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- เผยแพร่เมื่อ 1 ก.ค. 2015
- Many forms of medicine offer relief from pain, but what’s the difference between them?
Read More:
Nociceptors: the sensors of the pain pathway
www.ncbi.nlm.nih.gov/pmc/artic...
“Pain, as a submodality of somatic sensation, has been defined as a ‘complex constellation of unpleasant sensory, emotional and cognitive experiences provoked by real or perceived tissue damage and manifested by certain autonomic, psychological, and behavioral reactions.’”
Ibuprofen: Uses, Interactions and Side Effects
www.medicalnewstoday.com/artic...
“Ibuprofen blocks the production of prostaglandins, substances our body releases in response to illness and injury.”
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Ibuprofin, youbuprofin, we all..bu... I'll see myself out.
Lol
Jeremy Kean This sounds like something Julian would say
DNews rekt
DNews Haha
DNews Hope it makes him smile.
Ibuprofen or Acetaminophen? Hah, please - I'll take an IV drip of morphine, thanks.
Vandergrif Its called the "flower of joy" for a reason. Its the most useful drug we have today against pain and suffering. Its like her Lady of Life give a gift for us to help us in times of need. I think I remember a video in Periodic Table Channel on youtube by professor from Uni of Nottingham said that even the best chemist in the world, still cannot synthesize the morphine cheap enough for manufacturing. We still need to harvest the opium elixir from poppy pod to obtain morphine. In a sense, we owe our life to a simple plants that cannot even think.
lmao
What if you also have inflammation?
@@gdprice79 It doesn't even matter if it's not painful... The majority of doctor visits are due to pain but pain ends up being the most undertreated symptom or disease in the case of chronic pain.
I enjoy my liver functioning, so I'll stick with ibuprofen for most of the time
True but ibuprofen affects kidney function and its more likely someone will donate a piece of their liver rather than a whole kidney, there are so many people on dialysis waiting for one.
I enjoy not bleeding excessively when I get a wound so I will stick to acetaminophen
Acetaminophen is the to-go medicine in my country; you got a headache? 1-2 acetaminophens each 6-8hrs and you're good to go; injured your knee? same thing; got an arm chopped off? SAME FUCKING THING.
***** bahahahahha same in my country
***** Do you live in Puerto Rico?
No
El Salvador but is common in Latin America specially in the public health system to give you acetaminophen if they do not know what to do XD
Yeah, I now, that's why I wrote that. Here in Puerto Rico everything is cured with Panadol.
Jorge Alejandro Rodríguez From my experience I can say Acetaminophen is primarily used in Eastern Europe , but Ibuprofen in West.
so it's basically is a cox blocker - i hate cox blockers...
Lol
OMG you said COX!! HAHAHAHAA~!! dude you are so smart and funny! Kidding.. How about posting something original and useful? Children these days..
MOUTH OF THE APE you are supposed to guide my Cox. Not block it!
My best friend is a Cox Blocker.
She didn’t answer my question 😂😂😂
Death - best painkiller of them all.
Chris Carmona good one bro
Don’t commit suicide
do it
..u go first
Very true
(psst, acetaminowhatsit is american for paracetamol)
(*sigh* thank you)
Psst. This is an American channel so using American terms is expected.
***** psst. If you have a problem with it, nobody's forcing you to stay here. American media has no obligation to cater to the rest of the world. That being said, she has no reason to know what the alternative name is, or that one even existed.
Lily O thanks; for a moment i was afraid this video would only be relevant for me as far as ibuprofen was concerned
Lily O Thanks! Was just about to google it!
Ibuprofen for regular pain, Excederin for migraines and headaches. Nothing is better
lalamelol heroin is pretty good...
Nathan Jones ahahaha fucking mint
lalamelol I really like opiates, Morphine to be specific, 120mg at a time. However I don't drive or operate machinery.
lalamelol Recently, nothing stops migraines! I tried something called Magix from Life Mastery and it went in less than an hour. So fuck medicine!
lalamelol Recently, nothing stops migraines! I tried something called Magix from Life Mastery and it went in less than an hour. So fuck medicine!
Thank you for being well researched.
please never stop making videos they are so intresting!
Why not address each drugs down sides at all? Ibuprofen can be very damaging to the digestive tract causing bleeding while Tylenol is associated with Liver damage. I'd have loved to have this aspect of these drugs explored as well.
Ravinian yeah, but aspirin is MUCH more damaging,
Ravinian It's cause it wasn't about the downsides. Besides, including them would just get people worked up about how "drugs are bad (except weed cause it doesn't kill anyone amirite)" and big brother and junk
Dassault Aimpoint
Yep, they're both in the same family.
RainSnowHail
I know the video wasn't about the downsides..that's why I made a post lamenting that fact. Dnews has never stuck me as being bashful about presenting facts just because they might have a negative response.
Ravinian They are not exactly the same family. W.H.O. puts both in the same step in the "Pain Relief Ladder" as Non-opioid. But they are never treated as pure NSAID. Pretty close though.
Good job DNews, well reported.
I've used both. Ibuprofen is actually my favorite NSAID (over aspirin and naproxen), but since it's still hard on the GI, I was switched to celecoxib (Celebrex). Currently off it since doc is worried about liver damage.
thank you for the knowledge
Another fascinating video from DNews. I just wish I had a better understanding of the sciences behind this.
Ah well maybe I'll be able figure it all out later.
I'm allergic to ibuprofen, so I'll stick with Acetaminophen.
both are only good for gut rot try cannabis
Jonathon Dunn good idea
Jonathon Dunn I'm allergic to acetaminophen 😂sticking to ibuprofen
That's great, but ibuprofen works for pain and Tylenol is worthless for pain. So I had a stroke, and take aspirin, and on occasion ibuprofen.
The image for prostaglandins is wrong, but good info allround.
Some good info, but I was hoping for a clearer delineation of indications for using one or the other ( i.e. when suffering from this sort of pain, use this med, etc.)
My question would be: can you build up a tolerance to ibuprofen? It used to work great for me but over the years the effectiveness has dropped to near zero. For migraines, the over the counter pill that combines aspirin, acetaminophen and caffeine works wonders.
No
Yes
Maybe... I don't know, can you repeat the question?
I think I'm allergic to ibuprofen and plus it causes gut damage so I don't use it. I never take pain pills unless I feel like I'm dying, and when I use them I only use acetaminophen and it works like a charm. There's pros and cons to everything.
Good thing every on TH-cam is a doctor or other medical provider with at least 10 years of post-high school education...
Great video!
Good film!
Hello, which one do you recommend for swollen and injured knees? Damaged ACL to be particular.
Since I can't get my hands on the big stuff like Morphine and Vicodin!
Ibuprofen/NSAIDs is my favorite, but to be fair, I hardly ever use pain medicine. More research is needed! It does suck though that NSAIDs increase your risk of ulcers :(
If you take a mix of both it works REALLY well, just don't go overboard.
DNews Make a video about natural supplements compared to drugs. Like 5-HTP vs. Prozac for depression.
In Australia it is ibuprofen versus paracetamol. I always find ibuprofens works a lot better than paracetamol especially on period pain
Naproxen sodium seems to work the best for me. But acetaminophen works just as well.
Acetaminophen used to be my go to, but now I'm all about Ibuprof.
Julia,
Great job on this, and all your videos. You present the material very well, and you come across as an intelligent, good-natured person who is fun to be around. Keep up the good work!
Please be sure to check with your pharmacist. I cannot take Advil due to contra-indications with the other medicines I take. Whether it is an RX or over the counter, always check with your pharmacist.
I use Ibuprofen and/or Naproxen rather than Acetaminophen because I like to drink a few times a week, and acetaminophen can cause liver damage in people who use alcohol regularly.
Ibuprofen works better for me than acetaminophen, but I've had several doctors tell me taking up to 1000 mg of acetaminophen with up to 800 mg of ibuprofen is always best, and it works wonders for me, ALMOST as much as a 7.5 mg hydrocodone.
Were is Naproxen Sodium (Aleve) in all this?
This show was very interesting to more like this.
I have never taken either, especially not for headaches. I'm one of those few who very rarely get headaches.
ibuprofen is the go-to for me. tylenol has always made my head really foggy and it's really uncomfortable, so i don't like taking it. i wish i could just pop an ibuprofen when i get a migraine and feel better though like you said, it would be nice if life really worked that way.
its situational for me whether i use one or the other
Ibuprofen has always worked better for me, and I use it for any kind of pain, mild or severe. Prescription pain meds often make me feel sick to my stomach, so even when I had them available after I had my wisdom teeth out, I took ibuprofen instead.
Hey dnews make a video about aspirin and aleve. Where do these go in all the pain meds?
Hey DNews! Make a video similar to this but about cough medicine. I'm confused as to how it works but i know that it works in a very indirect way that just relieves symptoms and not the root cause. At least that's what i remember
Both. If I want to reduce swelling or reduce pain from physical trauma, I use Ibuprofen. If I want to relieve a migraine, be more wakeful, or help with a hangover (assuming I lack either Midol or Gatorade), I take Excedrin Migraine. If I am sick, I abuse Ibuprofen while consuming a lot of water, and either sinus/sleeping meds or Excedrin, based on what I am doing at the time. I use Ibuprofen additionally for things like toothache and new piercings.
Now, can you explain how allergies to anti-inflammatory and other medications arise?
Putting up with it is my pain killer of choice..
But for when that's not an option; Aspirin for less serious pain,
Codeine for anything more severe.
Ibuprofen is easier on the Liver! In fact, the leading cause of Liver failure in America, is Acetaminophen poisoning. (Overdose of Tylenol). You would think it would be Alcoholism, but it is not. Alcoholism is sometimes a contributing factor. Tylenol for a hangover headache. It is actually the Tylenol that causes the most damage. Take Ibuprofen!
But Ibuprofen can cause ulcers & those with clotting disorders to bleed more. So damned if you do & damned if you don't.
Don't get drunk would be the correct answer here
Pain medication has only worked for me sometimes. In fact, most of the time, it doesn't work be it acetaminophen, naproxen, or ibuprofen. Oxycodone works for pain but it is an opiate and opiates can be addictive. For menstrual cramps, Midol is the only pain medicine that is not an opiate and that works. I am not sure why but I seem to have developed a tolerance to acetaminophen and NSAIDS unless it is midol. I don't know what is in midol other than acetaminophen that makes it work so well but I don't want to take opiates simply because NSAIDS don't work. I guess I will have to endure every pain and just not take pain meds.
But here's the thing. My pain medication levels are usually 1 dose per month and at most 1 week's worth of pain medication per month(but it only reaches these levels when I am close to having a seizure despite taking anti-seizure meds or after surgery(of which I have had only 1, an appendectomy)). So why would I, at these low pain medication levels, become tolerant to acetaminophen and NSAIDS to the point where they don't work? Are my white blood cells producing different COX enzymes that NSAIDS just can't bind to because of having previously taken NSAIDS? Are the receptors in my brain that acetaminophen binds to being downregulated even though it is usually only once a month that I take it?
Hmm, Midol in my region has caffeine in it. Perhaps, that's in your Midol? 😀
How about Naproxen vs. Ibuprofen??
0:27 and send a signal slow* to the brain.
nociceptors are C type fibers and are actually the slowest type of nerve impulse. depending on how tall you are, it could take a full second or more for pain signals to reach your brain from your feet.
My brain started hurting when she started to try to explain acetaminophen lol
depends on side effects, one of those you mentioned have adverse effects on the liver... i would prefer to not take pain meds at all... except for a short time after surgery until it's at a point i can tolerate it.
As a pharmacist for pain, I prefer aspirin so long I know my kidney function is fine. At adequate doses, close to 3gm split every 4 to 6 hrs is equipotent to codeine as I recall from my pharmacology classes at UF. We are backing off from Ibuprofen because it may have undesirable cardiovascular effects and few benefits are gained at doses higher than 600mg every 8 hrs (or TID) in the lingo of the US.
Acetaminophen I had learned to be a selective cox3 produced solely in the brain. It is a good pain reliever when used at the correct dose, but the FDA is recommending to back of bcz of the opiod epidemic. Still, at 1000mg every 6 hrs it relieves pain very well without affecting renal flow nor risking people that are likely to bleed... Those with ulcers, warfarin or newer direct anticoagulants like rivaroxaban.
Make videos about Cymbalta
Acetaminophen (Paracetamol) coz I mostly have headaches that's why now I'm planning to experiment.
What about paracetamol possible working on COX-3 in the CNS?
I don't like either and in general I don't like taking meds unless needed. When i get headaches I literally go to bed and relax. That usually helps.
ok, this episode had a lot of big words.
i dont really understand it, but I'll accept the challenge!
I've always used Advil because it works better for my dad so it's what my parents kept around the house. Watching this video made me realize that I'm in my twenties, yet I don't think I've ever taken Tylenol. Weird...
it depends on the pain right? i tried taking ibuprofen for a wisdom tooth im getting in and it didn't do anything, while acetaminophen stopped that pain significantly. And with head aches for me, ibuprofen works better than acetaminophen
Naproxen ftw!
what about naproxen sodium? (aleve)
Is it true you can take a dose of each simultaneously without particularly adverse effects?
Hi D News. I have some suggestions on possible topics to discuss. Why haven't we cured gout yet? There is a lot of conflicting information on causes and cures. That led me to question why the FDA takes so long to approve new drugs? Europe seems to Excell at new meds, what are they doing right and why aren't we (the US) mimicking that system? Thank you for your consideration!
around 2:48 u mentioned researchers say they can actually activate pain instead of reduce it, for me and tooth pain, it absolutely for sure hurts worse when i smoke bud, its definitely noticeable and the m.o.a. or way i smoke doesnt make any bit of difference at all, it has nothing to do with smoke touching the teeth or a vacuum being pulled.
I have both rn for a filling I have and the IB works better for me with blocking pain. The Tylenol 3 has acetaminophen/codeine and it’s not working well for me.
In Argentina we only consume ibuprofen, and for very bad pains we use diclofenac. I've never seen tylenol here.
Tylenol works good for my leg pain which is believed to be cyatic nerve.But is it safe to take after having 3 heart stents out in 6 months ago.so Do I deal with possible heart problem ,or severe pain.?help
Acetaminophen, not because I think it's better, but because it was always in my house. My mother is allergic to Ibuprofen [and related drugs].
I use both with no preference for headaches. But for migraines it's Acetaminophen all the way.
This is wisdom from my mom and she seems to be right. You take acetaminophen for fevers, headaches, and pain if your wound is bleeding. You take ibuprofen for muscle pain or injuries to reduce swelling. For headaches you can also take ibuprofen if it is a tension or sinus headache. If it's a bad headache or migraine, I take 2 of each.
Thanks
What I hate the most about NSAIDs is heartburn
I grew up with acetaminophen, which has worked. I dont know which one works best though
All I know at this point is after my kidneys failed and had a transplant I'm not allowed to take ibuprofen, only acetaminophen. But the fact that I now know more about ibuprofen and not acetaminophen is kind of worrisome.
Naproxen (Aleve) is my go to over the counter pain reliever. Nothing is better than Aleve for me.
Ibuprofen is the only one that works on me. I never knew why but Acetaminophen makes me feel nauseated and sometimes increases the pain I've felt.
This video left me the question though - if we don't know now acetaminophen even works :| why is it an over the counter drug? If we don't know how it works how do we know what the long term side effects would be.
I generally find that Ibuprofen is the one I end up taking the most, although I personally would almost always take them in combination, because that's fine. But the one hang up I have about acetaminophen (paracetamol where I'm from) is the fact that it is metabolised through one of the enzymes which metabolises alcohol, making it more likely to have an overdose effect of the paracetamol when you're drinking or hungover, making you feel much worse than just that hangover (because Woohoo Pharmacology!). Just make sure you know the circumstances for each drug and you'll be fine :)
Ya
I'd take ibuprofin
I can't take ibuprofen with my dabigitran etexilate but I'm allowed to take cocodamol however I do sometimes cold filter out the acetaminophen
I'm now convinced on ibuprofen myself
***** yup. it is better at pain control than both ibuprofen and paracetamol.
***** Aspirin is only good for getting rid of warts and thinning the blood
The Junks That is inaccurate. go do some more research.
Jindorek Aspirin is shit and was invented by the same company that invented Heroin and Cylon-B... Bayer are evil pricks.
The Junks Aspirin wasn't invented... the active ingredient is naturally occurring in the bark of a white willow and was used in ancient egypt already. Due to the way it works it deals with pain for far longer than ibuprofen and paracetamol. like i said, do some actual research instead of just spewing hate. nobody cares what you think of Bayer.
my mom prefers advil because tylenol doesn't work for her but she's allergic to advil. :( she has a prescription to tramadol instead to use sparingly.
Which on do you take for period cramping? Ibuprofen? I am quite sure it is not asprin.
As a child I was able to take acetaminophen, as I got older however I became allergic to acetaminophen so now I have to take ibuprofen.
I've been told to take both after my appendectomy...
I prefer ibuprofen but for severe pain I usually use Norco or Percocet which has acetaminophen in it to strengthen the drug’s effect
I love them cox 2!
My migraines are caused by high intracranial blood pressure which can be triggered by anomalies in caffeine intake, stress, changes in barometric pressure, and ambient heat, among other things. I treat mine during early onset with a combination ibuprofen and cannabis which lowers my blood pressure and relieves the pressure on the arteries and nerves in my brain which are responsible for the pain.
The difference between ibuprofen and acetaminophen is that ibuprofen is an anti-inflammatory and acetaminophen a fever reducer. Acetaminophen reduces pain by cooling down the body which raises the pain threshold. So I would say that ibuprofen is better for pain specifically compared to acetaminophen, but it does reduce pain. But acetaminophen is definitely better for fevers and headaches.
Tylenol has always made my headaches worse. Ibuprofen is the only thing that works for headaches and migraines (for me) but, when it comes to physical pain somewhere else in my body, tylenol seems to help more.
I use them both. They seem to work the same for me.
But you can now take both with Advil Dual Action
I have a headache now after trying to follow this.
I have been diagnosed with Fibromyalgia and arthritis and the pain medications the doctors prescribe seem to always have Acetaminophen in them. I dont take very much Ibuprofen. If I werent allergic to Naproxin Id prefer to take it as a pain reliever.
I mostly use naproxen sodium, but when I don't use the I use Ibuprofen.
Me watching these cause I’m trying to believe the pain killers will work for the agonizing wisdom teeth pain
Julia is GORGEOUS. Wow.
could've put paracetamol in smaller letters under Acetaminophen. so we know what your talking about
I have a blood disease, Von Willebrands, and when i was a baby the doctor told my mom that I cant take ibuprofen but I CAN take acetaminophen... why is that?
No, it really is not an age old question. This isn't difficult