider, doctor, or hospital you go to it'll be out of network for when you actually need it to not die. North Korea will be more likely to fund it for their people than the USA is for it's own citizens at the rate of medical progress globally.
I mean, at the time it was a very appropriate headline. Before insulin, Type I diabetes could be a death sentence, particularly for children who at age 10 would have between 1-3 year life expectancy after showing symptoms. It was absolutely a terror, like being told you have terminal cancer. Then right after insulin use began the life expectancy shot up exponentially. By the 1940s that same 10 year old kid developing Type I diabetes could have a life expectancy of 30-40 years after symptom onset with the use of insulin.
@@SerendipityChild It works for a while, just so long as there are new suckers to fall for it. I regularly avoid channels where they have sucked me in with click bait. The shame is that an accurate title may have attracted me to watch and not left me pissed off.
@morbidmanmusic youtube could certainly change their algorithm so that long- form videos that are released less often aren't penalised compared to short, frequent content. Im sure a lot of people are like me: you see a new video is out, but its from a creator who make detailed and long content so you decide to watch it later. However the engagement rate in the first few minute of a video being released drastically impact its trajectory because it will either be boosted or quashed. On a more holistic level, if people didn't respond to advertising that used sex and hype music, advertising would be informative. If people didn't respond to celebrities chasing balls around a field, culture would be art and music instead of sport-ball. The thing is, attention grabbing is a science of sorts. We only have so much attention, so we have to be selective. The trick is to grab us in ways that poke the primordial brain: sex, food, fear, excitement
it also sounds like it still needs a constant dose smh, (they prolly love that people have to buy it over and over) but we shall take what we can get ig
This smart insulin is a treatment and we'll have to see how much it costs. A cure would mean fixing the immune response that kills the beta cells in the pancreas. Big Pharma likes treatments better than cures though, so it would probably have to be PhD students and/or government funded research that develops the cure.
@@Max24871 Just follow the money. They got founding from an insulin selling company, of course they'd never be allowed to find the cure. Only more expensive insulin to be sold :/
All I can say is thank you for working on this and bringing it to my attention. I've had type1 diabetes for 54 years and have been hoping for something like this every moment of those years and have been let down so many times after hearing about a great cure possibility which suddenly disappears from view so I really hope this succeeds and removes part of this burden from my life. I would even ask to be a guinea pig for when human trials start as this sounds very positive. God bless.😊
As a long time diabetic myself, I first heard that "a cure is just 5 years away" approximately 30 years ago, and there have been sporadic news about a cure being only 5 years away every few years since then. I quickly learned to temper my optimism.
Been T1 diabetic for 20 years now and it’s always fun to follow these advancements (with realistic expectations) - real time digital glucose monitoring is probably the most life changing thing I’ve experienced. Great work and super interesting history too, I’ll refer to my urine when I have high blood sugar as honey going forward 😂
Hey man, I watch your videos...recently I've had pancreatic necrosis and became T1 diabetic too, my lifestyle wasn't bad (no excessive drinking/smoking) I was in the middle of my PhD but now things seem bleak, anyways do a video explaining how CGMs work, it is useful and helps me exercise to release stress
Too bad the especially cool stuff seems to never hit the market. Read about regrown pancreas cells being put in a super fine "mesh", that allows insulin to be put in the bloodstream but keeps antibodies trying to reject or otherwise attack those cells out. Been like 15 years, nobody talking about it anymore. And thats what I'd really want. With this I'm still bound to my pump and probably still need to announce meals (unless we're wasting a ton of or by basically always giving way too much for it to then regulate itself down to the needed level). It's super cool from a science perspective and its another incremental improvement like CGMs and closed loops have been the past decade. But it's far from being a cure and fundamentally changing anything. My biggest gripe with Diabetes currently is stuff being out of stock or poor quality. NovoNordisk being one culprit here. Second time this year I cant get my Fiasp Pumpcharts, which is also to be discontinued starting 2027, because they rather produce more profitable lifestyle drugs like ozempic. Interesting technology, but this aint it chief.
Honey urine is the way of the future. 😅 I have a needle-free glucose monitor company recruiting for pre-clinical trials coming out of the Uni of Bath shortly if you're interested - let's chat when we next catch up
A sentiment that I’m increasingly hearing and agreeing with is that the last century was the century of physics, but the big innovations in the next century will be in biochemistry
Chemistry is the underappreciated science. Just compare the number of books on popular science bookshop shelves. Everyone can name multiple famous physicists, a few biologists like Darwin and Watson and Crick but few can name more than a couple of chemists, if any, but as nanotechnology and biotech become the frontiers of research, (bio)chemistry is where all the interesting things are happening.
@limpid_runaway1879 oh, you're absolutely right - the agricultural revolution in the post war period especially was due to this. In no way was my comment intended to dismiss the incredible advances that did happen - just that biochemistry is now at the cusp of something incredible, similar to how the transistor and subsequent semiconductor and nanoscale fabrication has changed the world
It’s such a sad thing to realize the number of individuals who have suffered due to the lack of medical understanding. I’m extremely pleased to see the few who know putting together an idea that will make all the difference. Thank You on behalf of those we’ve lost and for those who will be saved. Everyone deserves to live and do so comfortably. I see you. I want the world to see you. I’m sharing this video.
Your molecule works just like the thermostat of an air con, or thermostat of an electric rice cooker. So it should be called "glucostat insulin!" Amazing invention! Congratulations! Cheers!
Sorry, the molecule isn't a cure to diabetes. This is just another treatment that aims to keep on squeezing patients and their pockets. Dr is a Novo Nordisk brat.
As a type 1 diabetic, this, Dr Ben Miles... This is the best news I've heard since I got diagnosed back in 2013! Diabetes is a growing problem world wide, and this will definitely help whilst moving towards medicine 5.0. I'm looking forward to seeing human testing, and a final product being released in the future. I am very proud of you, and the team working dilligently on the subject. I'm in awe! Thank you, thank you, thank you!
As a 28 year type 1 veteran I'm more hopeful about this than any of the previous breakthroughs. I really hope it works out, and would willingly volunteer for trials regardless of risk. If not perhaps for me then for the generations that follow, no one should have to go through this condition if there is a potential for a better solution out there
@@averieway right after an action is taken about climate change and before fusion reactors are built. right when politicians actually help the little guy and not just deregulate for wall street. then you'll see!!!
@@____________________________.x fusion will never happen ( sustained fusion ) we lack the mass to produce a sustained chain reaction of this type on earth.
As someone who had a kidney and pancreas transplant a year ago, this is absolutely fantastic news. The difficulties with injections led to my kidney failure, so developing this is amazing!
Hi, Biochemist here. Theraputic peptides are very promising. The only problem is they are at least 10 times costly than the costlier 'regular' medicine. Unless we got a way to manufacture them as cheap as regular cough syrup or at least regular antibiotic, there's no medicine 4.0. And all those out there talking about trickle down from rich, just know this - brute force scaling up won't do here. Otherwise the market is already pretty massive.
It can depend on where you're buying it. Given my present medication, I'd pay 10 times for an effective medication that works better and has fewer side effects. Govt drug price negotiation and universal Medicare makes a huge difference.
@@thekaxmax Those can only go so far. Some new peptide manufactuing process is needed. Unfortunately, contrary to what may sound, I doubt investing in something like that actually doesn't benefit the bif pharmaceuticals. Also, paying 10 times more is easier said than done, specially something which is supposed to be used by millions.
Won't this will be used on those poor sod who become insulin resistant? I am not diabetic, but do have hepatorenal syndrome. No liver or kidneys so I go to dialysis. There are many who cannot get their disease under control. Most of it due to age and diet, but I've heard a few suffer from rejection of medicine somehow. I try not to pry, but hard to not overhear when you got Doctors talking to them 3 feet away. Maybe that will be the first patients is my point. But yeah, nano -machine- tech for daily management use? Ehhh... EHHHH. Maybe if it was a cure, yeah. For a routine I'm not so sure we will see it for reasons you stated. Insurance isn't paying extra for that. I hope we both are way way wrong, and tomorrow releases the first anti aging nano machine tech for pennies!
I'm no expert but is Therapeutic Peptide Medicine usually associated with medicine for smaller patient populations? Which would inturn represent a higher cost per unit. In the case of NCC2215. If it had a cost 10 times greater then normal insulin it would not be financially available to anyone. However, it sounds like NCC2215 may be present longer in your system and therefore, users may require less NCC2215. In any event, it would only be financially viable if production costs are low enough for the price per required units to be comparable to the most expensive insulin currently available. There are obviously so many dynamics at play here but the potential benefits NCC2215 could have on people with diabeties is greater then the sum of it's parts.
Brilliant! As a physician (who loved the Banting and Best story Glory Enough For All) and bench scientist, who worked on protein structure and topology, I am absolutely thrilled. Thank you.
I’m just a T2D old lady and the research you did is amazing. I’m doing intermittent fasting and very low keto diet. I’m doing well as long as I eat at home. Church get togethers are challenging. Some people don’t want to share how much sugar or carbs they put into their food. I try to just eat the veggies and skip fruits and desserts.
Cool! Congrats to the team. Engineering team building a laptop controlled skateboard seems like hilarious and ideal depiction of engineering teams doing side quests out of boredom lmao
Thank you for your work on this and for promoting it. As a Diagnostic Radiologist, I can tell you that the damage I see from Diabetes each day is dramatic and life limiting. Any future with less diabetes is a better future for humanity.
Probably be better off getting rid of the poison food rather than having big pharma sell people the "cure". 95% of diabetes is type 2, aka fat people stuffing their faces, they can fix it themselves with fasting. I feel for type 1s though, that sucks.
This is very impressive and I don't want to undermine that, but I don't like the clickbait title. This is a better treatment for diabetes, it isn't a cure. A cure would result in not needing treatment any more.
19:10 By the way, if you are a diabetic in the UK, you get insulin for free as diabetes is a terminal illness and the NHS covers the cost of the meds in full.
That true but it paid for out of a tax everybody working pays into called National Insurance and also the employer pays into it - Socialism at it best. lol
Amazing. I wish the MAGA crowd would see how beneficial universal healthcare is. We could save so many people and so much money on vital care. Good for you guys in the UK for taking care of your people.
@@PneumaNooseok, now look at how the NHS is crippling the UK and is completely unsustainable. Look at the 5 year wait for autism diagnosis, or patients on trolleys because there are no beds. There is a solution but it’s likely a middle ground. Universal healthcare is unaffordable in today’s world.
What an incredible project to be a part of for you. Thank you for sharing the story. As a healthy male, I occasionally do low risk medical trials to test the effects of new treatments. It would be great to help bring a medication that could benefit so many people to market. I've recently watched part two of a three part series on the history of insulin. This is a beautifully explained and animated side quest to that series.
This is amazing! Being very hopeful as I am a newly diagnosed diabetic and it can be brutal to get it under control. So thankful for scientists like yourself Dr. Miles. Thank you so much for what you do.
Cost to buy in America? Death, because let's face it, most Americans would not be able to afford it while the rest of the world will live long and healthy lives.
As someone who reversed Type 2 diabetes I find it offensive to call anything a "cure" if it allows you to continue to do whatever it was that got you sick in the first place.
Unfortunately since there's no financial incentive for Big Pharma to cure diabetes, the best we'll ever get is the current lifetime subscription model.
No financial incentive? Nothing except for exclusive rights to patent it foe the next 50 years or so. They would make a mountain of money!!! Making it into the history books would be another incentive. 5:33 these guys sold the patent for $1 fyi. Their incentive was helping patients.
I would like to point out that in "gestures vaguely" all the world that is not US the price is good enough for patients to not mind it. Yes, this is not a cure, and yes, this sucks, but at least it is not a death sentence if you lose your job, CRIST US. Automated pumps are becoming a thing more and more thanks to well, china and some people that write code, and so... it is becoming manageable to the point they are now "interested" to get a "new medicine", hence this ;)
What conspiratorial nonsense. There is immense money in actual cures.. Guess what? Actual cures are actually really, really hard. As the video pointed out repeatedly, many of these problems have been known for thousands of years. It's only in recent decades that we've learned enough to hope to go beyond mitigation. So much of what came before was geniuses fumbling in the dark because that was what they had to work with. It wasn't for lack of intellectual ability but rather the vast amount of research that had to be done so that later generations could build on that.
@@FrostekFerenczy my dad was a research scientist. It's amazing how/what people think of what "incentive" means for someone who dedicates their lives to doing one thing the best that they can . I get that the health care system in the states is "different" but they must believe that the reason that it wasn't cured 3500 years ago was the military industrial complex or some other equally silly BS.
It's insane how important the production of Insulin is to our bodily functions, which we often take for granted until we suddenly need to deal with having a whole host of problems which come with having diabetes.
Wish my mom was alive to see this. She was a diabetic, and eventually fell into a deep depression...miss her so much.♥She would have loved to see this. Thank you for sharing. Can't wait until this is available!
19:55 “if you help your neighbors it ends up helping you” - could not be more accurate and more of our policy and even personal choices should be based around it
I saw research a few years ago that confirms this. Countries that have smaller wealth differences have better health outcomes for both rich and poor citizens than in countries with greater income differences.
Helping your neighbor only can go so far. As someone who has worked for many homeless/rehabilitation organizations, I can personally tell you there are people who can NOT be helped as they refuse to abide by the rules/laws of civilized society.
T2 Down Under here. So glad I found your channel. Love how you take complex science and make it easier for the public to adsorb. I learned things today that I never dreamed possible - like the advent of 4.0 and especially working on 5.0. Good luck, mate, and "thank you" from the world, for all you are doing to help us.
Isn't T2 basically a systemic overload with glucose? i.e. your cells become resistant to glucose, because they already are saturated with it. Which begs for a simple solution - just stop eating anything that turns to glucose.
The coolest thing about this video is that the person who talks about the project actually took part in it! I think more scientists should make videos like that in their fields. Thank you for sharing this knowledge, it was very interesting!
Banting and Best actually isolated insulin at King's College in London, Ontario. They were based out of a lab in Toronto, which is why it is often thought that insulin was isolated in Toronto.
It's been a bit over 20 years since my 23 year old son was diagnosed with type 1. I do badly want him to be free of the constant injections and having to wear a Dexcom. We can hope that this treatment will become reality for you guys in the coming years ❤
@@monolith-zl4qt If you think it's all BS, why bother watching? are you a scientist? Doctor? Or like the rest of us. Laypeople who are trying to learn about new tech and treatments
Some research that I read some time ago showed that survivability in type 1 diabetes is highest in people with a stable 4.6 mmol/L, so this stopping at 4.5 mmol/L is, quite frankly, amazing. I have a semi-automatic insulin pump with an integrated CGM, and even with this it's incredibly difficult to manage a stable blood sugar. You need constant consistency in your life, which is not doable for many of us in real life. That is consistency in particular in diet and movement. If you work a physical job, don't expect to be able to have full mastery of your blood sugar, because it will depend on how much you will move that day.
THIS IS HUGE! It will definitively change a ton of lives and as a medical student cannot wait to see it. Diabetes and all of its complications, wether they come from medications or the disease itself is devastating, and this is a game changer.
This is so amazing. I have Type 1 and it has largely ruined my life. I was late-onset, meaning I was 31 years old when diagnosed. In the 22 years since then, it has killed my marriage, killed my career, and made life extremely difficult in many ways. I may never get to benefit from this development but it's really exciting nonetheless. Thanks for sharing.
@@milkydewymelon Yes, I did. I dropped to about 115 pounds before I was diagnosed. After starting insulin, my weight rapidly increased and leveled off at about 150 and I've stayed there ever since.
I'm type 1 also. It's not necessary that this disease should ruin your life. It's possible to have normal blood sugars almost all the time. Dr. Richard Bernstein is a lifelong type 1 diabetic who has worked out how to do this. He has written a book on how to do it. He has a channel on TH-cam. Check it out.
@@milkydewymelon Weight-loss is definitely one of the symptoms of type 1 diabetes as your body has to rely on its fat storage for energy since it cannot metabolize glucose properly. But it has nothing to do with how much candy you ate as a kid. Type 1 is a genetic autoimmune disorder and even newly born kids who have never eaten candy can have it.
@@milkydewymelon nobody here can diagnose you, but it doesn’t seem like something you would “think” you have.. it’s pretty devastating when unmanaged… and very easy to test for.
Thank you for pointing out how difficult and scary it is to have to keep your sugar from getting too high or too low, every day forever. It’s a ton of work and you feel crappy when it’s not “normal” levels. To not have to deal with very low sugars would be incredible.
is it true that "every cured patient is a lost customer" or "make them, all life renter. not one time buyer" thats why companies don't want to heal diabetes, cancer, hypertension with 1 time medicine?
Underdose seems possible, but since overdose is not, erring high is now safe, which solves underdose as well. If bonding strength is a good proxy for effect, then the overdose space is 12 times minimum effective, which is a huge window. The gap is probably less, but is still way wider.
(Warning: I know quite literally nothing about diabetes) I would assume it also means that you don’t need a dynamic dose and thus can stick to a static amount
You take more insulin depending of how many carbs are in what you eat. My ratio for example is 1 iu of insulin per 10 grams carbs. The benefit of this new type of insulin is that I can take more than I need safely. Blood glucose levels are affected by a lot of things so insulin per carb isn't a perfect solution.
this is my first video of yours, and i gotta say you explain complex chemistry very well! this is coming from someone who tends to draw a total blank because my brain just can't grasp it. this is such an exciting breakthrough and i'm glad i can understand it clearly!
10:57 They had the programmer mindset. Don't do boring or repetitive tasks yourself, code something that does it for you, even if creating the tool takes hours. That's TBH ~90% of the code I write.
Hate big pharma for their profit margins, eh? So you're hating economic phenomenon without thorough economic understanding. Think of it a bit. Any single one able to produce more effective treatment method like insulin discussed in this video would practically break out status quo, gaining customers from other big pharma and reap more profits for itself. It's oligopoly, not monopoly, and although it's super normal profits, it's the market structure that best allow for innovation.
@@NinaYahsikait's not about disruption or lack thereof, it's about perversion. even including underdogs, the market still has every incentive to wring people for every last cent they can, for care they need to survive. sickening
At least they are the biggest tax payer in my country (Denmark), since they are based here, so them milking every other country in the world of their wealth will benefit our tax system, so we can afford to subsidize the insulin for ourselves, lol.
I’ve been living with type 1 diabetes for 27 years now! It’s true-you often feel lonely, and I’ve taught myself not to "make a fuss." But the truth is, it’s incredibly tough to live with this condition. It becomes even harder because other people will never truly understand what you’re going through. It has definitely made me stronger, but I’m also starting to notice the neurological effects. Even so, this disease will not defeat me. I wish the same determination and energy to others who are fighting for understanding and everything else that comes with this terrible condition. Just go on!
What happens next is what I hope it won't happen: 1 - The company will be coerced by other insulin productors to shelf the patent for this medicine. 2 - It becomes yet another medicine for grossly huge profits at the cost of human health and quality of life. 3 - Companies delay it by 30 years because they can't give up their profit with insulin.
4) insulin is already profitable but once it becomes unpatented they'll introduce the latest insulin 2.0 to sell a premium product which does the same thing with a slight new feature. And they'll still not be cured from the diabetes.
10:11 you forget "Companies earns better for selling medicine rather than cure the sickness". It would be like a lightbulb company would create lightbulbs that lasts 10 years.. It did happen, but they realized soon that it was a bad idea.
Those "longer lasting" lightbulbs also required a lot more energy to use because the filament had to be much thicker. That's a good reason why they didn't become a thing.
@@GamesFromSpace They're thicker, but also produce more light for a given length so can be less long. Also the excess heat from the thicker filament just heats the room up, which at least for half the year is not wasted energy. Have you actually seen the calculations on this as I'm open to being corrected by actual research?
@@nonyobisniss7928 Dude, "excess heat" is evidence enough of the flaw. It doesn't have to be universally terrible in all seasons for them to rationally decide it was a bad idea, especially when electrification was new.
I know nothing about science, let's say, but I find this kind of things very interesting and really enjoy learning. Your channel just showed out of nowhere and I really appreciate it. Keep it up!
@@mpmpm I know some people in biotech, what's going to happen in the next few decades will blow your mind. Immune response for transplanted organs is almost a solved problem, pluripotent stem cells are able to be artificially induced, machine learning is solving unbelievable protein folding problems. It's going to be wild. If you are young-middle age, take care of yourself because there is a real possibility that biological immortality is very close.
@@Shrouded_reaper it's laughably ironic, AI is so incredibly effective in so many fields of science, but the public ends up getting LLM Artificial Idiocy foisted off on them. While we'll extend life by a fair amount, nothing is about to become a magic bullet for biological immortality, as the brain itself still will fail and no amount of stem cells will replace an already "wired and programmed" brain network. Still, just for shits and giggles, let's say we did manage actual biological immortality. Now, 8 billion people each have their children at our average population growth rate of 0.87% per year, how soon before we exhaust our food and water capacity for them?
@mpmpm actually not. When i sit in lectures, almost every doctor of any specialty is astonished and says "the last decade has been wild there have been so many advancements and exponential improvement in patients health", and i am positive that this will continue.
@@cc-bj9kvI'm sure you're right, but there are people suffering now that may not live long enough to see the benefits of these advancements. For some of those folks, the breakthroughs won't come fast enough, sadly.
For the full (drama-rich) story around the discovery of insulin with the dogs (and about how science really works), see Angela Collier's video 'who gets the nobel prize?'
Did you notice how recently so many people in health industry are coming forwards with new truths? The book called the 23 former doctor truths by lauren clark made me question everything
My own family developed new antibiotics but we never found a good time to actually push it out for the market since the major companies basically exist to take your idea and give you peanuts. But if there's some super plague out there I imagine every university to have a list of working antibiotics that would be effective.
“New truths” sounds _inherently_ sketchy. Do you mean they’re growing their field by refining, contributing towards, and/or building upon the available body of knowledge? Or some dogmatic rebellion loosely tethered around some (frequently mishandled) assumptions that sets them apart from the mainstream? Something else entirely? I get immediately skeptical with such ambiguous phrasing, either way.
This is wondering. I hope this works out as a common treatment. I lost someone very important to me to diabetes. She was fine one day. Gone the next.😓 Keep at it. The price issue IS deadly. No exaggeration.
"...you are essentially running your body on hard mode..." Yes, yes I am. I don't currently have a choice. Every day is a 24 hour chemistry experiment that might hurt or kill me. Thank you for this validation. It feels like nobody understands how challenging and frustrating it is to manage diabetes every day. I've been doing it for 46 years now, and I'm tired of it. These new advances in diabetes care give me hope that the children of the future can have an easier road than I had when I was little.
Man this is amazing! My mother is diabetic, and this would be such an amazing boon for her... Too bad here in the US this will probably end up selling for a grand a bottle...
I constantly talk about the "sweetness" of urine. I am a geriatric nurse- well, I was. Now I work with patients that are dependent of respirators, often after a tracheotomy and also somewhat often after a SARS-COV-2 infection. Anyway: In Germany old people just called diabetes "sugar" and often still call it that. In "some" cases they didn't really have much knowledge about their disease and, if open for it, I did explain it. The most often asked question: " My old family doctor told me to not eat any sugar. Is that still true? I love my Sunday cake with the family." Obviously I'm paraphrasing- everyone did ask something different to that same effect. I was surprised quite often. Normally NOTHING or better NO ONE was above their family doctor. Well, as soon as their doctors came after their guilty pleasure they were done with them.😂
@@RoosSkywalker I love the Dutch language. A bit like an old German dialect that was spoken mostly near the coast called "Plattdeutsch" . I have to admit that some words sound really funny to me. Like so funny it almost makes me laugh. But I guess everyone has a few words in every language that person knows that trigger that reaction. Or at least I hope everyone has.
This is a great achievement, but it doesn’t eliminate the need for insulin. In fact, people may use even more (and a more expensive type) since they won’t have to worry about high levels. No clue why Novo Nordisk was interested in it.
Well said. People will costantly overdose just to be safe if this comes to pass. They'll go through all these lengths to patch up a problem that can be fixed by simply eating less glucose, because there's no money in a simple cure.
I feel fortunate YT recommended your video to me. You have a gift in breaking down and explaining complicated science and having it make sense to "normal" people like me. This also hits close to home as two of my elderly loved ones struggle with the disease and have been hospitalized with hypoglycemia, Cheers!
I'm in my 3rd year of undergraduate school studying Physics. My interests include biophysics, materials science, and sustainability. I've been feeling a bit lost trying to decide what to do when I graduate. Should I go to grad school? If so what do I study? How do I ensure that I'm employable? Etc. But seeing inspiring work like this replaces my fears and anxieties with hope. I'm really grateful for content creators like yourself who make scientific news accessible for others. You are a great role model. Do you have any advice for someone in my situation?
My daughter is type 1 , Its a horrible thing to have to deal with . I would do anything to make her life better . Hopefully things like this become available .
Dr Jeremy Fung, you say you will do anything , well listen to alternatives to standard treatment.... medical world is there to make money not cure your daughter.... good luck
@@Dailyroach I'm a type 1 diabetic. The answer to your prayers is the method developed by Dr. Richard Bernstein.. He is a long time type diabetic himself. He is almost 90 years old and has maintained normal blood sugars since he devised his method when he was around 45. He has written a book on how to do this. He has a channel on TH-cam. check it out. He has been a life saver for me.
That's cool indeed. Hopefully it becomes accessible so that it really affects the people that need it. But it seems that it could be left in the CAR T-cells territory - yes, functional and effective, but prohibitively expensive. I really hope that it become accessible, either by the tech itself, or by economy of scale (as there's definitely scale there) , but until then I wonder about keto diet effects on the diabetes?
Great video with graphics that, as usual, are integral to making the material understandable for anyone rather than just something visual to drop in somewhere in the narrative. As a person with diabetes myself and a son-in-law whose right leg had to be amputated because of diabetes, I keep up with information about diabetes and treatments, so this has been a special edition of your videos for me.
dead people are known for not liking being alive and not liking being dead and not liking anything any longer… but if you are alive then you can click like 👍 on this video 😅
I'm type 3c diabetic myself as a complication of pancreaititis with some necrosis (had a cyst that went septic and eroded through my bowel). I had extreme phobia with needles so digital blood glucose monitoring has really been my savior. As it stands I only really need a single daily injection and can walk off some of the glucose when I go out of range. But type 3c means I randomly generate insulin, so even if eating the same foods daily I can end up going too high or too low depening, so I rely on constant glucose monitoring. Sensors really are a godsend. If I had been diagnosed earlier in life I'd be a wreck.
How is this in comparison to the Diabetes Cure that was announced from China, earlier this year? I am type 2, having to take Metformin, which raunches out my stomach. I am afraid to eat before going out, or eating outside and then having other errands to take care of. I literally have to plan my day around diarrhea, and do this at work, as well. This is not a problem since I work alone and I am supervisor of a small staff (different shifts). I need to plan my routine at work, with the idea of an explosive stomach than just suddenly happens. Personally, I think I have been misdiagnosed because my issue was chronic fatigue, and after 3 years of this medication, that problem still persists. But, Diabetes is the money-making flavour of the day. I detest GBM (Greed Based Medicine) and although I live in Canada, a lot still needs to be done to make health a fully paid-from-taxes Right.
Isn't T2 basically a systemic overload with glucose? i.e. your cells become resistant to glucose, because they already are saturated with it. Which begs for a simple solution - just stop eating anything that turns to glucose.
This was a really interesting video, but it left me with a question. If the NNC2215 is reusable, how long does it remain functional until it needs to be replaced?
Probably about as much as regular Insulin. In the animal trial they did a continuus injection. It's not like you inject yourself once a week and are basically cured in between shots requiring no further Intervention.
As an engineer myself.....Saying this it hard would be a huge understatement. Well done, at last . My father has diabetes. For almost 35 years now he's using insulin twice per day. I know how hard it can be for diabetic patients to live with it.
As best as I can tell (as a non-doctor, non-PhD) it doesn't. Replacing the insulin your body can't make on its own seems like a much easier problem to solve than making your body listen to the insulin you're already producing after it's basically become inured to it. So for the Type II folks like me, we're probably going to be stuck with metformin and limiting ourselves to a small bit of starch/sugar at a time for the foreseeable future.
@@IrishGerman +1. Yeah, there is lots of research showing that. I can add that my mother-in-law being on a keto diet for a month lowered her glucose and blood pressure levels by over 20%. But, being a stubborn old lady, she returned to her old diet full of processed carbs and her old results rapidly.
@@IrishGerman @krzysztofmaliszewski2589 keto diets are suicide for any who have the actual disease diabetes, it only helps those who do not have diabetes and just have symptoms mimicking it from being egregiously overweight
Great Video!! I love that you are so PASSIONATE about the current research findings and future possibilities of this clearly MAJOR breakthrough in the treatment of diabetes and soon other diseases as well! You have every right to feel very proud of what's already been accomplished and your own role in that most significant SUCCESS! Now I want to investigate investing in one of your mutual funds. Obviously only a tiny portion of the potential upside of these new technologies has been tapped so far. I want to be along for a longer ride up!!
So it's just a better version of insulin treatments? That doesn't stop the damage from sugars, or the weight gain. Modern science should be so much better by now.
Being a biochemist, I didn't quite understand why you need to engineer regulating add-ons to an artificial insulin molecule when the natural insulin molecule seems to do the job as well? Is it because the natural self-regulation mechanism is not designed to "hyperinsulinemia" since this would be prevented by the pancreas? What about a much longer half-life of this artificial and modified insulin to reduce the total amount of injected insulin then in longer intervalls? Else I really appreciate this progress and design evolution story!! 🙏😎
Natural insulin doesn’t work like this, it’s basically always on. In a normally functioning body the pancreas both creates and stores it. Then it releases as needed to regulate blood sugar. It’s the pancreas that does the work of regulating how much insulin is running around. type 2 diabetics like me lose the ability to store up the insulin and release when needed. Type 1 can’t even produce insulin. The biggest issue with taking insulin for type1 and severe type 2 is judging the dose needed to correct for what you eat, and not under/over dosing. Lowering carb intake helps reduce the degree of error, and makes it easier, but isn’t acceptable to a lot of folks. An insulin that self regulates would be a figurative godsend.
@ChuckvdL this was my knowledge as well till now, but in the video he mentioned that both tail ends can bind (but maybe don't usually do) to each other, so insulin doesn't bind anymore. Yeah, giving always-on-insulin is very hard to dose correctly according to food intake 🙈 Amazing protein engineering in this project!
This might be pessimistic of me, but I can't see "medicine 4.0" to be the most profitable since you are curing your customers, so to speak. With such a vast, privatised medical industry I can't help but think they'll do everything in their power to slow these kinds of technologies down. It doesn't fit in the neoliberal, everything is commodified, worldview... :/ Edit: That last bit made me surprisingly hopeful :)
Sort of. He did explain that medicine 4.0 doesn't solve the problem. 5.0 would get the liver to function as normal and not require diabetics to use insulin at all. 4.0 still requires diabetics to use insulin. The other thing is that it is mostly the U.S. that suffers from private medicine so while the U.S. might not want a cure, I don't see other countries with public healthcare actively avoiding a solution that would literally reduce strain on their healthcare. Someone can correct me if I am wrong but why would you not want a cure in a country that has public healthcare?
@@anubis520Ah fair. Those numbers are arbitrary. But the end goal I presume is to fix the illness instead of providing medicine. Which is amazing, but does not suit well with neoliberalism Well, due to things like the Marshall plan that helped out europe after the war, a lot of american tendencies do leak through. Although america's health care system is a lot worse, that of europe suffers from the same issues with big business dominating politics, and as they provide a lot of jobs, it is difficult to oppose them as a country. Same thing. Albeit to a lesser degree (for now). Lucklily there is a little more regulation. Still way to little for my taste. Coming from the Netherlands btw. A Dutch perspective here.
The US healthcare system needs a hard reset, these prices are insane! Let’s hope we get medicine 5.0 soon enough, maybe it will extend our lives a bit 🤞🏼🤞🏼🤞🏼
@@ioannisaliazis Greed is human nature and with the free market that greed had been channeled into something beneficial. But when the government stepped in and took control of the medical industry that made prices sky rocket. Because government is literally the opposite of the free market. The free market is the most efficient way to manage an economy, meanwhile government might be THE MOST INEFFICIENT institution in human history. Inefficiency has a cost.
Says the person who likely voted for ever higher prices in 2008 and 2012. The architect of Obamacare relates on camera that forcing costs increases were a key part of his scheme.
The difference in cost between the US and other places has No Excuse. Centralised or social medicine should not be necessary to manage prices. The US needs a law --- a simple one, not ten thousand lines of legalese --- that simply says "The cost of any medication sold in the United States and its territories shall not exceed by more than five percent the highest price found elsewhere."
That does not account for Purchasing Power Parity (PPP). The USD is worth more than a lot of other currencies. If you live in Elbonia, and you only make the equivalent of $2 an hour, that sounds bad. However, if everything only costs 10% of what it does in the US, then you actually have a very productive income. (That's why is easy for Americans to visit other countries, but not the reverse: our dollar buys more over there than theirs buys over here) So, if a US-based company conducts R&D in the US, paying US employees US salaries, then tries to market its drug, you have situation in which they MUST raise the price of the drug to off-set its US costs, but then that pushes out countries with weaker currencies. If fact, it pushes out poorer states that have the same currency, but not the same productivity. (This does not excuse "price gouging", but even if price gouging never occurred, the above statements are still true) So, if another country develops a similar drug, they could sell their version to us at reduced price (or price gouge us because we have more currency). If they can undercut us because of PPP, then R&D leaves the US. That means loss of jobs and independent sustainability. What you're offering is price-fixing. Sadly, it never works and only results in increased prices.
I recorded this twice saying NCC2215 the whole way through... 🖖 Use code 50DRBENMILES to get 50% OFF plus free shipping on your first Factor box at bit.ly/3OqNXuh!
NCC2215 - just cool.
As a Type 1 Diabetic, Thank you for working on this.
Ethically questionable ad-read considering it's a service only provided in the US and you do not live in the US, so how could you possibly be a customer?
@@ryanbentley6147 The delivery of this ad was pretty nice and although I try to block all forced ads, I tend to watch those incorporated into the clip by a maker. I live in Poland and just as you noticed - I will not be able to get this product even if I wanted. But, there are other companies starting to provide such services. And this is where such ad comes with good results - you have the idea, topic and basic data for search. In my country, they call it "the box diet" and I was able to find services like that in my town too 😊
Thank you for the work you and your team made. This is really wonderful to see, when universities get funded and their research is used. Combining all that Feynman spirit of having fun with science and imagination and creating something amazing for humanity well being 👍 Great thumbs up and more such positive news please! Live long and prosper 🖖
It's been almost two decades since a doctor explained insulin to me, and it still baffles me that my cells need a signal to remind them to not die but instead eat the ample food in the environment around them.
Evolution, am I right?
Yeah it sucks. Now I don't have diabetes, but I do have liver and kidney failure. Kidneys failed due to liver failing. It is called hepatorenal syndrome.
Man I remember the days they failed too. Could have given me a cup as big as the ocean full of liquid, and it wouldn't have satiated my thirst.
I was already on a liquid restriction. I remember burning through two liters of frozen juice just munching on it.
I actually went into the ER, because I wasn't going to the bathroom at all. I just got out of a two week stint, and from a coma. I did not want to go to the ER within 48 hours. So the third day I went where they went onto do horrible test. Like shoving a straight cath in my penis fishing for urine with No pain killers or muscle relaxers. Only stopped due to my vitals being dangerous!
Anyway just posting because I think the Egyptians weren't kidding with the thirst thing.
My insulin scares me honestly. Always sitting at 120 which I hear is pre diabetic, but no doc is taking it seriously since I have organ failure.
It's not that dissimilar with some depressed people I've met.
It makes sense, because if that signal doesnt work, you get cancer cells.
I do NOT know biology that well.
But I do know a bit more about fail safes...and that sounds like a failsafe.
Sounds like a way to prevent cells from going berzerk outside the body's support system. create a system that requires a specific and hard to get otherwise resource and make them dependent on it?
That, to me, sounds a way to prevent cancer. It's a feature not a bug.
My girlfriend was a type 1 diabetic. She also had kidney and heart disease. She looked healthy 5' 5" 120lbs. Less than a year into dating her she had a stroke. She told me she wouldn't live past 50 years old. She died when she was 37. Her name was Heather and she had two daughters.
I'm sorry to hear that
sorry that happened. Sad
Rip
Yikes
My condolences to you and Heather's daughters. 🙏🏻
As a type 1 diabetic since I was 5, I do appreciate the rare reminders that people are actually working to cure this disease. On the other hand I really wish we'd stop preemptively and wrongly labeling everything a cure. It gets very disheartening.
My wife and daughter are T1. It is nice to know work is being done around the world. I think most people this close to it understand that a proper cure is very complicated.
With any luck something like this can become the standard insulin and eliminate dangerous lows. That would be a big win in my books. Heck 36 years ago my wife was doing litmus tests to check blood glucose and not counting carbs. We've come far enough that i have hopes this thing becomes a minor nuisance.
Stay strong!
Actually, I doubt this guy is a proper MD. Modern Western doctors would never claim a treatment as a cure. you have to be so careful on TH-cam. the content creators care more about views than any other thing. pure greed driven. they tell themselves all kinds of things to help them not worry and sleep at night, but in the end, they are greedy and if they are not outright liars then they are bending the truth within millimeters of being a lie. im getting so frustrated with the direction TH-cam is taking. there was a time when YT was sprinkled with Bullshit, now it's almost everywhere. Clickbait was fairly common, but now its almost everywhere.
@@k-mac9798 yeah, just consider how much money the pharmaceutical manufacturer and intellectual rights holders will make!!! This is a gimmick and a money grab. Think critically.
Sorry, the people on this video aren't working to cure diabetes type 1, or 2. This is another treatment. The Chinese are working on a cure. Check "Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient" published last September on Cell magazine.
@@acmhfmggru Yep, and one I'm ready to pay for because after 35 years of type 1, my body is failing and I'm tiring. I hate the diabetes industry but my kids and wife are without a father and husband, without it. I would have been dead at 15, I've already tripled that and at 50 it's clear even with insulin, it's hard.
So... it is not a "cure" for Diabetes but rather a new and improved form of artificial insulin.
Exactly
Eat a proper diet and fast. This is how you cure diabetes.
Your body knows how to heal. Well not if your lazy and want a pill to cure everything
@@chillaxer8273 You don't know anything about diabetes.
@@Dosbomber neither do you. And neither do the doctors. I am sure you have never tried fasting since you seem to have a lazy mindset of dismissing.
Goodluck finding a pill that fixes everything
@@chillaxer8273 That's only for type 2 diabetes you muppet.
As a bioinformatician and someone who has Diabetes Type 1, I must say that if Novo Nordisk is able to push this through clinical trials successfully (which... realistically speaking is another 10 years or so) this can indeed really help people with diabetes. There is a huge catch however, while yes this feed is undeniably amazing, it does not cure the disease. Yes, administering insulin won't become as much of an accuracy art, but we'd still need to inject the new compound while monitoring glucose levels (as a really simple example; exercise for example can still cause hypoglycemia). This is by no means a dig at the amazing achievement, but it is still a very long ways away from actually curing diabetes.
I couldn't have said it better. Thank you. If you really want to follow someone seriously trying to actually "cure" Type1 diabetes, follow Dr. Denise Faustman, MD, Ph.D
Suddenly I'm quite glad that I bought some Novo Nordisk shares a few years ago haha
Study from Iran shows cbd as effective regimen for treating type 2 diabetes.. i'll let you check that on your own
If they invest at least a billion dollars, the medicine could be available by February. Lol
While I agree it's not a cure, if I haven't I misunderstood you could have a big dose once a day and it would effectively self regulate. No need to measure blood sugar, or even to be careful with sugar intake, just a daily jab. Possibly even some sort of slow release implant?
A cure would be better, but this sounds like a huge step in the right direction.
This is probably completely ridiculous, but if you could create an implant with GM cells in it which manufactured the drug, it would effectively be a cure?
I'm not in the biology field, so that's probably closer to scifi, but a nice idea.
The title is misleading. They haven't created a cure for diabetes, but a new form of insulin. A cure for diabetes would be a proper functioning pancreas. But great research indeed.
did you miss the ""?
That's the medicine 5.0 part. But I agree, misleading title. But the internet runs on clickbait so...meh.
"Have they robbed diabetes of its terrors" feels like modern clickbait but simultaneously is such a badass and poetic way of describing it.
This is overhyped. It isn't a cure. Compared to a well run closed loop this will provide marginally tighter controls (and still require the loop).
I wouldnt say no to it. But it's not a miracle drug.
@@lunakoala5053 The comment was referring to the 1921 newspaper article shown at 5:50
@@lunakoala5053 It's the headline to the discovery/creation of insulin, a drug that literally saves the lives of millions of people daily. It's as far from excessive hype as one can get.
Similarly, an improvement on this drug that helps prevent the much less numerous but still very much present lethal over/underdoses of insulin when people/pumps fail to monitor and administer it correctly still wouldn't qualify as "overhyped".
Even if it's a cure it will cost you 30 million USD out of pocket to afford, and no matter what provider, doctor, or hospital you go to it'll be out of network for when you actually need it to not die. North Korea will be more likely to fund it for their people than the USA is for it's own citizens at the rate of medical progress globally.
I mean, at the time it was a very appropriate headline. Before insulin, Type I diabetes could be a death sentence, particularly for children who at age 10 would have between 1-3 year life expectancy after showing symptoms. It was absolutely a terror, like being told you have terminal cancer. Then right after insulin use began the life expectancy shot up exponentially. By the 1940s that same 10 year old kid developing Type I diabetes could have a life expectancy of 30-40 years after symptom onset with the use of insulin.
In the name of science and wonderful content that makes the world better and more interesting. Thank you!
Wow! Thanks so much for the support guys! 💙
Awesome humans like you do. Sending good vibes!
👏🏻🙏🏻
Wow! thank you! For Ben and for everyone, thank you! 🙏
@@acex222 maybe not, but support is needed
Super amazing and interesting. Next I hope we create a cure for "clickbait" titles on TH-cam.
Click bait works. Anyone who doesn't use it get left behind. It sucks, but that's the algorithm on this social media
@@SerendipityChild It works for a while, just so long as there are new suckers to fall for it. I regularly avoid channels where they have sucked me in with click bait. The shame is that an accurate title may have attracted me to watch and not left me pissed off.
@@SerendipityChild if people ignored click bait it would switch back. it is more a statement on people, not social media/
@morbidmanmusic youtube could certainly change their algorithm so that long- form videos that are released less often aren't penalised compared to short, frequent content. Im sure a lot of people are like me: you see a new video is out, but its from a creator who make detailed and long content so you decide to watch it later. However the engagement rate in the first few minute of a video being released drastically impact its trajectory because it will either be boosted or quashed.
On a more holistic level, if people didn't respond to advertising that used sex and hype music, advertising would be informative.
If people didn't respond to celebrities chasing balls around a field, culture would be art and music instead of sport-ball.
The thing is, attention grabbing is a science of sorts. We only have so much attention, so we have to be selective. The trick is to grab us in ways that poke the primordial brain: sex, food, fear, excitement
It's not a cure until it's available.
it also sounds like it still needs a constant dose smh, (they prolly love that people have to buy it over and over) but we shall take what we can get ig
It's not a cure, period. It's normal medication, only overdosing is harder.
This smart insulin is a treatment and we'll have to see how much it costs. A cure would mean fixing the immune response that kills the beta cells in the pancreas. Big Pharma likes treatments better than cures though, so it would probably have to be PhD students and/or government funded research that develops the cure.
It's just 10 years away.
@@Max24871 Just follow the money. They got founding from an insulin selling company, of course they'd never be allowed to find the cure. Only more expensive insulin to be sold :/
All I can say is thank you for working on this and bringing it to my attention.
I've had type1 diabetes for 54 years and have been hoping for something like this every moment of those years and have been let down so many times after hearing about a great cure possibility which suddenly disappears from view so I really hope this succeeds and removes part of this burden from my life. I would even ask to be a guinea pig for when human trials start as this sounds very positive. God bless.😊
*54 years…? Well, at this point, you’re only dued immortality.*
Hoping and praying for you ❤😢
I would volunteer to be guinea pig too
As a long time diabetic myself, I first heard that "a cure is just 5 years away" approximately 30 years ago, and there have been sporadic news about a cure being only 5 years away every few years since then. I quickly learned to temper my optimism.
@vickiredfeather7655 maam. I think it would be called ' clinical trials participant ' noone here are animals. 🤣❤
0:13 "Behold... BALL IN HOLE"
"Oh no the ball fell out of the cup... But it's okay because the ball is on a string and attached to the cup."
This is doritos invisibility all over again
Been T1 diabetic for 20 years now and it’s always fun to follow these advancements (with realistic expectations) - real time digital glucose monitoring is probably the most life changing thing I’ve experienced. Great work and super interesting history too, I’ll refer to my urine when I have high blood sugar as honey going forward 😂
Hey man, I watch your videos...recently I've had pancreatic necrosis and became T1 diabetic too, my lifestyle wasn't bad (no excessive drinking/smoking) I was in the middle of my PhD but now things seem bleak, anyways do a video explaining how CGMs work, it is useful and helps me exercise to release stress
@@ironman5034man, I'm sorry to hear that. I hope you get better and are able to successfully do your PhD
Too bad the especially cool stuff seems to never hit the market.
Read about regrown pancreas cells being put in a super fine "mesh", that allows insulin to be put in the bloodstream but keeps antibodies trying to reject or otherwise attack those cells out.
Been like 15 years, nobody talking about it anymore.
And thats what I'd really want. With this I'm still bound to my pump and probably still need to announce meals (unless we're wasting a ton of or by basically always giving way too much for it to then regulate itself down to the needed level).
It's super cool from a science perspective and its another incremental improvement like CGMs and closed loops have been the past decade.
But it's far from being a cure and fundamentally changing anything.
My biggest gripe with Diabetes currently is stuff being out of stock or poor quality.
NovoNordisk being one culprit here. Second time this year I cant get my Fiasp Pumpcharts, which is also to be discontinued starting 2027, because they rather produce more profitable lifestyle drugs like ozempic.
Interesting technology, but this aint it chief.
Honey urine is the way of the future. 😅 I have a needle-free glucose monitor company recruiting for pre-clinical trials coming out of the Uni of Bath shortly if you're interested - let's chat when we next catch up
Type one here as well. Maybe someday things will be easier
A sentiment that I’m increasingly hearing and agreeing with is that the last century was the century of physics, but the big innovations in the next century will be in biochemistry
Chemistry is the underappreciated science. Just compare the number of books on popular science bookshop shelves. Everyone can name multiple famous physicists, a few biologists like Darwin and Watson and Crick but few can name more than a couple of chemists, if any, but as nanotechnology and biotech become the frontiers of research, (bio)chemistry is where all the interesting things are happening.
@@cmw3737I agree with this 100%
Chemistry along with physics had big innovations in the 19th and especially the 20th century. Yet, not a lot of people talk about these innovations.
This century is defined by pluridiscplinarity. Here for example you can see that physicists worked alongside biochemists
@limpid_runaway1879 oh, you're absolutely right - the agricultural revolution in the post war period especially was due to this. In no way was my comment intended to dismiss the incredible advances that did happen - just that biochemistry is now at the cusp of something incredible, similar to how the transistor and subsequent semiconductor and nanoscale fabrication has changed the world
It’s such a sad thing to realize the number of individuals who have suffered due to the lack of medical understanding. I’m extremely pleased to see the few who know putting together an idea that will make all the difference. Thank You on behalf of those we’ve lost and for those who will be saved. Everyone deserves to live and do so comfortably. I see you. I want the world to see you. I’m sharing this video.
Your molecule works just like the thermostat of an air con, or thermostat of an electric rice cooker. So it should be called "glucostat insulin!" Amazing invention! Congratulations! Cheers!
That's a catchy name.
THATS THE BEST NAME EVER
Trademark that name and then sell it to the highest bidder
GlucoStat is amazing.
Sorry, the molecule isn't a cure to diabetes. This is just another treatment that aims to keep on squeezing patients and their pockets. Dr is a Novo Nordisk brat.
As a type 1 diabetic, this, Dr Ben Miles... This is the best news I've heard since I got diagnosed back in 2013! Diabetes is a growing problem world wide, and this will definitely help whilst moving towards medicine 5.0. I'm looking forward to seeing human testing, and a final product being released in the future. I am very proud of you, and the team working dilligently on the subject. I'm in awe! Thank you, thank you, thank you!
As a 28 year type 1 veteran I'm more hopeful about this than any of the previous breakthroughs. I really hope it works out, and would willingly volunteer for trials regardless of risk. If not perhaps for me then for the generations that follow, no one should have to go through this condition if there is a potential for a better solution out there
Cure won't come from capitalist countries.
Ive been hearing this for 45 years. My grandmother heard this oo for 87 years. I will believe we have a cure when there is one
It has always been "only a decade away". I hope that has now changed to "within a decade"!
@@averieway right after an action is taken about climate change and before fusion reactors are built. right when politicians actually help the little guy and not just deregulate for wall street. then you'll see!!!
Same for Fusion reactors 😑
@@____________________________.x fusion will never happen ( sustained fusion ) we lack the mass to produce a sustained chain reaction of this type on earth.
@@MrDmadness Just read the article in Science, an interesting problem
As someone who had a kidney and pancreas transplant a year ago, this is absolutely fantastic news. The difficulties with injections led to my kidney failure, so developing this is amazing!
Hi, Biochemist here. Theraputic peptides are very promising. The only problem is they are at least 10 times costly than the costlier 'regular' medicine. Unless we got a way to manufacture them as cheap as regular cough syrup or at least regular antibiotic, there's no medicine 4.0. And all those out there talking about trickle down from rich, just know this - brute force scaling up won't do here. Otherwise the market is already pretty massive.
It can depend on where you're buying it.
Given my present medication, I'd pay 10 times for an effective medication that works better and has fewer side effects.
Govt drug price negotiation and universal Medicare makes a huge difference.
@@thekaxmax Those can only go so far. Some new peptide manufactuing process is needed. Unfortunately, contrary to what may sound, I doubt investing in something like that actually doesn't benefit the bif pharmaceuticals.
Also, paying 10 times more is easier said than done, specially something which is supposed to be used by millions.
Won't this will be used on those poor sod who become insulin resistant? I am not diabetic, but do have hepatorenal syndrome. No liver or kidneys so I go to dialysis.
There are many who cannot get their disease under control. Most of it due to age and diet, but I've heard a few suffer from rejection of medicine somehow. I try not to pry, but hard to not overhear when you got Doctors talking to them 3 feet away.
Maybe that will be the first patients is my point.
But yeah, nano -machine- tech for daily management use? Ehhh... EHHHH. Maybe if it was a cure, yeah. For a routine I'm not so sure we will see it for reasons you stated. Insurance isn't paying extra for that.
I hope we both are way way wrong, and tomorrow releases the first anti aging nano machine tech for pennies!
I totally hear ya on the financial side but I don't think it should stop us from focusing on these groundbreaking endeavors
I'm no expert but is Therapeutic Peptide Medicine usually associated with medicine for smaller patient populations? Which would inturn represent a higher cost per unit. In the case of NCC2215. If it had a cost 10 times greater then normal insulin it would not be financially available to anyone. However, it sounds like NCC2215 may be present longer in your system and therefore, users may require less NCC2215. In any event, it would only be financially viable if production costs are low enough for the price per required units to be comparable to the most expensive insulin currently available. There are obviously so many dynamics at play here but the potential benefits NCC2215 could have on people with diabeties is greater then the sum of it's parts.
Brilliant! As a physician (who loved the Banting and Best story Glory Enough For All) and bench scientist, who worked on protein structure and topology, I am absolutely thrilled. Thank you.
I’m just a T2D old lady and the research you did is amazing. I’m doing intermittent fasting and very low keto diet. I’m doing well as long as I eat at home. Church get togethers are challenging. Some people don’t want to share how much sugar or carbs they put into their food. I try to just eat the veggies and skip fruits and desserts.
Cool! Congrats to the team. Engineering team building a laptop controlled skateboard seems like hilarious and ideal depiction of engineering teams doing side quests out of boredom lmao
Thank you for your work on this and for promoting it. As a Diagnostic Radiologist, I can tell you that the damage I see from Diabetes each day is dramatic and life limiting. Any future with less diabetes is a better future for humanity.
Probably be better off getting rid of the poison food rather than having big pharma sell people the "cure". 95% of diabetes is type 2, aka fat people stuffing their faces, they can fix it themselves with fasting. I feel for type 1s though, that sucks.
This is very impressive and I don't want to undermine that, but I don't like the clickbait title. This is a better treatment for diabetes, it isn't a cure. A cure would result in not needing treatment any more.
19:10 By the way, if you are a diabetic in the UK, you get insulin for free as diabetes is a terminal illness and the NHS covers the cost of the meds in full.
That true but it paid for out of a tax everybody working pays into called National Insurance and also the employer pays into it - Socialism at it best. lol
Amazing. I wish the MAGA crowd would see how beneficial universal healthcare is. We could save so many people and so much money on vital care. Good for you guys in the UK for taking care of your people.
My husband gets his for free in the US, but he has decent, non-government insurance.
@@PneumaNooseok, now look at how the NHS is crippling the UK and is completely unsustainable. Look at the 5 year wait for autism diagnosis, or patients on trolleys because there are no beds. There is a solution but it’s likely a middle ground. Universal healthcare is unaffordable in today’s world.
Eating is a terminal disease. So is breathing. NOBODY ever finds a cure.
What an incredible project to be a part of for you. Thank you for sharing the story.
As a healthy male, I occasionally do low risk medical trials to test the effects of new treatments. It would be great to help bring a medication that could benefit so many people to market.
I've recently watched part two of a three part series on the history of insulin. This is a beautifully explained and animated side quest to that series.
Thanks
Thanks for the support!
This is amazing! Being very hopeful as I am a newly diagnosed diabetic and it can be brutal to get it under control. So thankful for scientists like yourself Dr. Miles. Thank you so much for what you do.
Cost of making the cure: 5 usd
Cost of the cure: 5 billion dollars
r&d costs are probably billions but yea i get what you mean
Hate this logic, buy the stock and take your share of the profits.
@@lore00star R&D paid for by taxpayers like you.
Cost to buy in America? Death, because let's face it, most Americans would not be able to afford it while the rest of the world will live long and healthy lives.
@@sylviawylie9218 if everyone who needs it buys stock of it, does everyone get more than they pay? :D
As someone who reversed Type 2 diabetes I find it offensive to call anything a "cure" if it allows you to continue to do whatever it was that got you sick in the first place.
So this is really about type 1. Not type 2. You can’t “reverse” type 1. Your body has just stopped making insulin. It’s mostly genetic.
Unfortunately since there's no financial incentive for Big Pharma to cure diabetes, the best we'll ever get is the current lifetime subscription model.
No financial incentive? Nothing except for exclusive rights to patent it foe the next 50 years or so. They would make a mountain of money!!!
Making it into the history books would be another incentive.
5:33 these guys sold the patent for $1 fyi. Their incentive was helping patients.
I would like to point out that in "gestures vaguely" all the world that is not US the price is good enough for patients to not mind it.
Yes, this is not a cure, and yes, this sucks, but at least it is not a death sentence if you lose your job, CRIST US.
Automated pumps are becoming a thing more and more thanks to well, china and some people that write code, and so... it is becoming manageable to the point they are now "interested" to get a "new medicine", hence this ;)
The world isn't your silly US for-profit healthcare system.
What conspiratorial nonsense. There is immense money in actual cures.. Guess what? Actual cures are actually really, really hard. As the video pointed out repeatedly, many of these problems have been known for thousands of years. It's only in recent decades that we've learned enough to hope to go beyond mitigation. So much of what came before was geniuses fumbling in the dark because that was what they had to work with. It wasn't for lack of intellectual ability but rather the vast amount of research that had to be done so that later generations could build on that.
@@FrostekFerenczy my dad was a research scientist. It's amazing how/what people think of what "incentive" means for someone who dedicates their lives to doing one thing the best that they can .
I get that the health care system in the states is "different" but they must believe that the reason that it wasn't cured 3500 years ago was the military industrial complex or some other equally silly BS.
It's insane how important the production of Insulin is to our bodily functions, which we often take for granted until we suddenly need to deal with having a whole host of problems which come with having diabetes.
Wish my mom was alive to see this. She was a diabetic, and eventually fell into a deep depression...miss her so much.♥She would have loved to see this. Thank you for sharing. Can't wait until this is available!
19:55 “if you help your neighbors it ends up helping you” - could not be more accurate and more of our policy and even personal choices should be based around it
I saw research a few years ago that confirms this. Countries that have smaller wealth differences have better health outcomes for both rich and poor citizens than in countries with greater income differences.
@@hamsternchips There are many orders of magnitude more reasons for this differential in health level other than was described in your comment.
Helping your neighbor only can go so far. As someone who has worked for many homeless/rehabilitation organizations, I can personally tell you there are people who can NOT be helped as they refuse to abide by the rules/laws of civilized society.
On that note, I can't wait for this to be sold for $700 a dose in the US
@@youdontneedmyrealnameyeah, because that's relevant to the video topic and sentiment expressed
T2 Down Under here. So glad I found your channel. Love how you take complex science and make it easier for the public to adsorb. I learned things today that I never dreamed possible - like the advent of 4.0 and especially working on 5.0. Good luck, mate, and "thank you" from the world, for all you are doing to help us.
Isn't T2 basically a systemic overload with glucose? i.e. your cells become resistant to glucose, because they already are saturated with it. Which begs for a simple solution - just stop eating anything that turns to glucose.
T2 is curable with a lifestyle change
@@denofpigs2575 Yet people still want to much on their carbs and take a pill that would mitigate the damage.
The coolest thing about this video is that the person who talks about the project actually took part in it! I think more scientists should make videos like that in their fields. Thank you for sharing this knowledge, it was very interesting!
Banting and Best actually isolated insulin at King's College in London, Ontario. They were based out of a lab in Toronto, which is why it is often thought that insulin was isolated in Toronto.
And dont forget Dr Collip.
I was diagnosed with type 1 diabetes almost 25 years ago. This video nearly made me cry.
It's been a bit over 20 years since my 23 year old son was diagnosed with type 1. I do badly want him to be free of the constant injections and having to wear a Dexcom. We can hope that this treatment will become reality for you guys in the coming years
❤
even if it's true. and that's a big if for youtube BS videos.... it's at least 15 years until it hits the stores, but more likely more decades
go look into keto and diabetes. no sugar, no need for insulin...
@@monolith-zl4qt If you think it's all BS, why bother watching? are you a scientist? Doctor? Or like the rest of us. Laypeople who are trying to learn about new tech and treatments
Very informative, and i am in awe of your diction and delivery !
I wish i could talk as fast and be as clear as this. Well done fella !!
Some research that I read some time ago showed that survivability in type 1 diabetes is highest in people with a stable 4.6 mmol/L, so this stopping at 4.5 mmol/L is, quite frankly, amazing. I have a semi-automatic insulin pump with an integrated CGM, and even with this it's incredibly difficult to manage a stable blood sugar. You need constant consistency in your life, which is not doable for many of us in real life. That is consistency in particular in diet and movement. If you work a physical job, don't expect to be able to have full mastery of your blood sugar, because it will depend on how much you will move that day.
death, which people tend not to like.. pure gold.
the good thing is one stops to care after the first time.
@@blueckaym agreed. i would like soon too.
@eduardostapenko6808 , are you planning on it, or is it unavoidable? :/
@@blueckaym nah. tried, failed. it is allright.
Don't give up!
THIS IS HUGE! It will definitively change a ton of lives and as a medical student cannot wait to see it. Diabetes and all of its complications, wether they come from medications or the disease itself is devastating, and this is a game changer.
what an amazing breakthrough, HUGE thanks to the team for their dedication and patience, you deserve all the rewards you can get
This is so amazing. I have Type 1 and it has largely ruined my life. I was late-onset, meaning I was 31 years old when diagnosed. In the 22 years since then, it has killed my marriage, killed my career, and made life extremely difficult in many ways. I may never get to benefit from this development but it's really exciting nonetheless. Thanks for sharing.
Hey there, I think I might be a type 1 since I have been a candy lover when I was a kid. Do you experience severe weight loss?
@@milkydewymelon Yes, I did. I dropped to about 115 pounds before I was diagnosed. After starting insulin, my weight rapidly increased and leveled off at about 150 and I've stayed there ever since.
I'm type 1 also. It's not necessary that this disease should ruin your life. It's possible to have normal
blood sugars almost all the time. Dr. Richard Bernstein is a lifelong type 1 diabetic who has worked
out how to do this. He has written a book on how to do it. He has a channel on TH-cam. Check it out.
@@milkydewymelon Weight-loss is definitely one of the symptoms of type 1 diabetes as your body has to rely on its fat storage for energy since it cannot metabolize glucose properly. But it has nothing to do with how much candy you ate as a kid. Type 1 is a genetic autoimmune disorder and even newly born kids who have never eaten candy can have it.
@@milkydewymelon nobody here can diagnose you, but it doesn’t seem like something you would “think” you have.. it’s pretty devastating when unmanaged… and very easy to test for.
Thank you for pointing out how difficult and scary it is to have to keep your sugar from getting too high or too low, every day forever. It’s a ton of work and you feel crappy when it’s not “normal” levels. To not have to deal with very low sugars would be incredible.
As someone who works in the pharma industry, this is incredible news!
is it true that "every cured patient is a lost customer"
or "make them, all life renter. not one time buyer"
thats why companies don't want to heal diabetes, cancer, hypertension with 1 time medicine?
Underdose seems possible, but since overdose is not, erring high is now safe, which solves underdose as well. If bonding strength is a good proxy for effect, then the overdose space is 12 times minimum effective, which is a huge window. The gap is probably less, but is still way wider.
(Warning: I know quite literally nothing about diabetes)
I would assume it also means that you don’t need a dynamic dose and thus can stick to a static amount
Safe perhaps, but possibly too expensive to "waste"?
You take more insulin depending of how many carbs are in what you eat. My ratio for example is 1 iu of insulin per 10 grams carbs. The benefit of this new type of insulin is that I can take more than I need safely. Blood glucose levels are affected by a lot of things so insulin per carb isn't a perfect solution.
this is my first video of yours, and i gotta say you explain complex chemistry very well! this is coming from someone who tends to draw a total blank because my brain just can't grasp it. this is such an exciting breakthrough and i'm glad i can understand it clearly!
10:57 They had the programmer mindset. Don't do boring or repetitive tasks yourself, code something that does it for you, even if creating the tool takes hours. That's TBH ~90% of the code I write.
A dream turned into nightmare as NovoNordisk enters the scene. I can bet some money, they will turn it into a milking cow.
Yep!!!! The fork is the cure anyways
The usual story
Hate big pharma for their profit margins, eh? So you're hating economic phenomenon without thorough economic understanding. Think of it a bit. Any single one able to produce more effective treatment method like insulin discussed in this video would practically break out status quo, gaining customers from other big pharma and reap more profits for itself. It's oligopoly, not monopoly, and although it's super normal profits, it's the market structure that best allow for innovation.
@@NinaYahsikait's not about disruption or lack thereof, it's about perversion. even including underdogs, the market still has every incentive to wring people for every last cent they can, for care they need to survive. sickening
At least they are the biggest tax payer in my country (Denmark), since they are based here, so them milking every other country in the world of their wealth will benefit our tax system, so we can afford to subsidize the insulin for ourselves, lol.
I’ve been living with type 1 diabetes for 27 years now! It’s true-you often feel lonely, and I’ve taught myself not to "make a fuss." But the truth is, it’s incredibly tough to live with this condition. It becomes even harder because other people will never truly understand what you’re going through. It has definitely made me stronger, but I’m also starting to notice the neurological effects. Even so, this disease will not defeat me. I wish the same determination and energy to others who are fighting for understanding and everything else that comes with this terrible condition.
Just go on!
What happens next is what I hope it won't happen:
1 - The company will be coerced by other insulin productors to shelf the patent for this medicine.
2 - It becomes yet another medicine for grossly huge profits at the cost of human health and quality of life.
3 - Companies delay it by 30 years because they can't give up their profit with insulin.
It will be the second option.
did you mean coerced?
and people think capitalism is a good thing
4) insulin is already profitable but once it becomes unpatented they'll introduce the latest insulin 2.0 to sell a premium product which does the same thing with a slight new feature. And they'll still not be cured from the diabetes.
Or it just gets subsidized by the us government, meanwhile everywhere else in the world it's available at a fair price
10:11 you forget "Companies earns better for selling medicine rather than cure the sickness". It would be like a lightbulb company would create lightbulbs that lasts 10 years.. It did happen, but they realized soon that it was a bad idea.
Yep. Today's "medicine" is not created to cure. This "cure" will disappear very quickly when bought by some pharmaceutical company.
Those "longer lasting" lightbulbs also required a lot more energy to use because the filament had to be much thicker. That's a good reason why they didn't become a thing.
WHAT can i do if i timetravel and wanna beat Diabetes at-least a bit?
@@GamesFromSpace They're thicker, but also produce more light for a given length so can be less long. Also the excess heat from the thicker filament just heats the room up, which at least for half the year is not wasted energy. Have you actually seen the calculations on this as I'm open to being corrected by actual research?
@@nonyobisniss7928 Dude, "excess heat" is evidence enough of the flaw. It doesn't have to be universally terrible in all seasons for them to rationally decide it was a bad idea, especially when electrification was new.
I know nothing about science, let's say, but I find this kind of things very interesting and really enjoy learning. Your channel just showed out of nowhere and I really appreciate it. Keep it up!
If the medicine advances at this rate I will be able to play another version of GTA.
The rate is currently extremely slow.
@@mpmpm I know some people in biotech, what's going to happen in the next few decades will blow your mind. Immune response for transplanted organs is almost a solved problem, pluripotent stem cells are able to be artificially induced, machine learning is solving unbelievable protein folding problems. It's going to be wild. If you are young-middle age, take care of yourself because there is a real possibility that biological immortality is very close.
@@Shrouded_reaper it's laughably ironic, AI is so incredibly effective in so many fields of science, but the public ends up getting LLM Artificial Idiocy foisted off on them.
While we'll extend life by a fair amount, nothing is about to become a magic bullet for biological immortality, as the brain itself still will fail and no amount of stem cells will replace an already "wired and programmed" brain network.
Still, just for shits and giggles, let's say we did manage actual biological immortality. Now, 8 billion people each have their children at our average population growth rate of 0.87% per year, how soon before we exhaust our food and water capacity for them?
@mpmpm actually not. When i sit in lectures, almost every doctor of any specialty is astonished and says "the last decade has been wild there have been so many advancements and exponential improvement in patients health", and i am positive that this will continue.
@@cc-bj9kvI'm sure you're right, but there are people suffering now that may not live long enough to see the benefits of these advancements. For some of those folks, the breakthroughs won't come fast enough, sadly.
Congrats on helping to create an awesome upgrade to Insulin. That is brilliant.
Wonderful stuff! Congrats on your part. We must hope and pray it will be affordable, so at least insurance will cover it.
So. The picture of your account is from 10 years ago? time to update it! :d
For the full (drama-rich) story around the discovery of insulin with the dogs (and about how science really works), see Angela Collier's video 'who gets the nobel prize?'
As a type 1 diabetic first and foremost, and a science student second. Thank you, I want to give you a big hug.
Did you notice how recently so many people in health industry are coming forwards with new truths? The book called the 23 former doctor truths by lauren clark made me question everything
Totally agree with you
thanks on sharing that book Im searching for it now
My own family developed new antibiotics but we never found a good time to actually push it out for the market since the major companies basically exist to take your idea and give you peanuts. But if there's some super plague out there I imagine every university to have a list of working antibiotics that would be effective.
“New truths” sounds _inherently_ sketchy. Do you mean they’re growing their field by refining, contributing towards, and/or building upon the available body of knowledge? Or some dogmatic rebellion loosely tethered around some (frequently mishandled) assumptions that sets them apart from the mainstream? Something else entirely? I get immediately skeptical with such ambiguous phrasing, either way.
Never mind! This is an SEO account. Probably a bot, or else an underpaid and exploited worker. Report and ignore.
This is wondering. I hope this works out as a common treatment. I lost someone very important to me to diabetes. She was fine one day. Gone the next.😓 Keep at it. The price issue IS deadly. No exaggeration.
"...you are essentially running your body on hard mode..." Yes, yes I am. I don't currently have a choice. Every day is a 24 hour chemistry experiment that might hurt or kill me. Thank you for this validation. It feels like nobody understands how challenging and frustrating it is to manage diabetes every day. I've been doing it for 46 years now, and I'm tired of it. These new advances in diabetes care give me hope that the children of the future can have an easier road than I had when I was little.
Man this is amazing! My mother is diabetic, and this would be such an amazing boon for her... Too bad here in the US this will probably end up selling for a grand a bottle...
Regular trips to Canada....
I constantly talk about the "sweetness" of urine. I am a geriatric nurse- well, I was. Now I work with patients that are dependent of respirators, often after a tracheotomy and also somewhat often after a SARS-COV-2 infection.
Anyway: In Germany old people just called diabetes "sugar" and often still call it that. In "some" cases they didn't really have much knowledge about their disease and, if open for it, I did explain it.
The most often asked question: " My old family doctor told me to not eat any sugar. Is that still true? I love my Sunday cake with the family."
Obviously I'm paraphrasing- everyone did ask something different to that same effect. I was surprised quite often. Normally NOTHING or better NO ONE was above their family doctor. Well, as soon as their doctors came after their guilty pleasure they were done with them.😂
Diabetes in my native Hungarian literally translates to sugar illness and i often hear old people refer to it as being sugary.
In Dutch diabetes is called ''sugar disease'' suikerziekte
@@RoosSkywalker I love the Dutch language. A bit like an old German dialect that was spoken mostly near the coast called "Plattdeutsch" . I have to admit that some words sound really funny to me. Like so funny it almost makes me laugh. But I guess everyone has a few words in every language that person knows that trigger that reaction. Or at least I hope everyone has.
It's called "sugar disease" in the Balkans too.
It's also sometimes "sugar" by Black folks in the southern U.S. Interesting.
This is a great achievement, but it doesn’t eliminate the need for insulin. In fact, people may use even more (and a more expensive type) since they won’t have to worry about high levels. No clue why Novo Nordisk was interested in it.
Well said. People will costantly overdose just to be safe if this comes to pass. They'll go through all these lengths to patch up a problem that can be fixed by simply eating less glucose, because there's no money in a simple cure.
Because they want to be able to have a controlling stake in something that may be able to take away their profits...
Please let me know when you need some type 1 to experiment on to develop that stuff. I'm ready to try it.
This is really cool on a scientific level, but for humanity i worry it will be buried or denied to the people who really need it
I feel fortunate YT recommended your video to me. You have a gift in breaking down and explaining complicated science and having it make sense to "normal" people like me. This also hits close to home as two of my elderly loved ones struggle with the disease and have been hospitalized with hypoglycemia, Cheers!
I'm in my 3rd year of undergraduate school studying Physics. My interests include biophysics, materials science, and sustainability. I've been feeling a bit lost trying to decide what to do when I graduate. Should I go to grad school? If so what do I study? How do I ensure that I'm employable? Etc.
But seeing inspiring work like this replaces my fears and anxieties with hope. I'm really grateful for content creators like yourself who make scientific news accessible for others. You are a great role model.
Do you have any advice for someone in my situation?
My daughter is type 1 , Its a horrible thing to have to deal with . I would do anything to make her life better . Hopefully things like this become available .
Dr Jeremy Fung, you say you will do anything , well listen to alternatives to standard treatment.... medical world is there to make money not cure your daughter.... good luck
@@popeyedog She is type 1 , Diet and fasting has little effect when you need insulin to live . that said she already eats healthy :)
@@Dailyroach I'm a type 1 diabetic. The answer to your prayers is the method developed by
Dr. Richard Bernstein.. He is a long time type diabetic himself. He is almost 90 years old and
has maintained normal blood sugars since he devised his method when he was around 45.
He has written a book on how to do this. He has a channel on TH-cam. check it out.
He has been a life saver for me.
@@popeyedogwow. Read a book sometime. how condescending and wrong..
@@popeyedog Don't advise people on medical matters when you haven't got a clue what you are talking about.
_”Interestingly, when you help your neighbor you help yourself.”_
Awesome story, well told. Here's hoping that it survives the human trials and makes it to market at an affordable price.
That's cool indeed. Hopefully it becomes accessible so that it really affects the people that need it.
But it seems that it could be left in the CAR T-cells territory - yes, functional and effective, but prohibitively expensive.
I really hope that it become accessible, either by the tech itself, or by economy of scale (as there's definitely scale there) ,
but until then I wonder about keto diet effects on the diabetes?
Great video with graphics that, as usual, are integral to making the material understandable for anyone rather than just something visual to drop in somewhere in the narrative. As a person with diabetes myself and a son-in-law whose right leg had to be amputated because of diabetes, I keep up with information about diabetes and treatments, so this has been a special edition of your videos for me.
dead people are known for not liking being alive and not liking being dead and not liking anything any longer… but if you are alive then you can click like 👍 on this video 😅
I'm type 3c diabetic myself as a complication of pancreaititis with some necrosis (had a cyst that went septic and eroded through my bowel). I had extreme phobia with needles so digital blood glucose monitoring has really been my savior. As it stands I only really need a single daily injection and can walk off some of the glucose when I go out of range.
But type 3c means I randomly generate insulin, so even if eating the same foods daily I can end up going too high or too low depening, so I rely on constant glucose monitoring. Sensors really are a godsend. If I had been diagnosed earlier in life I'd be a wreck.
aidrugsearch AI fixes this. Scientists create diabetes breakthrough cure.
Organic chemistry is so cool!
How is this in comparison to the Diabetes Cure that was announced from China, earlier this year? I am type 2, having to take Metformin, which raunches out my stomach. I am afraid to eat before going out, or eating outside and then having other errands to take care of. I literally have to plan my day around diarrhea, and do this at work, as well. This is not a problem since I work alone and I am supervisor of a small staff (different shifts). I need to plan my routine at work, with the idea of an explosive stomach than just suddenly happens. Personally, I think I have been misdiagnosed because my issue was chronic fatigue, and after 3 years of this medication, that problem still persists. But, Diabetes is the money-making flavour of the day. I detest GBM (Greed Based Medicine) and although I live in Canada, a lot still needs to be done to make health a fully paid-from-taxes Right.
Isn't T2 basically a systemic overload with glucose? i.e. your cells become resistant to glucose, because they already are saturated with it. Which begs for a simple solution - just stop eating anything that turns to glucose.
This was a really interesting video, but it left me with a question. If the NNC2215 is reusable, how long does it remain functional until it needs to be replaced?
Probably about as much as regular Insulin. In the animal trial they did a continuus injection. It's not like you inject yourself once a week and are basically cured in between shots requiring no further Intervention.
It will probably be discarded from the system much the same way as regular insulin.
The chemistry team working to make a modern miracle, meanwhile the physics team making an electric skateboard is so on point for us.
As an engineer myself.....Saying this it hard would be a huge understatement. Well done, at last .
My father has diabetes. For almost 35 years now he's using insulin twice per day. I know how hard it can be for diabetic patients to live with it.
Yes but how does this affect type 2 diabetes where the problem isn't lack of insulin but insulin insensitivity?
As best as I can tell (as a non-doctor, non-PhD) it doesn't. Replacing the insulin your body can't make on its own seems like a much easier problem to solve than making your body listen to the insulin you're already producing after it's basically become inured to it. So for the Type II folks like me, we're probably going to be stuck with metformin and limiting ourselves to a small bit of starch/sugar at a time for the foreseeable future.
@@doublej1076every day is a struggle not to eat as not eating carbs leaves you always hungry.
Have either of you tried the low carb / keto diet? Many, many people have reversed their insulin resistance with this diet
@@IrishGerman +1. Yeah, there is lots of research showing that.
I can add that my mother-in-law being on a keto diet for a month lowered her glucose and blood pressure levels by over 20%. But, being a stubborn old lady, she returned to her old diet full of processed carbs and her old results rapidly.
@@IrishGerman @krzysztofmaliszewski2589 keto diets are suicide for any who have the actual disease diabetes, it only helps those who do not have diabetes and just have symptoms mimicking it from being egregiously overweight
Great Video!! I love that you are so PASSIONATE about the current research findings and future possibilities of this clearly MAJOR breakthrough in the treatment of diabetes and soon other diseases as well! You have every right to feel very proud of what's already been accomplished and your own role in that most significant SUCCESS! Now I want to investigate investing in one of your mutual funds. Obviously only a tiny portion of the potential upside of these new technologies has been tapped so far. I want to be along for a longer ride up!!
So it's just a better version of insulin treatments? That doesn't stop the damage from sugars, or the weight gain. Modern science should be so much better by now.
Pretty smart to make a video about his findings and research. There are enough scientists who mysteriously disappear shortly before the breakthrough
Being a biochemist, I didn't quite understand why you need to engineer regulating add-ons to an artificial insulin molecule when the natural insulin molecule seems to do the job as well?
Is it because the natural self-regulation mechanism is not designed to "hyperinsulinemia" since this would be prevented by the pancreas?
What about a much longer half-life of this artificial and modified insulin to reduce the total amount of injected insulin then in longer intervalls?
Else I really appreciate this progress and design evolution story!! 🙏😎
Natural insulin doesn’t work like this, it’s basically always on. In a normally functioning body the pancreas both creates and stores it. Then it releases as needed to regulate blood sugar. It’s the pancreas that does the work of regulating how much insulin is running around. type 2 diabetics like me lose the ability to store up the insulin and release when needed. Type 1 can’t even produce insulin.
The biggest issue with taking insulin for type1 and severe type 2 is judging the dose needed to correct for what you eat, and not under/over dosing. Lowering carb intake helps reduce the degree of error, and makes it easier, but isn’t acceptable to a lot of folks. An insulin that self regulates would be a figurative godsend.
@ChuckvdL this was my knowledge as well till now, but in the video he mentioned that both tail ends can bind (but maybe don't usually do) to each other, so insulin doesn't bind anymore.
Yeah, giving always-on-insulin is very hard to dose correctly according to food intake 🙈
Amazing protein engineering in this project!
I'm a carnivore which has reversed my type 2 diabetes plant are not good for me.
This might be pessimistic of me, but I can't see "medicine 4.0" to be the most profitable since you are curing your customers, so to speak. With such a vast, privatised medical industry I can't help but think they'll do everything in their power to slow these kinds of technologies down. It doesn't fit in the neoliberal, everything is commodified, worldview... :/
Edit: That last bit made me surprisingly hopeful :)
We really need a Mutualist shift in our economic systems.
Sort of. He did explain that medicine 4.0 doesn't solve the problem. 5.0 would get the liver to function as normal and not require diabetics to use insulin at all. 4.0 still requires diabetics to use insulin.
The other thing is that it is mostly the U.S. that suffers from private medicine so while the U.S. might not want a cure, I don't see other countries with public healthcare actively avoiding a solution that would literally reduce strain on their healthcare. Someone can correct me if I am wrong but why would you not want a cure in a country that has public healthcare?
@@anubis520 @Quadr44t Shittiness gets outcompeted anyway. We are living through a temporary sideeffect of rapid globalization.
@@anubis520Ah fair. Those numbers are arbitrary. But the end goal I presume is to fix the illness instead of providing medicine. Which is amazing, but does not suit well with neoliberalism
Well, due to things like the Marshall plan that helped out europe after the war, a lot of american tendencies do leak through. Although america's health care system is a lot worse, that of europe suffers from the same issues with big business dominating politics, and as they provide a lot of jobs, it is difficult to oppose them as a country. Same thing. Albeit to a lesser degree (for now). Lucklily there is a little more regulation. Still way to little for my taste. Coming from the Netherlands btw. A Dutch perspective here.
What's impressive is that you work on this stuff and also on the musicals
The US healthcare system needs a hard reset, these prices are insane! Let’s hope we get medicine 5.0 soon enough, maybe it will extend our lives a bit 🤞🏼🤞🏼🤞🏼
@ioannisaliazis Over regulation and it's consequences.
@ more like greed and its consequences.
@@ioannisaliazis Greed is human nature and with the free market that greed had been channeled into something beneficial. But when the government stepped in and took control of the medical industry that made prices sky rocket. Because government is literally the opposite of the free market. The free market is the most efficient way to manage an economy, meanwhile government might be THE MOST INEFFICIENT institution in human history. Inefficiency has a cost.
But it's so much more profitable to just treat something when people are dying to have it.
Says the person who likely voted for ever higher prices in 2008 and 2012. The architect of Obamacare relates on camera that forcing costs increases were a key part of his scheme.
Just a friendly reminder, that everyone working on this is not suicidal.
As a diabetic who's nearly died a few times thank you and your team.
The difference in cost between the US and other places has No Excuse.
Centralised or social medicine should not be necessary to manage prices.
The US needs a law --- a simple one, not ten thousand lines of legalese --- that simply says
"The cost of any medication sold in the United States and its territories
shall not exceed by more than five percent the highest price found elsewhere."
That does not account for Purchasing Power Parity (PPP). The USD is worth more than a lot of other currencies.
If you live in Elbonia, and you only make the equivalent of $2 an hour, that sounds bad. However, if everything only costs 10% of what it does in the US, then you actually have a very productive income.
(That's why is easy for Americans to visit other countries, but not the reverse: our dollar buys more over there than theirs buys over here)
So, if a US-based company conducts R&D in the US, paying US employees US salaries, then tries to market its drug, you have situation in which they MUST raise the price of the drug to off-set its US costs, but then that pushes out countries with weaker currencies. If fact, it pushes out poorer states that have the same currency, but not the same productivity.
(This does not excuse "price gouging", but even if price gouging never occurred, the above statements are still true)
So, if another country develops a similar drug, they could sell their version to us at reduced price (or price gouge us because we have more currency). If they can undercut us because of PPP, then R&D leaves the US. That means loss of jobs and independent sustainability.
What you're offering is price-fixing. Sadly, it never works and only results in increased prices.
I hope this gets big
Me too
That's what she said
Really great video, as a Type 1 Diabetic and video editor I have to say you have earned my like and subscription. :)