Thank you for watching. If you enjoyed this topic and episode, please click the "like" button and subscribe to our channel here on TH-cam. Thank you for your interest in science! -- Andrew
Psychedelics are just an exceptional mental health breakthrough. It's quite fascinating how effective they are against depression and anxiety. Saved my life.
Can you help with the reliable source I would really appreciate it. Many people talk about mushrooms and psychedelics but nobody talks about where to get them. Very hard to get a reliable source here in Australia. Really need!
Yes, dr.sporees I have the same experience with anxiety, depression, PTSD and addiction and Mushrooms definitely made a huge huge difference to why am clean today.
I started with edibles at 15. 100 mg’s consistently. 250 mg’s. The high was euphoric. Then it was into pens throughout high school. I would hate being in class without being high. I discovered joints and would smoke my day away every single day. Bong rips. Every single day. Then onto dabs. Rigs, e rigs jumping between flower and dabs daily. It wasn’t until huberman pointed out you want to shoot for 2 smokes a week. I realized I was smoking about 70-80 times a week. Every time I would feel stress or discomfort or pressure I would run to that crutch. Please don’t be like me in my past: please get help, help yourself. Face reality sober. Exercise and learn sober. It’s worth it. I’m only 9 days without weed. Since being 15 I’ve been smoking out of compulsive habit. It can be done and i have faith that I’ll never turn back.
When I use to smoke awhile back, I found it very easy to only smoke 2 or 3 times a week. I would only use it as a reward system. I would only smoke if I crushed whatever weekly goals I had for myself, but I wouldn't smoke if I had a lazy and un-productive week. I guess it's like Beer. I mean I I could have 2 or 3 beers a week and never ever have the threat of becoming an alcoholic. No addiction is good and weed is the same way. Used every now and then it's perfectly fine and won't hurt you. But yea if one becomes a stoner, trying to numb pain etc, then yea they need to flat out quit.
32 yo here. I quit 7 months ago for different medium term purposes. Now I'm at a point where I can stay sober for the rest of my life after a decade of hard smoking. I feel more awake and energetic, and I feel like I can drive myself into that "high" state of visual appreciation without being intoxicated. It's cool to know both worlds.
Same here! I’m 31 and quit 7 months ago after using daily for almost 10 years. It’s true what they say - you get things done. Your mindset improves significantly, meaning your cognitive processes become sharper and more optimistic. Over time, you experience deeper and more restful sleep, too. It was a difficult process in the beginning, but the rewards are definitely worth it.
Allen Car’s Easy Way (Cannabis version) makes it very easy to quit. Highly recommended. You don’t need to use any willpower. Just listen/read it while sober and it will do the rest for you.
What I love most about this conversation is there are several times where it’s clarified and admitted that there isn’t enough evidence or data to suggest certain conclusions. In this space so many people talk in absolutes while having very little to prove it.
Very true. In Germany for example many people try to suggest that cannabis is worse than alcohol, because we have such a heavy culture in drinking. They have literally zero clue about weed.
@@TrixxPlay Hello neighbor, same in Poland. Drinking alcohol is a cultural norm, and smoking weed is considered as something that will melt your brain. I see some progress, but it will take at least one generation to shift it to a level that Netherlands have.
These things aren’t uncommon. They come up with theories. Theories are not facts. They are ideas created by intelligent people to help give some form of an answer to things unknown. Their ideas & theories change often. They think they know then, they don’t know then, they do know. It’s a cycle that continues to move forward like everything else. 🌞
The problem with pot is that over time, it kills ambitions in a person. And if you smoke weed and think you're successful and ambitious, if you quit, you'd be multiple times more successful and ambitious. After you go through withdrawal, of course.
🎯 Key points for quick navigation: 00:00 *🌿 Introduction to Cannabis and Dr. Matthew Hill's Background* - Introduction to cannabis, its historical use, and modern popularity. - Overview of cannabinoids, focusing on THC and CBD. 07:19 *🧠 Psychoactive Effects of Cannabis* - Description of psychoactive effects including euphoria and altered perception. - Differentiation between THC and CBD effects. 12:49 *⏳ Time Perception and Cannabis* - Effects of cannabis on time perception, including temporal distortion. - Mechanisms influencing perceived time intervals under the influence of cannabis. 19:55 *🧠 Understanding endocannabinoid signaling* - Endocannabinoids, like anandamide and 2AG, regulate neurotransmitter release through retrograde signaling. - CB1 receptors are crucial in this process, found on most neurons except dopamine neurons. 24:21 *🌿 The role of endocannabinoids in euphoria and dopamine regulation* - Endocannabinoids indirectly influence dopamine neurons by modulating inhibitory control. - CB1 receptors in the ventral tegmental area can enhance dopamine release, impacting motivation and reward. 30:25 *🏠 Anandamide and 2AG: Tonic vs phasic roles* - Anandamide acts as a tonic regulator, maintaining baseline neural activity levels. - 2AG serves a phasic role, responding to increased neural activity and regulating synaptic plasticity. 38:55 *🍔 THC's impact on appetite and motivation* - THC increases appetite even after satiation. - Animals under the influence of THC will work harder for food rewards, showing increased motivation. 42:25 *🥦 The role of AG1 as foundational nutrition* - AG1 provides foundational nutrition with vitamins, minerals, probiotics, and adaptogens. - It supports energy levels, digestion, and overall well-being. 44:17 *🧠 Increasing endocannabinoid activity without THC* - Methods to boost endocannabinoid activity experimentally or therapeutically without THC. - Comparing THC's partial agonist effect on CB1 receptors with endocannabinoids like anandamide. 57:51 *🌿 Cannabis and Food Seeking Behavior* - Cannabis intoxication can induce food-seeking behavior similar to the response seen in fasting. - Users often crave high-calorie foods like those high in carbs and fats to replenish energy stores. 59:03 *🧠 Cannabis and Psychological Effects* - Cannabis affects focus and memory differently depending on the individual and context. - Anecdotal reports suggest some people use cannabis to enhance focus despite potential impairments in certain memory tasks. 01:05:57 *🚬 Routes of Cannabis Administration* - Inhaled cannabis (smoking) delivers THC rapidly to the bloodstream and brain, typically within 2 to 5 minutes. - Differences in administration routes (smoking vs. edibles) significantly affect onset speed and subjective effects. 01:16:55 *🌿 THC titration and potency concerns* - THC potency has increased significantly over the decades, leading to challenges in titration. - Higher potency cannabis and concentrates can make it difficult for users to regulate intake effectively. 01:22:40 *💉 Insights on cannabis addiction and dependence* - Cannabis can lead to dependence and potentially meet criteria for a use disorder. - The concept of addiction versus dependence in cannabis use is nuanced but significant. 01:29:34 *🚓 Legalization and societal perceptions of cannabis* - Legalization of cannabis has shifted public perception from illicit drug to regulated substance, akin to alcohol. - Despite legalization, societal views on cannabis safety versus legality remain complex. 01:36:45 *🍪 Understanding the unique risks of cannabis edibles:* - Cannabis edibles, due to their delayed onset and prolonged effects, often lead to unexpected intoxication. - Standardizing dosing units for edibles, similar to alcohol units, is crucial for public safety and consumer understanding. 01:41:28 *🕰️ Duration of cannabis in the body and its impact on drug testing:* - THC's lipophilic nature allows it to accumulate in fat cells, leading to prolonged presence in the body. - Exercise and weight loss can release stored THC, potentially causing unexpected positive drug tests. 01:46:15 *🧪 Effects of cannabis on hormones: Insights and contradictions:* - Cannabis's impact on hormones like testosterone and estrogen is highly variable and not fully understood. - Studies show conflicting results regarding cannabis's role in aromatization of testosterone into estrogen. 01:55:03 *🤰 Cannabis use during pregnancy* - Discussion on varying statistics and concerns regarding cannabis use during pregnancy, - Factors influencing reported numbers include self-reporting versus verified blood levels, 01:56:36 *🤢 Risks and motivations for cannabis use during pregnancy* - Motivations for using cannabis during pregnancy, often related to managing morning sickness, - Comparison of cannabis use versus traditional pharmaceuticals like thalidomide, 01:58:55 *🍻 Education and responsible cannabis sales* - Advocacy for mandatory education for cannabis sellers similar to alcohol servers, - Concerns about misinformation and lack of education among cannabis dispensary staff, 02:04:13 *🌿 Different methods of cannabis consumption* - Discussion on harm reduction strategies for cannabis consumption, - Comparison of oral consumption, vaping, and smoking methods, 02:07:26 *🧠 Cannabis, THC, and psychosis* - Exploration of the relationship between high THC cannabis use and psychosis, - Distinction between acute drug-induced psychosis and chronic psychotic diseases, 02:14:10 *🧠 THC's impact on anxiety and excitatory transmission* - THC initially reduces anxiety by quieting down excitatory transmission. - Increasing THC doses can saturate CB1 receptors on inhibitory neurons, leading to an amplification of anxiety. 02:15:32 *🚫 Rare occurrence of psychotic responses to cannabis* - Psychotic responses to cannabis are rare and typically make headlines due to their unpredictability. - Cannabis-induced psychosis is more likely in individuals with a predisposition or vulnerability. 02:19:00 *🧬 Cannabis use and schizophrenia risk* - Cannabis use is associated with an increased risk of schizophrenia initiation. - Individuals with schizophrenia use cannabis at higher rates than the general population. 02:23:20 *🔄 Debating cannabis as a causal factor in schizophrenia* - The debate around cannabis causing schizophrenia centers on statistical associations rather than definitive causality. - Variations in schizophrenia prevalence across different cannabis consumption cultures suggest complex interactions. 02:33:29 *🧠 Understanding the debate on cannabis and schizophrenia* - Debate centers on whether cannabis causes schizophrenia or is used more by those prone to it. - Evidence from Scandinavia suggests low cannabis use but similar schizophrenia rates. 02:34:39 *🌿 Cannabis use and bipolar conditions* - Discussion on the relationship between cannabis use and bipolar disorder. - Genetic and hereditary links between schizophrenia and bipolar disorders. 02:36:16 *📑 High-potency cannabis and its implications* - Examination of arguments regarding high-potency "skunk" cannabis. - Analysis challenges linking potency to schizophrenia risk. 02:39:03 *🤔 Biological predisposition and cannabis use* - Exploration of why individuals prone to schizophrenia might prefer cannabis. - Discussion on the broader factors influencing substance use in schizophrenia. 02:42:04 *🌐 Public perception and policy implications* - Critique of public perceptions linking cannabis use to schizophrenia. - Impact of media and research on public health perceptions. 02:53:24 *🌿 The influence of terpenes on THC-induced anxiety,* - Terpenes like lemine can modulate the anxiety-inducing effects of THC. 02:57:23 *🧠 The therapeutic potential of CBD in epilepsy,* - CBD, historically bred out of cannabis for higher THC content, shows significant efficacy in treating pediatric epilepsy. 03:00:21 *🌱 CBD's scarcity and its medical implications,* - CBD is naturally scarce in cannabis due to historical breeding for high THC content. 03:12:16 *🌿 CBD efficacy and dosing considerations* 03:17:22 *🚫 Challenges and skepticism regarding CBD* - Despite widespread use, clinical studies have yet to find significant efficacy of CBD at low doses (10-20 milligrams). 03:19:25 *⚠️ Potential health risks of cannabis use* - Cannabis smoking poses risks for lung damage, although evidence for lung cancer is inconclusive compared to cigarette smoking. 03:31:10 *🌿 Cannabis health risks and syndromes* - Cannabis can potentially lead to schizophrenia, bipolar disorder, cardiovascular issues, lung damage from smoking. 03:31:51 *🩺 Medical uses and benefits of cannabis* - Medical uses include appetite stimulation, glaucoma treatment, nausea reduction, anxiety relief, and chronic pain management. 03:33:02 *🩸 Cannabis as a pain management tool* - Cannabis alleviates pain by reducing the emotional response to pain rather than acting as a strong analgesic. Made with HARPA AI
I started smoking cannabis years ago as a teenage, switched to cigarettes. Spent my whole life fighting Cigarettes addiction. I suffered severe depression and mental disorder. Got diagnosed with cptsd. Cigarettes addiction actually destroyed my life. Not until my mom recommended me to psilocybin mushrooms treatment. Psilocybin treatment saved my life honestly. 6 years totally clean. Much respect to mother nature the great magic shrooms.
Yes he's Dr.alishrooms. Shrooms to me is a natrual healer. I know a guy who has used mushrooms in the same way and they have really helped him. mah dudes have safe trips all.
Saw people talking about..checked him out, I must say he's good at what he does. My son is clean 1 year now. Good luck. just micro dose and you won't trip. Mushrooms helped my son get off opioid.
@anotherjewishsharpnicholas9425 it's also the amount, if you go too far you can fall sleep in a way that feels almost like passing out, and get that body high which makes your body heavy
@@shanewitt Science shows only a small percentage become addicted, and of that group a large amount is simply a result of them having a personality disorder.
Absolutely loved this episode! I'm an Infantry Veteran ('02-'07) and I use cannabis for my combat PTSD and tinnitus. It makes the tinnitus from 23 IEDs turn into background noise. It prevents me from having nightmares and helps manage daytime anxiety especially around crowds. But I honestly think it's the combination of cannabis, learning my sleep chrono type and adjust my life to it, getting my morning sun light, running 3x week, lifting 3x a week and all the other protocols I've learned from the Hubermanlab Podcast have really made me feel better than I ever have. So a HUGE thank you Dr. Huberman and Dr. Hill for helping me understand the science behind my favorite medication and recreational drug.
smoking weed is no longer cool. When you hit 30 and haven't achieved your goals.. I quit a few months ago and realised how much time i've wasted. The issue with weed is it makes you content with doing nothing. It takes away your ambition. If you are an introvert, be careful that weed doesn't become your best friend.
I'd say this is false from my experience and scientists I see... cannabis expounds your slackyness. I have been smoking since 18 myself and NEVER been content with doing Nothing. Thought you also shouldn't get reliant on it. So not bad input... Just diffrent than my experience.
Anyone else smoking while listening? While ive smoked for 10+ years pretty much daily. There is DEFINITELY negative effects.. i myself at points have realized its more of a habit than a "relaxing" thing. Its important to understand your personal relationship with weed and the negative habits it may form. And i ALWAYS treat the plant with respect and gratefulness while consuming. Very interesting information in this one.. as with everything, MODERATION IS IMPORTANT. PEACE to my fellow stoners and those who don't partake!
btw this plant is now mostly available in adultered forms such as concentrates tinctures waxes most is created in labs and far from the natural plant it was 30 years ago i find it hard to come to terms with people using the word plant to refer to todays cannabis its like saying poppy seeds instead of opioids and coca beans instead of cocaine Most THC today s high potency therefore lab synthesized into something completely un natural derived from cannabis plant
Same just not on the growing but I'd love to. Weed saved my life. I got off of the narcotics, opiods, I got through my surgery without any pain killers. It literally saved me from dying of gastroparesis. People gate on what they don't understand. It's amazing for depression and anxiety too
@@1jazzyphae People hate what they don’t know, very true. Nothing beats being calm, cool, collective unlike most people nowadays: low EQ, closed-minded, addicted to medications. Clean cannabis heals. Especially FECO
Surprised this guy actually showed up after being so condescending and abrasive on Twitter. Good on Huberman for being the bigger man in this situation and handling it with the utmost professionalism.
@@Alex-cw7xf I don't disagree, but there's a right and wrong way to go about that. He went about it in all the wrong ways, yet Huberman still graciously invited him on his podcast is my point. He has never claimed to be a de facto source of information and is open to being corrected.
@@Spuddy10 It's not what Huberman claims that I find concerning, it is the overall effect of his authority on his audience often without effective pushback that is the problem. Huberman was clearly out of his depth on the subject, and it's refreshing to hear it from the horse's mouth firsthand from someone who studies this topic on a daily basis. Huberman has a wealth of information but I would much rather it stay topical to what he has experience with firsthand because health recommendations are nothing to f with. Put it to you this way, if I went to culinary school to study how to be a pastry chef but one day wanted to podcast about barbecue and somehow I mix up different regions and their rubs/sauces, I wouldn't be suprised if I get roasted (pun intended) by some pit master who has been grilling their whole life. It would be silly for me (pastry chef) to then clutch my pearls. Just because I know how an oven works doesn't mean I can grill. I agree there is a time and a place for civility, but not when you are spouting off completely garbage interpretations of data based on your own subjective biases regarding a topic.
I don't follow Twitter/X but this guest seems a LOT less eloquent than most guests. I couldn't listen - even if he had good info to impart he had a puffed up, aggressive undertone.
Im 36 and have smoked for many years. But ive never been an all-day smoker. I rip a cone at 830 every night to take the edge off. I have a family and a busy, reasonably well organized life.
Yes, you got to moderate it. I find the comments funny where people tell their story of non stop weed smoking for years and then quitting. You would feel sick from anything if you do it all the time. Working out is good for you but non stop? Weed is to be used as a tool, in moderation.
My rule for myself is to smoke during my evening walk. Keeps me active even afterwards. If I smoke right after work, I'll just be lazy for the rest of the evening.
Quitting weed was extremely stressful for me. I basically lost my mind for a couple months. Extreme anxiety and nausea especially in the morning. Panic attacks from absolutely nothing. Waking up every night feeling hypoglycemic and needing to eat to get back to sleep. That was enough for me to never want to touch the stuff again. Your neuro chemistry can adapt to the stuff in weird ways where without it I had to figure out how to exist again. It took months but I’m back to normal and my overall mood and outlook on life has improved so much. The negative rumination has minimized. I was hitting the bong throughout the day everyday for many years
how long after quitting did your need to eat to get back to sleep at night end? Asking because my husband is the same and it has been 3-4 months since he quit (or so he says) but still does this at night and still has munchies.
@@joebillage3578nah its a real thing. He probably has CHS (Cannabinoid syndrome). I also have it, just unlucky i guess. I have “quit” smoking 10+ times in the past 3 years and without fail, i have extreme nausea and dry heaving in the mornings, usually pretty bad for a week or so.
dont make your drug addiction the center of your identity & you wont take it personally when science says that you're damaging your body. the weed isnt who you are, its just something you do
I enjoy a little after work, but it sure makes me sleepy. Always wondered how different bodies and brains process it to be able to smoke early in the day and not be in bed by the afternoon! Enjoy.
By the way, if you read the X thread, you'll find that this podcast started from a toxic string of comments including Dr. Hill's reply. The ability for Dr. Huberman to look past the way in which Dr. Hill initially responded to the thread gives me great respect for Dr. Huberman. Personally, I don't understand how anything productive comes from X - the number of "people" (bots?) who are simply there to tear down Huberman's good faith hard work is astounding.
I thought him being a literal expert on the subject, his comment was warranted if Andrew was giving false information. If he didn't reply in such a way, Andrew would have ignored it and we wouldn't have this great episode.
Huberman is all class. This guest has been extremely unprofessional and insulting toward him on Twitter. Funny how people act differently face to face.
Andrew was on Lex Fridman's podcast last week and talked about ongoing friction with someone in the online community surrounding cannabis but didn't mention his name. I'm guessing it's him.
@@pukuipzit was interesting to hear that no strain will test above 30%. I've seen some strains advertised at over 35% which I was always skeptical about but I now know to be really question that fact about percentages. Also, not all testing is honest. I've honestly never shopped by THC percentage but rather Terpenes and the percentage. I still have over an hour left of this episode but that so far really stuck out to me
@EfTheQuiet1 word up. I'm not at that part yet, but i imagine it's true that no flower is above 30% THC. I relate and like to think you're a real smoker because you're going off terpenes and percentages rather than just thc - that's the move for consistency in quality. Side note- I notice strains that have very high thc %'s tend to have low terp %'s. 🙏🏼 bless up, lmk if anything else stands out
I have to say, I came to this video after listening to the episode on spotify and have to say, as problematic as the relationship started on Twitter, this was probably my favourite episode ever. Dr Hill is extremely grounded and knowledgeable. I hope to see you bring him back in the future and put the rocky start behind you guys.
To be fair, this is a guy who hides his tattoos to avoid distracting from the science. The "my business" is maybe a poor use of words since it infers privacy. But withholding his own use or lack thereof would be in keeping with his intention to provide an unbiased presentation of the facts.
One of the reasons I personally find cannabis useful is to calm the stimulation from my tinnitus. Auditory issues and their different findings would be an awesome episode.
I hear sizzling sounds in my left ear. It started 2 weeks ago. I don’t know why or how it happened. Just woke up one day feeling like one of my ears was clogged. I can hear in the ear, but I noticed I don’t hear sharp frequencies in that ear. There’s also a constant sizzling sound
I listen to this podcast twice on my commute to work. The information density was amazing. I do wish Hill wasn't so condescending, there is enough that we don't know about neurobiology. Huberman is a class act.
It feels like in this episode it’s extremely hard to find any definitive statements or even *informative* nuance, clicking through the timestamps and I feel like I’m not learning anything
Agreed. There are tidbits of pure fact here and there, but it seems like we have a long way to go in cannabis research. I consume it multiple times a week and really struggle with withdrawals; mostly headaches, irritability, and anxiety. I personally use edibles mostly because of the lung impacts of smoking and the brain fog the next morning after edibles can be bad even after low doses. I am an anxious person without weed, and I’d say weed makes my anxiety sometimes lower and sometimes higher than my sober baseline. There are a lot of factors that go into it. I’ve thought about running a trial on myself and doing, say, 90 days using it semi-regularly (I’ve never been a daily user) and 90 days sober and charting my mood, energy, anxiety, etc each day.
I am disappointed by this episode for this reason, and guests like this make me appreciate even more so how Dr. Huberman can translate his wisdom into a fluid conversation I can understand and benefit from. What a rare skill for a scientist!!
@@MadMan14782 I went 45 days at the beginning of this year, which I’d think would be enough for someone using cannabis 3-4 times per week, but I could see it taking longer.
This is how it often goes when experts actually stick to the science and refrain from overstating the evidence. Huberman’s mo is to draw clear and interesting conclusions from single and often woefully under-powered studies. It makes for great content, but it is not science.
I quit weed around two years ago. Best decision I ever made. I feel motivated and I am extremely productive every day. It's down to the individual. But if you smoke regularly and are also depressed, consider stopping even for a while.
I vape one or two vaporizers every evening after everything is done - work, family, socialising. I‘m a vinyl-collector and like to listen to records when I‘m high. Music just sounds and feels better.
I'm that person that skips the first few moments of the episode to get to the "goods". So when I dug in and heard this guest sighing on some responses early in, it made me feel - different from the other episodes. Now that I heard the full episode and connected the dots this is the heavy critic Lex and Andrew spoke of, this all makes sense. Dr. H, I love and admire how much you showed complete respect for someone who said things that I'd say were more than a "healthy discussion online". Hats off to you- great discussion. ❤ from EPTX
I’ve been a daily user for about 8 years now. For so long I would attribute cannabis to a lot of my ability to do certain things or handle certain things or situations and my ability to functionally operate at an extremely high level. With work, coaching, parenting, exercise, etc… After listening to the first 90 minutes of this it’s become clear to me that these things I’ve been able to learn, accomplish, and strive for have nothing to do with cannabis and that it is the case that it enhances everything I’m doing. I think a deeper understanding of how my ego works and the way my mind operates when it comes to certain things is what allows for me to avoid the pitfalls of most heavy use individuals. And even have the ability to go a day, or multiple days without using and it won’t affect me the same way it would someone else who is in the same bracket of use. I love conversations like this because it really highlights how vastly different this amazing plant can affect people on an individual level. I’m very excited to hear the rest of this conversation. Cheers family
I've gotta ask- how did you develop a deeper understanding of how your ego operates? I've never quite understood when people say to just 'detach' from an unpleasant or emotionally- provocative situation, and I assume it is to do with a better understanding of ego (as opposed to 'dissociating').
@@Gnu58431 great question and I apologize for the late reply. I’ve been studying emotions and personal development and the ego for over a decade now. I’ve been in very deep meditative states on psychedelics and it was in those states that I was able to observe my thoughts from an outside perspective where as in the past I was identifying with them and thought it was me thinking them. When people are saying detach from those type of experiences it’s usually disassociating. However it’s not impossible to be involved in a situation that invokes those feelings and not let it break you all the way down. It’s a tricky topic but I think it’s well worth the effort to learn about. If you have any other questions or if I didn’t answer you the way you wanted lmk
@@andymeissner8727 that's really helpful, thank you. Some of the topics of your study overlap with some significant issues I've been recently struggling with mostly as a result of some traumas. I have been doing a bunch of CBT but I'm not sure it's proving super effective for me and I'm interested in exploring adjunctive therapeutic solutions. If you might have any pointers or know of particular websites books papers etc that could be useful for someone struggling with I suppose emotional dysregulation/ distress tolerance flowing from trauma, stunted personal growth etc, I'd be very grateful for your advice. The meditative psychedelic experiences sound intriguing and intimidating at the same time! There's certainly a lot been said about psychedelics & therapeutic value, in addition to mdma and ketamine I think they are also running medical trials on. I suppose there is a lot of nuance to ensure an appropriately therapeutic psychedelic experience.
I really wish we could spend some more time discussing the differences in effects caused by edibles versus inhalation. As Dr. Hill mentioned this is hard to ascertain but this is why I'm interested in learning what we know so far.
To my understanding, they did. The biggest difference is the first-pass metabolism converting most of the THC to 11-OH-THC. The difficulty is in directly comparing doses to effect for inhalation vs oral consumption
As someone who start smoking at 18 senior year to age 21 almost everyday, i stopped cold turkey on june 1st 2024 for im enlisting. - I was never addicted but everything in the podcast was so helpful to keep me from craving if I did.
Everyone talking about the controversy but it’s clear that there’s no bad blood and these are just two professionals who want to inform the public, I greatly enjoyed watching the way they responded to one another and how they sequentially moved the conversation forward
As an instrumentation engineer, the elephant in the room, is the lack of standardised testing for cannabinoids. You could take the same plant to different labs and get completely different results. You can take the same plant to the same lab as different samples and get different results. Older varieties of cannabis tend to have a more mixed cannabinoid profile than modern varieties because they didn't specifically know about THC. This meant that plant selection was very much more about the subjective experience and plants were selected on this basis. Unfortunately, they're now selected based on inconsistent lab reports that highlight THC and CBD only. Cannabis should be considered an experience, much like food (It is a plant after all and did form a staple part of many cultures diets) - does it smell nice, does it taste nice, how does it make me feel? Your body knows what it likes and will tell you. With regards to expectancy bias, that only goes so far, for example, you could tell me that an oyster tastes lovely and is really good for me and it may give me that expectation... But I've tasted oysters and they're like salty fishy snot 😂
You both deserve our utmost respect and appreciation in so many ways. The thirst for accurate knoweledge and just the 'WANT' to help people, moves me in a way I can not put into words.
I have so much respect for Dr Huberman. Having this kind of discourse without cancellation or character assassination is much needed everywhere these days. It took a humbling act to make this happen on his part given the way this guy reacted on X. Dr H will be remembered long term. Not sure about those who argue on X/Twitter.
Yeah, I was appalled when I actually went and read this guy’s comments on the X thread. Absolutely blown away at how humble Huberman is to have someone on who I’ll say was a total asshole going after Huberman as a person/podcaster instead of just talking about the science. Huberman has my great respect
I can attest to the chronic throwing up, I have been smoking day and night everyday for the last 4-5yrs, without any tolerance break. It almost always starts in the morning or after work because it's a short period of time that I didn't smoke, it hasn't gotten to the point where I legitimately throw up but I can just open my mouth and salivate for straight up minutes all coming from my stomach. Sitting in a hot shower helps it instantly. After watching this, I'll be quitting even if it ends up as a tolerance break this was a huge wake up call for me. Thank you, Andrew and Matt.
I can definitely back you on this. The vomitting started in the morning when I had it and didn't stop till I ended up in hospital on a IV drip as I had lost over 1.5kg in water from sweating and throwing up. I found out about the shower saviour the second time it happened because I had the worst fever and everything felt cold and my skin was so sensitive. Decided to get in the shower and it immediately stopped the nausea. I haven't had it since and I have continued smoking though I hope to quit one day... Not for me but for my daughter as I wouldn't want her seeing me smoke
It doesn't sound like CHS. CHS is much more intense and can land you in the hospital. I used to feel the same way in the mornings-gagging until I smoked, also unable to eat, and losing my appetite. I skipped meals and smoked instead, even though I used to eat well and get the munchies from smoking. Over time, I lowered my dose because I was overdoing it. I went through cold sweats, and when it got too much, I'd take a hit. Now, I eat every couple of hours, and my appetite is back to normal. I try not to skip meals anymore to avoid messing up my system by smoking and numbing my hunger.
@@drxzt same here, I immediately cut my intake by half so far and I'm already realizing how much I was crutching it from smoking everytime before meals, work and bed. Personally my biggest problem is when I'm at home with the silence of not doing anything, I'll smoke and watch TH-cam until the day is gone. Starting to realize that weed makes you feel okay doing nothing or anything which is dangerous to dreamers.
@@gorrvaskr5963 I get you 100% I been struggling with the same kind of thing and I'm not entirely out of it, like I said, I just fixed my appetite and got back again into calisthenics this week, so it's helping but I still consume, and still waste a lot of time on places like TH-cam. I don't necessarily think it's bad to watch informational stuff like this but spending hours on yt gets you overstimulated and eventually feels like a waste. It can also get complex cause im pretty sure now that im bipolar and even though I picked up weed years ago because it felt like it helped a lot with anxiety and similar symptoms now I feel like im starting to be aware about me having hypomania episodes and also what you were just talking about, I hyperfocus/fixate on whatever im doing and when being home that becomes TH-cam.
Weed gave me panic attacks at 15 years old and it has been an absolute blessing. Learning how to manage unwanted thoughts and become keenly aware of my mortality have helped me gain an edge in life and it’s all thanks to this drug. It is to be respected and used as a tool. It’s given me context and a reference point for negative mental experiences. I can’t imagine having never done weed and developing sudden panic disorder without any context or coping mechanisms.
I had a panic attack disorder as a uni student and only managed to chill my shit out with weed and meditation. Granted I had to dial it back once I left school but I genuinely would have dropped out cause it was becoming truly unmanageable. Moderation is everything folks!!! Dont let any substance control your life, whether it's weed or coffee or anything else.
This turned out to be one of my favorite Huberman guest episodes. Great and challenging conversation between this two. I appreciate Dr. Hill taking the time to share his expertise.
Couple hits at night goes a long way, I got diagnosed with diabetes 2 weeks shy of 15 years old. My night time anxiety was pretty awful, and falling sleep was tough. Totally coincidental, when I tried it eventually in college at 21, I started finding my nights to be relaxing, euphoric and introspective after some cannabis. 37 now. I do stay mindful of lung irritation for the long haul, but truthfully keep usage to less than a bowl pack. We all need a lil something in this life.
It's so rare to find two people discuss any topic with as much respect and open mindedness. Thank you both for such an interesting podcast, halfway between science popularisation and scientific conversation and thanks to Andrew for coming back elegantly on some of the points he made in his solo episode. Sincerely, a biologist.
Please continue with these long, informative videos. You are such a treasure ❤ I've learned so much from listening and recommend this channel all the time.
Cannabis addiction is real. I've been smoking it for 32 yrs. When I quit, i was relieved of my depression. Sometimes, what's good for one person isn't good for another.
Huberman is such an inspiration. I remember when my now husband showed me his channel and I was impressed. Now we also have a channel and share knowledge!
I smoked around 3.5/4g per day. Every single day for over 10 years. Didn’t have a single day without smoking in those 10 years. And i quit in January this year. Not once did i experience any withdrawal or loss of appetite or the inability to sleep. Quite the opposite infact. Straight away my sleep improved and i had a better appetite
This was a great episode and I'd like to thank dr. Hill for coming in to talk about this. We all get carried away sometimes and it especially shows in things that are near and dear to our hearts. I'm sure this experience with Andrew has been a great learning point and maybe next time this happens he will react in a very different way. We can all learn from how this episode came to be, it's inspiring. Thank you both ❤
thank you andrew huberman for the knowledge you are giving to us for free of cost and its really changing my life in a postive way and lots of love from india
Hi Andrew, Thanks for another lesson in science, but overall, thanks for a great lesson in practical humbleness and a constructive way to deal with diverging views.
I personally suffered from cannibas induced psychosis which lasted for a few years. I consider myself lucky that I got through it and did not go completely insane.
I had a bad case of depersonalization. One bong hit was all it took. Wasn’t laced as 3 other people hit the same stuff. 3 months of full blown depression, 6 months of complete numbness in all of my extremities, and feeling like I’m playing a character in a video game (that is also lagging). I felt trapped in an alternate reality. This was legit 6-9 months. Slowly came out of it, but then for another 3-4 years sometimes I’d have a sort of panic attack and lose control of feeling in my body again for days or weeks. I only smoked once. Weed was the most psychoactive thing I’ve ever done. People need to know it’s not risk free
@jsuss98 It began with a "heroic" dose of mushrooms, leading to a very intense experience where I saw myself trapped in hell for eternity. However, this sensation subsided once the effects wore off. A few months later, I did a bit of edibles, and that exact experience returned in full force, convincing me that it was the true reality and everything else I remembered from my life was just a dream I had induced to escape my eternal misery. This thought lingered with me for a few years. I would often fully relive the experience at night and sometimes during the day as well. So, it wasn’t exactly psychosis, but rather intense flashbacks and severe derealization. The episodes would come and go on their own, and each time they returned, they terrified me because I knew they would last a while. Often, I found myself doubting which reality was true. I should add that it was my first time using shrooms, but I had smoked and had done edibles many times and always had a great time.
Thank you for this newer video. As a someone who is 4 months dry but a regular cannabis user, ive really been hoping for some updated content around it.
Hubberman i love the way you put togther your content. I love the wide spectrum of content relating to the mind, body, and soul! Your nsdr! Came across this while trying to get use to working night shifts. It was a life changer to my mental health!
I remember in the early 2000.. I had an exam coming up - the day after a party I started to study and after reading an entire page I couldn't recall anything I just worked through. that was when I realized that if I want to get through college, I have to stay away from cannabis. Sadly.
Funnny you say that I’m the opposite, if I study on cannabis I absorb everything and it is so much more interesting. I get wowed by everything I read and I become so much more passionate about it.
@theman2223 I am pretty sure it also depents on your specialization.. I can imagine it's great in any field that requires creativity - in my case it was law and the learning of legal paragraphs and dates/numbers of court decisions.. so yes
@anFy81 Makes complete sense! For me it doesn’t matter what field or subject but also for me law is so boring that if I smoked during study I would sleep for sure and that good affect would not take place hahaha I take my hat off to you for doing what you do, your a champion!
My friend was diagnosed with schizophrenia at around 18 probably triggered by cannabis but as CBD came into the market she now can use cannabis therapeutically in the right CBD/THC ratio very effectively as an essential medicine. She is now in her 30s.
I started smoking weed at 18 years old. I didn’t quit till 24/25. Im 28 now. I thank God every day for not having to smoke weed to be in a good mood or numb any emotional/physical pain I have. Weed made me lazy & I was scared to do important things to do in life to make big steps in responsibility & personal life. Once I quit smoking weed the strides I made in my personal life I couldnt believe it. I didnt think I could handle a business, financial responsibility, family life, social life, fitness & other hobbies. I didnt think I could juggle all those. Once I quit smoking I could do all those things plus some.
By "YouSum Live" 00:00:00 Cannabis biology and effects discussed 00:01:01 Dr. Hill's critique on cannabis data 00:01:54 Invitation to Dr. Hill for podcast 00:02:01 In-depth discussion on cannabis biology 00:02:14 THC vs. CBD effects and differences 00:02:21 Cannabis correlation with psychosis 00:02:33 Cannabis effects on hunger, memory, anxiety 00:02:49 Cannabis use implications and decision-making 00:03:18 Sponsorship acknowledgment and product details 00:04:54 Introduction to Element electrolyte drink 00:05:00 Importance of hydration and electrolytes 00:06:07 BetterHelp online therapy benefits 00:07:15 Insight into cannabis biology and history 00:10:31 Cannabis psychoactive effects description 00:15:49 Cannabis impact on time perception 00:17:00 Cannabis stimulation of appetite mechanism 00:17:45 THC acts on CB1 receptors in the brain 00:17:59 CB1 receptor widely expressed, crucial for biological processes 00:18:43 Evolutionary redundancy, not specific to cannabis 00:19:36 CB2 receptor mainly regulates inflammation 00:20:10 Endocannabinoids regulate neurotransmitter release bidirectionally 00:21:36 Endocannabinoids maintain homeostasis and plasticity 00:23:55 Cannabinoid receptors spare dopamine neurons, unique regulation 00:27:03 Anandamide and 2-AG play differential roles in brain circuits 00:30:19 Anandamide acts as a tonic, 2-AG as a phasic regulator 00:34:54 Cannabinoid receptors in feeding circuits 00:35:11 Regulation of food-seeking behavior through neurons 00:35:32 Cannaboids disinhibit agrp neurons driving food-seeking 00:35:45 Reward component in food intake 00:36:22 Cannaboids enhance response to sweet taste buds 00:36:38 Munchies involve brain's processing of sweet foods 00:37:33 THC overrides satiety signals, promoting eating 00:39:07 THC motivates animals to work for food 00:40:30 THC can block satiety signals, enhancing food intake 00:44:10 Boosting endocannabinoid activity without THC 00:51:57 Cannabis effects on brain receptors 00:53:22 THC vs. endocannabinoids in brain signaling 00:53:59 THC's broad impact on brain networks 00:57:26 THC's influence on food-seeking behavior 01:05:52 Routes of cannabis administration and effects 01:06:00 Onset of subjective effects after cannabis use 01:08:00 Research challenges with cannabis potency 01:10:21 Innovative approach to studying cannabis in real-world settings 01:11:00 Comparison of lab-based and ecological data for insights 01:13:00 Self-titration ability with different cannabis potencies 01:13:25 Challenges with concentrates due to high THC levels 01:15:20 Tolerance development more prominent with concentrates 01:25:28 Cannabis use disorder potential and comparison to other substances 01:26:44 Cannabis use disorder prevalence among weekly users is 30% 01:27:24 Perception of cannabis use varies based on personal experience 01:29:00 Transition of cannabis from illicit to legal status analyzed 01:29:54 Legalization aims to reduce harms of prohibition 01:31:44 Elderly and female demographics show increased cannabis use 01:37:24 Edibles pose risks due to delayed onset and dosing confusion 01:41:30 THC metabolism in fat cells affects drug test results 01:44:07 Challenges in cannabis testing due to body processing biology 01:44:17 Variability in THC levels based on consumption method 01:45:04 Inconsistencies in THC detection among different users 01:46:08 Lack of conclusive evidence on cannabis effects on hormones 01:46:49 Mixed findings on cannabis impact on testosterone and estrogen 01:57:59 Dispensaries recommending cannabis for morning sickness 02:00:22 Importance of education for cannabis sellers to provide accurate information 02:01:35 Awareness of safe cannabis consumption 02:02:45 Importance of dosing and understanding effects 02:02:51 Proceed with caution, start low and slow 02:03:47 Guidelines for harm reduction in cannabis use 02:04:17 Different effects of THC concentration in blood 02:05:27 Risks of vaping oil-based cannabis products 02:06:23 Lack of federal regulatory framework for cannabis 02:07:10 Psychotic responses to cannabis and schizophrenia link 02:08:36 Cannabis use and potential psychosis risk 02:19:02 Relationship between cannabis use and schizophrenia 02:19:25 Cannabis and schizophrenia statistical association 02:19:41 Males may have bias towards psychosis 02:20:52 Cannabis contraindicated for schizophrenia 02:21:00 Genetic predisposition increases schizophrenia risk 02:21:30 Cannabis may trigger psychotic episodes 02:21:33 Cannabis accelerates schizophrenia onset 02:22:00 Debate on cannabis causing schizophrenia 02:30:39 Self-medication hypothesis for cannabis use 02:35:02 High THC cannabis impact on bipolar disorder 02:36:49 Expectancy bias influences subjective effects of cannabis strains 02:40:49 Chemical composition doesn't align with Indica vs. Sativa labels 02:51:52 THC is the primary driver of the high 02:52:52 Placebo effect heavily impacts perceived cannabis effects 02:53:05 Entourage effect theory suggests other compounds may modulate effects 02:53:27 Research on terpenes like limonene influencing THC effects 02:53:51 Subjective reports often influenced by prior expectations 02:54:06 Clinical trials needed to validate strain effects objectively 02:54:10 Nuanced understanding required to separate bias from actual effects 02:55:01 Placebo effects in clinical trials complicate sound statements 02:55:20 Overwhelming complexity of cannabis components and interactions 02:57:34 CBD's role in epilepsy treatment, particularly Charlotte's Web strain 02:58:39 CBD's absence in street cannabis due to breeding for THC 03:05:25 CBD's mechanism through adenosine modulation, anti-inflammatory effects 03:09:09 Challenges in conducting blinded studies with THC and CBD 03:11:50 Majority of CBD effects attributed to placebo responses 03:12:44 CBD dosing and bioavailability challenges 03:13:22 Lack of blinded clinical studies on CBD efficacy 03:17:22 CBD market expansion and societal acceptance 03:20:53 Risks of cannabis smoking on lung health 03:23:10 Potential cardiovascular effects of cannabis use 03:27:21 Cyclic vomiting syndrome associated with cannabis 03:30:00 Activation of CB1 receptors and homeostasis 03:30:14 Chronic cannabis use may desensitize receptors 03:30:21 Potential involvement of insular cortex in effects 03:30:59 Uncommon but documented adverse effects of cannabis 03:31:39 Limited conclusive evidence on medical benefits of cannabis 03:31:56 Medical uses: appetite, glaucoma, nausea, anxiety 03:33:16 Cannabis as a mild analgesic and pain affective component 03:33:27 Cannabis helps chronic pain patients manage pain 03:34:31 Cannabis's role in reducing anxiety and stress 03:36:03 THC's potential in managing anxiety disorders 03:42:20 Endocannabinoid system's impact on anxiety levels 03:46:38 Evolution from confrontation to collaboration 03:46:46 Appreciation for education and clarity enhancement 03:47:11 Acknowledgment of complex nature of cannabis effects 03:47:41 Importance of scientists' disagreements for progress 03:48:52 Emulating real-world scientific discussions for clarity 03:49:37 Correcting mistakes and striving for accuracy 03:49:48 Invitation for future discussions as research evolves 03:50:01 Promotion of podcast and book for further learning 03:51:20 Encouragement for engagement through social media and newsletter By "YouSum Live"
This is really bad, it gives a list of topics but removes the facts and findings! A good AI works oppositely, it extracts the facts and shows the core information.
@@tonfilm It gives the general tipic so that people can click on an area that sounds interesting and get filled in by listening at that spot. Its quite convenient for some.
Gotta appreciate Dr. Hill's careful assessements. In contrast to Huberman, he really only confidently says what the data shows without a doubt. No jumping to conclusions or inferring causalities that aren't there.
This was a fascinating discussion and I thoroughly enjoyed the exploration of the contemporary understandings on various perspectives of this potent plant. One of the points made towards the end of the discussion was its benefit in survivors of trauma, in both alleviating anxiety (perhaps by recalibrating Anandimide levels) and reducing REM sleep thereby stopping nightmares and improving sleep, lower overall anxiety and better quality of sleep. For those that do not find a litany of prescription medicines to be helping them with their trauma distress (and those medications often come with their own side effects) I suppose it's a question not of drug-seeking behaviors but what works best for a patient's results and overall quality of life. Perhaps intermittent low dosage can help short term to aid longer term recovery?
@@Gnu58431 if you can moderate your marijuana intake it’s an amazing plant. If you’re like me and have to smoke all day everyday and become a drug addict it sucks.
I workout often after smoking, and I've never had issues performing. I've ran 10 miles after smoking without issue. I continue to partake and workout and show improvement with strength.
That’s because it helps you breathe better. Australia’s best ever Olympic swimmer smoked prior to training. It opens sacks in your lungs that’s why they use it for treatment for people with asthma
@@lesmoe524 Not from the weed. I had body dysmorphia, anxiety and depression which led to psychosis. After a couple of psychotic episodes it turned into insomnia induced psychosis with several episodes more. All from 2017 Summer till now. I've been 51/50'd about 10 times.
@@CoolStoryBro455most people can’t, unfortunately. Most pro-weed users in this comment section smoke daily, and would legitimately be more irritated or physically “ill” if they didn’t smoke. That says everything most people need to know. But yes, everything in moderation (if possible).
I was a heavy cigarette smoker from 13 to 20 and I tried weed to help quit cigarettes. I managed to quit cigarettes (that I loved deeply!) and I quit weed too to avoid replacing the addiction. I’ve settled on smoking a joint every once in an a while and it’s always good!
I've been a stoner for 13 years, and I'm 32 now. I used to smoke weed with tobacco, only using a bong, every single day. My routine was starting the day with a bowl and ending it the same way. But I didn't just smoke one bowl, I'd always smoke at least 3 or 4. Last year, I got busted, so I took that as a chance to quit smoking. I always wanted to stop but couldn't because I loved it and quitting was always hard. I spent a year mostly sober and started vaping again when I got COVID. With my Mighty vaporizer, I only needed about 0.07g a day, and that was just to sleep. I was very skinny then, around 60kg at 1.81m. During that smoke-free year, I gained about 17kg, looked really good, and even built some muscle. Then, I decided to smoke a bong again. It was disgusting, but that didn’t stop me from smoking more often. Now I'm back to smoking from morning to evening, and I don't feel good. I think about quitting every day, but when I get home, I just smoke a bong again, or when I'm with friends. Now I've lost about 10kg and am down to 65kg. Almost all the weight and muscle I gained during my sober year are gone. This is the main reason I'm going to stop again now. I just can't eat with my extreme usage. When I quit smoking, I could eat like a normal person for the first time in 10 years.
find the right ppl who can support you, don’t hang out with friends who smokes, unfortunately or fortunately, having the right ppl around yourself for quitting any addiction is the first and most important step, make your environment healthy, otherwise yoy just can’t, yes you need to sacrifice sometime, but if quitting is something that you think about it every day, it WORTH it!
33 y/o disabled veteran here, joined the Navy at 17 after getting my GED in Youth challenge. Was a fleet marine force corpsman for 5 years, saw alot of death, amputees, gsw, etc. Got out in 2013 and started smoking in 2014 ish. Started college 2015, kept smoking until present, graduating with my degree in computer science, and a programmer for 7 years now. Always questioning if cannabis was going to prevent me from accomplishing my goals, but ive always tried to monitor my usage, and push forward. I moved to grow legal cannabis 2 years ago to make my own hash rosin. Ive probably used an avg of 4-5 grams of concentrates/rosin a week for the last 8 years. Had t breaks here and there to help the family businesses. But not the last 7 years. Even blasted my own bho for about 4 years, since i couldnt trust other peoples garbage.
I love how, regardless of the fact that Hubz is a scientist himself, he allows the guest to develop thoughts and explanations without interruptions, adding only when necessary to further expand or lighten the mood even further. Absolute pro.
It's great when experts engage in open, respectful discussions, especially when they have differing viewpoints. It promotes a deeper understanding and helps listeners appreciate the complexity of scientific issues.
Grateful to have found this the week before my adult daughter was diagnosed with CHS. She is in bad shape but because of this, I had an understanding and could get her help.
For those who don't know, Matt Hill went after Huberman pretty hard on twitter, months ago. Bit unprofessional, but Huberman responded in a way we can all learn from. This informative convo is the outcome.
This is an outstanding example of how professionals in the scientific community should interact. Thank you both so much for the clarifications and professionalism to explore the opinions of others!
Me and my wife smoked our whole lives. (12-36 for me) She got pregnant so she quit and to be fair to her I did too. We both lost and forgot things on a daily basis multiple times a day until then and over a few years our memory got much better after quitting. She just started up again a few months ago and her memory went out the window. Misplaces everything and forgets recent events and conversation left and right. She says she doesn't notice it so I decided to subtly point it out every time it happens and now that I'm paying more attention to it, it's like watching someone go through Alzheimer's(my grandma had it). It's like watching someone lose their intelligence. It's sad. I wish I could talk her into quitting but she enjoys being high so much I doubt I ever will. She had the motivation when she was scared of it affecting her pregnancy but now I don't think anything else will provide enough motivation because just like when I used to smoke, when life presents you a problem, smoke and you'll forget all about it. 😔
This is bullshit. Are you a bot? Who forgets about their fuckin life smoking a little weed? This is crazy reefer madness bullshit. What the fuck? No one questions this garbage?
@@Zhdhcjen I did. Then I realized I care more about seeing my little girl everyday than her smoking pot. And even worse, the idea that she would have another Dad other than me 50% of the time.
@@Mikaeel84 That’s seriously fucked up. But you can sue her and take custody away from her on the grounds of her incapacitating herself of raising a child by smoking pot
Dr. Matthew Hill is brilliant! His description and nuanced understanding of the mechanism of many biological systems is greatly appreciated. I learned many new things about Canabis. Personally, I think the issue on Twitter was just a misunderstanding. Dr. Matthew saw edge-cases/nuances in some of Andrew's Statements, Andrew gave information but didn't go too deep into nuances to make this podcast fit non-technical audiences. Both are high-minded approaches, sparking new public benefit! Thank you to both for making this episode. Many information are relevant to me. Edit: Just noticed the Sativa vs Indica topic. Time to Google to see who's right.
It's funny to read so many comments where some people say that quitting cannabis was the best decision of their life. They've come out of one illusion and into a more sophisticated one. When you're unable to keep a measure, to be balanced, cannabis will be replaced by another excess.
It isn’t funny and it’s a big step in the direction toward facing life and their emotions instead of avoiding them, and doing so without a substance used primarily for the purpose of getting away from themselves. And by doing the honest work on themselves, and finding support from a good community and/or therapist, they can learn to channel that pain they carry into something beneficial and find greater balance and wellbeing. That is possible too
![ทางเดินชีวิต - ธีเดช ทองอภิชาติ x อ.ไข่ มาลีฮวนน่า [Official MV]](http://i.ytimg.com/vi/1f3wcG16dd4/mqdefault.jpg)
Thank you for watching. If you enjoyed this topic and episode, please click the "like" button and subscribe to our channel here on TH-cam.
Thank you for your interest in science! -- Andrew
I was wondering if you have anything on varicose
Hi!
th-cam.com/play/PLLFew4xL_sZcLK2SkmLSxXuf-As2fZWTB.html&si=yhBUVCDz6rXC1EJh
Weed is so overrated.
for me personally it heightened my focus to another spectrum but i used to always forgot the thing that i want to focus upon, that's why i stopped.
As a daily smoker. I love these.
Psychedelics are just an exceptional mental health breakthrough. It's quite fascinating how effective they are against depression and anxiety. Saved my life.
Can you help with the reliable source I would really appreciate it. Many people talk about mushrooms and psychedelics but nobody talks about where to get them. Very hard to get a reliable source here in Australia. Really need!
Yes, dr.sporees I have the same experience with anxiety, depression, PTSD and addiction and Mushrooms definitely made a huge huge difference to why am clean today.
Anxiety happens when you think you have to figure out everything all at once.
Breathe. You're strong. You got this Take it day by
day.
Is he on instagram?
Yes he is. dr.sporees
Dr. Hill and Dr. Huberman in a joint effort to weed out misinformation.
😉😎
Haaaaaaa that's punny
This should be good because they are both ✨highly✨educated!
Dope comment. Highly appreciate the bluntness. Shows that you don’t have to get your opponent stoned, even if the argument gets lit.
😂
Let me roll a joint so I can lock in, and listen to this interview
Haha 😂
Absolutely the best focus methodology to get through this whole pod: pack another bowl💚
My man
My man
Remember, if you didn’t have that joint, you wouldn’t be able to lock in. Makes ya think 🤣🤣
I started with edibles at 15. 100 mg’s consistently. 250 mg’s. The high was euphoric. Then it was into pens throughout high school. I would hate being in class without being high. I discovered joints and would smoke my day away every single day. Bong rips. Every single day. Then onto dabs. Rigs, e rigs jumping between flower and dabs daily. It wasn’t until huberman pointed out you want to shoot for 2 smokes a week. I realized I was smoking about 70-80 times a week. Every time I would feel stress or discomfort or pressure I would run to that crutch. Please don’t be like me in my past: please get help, help yourself. Face reality sober. Exercise and learn sober. It’s worth it. I’m only 9 days without weed. Since being 15 I’ve been smoking out of compulsive habit. It can be done and i have faith that I’ll never turn back.
Perhaps indulge, do not over indulge as I did. I found that euphoria and ran with it endlessly.
You were definitely masking some other problems you need to deal with if you were using that much herb
almost definitely you will go back. but that will be the stumble, from which you should try and recover. Dont give up, just because you gave in
dab and smoke daily suffer with severe adhd , .....it helps ....the end 😊
When I use to smoke awhile back, I found it very easy to only smoke 2 or 3 times a week. I would only use it as a reward system. I would only smoke if I crushed whatever weekly goals I had for myself, but I wouldn't smoke if I had a lazy and un-productive week. I guess it's like Beer. I mean I I could have 2 or 3 beers a week and never ever have the threat of becoming an alcoholic. No addiction is good and weed is the same way. Used every now and then it's perfectly fine and won't hurt you. But yea if one becomes a stoner, trying to numb pain etc, then yea they need to flat out quit.
32 yo here. I quit 7 months ago for different medium term purposes. Now I'm at a point where I can stay sober for the rest of my life after a decade of hard smoking. I feel more awake and energetic, and I feel like I can drive myself into that "high" state of visual appreciation without being intoxicated. It's cool to know both worlds.
i'm 32 too and recently kicked alcohol (three years without a drop now) but still smoke a lot of weed, and feel pretty good about it
32 also here. I love weed and won’t ever quit.
Congrats bro
@@erveyvazquez8842 I been sober for 5 months and feel like it's been a waste of time. Much rather been smoking weed
Same here! I’m 31 and quit 7 months ago after using daily for almost 10 years. It’s true what they say - you get things done. Your mindset improves significantly, meaning your cognitive processes become sharper and more optimistic. Over time, you experience deeper and more restful sleep, too.
It was a difficult process in the beginning, but the rewards are definitely worth it.
What are the odds? The day I decide to stop smoking, this pops up. What a blessing.
It's not just keep token bro
@@seanmcgonigle1182don’t try and drag other people down with you
Literally! The timing is perfect.
Literally same and then the science said it isn't bad 😅😅
Allen Car’s Easy Way (Cannabis version) makes it very easy to quit. Highly recommended. You don’t need to use any willpower. Just listen/read it while sober and it will do the rest for you.
What I love most about this conversation is there are several times where it’s clarified and admitted that there isn’t enough evidence or data to suggest certain conclusions. In this space so many people talk in absolutes while having very little to prove it.
Very true. In Germany for example many people try to suggest that cannabis is worse than alcohol, because we have such a heavy culture in drinking. They have literally zero clue about weed.
@@TrixxPlay Hello neighbor, same in Poland. Drinking alcohol is a cultural norm, and smoking weed is considered as something that will melt your brain. I see some progress, but it will take at least one generation to shift it to a level that Netherlands have.
These things aren’t uncommon. They come up with theories. Theories are not facts. They are ideas created by intelligent people to help give some form of an answer to things unknown.
Their ideas & theories change often. They think they know then, they don’t know then, they do know. It’s a cycle that continues to move forward like everything else. 🌞
Thank you.
The problem with pot is that over time, it kills ambitions in a person. And if you smoke weed and think you're successful and ambitious, if you quit, you'd be multiple times more successful and ambitious. After you go through withdrawal, of course.
🎯 Key points for quick navigation:
00:00 *🌿 Introduction to Cannabis and Dr. Matthew Hill's Background*
- Introduction to cannabis, its historical use, and modern popularity.
- Overview of cannabinoids, focusing on THC and CBD.
07:19 *🧠 Psychoactive Effects of Cannabis*
- Description of psychoactive effects including euphoria and altered perception.
- Differentiation between THC and CBD effects.
12:49 *⏳ Time Perception and Cannabis*
- Effects of cannabis on time perception, including temporal distortion.
- Mechanisms influencing perceived time intervals under the influence of cannabis.
19:55 *🧠 Understanding endocannabinoid signaling*
- Endocannabinoids, like anandamide and 2AG, regulate neurotransmitter release through retrograde signaling.
- CB1 receptors are crucial in this process, found on most neurons except dopamine neurons.
24:21 *🌿 The role of endocannabinoids in euphoria and dopamine regulation*
- Endocannabinoids indirectly influence dopamine neurons by modulating inhibitory control.
- CB1 receptors in the ventral tegmental area can enhance dopamine release, impacting motivation and reward.
30:25 *🏠 Anandamide and 2AG: Tonic vs phasic roles*
- Anandamide acts as a tonic regulator, maintaining baseline neural activity levels.
- 2AG serves a phasic role, responding to increased neural activity and regulating synaptic plasticity.
38:55 *🍔 THC's impact on appetite and motivation*
- THC increases appetite even after satiation.
- Animals under the influence of THC will work harder for food rewards, showing increased motivation.
42:25 *🥦 The role of AG1 as foundational nutrition*
- AG1 provides foundational nutrition with vitamins, minerals, probiotics, and adaptogens.
- It supports energy levels, digestion, and overall well-being.
44:17 *🧠 Increasing endocannabinoid activity without THC*
- Methods to boost endocannabinoid activity experimentally or therapeutically without THC.
- Comparing THC's partial agonist effect on CB1 receptors with endocannabinoids like anandamide.
57:51 *🌿 Cannabis and Food Seeking Behavior*
- Cannabis intoxication can induce food-seeking behavior similar to the response seen in fasting.
- Users often crave high-calorie foods like those high in carbs and fats to replenish energy stores.
59:03 *🧠 Cannabis and Psychological Effects*
- Cannabis affects focus and memory differently depending on the individual and context.
- Anecdotal reports suggest some people use cannabis to enhance focus despite potential impairments in certain memory tasks.
01:05:57 *🚬 Routes of Cannabis Administration*
- Inhaled cannabis (smoking) delivers THC rapidly to the bloodstream and brain, typically within 2 to 5 minutes.
- Differences in administration routes (smoking vs. edibles) significantly affect onset speed and subjective effects.
01:16:55 *🌿 THC titration and potency concerns*
- THC potency has increased significantly over the decades, leading to challenges in titration.
- Higher potency cannabis and concentrates can make it difficult for users to regulate intake effectively.
01:22:40 *💉 Insights on cannabis addiction and dependence*
- Cannabis can lead to dependence and potentially meet criteria for a use disorder.
- The concept of addiction versus dependence in cannabis use is nuanced but significant.
01:29:34 *🚓 Legalization and societal perceptions of cannabis*
- Legalization of cannabis has shifted public perception from illicit drug to regulated substance, akin to alcohol.
- Despite legalization, societal views on cannabis safety versus legality remain complex.
01:36:45 *🍪 Understanding the unique risks of cannabis edibles:*
- Cannabis edibles, due to their delayed onset and prolonged effects, often lead to unexpected intoxication.
- Standardizing dosing units for edibles, similar to alcohol units, is crucial for public safety and consumer understanding.
01:41:28 *🕰️ Duration of cannabis in the body and its impact on drug testing:*
- THC's lipophilic nature allows it to accumulate in fat cells, leading to prolonged presence in the body.
- Exercise and weight loss can release stored THC, potentially causing unexpected positive drug tests.
01:46:15 *🧪 Effects of cannabis on hormones: Insights and contradictions:*
- Cannabis's impact on hormones like testosterone and estrogen is highly variable and not fully understood.
- Studies show conflicting results regarding cannabis's role in aromatization of testosterone into estrogen.
01:55:03 *🤰 Cannabis use during pregnancy*
- Discussion on varying statistics and concerns regarding cannabis use during pregnancy,
- Factors influencing reported numbers include self-reporting versus verified blood levels,
01:56:36 *🤢 Risks and motivations for cannabis use during pregnancy*
- Motivations for using cannabis during pregnancy, often related to managing morning sickness,
- Comparison of cannabis use versus traditional pharmaceuticals like thalidomide,
01:58:55 *🍻 Education and responsible cannabis sales*
- Advocacy for mandatory education for cannabis sellers similar to alcohol servers,
- Concerns about misinformation and lack of education among cannabis dispensary staff,
02:04:13 *🌿 Different methods of cannabis consumption*
- Discussion on harm reduction strategies for cannabis consumption,
- Comparison of oral consumption, vaping, and smoking methods,
02:07:26 *🧠 Cannabis, THC, and psychosis*
- Exploration of the relationship between high THC cannabis use and psychosis,
- Distinction between acute drug-induced psychosis and chronic psychotic diseases,
02:14:10 *🧠 THC's impact on anxiety and excitatory transmission*
- THC initially reduces anxiety by quieting down excitatory transmission.
- Increasing THC doses can saturate CB1 receptors on inhibitory neurons, leading to an amplification of anxiety.
02:15:32 *🚫 Rare occurrence of psychotic responses to cannabis*
- Psychotic responses to cannabis are rare and typically make headlines due to their unpredictability.
- Cannabis-induced psychosis is more likely in individuals with a predisposition or vulnerability.
02:19:00 *🧬 Cannabis use and schizophrenia risk*
- Cannabis use is associated with an increased risk of schizophrenia initiation.
- Individuals with schizophrenia use cannabis at higher rates than the general population.
02:23:20 *🔄 Debating cannabis as a causal factor in schizophrenia*
- The debate around cannabis causing schizophrenia centers on statistical associations rather than definitive causality.
- Variations in schizophrenia prevalence across different cannabis consumption cultures suggest complex interactions.
02:33:29 *🧠 Understanding the debate on cannabis and schizophrenia*
- Debate centers on whether cannabis causes schizophrenia or is used more by those prone to it.
- Evidence from Scandinavia suggests low cannabis use but similar schizophrenia rates.
02:34:39 *🌿 Cannabis use and bipolar conditions*
- Discussion on the relationship between cannabis use and bipolar disorder.
- Genetic and hereditary links between schizophrenia and bipolar disorders.
02:36:16 *📑 High-potency cannabis and its implications*
- Examination of arguments regarding high-potency "skunk" cannabis.
- Analysis challenges linking potency to schizophrenia risk.
02:39:03 *🤔 Biological predisposition and cannabis use*
- Exploration of why individuals prone to schizophrenia might prefer cannabis.
- Discussion on the broader factors influencing substance use in schizophrenia.
02:42:04 *🌐 Public perception and policy implications*
- Critique of public perceptions linking cannabis use to schizophrenia.
- Impact of media and research on public health perceptions.
02:53:24 *🌿 The influence of terpenes on THC-induced anxiety,*
- Terpenes like lemine can modulate the anxiety-inducing effects of THC.
02:57:23 *🧠 The therapeutic potential of CBD in epilepsy,*
- CBD, historically bred out of cannabis for higher THC content, shows significant efficacy in treating pediatric epilepsy.
03:00:21 *🌱 CBD's scarcity and its medical implications,*
- CBD is naturally scarce in cannabis due to historical breeding for high THC content.
03:12:16 *🌿 CBD efficacy and dosing considerations*
03:17:22 *🚫 Challenges and skepticism regarding CBD*
- Despite widespread use, clinical studies have yet to find significant efficacy of CBD at low doses (10-20 milligrams).
03:19:25 *⚠️ Potential health risks of cannabis use*
- Cannabis smoking poses risks for lung damage, although evidence for lung cancer is inconclusive compared to cigarette smoking.
03:31:10 *🌿 Cannabis health risks and syndromes*
- Cannabis can potentially lead to schizophrenia, bipolar disorder, cardiovascular issues, lung damage from smoking.
03:31:51 *🩺 Medical uses and benefits of cannabis*
- Medical uses include appetite stimulation, glaucoma treatment, nausea reduction, anxiety relief, and chronic pain management.
03:33:02 *🩸 Cannabis as a pain management tool*
- Cannabis alleviates pain by reducing the emotional response to pain rather than acting as a strong analgesic.
Made with HARPA AI
wow, impressive. thank you.
if you did all this sober, respect.
i would need adderall to write all this out😂😂
Don’t you know… AI is good cause it’s sober
Cool, thanks!
Wow, very useful. Thank you.
I started smoking cannabis years ago as a teenage, switched to cigarettes. Spent my whole life fighting Cigarettes addiction. I suffered severe depression and mental disorder. Got diagnosed with cptsd. Cigarettes addiction actually destroyed my life. Not until my mom recommended me to psilocybin mushrooms treatment. Psilocybin treatment saved my life honestly. 6 years totally clean. Much respect to mother nature the great magic shrooms.
Hey! Yes Dr.alishrooms
How do I reach out to him? Is he on insta
Yes he's Dr.alishrooms. Shrooms to me is a natrual healer. I know a guy who has used mushrooms in the same way and they have really helped him. mah dudes have safe trips all.
Thanks for sharing this great information,
this would help my son.
Saw people talking about..checked him out, I must say he's good at what he does. My son is clean 1 year now. Good luck. just micro dose and you won't trip. Mushrooms
helped my son get off opioid.
Anyone who says weed makes you a lazy person just can't own up to the fact that they are a lazy person and blaming the weed for it💀
Smoking does effect mitochondria levels, but yes not enough to make someone lazy. Of course one doesn't need to light it on fire.
@anotherjewishsharpnicholas9425 it's also the amount, if you go too far you can fall sleep in a way that feels almost like passing out, and get that body high which makes your body heavy
If theres no excuse theyll make one up. 😅
Anyone who defends cannabis is probably addicted lol
@@shanewitt Science shows only a small percentage become addicted, and of that group a large amount is simply a result of them having a personality disorder.
1 month sober from Marijuana and 525 days sober from alcohol. The best decision I’ve made in my entire life
Gay 😂
@@SaviorMoney-777 Happy Gay it is.
@@SaviorMoney-777 Government worker much saviormoney? Pretty new profil
@@SaviorMoney-777 Government workers are very gay.
@@SaviorMoney-777 You are the biggest gay of them all
Absolutely loved this episode! I'm an Infantry Veteran ('02-'07) and I use cannabis for my combat PTSD and tinnitus. It makes the tinnitus from 23 IEDs turn into background noise. It prevents me from having nightmares and helps manage daytime anxiety especially around crowds. But I honestly think it's the combination of cannabis, learning my sleep chrono type and adjust my life to it, getting my morning sun light, running 3x week, lifting 3x a week and all the other protocols I've learned from the Hubermanlab Podcast have really made me feel better than I ever have. So a HUGE thank you Dr. Huberman and Dr. Hill for helping me understand the science behind my favorite medication and recreational drug.
smoking weed is no longer cool. When you hit 30 and haven't achieved your goals.. I quit a few months ago and realised how much time i've wasted. The issue with weed is it makes you content with doing nothing. It takes away your ambition. If you are an introvert, be careful that weed doesn't become your best friend.
kinda weird to blame your own problems on a plant.
I am an introvert, and you're right it has become my companion. I woke up with plans to quit today and then I saw this notification ❤
Maybe if you didn't smoke weed you wouldn't have learned any lessons and would be a total loser..
Also that is probably a reflection of your ideology of weed, you wanted an excuse to do nothing and weed was your excuse... IV seen it in myself.
I'd say this is false from my experience and scientists I see... cannabis expounds your slackyness. I have been smoking since 18 myself and NEVER been content with doing Nothing. Thought you also shouldn't get reliant on it. So not bad input... Just diffrent than my experience.
Listened to this twice, once sober and a second time completely baked. I must say definitely absorbed it more the second time.
Burnt in neural circuit aka ur fried
That’s literally impossible
Absolutely possible
@@calebford6318It definitely is not. Huberman talked in the first weed podcast how weed can help you lock your focus in on certain things
I get it
Anyone else smoking while listening? While ive smoked for 10+ years pretty much daily. There is DEFINITELY negative effects.. i myself at points have realized its more of a habit than a "relaxing" thing. Its important to understand your personal relationship with weed and the negative habits it may form. And i ALWAYS treat the plant with respect and gratefulness while consuming. Very interesting information in this one.. as with everything, MODERATION IS IMPORTANT. PEACE to my fellow stoners and those who don't partake!
btw this plant is now mostly available in adultered forms such as concentrates tinctures waxes most is created in labs and far from the natural plant it was 30 years ago i find it hard to come to terms with people using the word plant to refer to todays cannabis its like saying poppy seeds instead of opioids and coca beans instead of cocaine Most THC today s high potency therefore lab synthesized into something completely un natural derived from cannabis plant
One love, cannabis saved my life ❤
I’m 45 y/o and looking back been growing my own clean meds for the last 10 years. I can’t imagine a day without Mary Jane.
That is pathetic.
Same just not on the growing but I'd love to. Weed saved my life. I got off of the narcotics, opiods, I got through my surgery without any pain killers. It literally saved me from dying of gastroparesis. People gate on what they don't understand. It's amazing for depression and anxiety too
@@1jazzyphae People hate what they don’t know, very true. Nothing beats being calm, cool, collective unlike most people nowadays: low EQ, closed-minded, addicted to medications. Clean cannabis heals. Especially FECO
@@CarlHungus-y1t Nah you are.
"That's just like, your opinion man." @@CarlHungus-y1t
Surprised this guy actually showed up after being so condescending and abrasive on Twitter. Good on Huberman for being the bigger man in this situation and handling it with the utmost professionalism.
@@Alex-cw7xf I don't disagree, but there's a right and wrong way to go about that. He went about it in all the wrong ways, yet Huberman still graciously invited him on his podcast is my point. He has never claimed to be a de facto source of information and is open to being corrected.
@@Spuddy10 It's not what Huberman claims that I find concerning, it is the overall effect of his authority on his audience often without effective pushback that is the problem. Huberman was clearly out of his depth on the subject, and it's refreshing to hear it from the horse's mouth firsthand from someone who studies this topic on a daily basis. Huberman has a wealth of information but I would much rather it stay topical to what he has experience with firsthand because health recommendations are nothing to f with. Put it to you this way, if I went to culinary school to study how to be a pastry chef but one day wanted to podcast about barbecue and somehow I mix up different regions and their rubs/sauces, I wouldn't be suprised if I get roasted (pun intended) by some pit master who has been grilling their whole life. It would be silly for me (pastry chef) to then clutch my pearls. Just because I know how an oven works doesn't mean I can grill. I agree there is a time and a place for civility, but not when you are spouting off completely garbage interpretations of data based on your own subjective biases regarding a topic.
yeah dude seemed like a huge fucking prick. i will give him props for going on though and not just talking shit
I don't follow Twitter/X but this guest seems a LOT less eloquent than most guests. I couldn't listen - even if he had good info to impart he had a puffed up, aggressive undertone.
I was wondering why it seemed tense 😮
Im 36 and have smoked for many years. But ive never been an all-day smoker. I rip a cone at 830 every night to take the edge off. I have a family and a busy, reasonably well organized life.
Yes, you got to moderate it.
I find the comments funny where people tell their story of non stop weed smoking for years and then quitting. You would feel sick from anything if you do it all the time. Working out is good for you but non stop?
Weed is to be used as a tool, in moderation.
Like thats really any better
My rule for myself is to smoke during my evening walk. Keeps me active even afterwards. If I smoke right after work, I'll just be lazy for the rest of the evening.
Quitting weed was extremely stressful for me. I basically lost my mind for a couple months. Extreme anxiety and nausea especially in the morning. Panic attacks from absolutely nothing. Waking up every night feeling hypoglycemic and needing to eat to get back to sleep. That was enough for me to never want to touch the stuff again.
Your neuro chemistry can adapt to the stuff in weird ways where without it I had to figure out how to exist again.
It took months but I’m back to normal and my overall mood and outlook on life has improved so much. The negative rumination has minimized. I was hitting the bong throughout the day everyday for many years
how long after quitting did your need to eat to get back to sleep at night end? Asking because my husband is the same and it has been 3-4 months since he quit (or so he says) but still does this at night and still has munchies.
That likely wasn’t correlated to cannabis. You should visit a GP even though you feel better now.
@@joebillage3578what's a GP
@@joebillage3578nah its a real thing. He probably has CHS (Cannabinoid syndrome). I also have it, just unlucky i guess. I have “quit” smoking 10+ times in the past 3 years and without fail, i have extreme nausea and dry heaving in the mornings, usually pretty bad for a week or so.
Cannabanoid hyperemesis syndrome*
I guess we stoners are the minority listening to this pod. Love you Hubey and all of us listeners. Hope everyone has a beautiful day
Sad he doesn't consider science on this topic, only religious views. Huberman is too much the pundit, not enough the intellectual.
dont make your drug addiction the center of your identity & you wont take it personally when science says that you're damaging your body. the weed isnt who you are, its just something you do
Mr. Mackey taught me all I need to know about drugs.
Thank you, South Park.
Same here, mmmmmmmmmkay lol
Drugs are bad mmmkay
Drugs R behd mkay. You shouldn’t do drugs
Funny because the medical marijuana episode is what actually got me off my butt to buy weed for the first time at 13
Chef taught me everything
I smoke multiple times a day! It would be silly for me not to listen to this one. Thanks Dr H, looking forward to your book
Same
same
same! already learned a lot!
I enjoy a little after work, but it sure makes me sleepy. Always wondered how different bodies and brains process it to be able to smoke early in the day and not be in bed by the afternoon! Enjoy.
@@hanaf1231 have an afternoon nap then... or especially after a heavy meal you might feel sleepy.
By the way, if you read the X thread, you'll find that this podcast started from a toxic string of comments including Dr. Hill's reply. The ability for Dr. Huberman to look past the way in which Dr. Hill initially responded to the thread gives me great respect for Dr. Huberman.
Personally, I don't understand how anything productive comes from X - the number of "people" (bots?) who are simply there to tear down Huberman's good faith hard work is astounding.
Hill certainly came across as arrogant, conceited and egotistical.
Xitter's usefulness as a means of sharing information has reached the point of rapidly diminishing returns.
I would argue that Hill is a bot. I read his tweet after I heard the controversy. He was acting like a child.
Lmaoo yeah i saw this and wondered if this was the dude who was fighting on twitter
I thought him being a literal expert on the subject, his comment was warranted if Andrew was giving false information. If he didn't reply in such a way, Andrew would have ignored it and we wouldn't have this great episode.
Huberman is all class. This guest has been extremely unprofessional and insulting toward him on Twitter. Funny how people act differently face to face.
Why has he been insulting/what is he saying?
What he say?
No, he was responding to Huberman’s terrible videos about cannabis.
Andrew was on Lex Fridman's podcast last week and talked about ongoing friction with someone in the online community surrounding cannabis but didn't mention his name. I'm guessing it's him.
This guest is a total retard. He lies and lies, what a joke!
As cannabis user daily for over 15 years, this is an immediate listen
Great to hear. Starting to listen now. Are there any key points you found interesting / actionable, maybe important to you personally?
@@pukuipzit was interesting to hear that no strain will test above 30%. I've seen some strains advertised at over 35% which I was always skeptical about but I now know to be really question that fact about percentages. Also, not all testing is honest. I've honestly never shopped by THC percentage but rather Terpenes and the percentage. I still have over an hour left of this episode but that so far really stuck out to me
@EfTheQuiet1 word up. I'm not at that part yet, but i imagine it's true that no flower is above 30% THC. I relate and like to think you're a real smoker because you're going off terpenes and percentages rather than just thc - that's the move for consistency in quality.
Side note- I notice strains that have very high thc %'s tend to have low terp %'s.
🙏🏼 bless up, lmk if anything else stands out
@@EfTheQuiet1so is weed good or bad?
@@dimakurkin8201it has benefits and harm. The harm outweighs the benefits. In order to avoid the harm you cannot use it recreationally.
I have to say, I came to this video after listening to the episode on spotify and have to say, as problematic as the relationship started on Twitter, this was probably my favourite episode ever.
Dr Hill is extremely grounded and knowledgeable. I hope to see you bring him back in the future and put the rocky start behind you guys.
“Does Huberman not know because he has never done it? Well, that’s my own business.” 😂
To be fair, this is a guy who hides his tattoos to avoid distracting from the science. The "my business" is maybe a poor use of words since it infers privacy. But withholding his own use or lack thereof would be in keeping with his intention to provide an unbiased presentation of the facts.
@@aaroncrandal I love his podcast. I learn so much for free. 😁😂
He pretty much has to have done it since he has talked about doing acid as a teenager and geting stuck in a elevator during prom.
12:14
He openly talks about his participation in mdma studies and testing peptides and androgens but god forbid he ever mentions his cannabis use
im lighting a joint right now to listen to this ! thx
One of the reasons I personally find cannabis useful is to calm the stimulation from my tinnitus. Auditory issues and their different findings would be an awesome episode.
Occasionally Tinnitus is caused by jaw dysfunction and issues, worth checking out maybe. Best of luck!
I hear sizzling sounds in my left ear. It started 2 weeks ago. I don’t know why or how it happened. Just woke up one day feeling like one of my ears was clogged.
I can hear in the ear, but I noticed I don’t hear sharp frequencies in that ear. There’s also a constant sizzling sound
I listen to this podcast twice on my commute to work. The information density was amazing. I do wish Hill wasn't so condescending, there is enough that we don't know about neurobiology. Huberman is a class act.
I'm sorry but how much he glossed over the various cannabinoids was atrocious.
It feels like in this episode it’s extremely hard to find any definitive statements or even *informative* nuance, clicking through the timestamps and I feel like I’m not learning anything
Agreed
Agreed. There are tidbits of pure fact here and there, but it seems like we have a long way to go in cannabis research. I consume it multiple times a week and really struggle with withdrawals; mostly headaches, irritability, and anxiety. I personally use edibles mostly because of the lung impacts of smoking and the brain fog the next morning after edibles can be bad even after low doses. I am an anxious person without weed, and I’d say weed makes my anxiety sometimes lower and sometimes higher than my sober baseline. There are a lot of factors that go into it. I’ve thought about running a trial on myself and doing, say, 90 days using it semi-regularly (I’ve never been a daily user) and 90 days sober and charting my mood, energy, anxiety, etc each day.
I am disappointed by this episode for this reason, and guests like this make me appreciate even more so how Dr. Huberman can translate his wisdom into a fluid conversation I can understand and benefit from. What a rare skill for a scientist!!
@@MadMan14782 I went 45 days at the beginning of this year, which I’d think would be enough for someone using cannabis 3-4 times per week, but I could see it taking longer.
This is how it often goes when experts actually stick to the science and refrain from overstating the evidence. Huberman’s mo is to draw clear and interesting conclusions from single and often woefully under-powered studies. It makes for great content, but it is not science.
I quit weed around two years ago.
Best decision I ever made. I feel motivated and I am extremely productive every day.
It's down to the individual. But if you smoke regularly and are also depressed, consider stopping even for a while.
Missin out
@@Test7017 smoked for years. Did other drugs like LSD too.
I haven't missed being high a single day.
@@Test7017
I've smoked w for years. Even done harder psychedelics. Haven't missed them a dingle day.
Now you are a productive worker. Congrats.
@@jbartmontage6737
I am my own boss, I'm productive to myself.
I am a content creator on YT, TW and other platforms.
I am happier than ever.
I vape one or two vaporizers every evening after everything is done - work, family, socialising. I‘m a vinyl-collector and like to listen to records when I‘m high. Music just sounds and feels better.
yesss I'm with you bro
Yeah your hooked
I'm that person that skips the first few moments of the episode to get to the "goods". So when I dug in and heard this guest sighing on some responses early in, it made me feel - different from the other episodes. Now that I heard the full episode and connected the dots this is the heavy critic Lex and Andrew spoke of, this all makes sense. Dr. H, I love and admire how much you showed complete respect for someone who said things that I'd say were more than a "healthy discussion online". Hats off to you- great discussion. ❤ from EPTX
I’ve been a daily user for about 8 years now.
For so long I would attribute cannabis to a lot of my ability to do certain things or handle certain things or situations and my ability to functionally operate at an extremely high level. With work, coaching, parenting, exercise, etc…
After listening to the first 90 minutes of this it’s become clear to me that these things I’ve been able to learn, accomplish, and strive for have nothing to do with cannabis and that it is the case that it enhances everything I’m doing.
I think a deeper understanding of how my ego works and the way my mind operates when it comes to certain things is what allows for me to avoid the pitfalls of most heavy use individuals. And even have the ability to go a day, or multiple days without using and it won’t affect me the same way it would someone else who is in the same bracket of use.
I love conversations like this because it really highlights how vastly different this amazing plant can affect people on an individual level.
I’m very excited to hear the rest of this conversation.
Cheers family
I really appreciate this comment!
Very useful to contextualize subjective experiences with respect to each unique individual!
I've gotta ask- how did you develop a deeper understanding of how your ego operates? I've never quite understood when people say to just 'detach' from an unpleasant or emotionally- provocative situation, and I assume it is to do with a better understanding of ego (as opposed to 'dissociating').
@@Gnu58431 great question and I apologize for the late reply.
I’ve been studying emotions and personal development and the ego for over a decade now. I’ve been in very deep meditative states on psychedelics and it was in those states that I was able to observe my thoughts from an outside perspective where as in the past I was identifying with them and thought it was me thinking them.
When people are saying detach from those type of experiences it’s usually disassociating. However it’s not impossible to be involved in a situation that invokes those feelings and not let it break you all the way down. It’s a tricky topic but I think it’s well worth the effort to learn about. If you have any other questions or if I didn’t answer you the way you wanted lmk
@@andymeissner8727 that's really helpful, thank you. Some of the topics of your study overlap with some significant issues I've been recently struggling with mostly as a result of some traumas. I have been doing a bunch of CBT but I'm not sure it's proving super effective for me and I'm interested in exploring adjunctive therapeutic solutions. If you might have any pointers or know of particular websites books papers etc that could be useful for someone struggling with I suppose emotional dysregulation/ distress tolerance flowing from trauma, stunted personal growth etc, I'd be very grateful for your advice. The meditative psychedelic experiences sound intriguing and intimidating at the same time! There's certainly a lot been said about psychedelics & therapeutic value, in addition to mdma and ketamine I think they are also running medical trials on. I suppose there is a lot of nuance to ensure an appropriately therapeutic psychedelic experience.
Same thing. Cannabis benefits me immensely, so there's no reason for me to quit it. Just have to consume in moderation
I quit on June 1st this year, stoked to listen to this episode!
I really wish we could spend some more time discussing the differences in effects caused by edibles versus inhalation. As Dr. Hill mentioned this is hard to ascertain but this is why I'm interested in learning what we know so far.
To my understanding, they did. The biggest difference is the first-pass metabolism converting most of the THC to 11-OH-THC. The difficulty is in directly comparing doses to effect for inhalation vs oral consumption
As someone who start smoking at 18 senior year to age 21 almost everyday, i stopped cold turkey on june 1st 2024 for im enlisting. - I was never addicted but everything in the podcast was so helpful to keep me from craving if I did.
Everyone talking about the controversy but it’s clear that there’s no bad blood and these are just two professionals who want to inform the public, I greatly enjoyed watching the way they responded to one another and how they sequentially moved the conversation forward
Is this THE doctor, who acted like an "rude teenager" on social media?
He is a idiot on cannabis.. He lies and lies...
"dr."
Yes
He’s the big sh agg er
@@SteinBergsson He’s trying to hide the “rude teenager “ part of himself, but it’s still obvious.😂
As an instrumentation engineer, the elephant in the room, is the lack of standardised testing for cannabinoids. You could take the same plant to different labs and get completely different results. You can take the same plant to the same lab as different samples and get different results. Older varieties of cannabis tend to have a more mixed cannabinoid profile than modern varieties because they didn't specifically know about THC. This meant that plant selection was very much more about the subjective experience and plants were selected on this basis. Unfortunately, they're now selected based on inconsistent lab reports that highlight THC and CBD only. Cannabis should be considered an experience, much like food (It is a plant after all and did form a staple part of many cultures diets) - does it smell nice, does it taste nice, how does it make me feel? Your body knows what it likes and will tell you. With regards to expectancy bias, that only goes so far, for example, you could tell me that an oyster tastes lovely and is really good for me and it may give me that expectation... But I've tasted oysters and they're like salty fishy snot 😂
You both deserve our utmost respect and appreciation in so many ways. The thirst for accurate knoweledge and just the 'WANT' to help people, moves me in a way I can not put into words.
I have so much respect for Dr Huberman. Having this kind of discourse without cancellation or character assassination is much needed everywhere these days. It took a humbling act to make this happen on his part given the way this guy reacted on X. Dr H will be remembered long term. Not sure about those who argue on X/Twitter.
Yeah, I was appalled when I actually went and read this guy’s comments on the X thread. Absolutely blown away at how humble Huberman is to have someone on who I’ll say was a total asshole going after Huberman as a person/podcaster instead of just talking about the science. Huberman has my great respect
Legend.
I can attest to the chronic throwing up, I have been smoking day and night everyday for the last 4-5yrs, without any tolerance break.
It almost always starts in the morning or after work because it's a short period of time that I didn't smoke, it hasn't gotten to the point where I legitimately throw up but I can just open my mouth and salivate for straight up minutes all coming from my stomach. Sitting in a hot shower helps it instantly.
After watching this, I'll be quitting even if it ends up as a tolerance break this was a huge wake up call for me.
Thank you, Andrew and Matt.
I can definitely back you on this. The vomitting started in the morning when I had it and didn't stop till I ended up in hospital on a IV drip as I had lost over 1.5kg in water from sweating and throwing up. I found out about the shower saviour the second time it happened because I had the worst fever and everything felt cold and my skin was so sensitive. Decided to get in the shower and it immediately stopped the nausea. I haven't had it since and I have continued smoking though I hope to quit one day... Not for me but for my daughter as I wouldn't want her seeing me smoke
It doesn't sound like CHS. CHS is much more intense and can land you in the hospital. I used to feel the same way in the mornings-gagging until I smoked, also unable to eat, and losing my appetite. I skipped meals and smoked instead, even though I used to eat well and get the munchies from smoking.
Over time, I lowered my dose because I was overdoing it. I went through cold sweats, and when it got too much, I'd take a hit. Now, I eat every couple of hours, and my appetite is back to normal. I try not to skip meals anymore to avoid messing up my system by smoking and numbing my hunger.
@@drxzt same here, I immediately cut my intake by half so far and I'm already realizing how much I was crutching it from smoking everytime before meals, work and bed. Personally my biggest problem is when I'm at home with the silence of not doing anything, I'll smoke and watch TH-cam until the day is gone.
Starting to realize that weed makes you feel okay doing nothing or anything which is dangerous to dreamers.
Take a substance every day and you get sick? Its the substances' fault!
@@gorrvaskr5963 I get you 100%
I been struggling with the same kind of thing and I'm not entirely out of it, like I said, I just fixed my appetite and got back again into calisthenics this week, so it's helping but I still consume, and still waste a lot of time on places like TH-cam.
I don't necessarily think it's bad to watch informational stuff like this but spending hours on yt gets you overstimulated and eventually feels like a waste.
It can also get complex cause im pretty sure now that im bipolar and even though I picked up weed years ago because it felt like it helped a lot with anxiety and similar symptoms now I feel like im starting to be aware about me having hypomania episodes and also what you were just talking about, I hyperfocus/fixate on whatever im doing and when being home that becomes TH-cam.
Weed gave me panic attacks at 15 years old and it has been an absolute blessing. Learning how to manage unwanted thoughts and become keenly aware of my mortality have helped me gain an edge in life and it’s all thanks to this drug. It is to be respected and used as a tool. It’s given me context and a reference point for negative mental experiences. I can’t imagine having never done weed and developing sudden panic disorder without any context or coping mechanisms.
very very good mentality.
Exactly how it was with me ^^
I had a panic attack disorder as a uni student and only managed to chill my shit out with weed and meditation. Granted I had to dial it back once I left school but I genuinely would have dropped out cause it was becoming truly unmanageable.
Moderation is everything folks!!! Dont let any substance control your life, whether it's weed or coffee or anything else.
This turned out to be one of my favorite Huberman guest episodes. Great and challenging conversation between this two. I appreciate Dr. Hill taking the time to share his expertise.
Couple hits at night goes a long way, I got diagnosed with diabetes 2 weeks shy of 15 years old. My night time anxiety was pretty awful, and falling sleep was tough. Totally coincidental, when I tried it eventually in college at 21, I started finding my nights to be relaxing, euphoric and introspective after some cannabis. 37 now. I do stay mindful of lung irritation for the long haul, but truthfully keep usage to less than a bowl pack. We all need a lil something in this life.
I quit a few months ago after years of usage when it became legal in my country and i have never felt better in my life ❤
It’s not easy, proud of you! Currently 1 month clean from Grass
Why is weed so bad, yet alcohol has been legal for decades?
@@Willyyyyyyyyyyyyy its not about alcohol.
We have been made immature by propaganda
Happy for you!
IT doesn't quite the voices... IT just makes them get along 😂❤ thanks!!! Great information 🙏
It's so rare to find two people discuss any topic with as much respect and open mindedness. Thank you both for such an interesting podcast, halfway between science popularisation and scientific conversation and thanks to Andrew for coming back elegantly on some of the points he made in his solo episode. Sincerely, a biologist.
I saw this discussion on Twitter, I am so happy that discussion has become such a positive, important conversation!
Please continue with these long, informative videos. You are such a treasure ❤ I've learned so much from listening and recommend this channel all the time.
Huberman was very kind to him, he was very rude on Twitter, and I feel like he should have apologised better.
Andrew knows he could beat his ass if he ever needed and he is also smarter 😂😎
@@MIOLAZARUS glazing hubes a bit hard there buddy lmao
@@Youttubeuser20932 How could I not. He is so beautiful 😂🤣❤️
I'm SO impressed with how gracious and open Huberman is with this gentleman. Hats off to them both for actually doing this podcast!
Cannabis addiction is real. I've been smoking it for 32 yrs. When I quit, i was relieved of my depression. Sometimes, what's good for one person isn't good for another.
Huberman is such an inspiration. I remember when my now husband showed me his channel and I was impressed. Now we also have a channel and share knowledge!
Those first two weeks after quitting smoking heavy is terrible
The sweating and no appetite woooooooooo boy
Good luck you got this
The nightmares, stomach probs, irritability..
You got it . Once you make pass a month you literally forget about cannabis and you realize you’re better of w/o it trust
I smoked around 3.5/4g per day. Every single day for over 10 years. Didn’t have a single day without smoking in those 10 years. And i quit in January this year. Not once did i experience any withdrawal or loss of appetite or the inability to sleep. Quite the opposite infact. Straight away my sleep improved and i had a better appetite
This was a great episode and I'd like to thank dr. Hill for coming in to talk about this.
We all get carried away sometimes and it especially shows in things that are near and dear to our hearts. I'm sure this experience with Andrew has been a great learning point and maybe next time this happens he will react in a very different way. We can all learn from how this episode came to be, it's inspiring.
Thank you both ❤
this podcast enhances my roll, literally listening to this and enjoying my roll.
thank you andrew huberman for the knowledge you are giving to us for free of cost and its really changing my life in a postive way and lots of love from india
When you’re sober, you want to be high. When you’re high, you want to be sober. iykyk
yup
Hi Andrew, Thanks for another lesson in science, but overall, thanks for a great lesson in practical humbleness and a constructive way to deal with diverging views.
I personally suffered from cannibas induced psychosis which lasted for a few years. I consider myself lucky that I got through it and did not go completely insane.
Same
can you elaborate a little bit more on your story?
I had a bad case of depersonalization. One bong hit was all it took. Wasn’t laced as 3 other people hit the same stuff.
3 months of full blown depression, 6 months of complete numbness in all of my extremities, and feeling like I’m playing a character in a video game (that is also lagging). I felt trapped in an alternate reality. This was legit 6-9 months.
Slowly came out of it, but then for another 3-4 years sometimes I’d have a sort of panic attack and lose control of feeling in my body again for days or weeks.
I only smoked once. Weed was the most psychoactive thing I’ve ever done. People need to know it’s not risk free
@jsuss98 It began with a "heroic" dose of mushrooms, leading to a very intense experience where I saw myself trapped in hell for eternity. However, this sensation subsided once the effects wore off. A few months later, I did a bit of edibles, and that exact experience returned in full force, convincing me that it was the true reality and everything else I remembered from my life was just a dream I had induced to escape my eternal misery.
This thought lingered with me for a few years. I would often fully relive the experience at night and sometimes during the day as well. So, it wasn’t exactly psychosis, but rather intense flashbacks and severe derealization. The episodes would come and go on their own, and each time they returned, they terrified me because I knew they would last a while. Often, I found myself doubting which reality was true.
I should add that it was my first time using shrooms, but I had smoked and had done edibles many times and always had a great time.
@@jaketucker2002I'm sorry to hear that. Your experience sounds similar to what I went through so I get how difficult it must have been.
Thank you for this newer video. As a someone who is 4 months dry but a regular cannabis user, ive really been hoping for some updated content around it.
I quit over a year and a half ago. Best decision I’ve ever made in my life!
I had never used cannabis was prescribed cannabis at 32 and it changed my life in the best way possible.
Are you addicted yet?@@boicutt
Thank you for coming together and making this episode. One of the best and most informative podcasts I’ve ever watched.
Hubberman i love the way you put togther your content. I love the wide spectrum of content relating to the mind, body, and soul! Your nsdr! Came across this while trying to get use to working night shifts. It was a life changer to my mental health!
I remember in the early 2000.. I had an exam coming up - the day after a party I started to study and after reading an entire page I couldn't recall anything I just worked through. that was when I realized that if I want to get through college, I have to stay away from cannabis. Sadly.
sounds like you didnt have a strong tolerance. maybe dont smoke the only joint u ever smoked the day before you study lmao.
@@BlazeIsBOSS eh I used to smoke morning to night for months and the head fog was so real I couldn't recall anything I did the previous day.
Funnny you say that I’m the opposite, if I study on cannabis I absorb everything and it is so much more interesting. I get wowed by everything I read and I become so much more passionate about it.
@theman2223 I am pretty sure it also depents on your specialization.. I can imagine it's great in any field that requires creativity - in my case it was law and the learning of legal paragraphs and dates/numbers of court decisions.. so yes
@anFy81 Makes complete sense! For me it doesn’t matter what field or subject but also for me law is so boring that if I smoked during study I would sleep for sure and that good affect would not take place hahaha I take my hat off to you for doing what you do, your a champion!
My friend was diagnosed with schizophrenia at around 18 probably triggered by cannabis but as CBD came into the market she now can use cannabis therapeutically in the right CBD/THC ratio very effectively as an essential medicine. She is now in her 30s.
Bs that is way more likely to be genetic!
It's not like sugar and type 2 diabetes. Consuming cannabis doesn't give you schizophrenia.
Absolutely amazing discussion. Dr Hill is no doubt a leader in the field of Cannabis and human biology. Thanks for the interview Dr Huberman.
Good job Hubs! Appreciate you bringing an opposing opinion on the show and updating your knowledge on the subject.
I started smoking weed at 18 years old. I didn’t quit till 24/25. Im 28 now.
I thank God every day for not having to smoke weed to be in a good mood or numb any emotional/physical pain I have.
Weed made me lazy & I was scared to do important things to do in life to make big steps in responsibility & personal life. Once I quit smoking weed the strides I made in my personal life I couldnt believe it. I didnt think I could handle a business, financial responsibility, family life, social life, fitness & other hobbies. I didnt think I could juggle all those. Once I quit smoking I could do all those things plus some.
My experience too 👍
By "YouSum Live"
00:00:00 Cannabis biology and effects discussed
00:01:01 Dr. Hill's critique on cannabis data
00:01:54 Invitation to Dr. Hill for podcast
00:02:01 In-depth discussion on cannabis biology
00:02:14 THC vs. CBD effects and differences
00:02:21 Cannabis correlation with psychosis
00:02:33 Cannabis effects on hunger, memory, anxiety
00:02:49 Cannabis use implications and decision-making
00:03:18 Sponsorship acknowledgment and product details
00:04:54 Introduction to Element electrolyte drink
00:05:00 Importance of hydration and electrolytes
00:06:07 BetterHelp online therapy benefits
00:07:15 Insight into cannabis biology and history
00:10:31 Cannabis psychoactive effects description
00:15:49 Cannabis impact on time perception
00:17:00 Cannabis stimulation of appetite mechanism
00:17:45 THC acts on CB1 receptors in the brain
00:17:59 CB1 receptor widely expressed, crucial for biological processes
00:18:43 Evolutionary redundancy, not specific to cannabis
00:19:36 CB2 receptor mainly regulates inflammation
00:20:10 Endocannabinoids regulate neurotransmitter release bidirectionally
00:21:36 Endocannabinoids maintain homeostasis and plasticity
00:23:55 Cannabinoid receptors spare dopamine neurons, unique regulation
00:27:03 Anandamide and 2-AG play differential roles in brain circuits
00:30:19 Anandamide acts as a tonic, 2-AG as a phasic regulator
00:34:54 Cannabinoid receptors in feeding circuits
00:35:11 Regulation of food-seeking behavior through neurons
00:35:32 Cannaboids disinhibit agrp neurons driving food-seeking
00:35:45 Reward component in food intake
00:36:22 Cannaboids enhance response to sweet taste buds
00:36:38 Munchies involve brain's processing of sweet foods
00:37:33 THC overrides satiety signals, promoting eating
00:39:07 THC motivates animals to work for food
00:40:30 THC can block satiety signals, enhancing food intake
00:44:10 Boosting endocannabinoid activity without THC
00:51:57 Cannabis effects on brain receptors
00:53:22 THC vs. endocannabinoids in brain signaling
00:53:59 THC's broad impact on brain networks
00:57:26 THC's influence on food-seeking behavior
01:05:52 Routes of cannabis administration and effects
01:06:00 Onset of subjective effects after cannabis use
01:08:00 Research challenges with cannabis potency
01:10:21 Innovative approach to studying cannabis in real-world settings
01:11:00 Comparison of lab-based and ecological data for insights
01:13:00 Self-titration ability with different cannabis potencies
01:13:25 Challenges with concentrates due to high THC levels
01:15:20 Tolerance development more prominent with concentrates
01:25:28 Cannabis use disorder potential and comparison to other substances
01:26:44 Cannabis use disorder prevalence among weekly users is 30%
01:27:24 Perception of cannabis use varies based on personal experience
01:29:00 Transition of cannabis from illicit to legal status analyzed
01:29:54 Legalization aims to reduce harms of prohibition
01:31:44 Elderly and female demographics show increased cannabis use
01:37:24 Edibles pose risks due to delayed onset and dosing confusion
01:41:30 THC metabolism in fat cells affects drug test results
01:44:07 Challenges in cannabis testing due to body processing biology
01:44:17 Variability in THC levels based on consumption method
01:45:04 Inconsistencies in THC detection among different users
01:46:08 Lack of conclusive evidence on cannabis effects on hormones
01:46:49 Mixed findings on cannabis impact on testosterone and estrogen
01:57:59 Dispensaries recommending cannabis for morning sickness
02:00:22 Importance of education for cannabis sellers to provide accurate information
02:01:35 Awareness of safe cannabis consumption
02:02:45 Importance of dosing and understanding effects
02:02:51 Proceed with caution, start low and slow
02:03:47 Guidelines for harm reduction in cannabis use
02:04:17 Different effects of THC concentration in blood
02:05:27 Risks of vaping oil-based cannabis products
02:06:23 Lack of federal regulatory framework for cannabis
02:07:10 Psychotic responses to cannabis and schizophrenia link
02:08:36 Cannabis use and potential psychosis risk
02:19:02 Relationship between cannabis use and schizophrenia
02:19:25 Cannabis and schizophrenia statistical association
02:19:41 Males may have bias towards psychosis
02:20:52 Cannabis contraindicated for schizophrenia
02:21:00 Genetic predisposition increases schizophrenia risk
02:21:30 Cannabis may trigger psychotic episodes
02:21:33 Cannabis accelerates schizophrenia onset
02:22:00 Debate on cannabis causing schizophrenia
02:30:39 Self-medication hypothesis for cannabis use
02:35:02 High THC cannabis impact on bipolar disorder
02:36:49 Expectancy bias influences subjective effects of cannabis strains
02:40:49 Chemical composition doesn't align with Indica vs. Sativa labels
02:51:52 THC is the primary driver of the high
02:52:52 Placebo effect heavily impacts perceived cannabis effects
02:53:05 Entourage effect theory suggests other compounds may modulate effects
02:53:27 Research on terpenes like limonene influencing THC effects
02:53:51 Subjective reports often influenced by prior expectations
02:54:06 Clinical trials needed to validate strain effects objectively
02:54:10 Nuanced understanding required to separate bias from actual effects
02:55:01 Placebo effects in clinical trials complicate sound statements
02:55:20 Overwhelming complexity of cannabis components and interactions
02:57:34 CBD's role in epilepsy treatment, particularly Charlotte's Web strain
02:58:39 CBD's absence in street cannabis due to breeding for THC
03:05:25 CBD's mechanism through adenosine modulation, anti-inflammatory effects
03:09:09 Challenges in conducting blinded studies with THC and CBD
03:11:50 Majority of CBD effects attributed to placebo responses
03:12:44 CBD dosing and bioavailability challenges
03:13:22 Lack of blinded clinical studies on CBD efficacy
03:17:22 CBD market expansion and societal acceptance
03:20:53 Risks of cannabis smoking on lung health
03:23:10 Potential cardiovascular effects of cannabis use
03:27:21 Cyclic vomiting syndrome associated with cannabis
03:30:00 Activation of CB1 receptors and homeostasis
03:30:14 Chronic cannabis use may desensitize receptors
03:30:21 Potential involvement of insular cortex in effects
03:30:59 Uncommon but documented adverse effects of cannabis
03:31:39 Limited conclusive evidence on medical benefits of cannabis
03:31:56 Medical uses: appetite, glaucoma, nausea, anxiety
03:33:16 Cannabis as a mild analgesic and pain affective component
03:33:27 Cannabis helps chronic pain patients manage pain
03:34:31 Cannabis's role in reducing anxiety and stress
03:36:03 THC's potential in managing anxiety disorders
03:42:20 Endocannabinoid system's impact on anxiety levels
03:46:38 Evolution from confrontation to collaboration
03:46:46 Appreciation for education and clarity enhancement
03:47:11 Acknowledgment of complex nature of cannabis effects
03:47:41 Importance of scientists' disagreements for progress
03:48:52 Emulating real-world scientific discussions for clarity
03:49:37 Correcting mistakes and striving for accuracy
03:49:48 Invitation for future discussions as research evolves
03:50:01 Promotion of podcast and book for further learning
03:51:20 Encouragement for engagement through social media and newsletter
By "YouSum Live"
This is really bad, it gives a list of topics but removes the facts and findings! A good AI works oppositely, it extracts the facts and shows the core information.
@@tonfilm
It gives the general tipic so that people can click on an area that sounds interesting and get filled in by listening at that spot.
Its quite convenient for some.
Gotta appreciate Dr. Hill's careful assessements. In contrast to Huberman, he really only confidently says what the data shows without a doubt. No jumping to conclusions or inferring causalities that aren't there.
I stopped smoking weed in October of 2022, on my 37th attempt. You CAN do this and you CAN change and you WILL grow
This was a fascinating discussion and I thoroughly enjoyed the exploration of the contemporary understandings on various perspectives of this potent plant. One of the points made towards the end of the discussion was its benefit in survivors of trauma, in both alleviating anxiety (perhaps by recalibrating Anandimide levels) and reducing REM sleep thereby stopping nightmares and improving sleep, lower overall anxiety and better quality of sleep. For those that do not find a litany of prescription medicines to be helping them with their trauma distress (and those medications often come with their own side effects) I suppose it's a question not of drug-seeking behaviors but what works best for a patient's results and overall quality of life. Perhaps intermittent low dosage can help short term to aid longer term recovery?
@@Gnu58431 if you can moderate your marijuana intake it’s an amazing plant. If you’re like me and have to smoke all day everyday and become a drug addict it sucks.
I workout often after smoking, and I've never had issues performing. I've ran 10 miles after smoking without issue. I continue to partake and workout and show improvement with strength.
Beginner
that makes you an outlier
Imagine how good you do without it. Unless you quit and cross reference your results with previous ones you will never know.
That’s because it helps you breathe better. Australia’s best ever Olympic swimmer smoked prior to training. It opens sacks in your lungs that’s why they use it for treatment for people with asthma
@theman2223 yup it in my experience it improves oxygen uptake and improves performance in repeat explosive, sports such as 7 aside football
About 2 weeks out from quitting use after 6 years of daily, heavy smoking. It’s been tough but this episode gives me strength
What about this episode gives you strength or incentive to quit?
Thank you dr. Huberman and dr. Hill only halfway through and finding this very informative 👏
I'm schizophrenic and I smoke 0.4g-0.6g a day. Every evening to wind down.
@@lesmoe524 Yeah no side effects. I find it relaxing.
@@lesmoe524 Not from the weed. I had body dysmorphia, anxiety and depression which led to psychosis. After a couple of psychotic episodes it turned into insomnia induced psychosis with several episodes more. All from 2017 Summer till now. I've been 51/50'd about 10 times.
Nothing better than a joint, a nice glass of wine, and some sweet tunes 😮💨
Oh, I think that there might be a few things. Human contact, perhaps?
@@Cathy-xi8cbYeah, that. An amazing workout. An amazing meal. Spiritual experiences.
Just moderation. People here act like it has to be done every day.
Have a bit fun on the weekend and you should be fine
@@CoolStoryBro455most people can’t, unfortunately. Most pro-weed users in this comment section smoke daily, and would legitimately be more irritated or physically “ill” if they didn’t smoke. That says everything most people need to know. But yes, everything in moderation (if possible).
Thank you Andrew Huberman 🙏🏾
I was a heavy cigarette smoker from 13 to 20 and I tried weed to help quit cigarettes. I managed to quit cigarettes (that I loved deeply!) and I quit weed too to avoid replacing the addiction. I’ve settled on smoking a joint every once in an a while and it’s always good!
Those mammoth podcasts will cure me of my podcast addiction.
My attempts to keep up are obviously unreasonable.
How come so many of us quit around the time this was released?
What in tf is going on?
I’m staying of cannabis still, but good to know
I've been a stoner for 13 years, and I'm 32 now. I used to smoke weed with tobacco, only using a bong, every single day. My routine was starting the day with a bowl and ending it the same way. But I didn't just smoke one bowl, I'd always smoke at least 3 or 4.
Last year, I got busted, so I took that as a chance to quit smoking. I always wanted to stop but couldn't because I loved it and quitting was always hard. I spent a year mostly sober and started vaping again when I got COVID. With my Mighty vaporizer, I only needed about 0.07g a day, and that was just to sleep. I was very skinny then, around 60kg at 1.81m. During that smoke-free year, I gained about 17kg, looked really good, and even built some muscle.
Then, I decided to smoke a bong again. It was disgusting, but that didn’t stop me from smoking more often. Now I'm back to smoking from morning to evening, and I don't feel good. I think about quitting every day, but when I get home, I just smoke a bong again, or when I'm with friends. Now I've lost about 10kg and am down to 65kg. Almost all the weight and muscle I gained during my sober year are gone. This is the main reason I'm going to stop again now. I just can't eat with my extreme usage. When I quit smoking, I could eat like a normal person for the first time in 10 years.
Good luck 💪🏿
take every day as an opportunity to step in the RIGHT direction
Those backy bongs are the worst to quit. Currently trying to do the same.
find the right ppl who can support you, don’t hang out with friends who smokes, unfortunately or fortunately, having the right ppl around yourself for quitting any addiction is the first and most important step, make your environment healthy, otherwise yoy just can’t, yes you need to sacrifice sometime, but if quitting is something that you think about it every day, it WORTH it!
Sad.
33 y/o disabled veteran here, joined the Navy at 17 after getting my GED in Youth challenge. Was a fleet marine force corpsman for 5 years, saw alot of death, amputees, gsw, etc. Got out in 2013 and started smoking in 2014 ish. Started college 2015, kept smoking until present, graduating with my degree in computer science, and a programmer for 7 years now. Always questioning if cannabis was going to prevent me from accomplishing my goals, but ive always tried to monitor my usage, and push forward. I moved to grow legal cannabis 2 years ago to make my own hash rosin. Ive probably used an avg of 4-5 grams of concentrates/rosin a week for the last 8 years. Had t breaks here and there to help the family businesses. But not the last 7 years. Even blasted my own bho for about 4 years, since i couldnt trust other peoples garbage.
I love how, regardless of the fact that Hubz is a scientist himself, he allows the guest to develop thoughts and explanations without interruptions, adding only when necessary to further expand or lighten the mood even further. Absolute pro.
Watching this while I get high as fuck. Education is key.
😂😂
It's great when experts engage in open, respectful discussions, especially when they have differing viewpoints. It promotes a deeper understanding and helps listeners appreciate the complexity of scientific issues.
Grateful to have found this the week before my adult daughter was diagnosed with CHS. She is in bad shape but because of this, I had an understanding and could get her help.
wow the amount of detailed knowledge of the guest is impressive
For those who don't know, Matt Hill went after Huberman pretty hard on twitter, months ago. Bit unprofessional, but Huberman responded in a way we can all learn from. This informative convo is the outcome.
This is an outstanding example of how professionals in the scientific community should interact. Thank you both so much for the clarifications and professionalism to explore the opinions of others!
Dr. Hill brought so much to the table! Thank you both!
TIL America has a general binge disorder… name the vice… we binge it harder than any other country 😅
Me and my wife smoked our whole lives. (12-36 for me) She got pregnant so she quit and to be fair to her I did too. We both lost and forgot things on a daily basis multiple times a day until then and over a few years our memory got much better after quitting. She just started up again a few months ago and her memory went out the window. Misplaces everything and forgets recent events and conversation left and right. She says she doesn't notice it so I decided to subtly point it out every time it happens and now that I'm paying more attention to it, it's like watching someone go through Alzheimer's(my grandma had it). It's like watching someone lose their intelligence. It's sad. I wish I could talk her into quitting but she enjoys being high so much I doubt I ever will. She had the motivation when she was scared of it affecting her pregnancy but now I don't think anything else will provide enough motivation because just like when I used to smoke, when life presents you a problem, smoke and you'll forget all about it. 😔
Thanks for sharing. Great points. Good luck to you and your wife.
This is bullshit. Are you a bot? Who forgets about their fuckin life smoking a little weed? This is crazy reefer madness bullshit. What the fuck? No one questions this garbage?
Threaten divorce.
@@Zhdhcjen I did. Then I realized I care more about seeing my little girl everyday than her smoking pot. And even worse, the idea that she would have another Dad other than me 50% of the time.
@@Mikaeel84 That’s seriously fucked up. But you can sue her and take custody away from her on the grounds of her incapacitating herself of raising a child by smoking pot
Dr. Matthew Hill is brilliant! His description and nuanced understanding of the mechanism of many biological systems is greatly appreciated. I learned many new things about Canabis.
Personally, I think the issue on Twitter was just a misunderstanding.
Dr. Matthew saw edge-cases/nuances in some of Andrew's Statements, Andrew gave information but didn't go too deep into nuances to make this podcast fit non-technical audiences.
Both are high-minded approaches, sparking new public benefit!
Thank you to both for making this episode. Many information are relevant to me.
Edit: Just noticed the Sativa vs Indica topic. Time to Google to see who's right.
Been high for about 2 years straight. I’m 22. I don’t wanna waste my 1 life on this earth anymore
It's funny to read so many comments where some people say that quitting cannabis was the best decision of their life. They've come out of one illusion and into a more sophisticated one. When you're unable to keep a measure, to be balanced, cannabis will be replaced by another excess.
It isn’t funny and it’s a big step in the direction toward facing life and their emotions instead of avoiding them, and doing so without a substance used primarily for the purpose of getting away from themselves. And by doing the honest work on themselves, and finding support from a good community and/or therapist, they can learn to channel that pain they carry into something beneficial and find greater balance and wellbeing. That is possible too
Life is real, it's not an illusion.