Neuroscientists Talk Shop: Rakez Kayed on tau protein and neurodegeneration.

On February 16, 2023 we got a chance to chat with Rakez Kayed on the tau protein, the key constituent in neurofibrillary tangles that are seen in the brain in Alzheimer's disease, and present in many other kinds of neurodegeneration. He answered our questions about what tau protein is, how it is changed in neurodegenerative diseases, and what might be done about it.
Guest: Rakez Kayed, Professor in the Department of Neurology and the George and Cynthia Mitchell Center for Neurodegenerative Diseases
University of Texas Medical Branch, Galveston Texas.
Participating: George Perry, Department of Neuroscience, Developmental and Regenerative Biology, UTSA
Host: Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA

[@udonloews1301]

This is so fascinating! Thank you.

[@aleckdwyer4490]

Awesome.....

[@alexw890]

Go SAVA

[@juan-fernandogomez-molina645]

Protein accumulations: when are they toxic or physiological? It depends on their size, their surface, cell activity at that moment/age and other protein accumulations that can induce compensation in the first ones! Alzheimer's disease is, then, not caused when one or two proteins (e.g. Tau, amyloid) reach certain rigid levels of accumulation (oligomers of certain size) but when these levels are relatively inappropriate to each other, so they become toxic... It is what I can understand, at least (😁)... great debate; thanks to all!