Entresto
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- เผยแพร่เมื่อ 7 ก.ย. 2024
- Advertisements champion Entresto as a phenomenal treatment for heart failure capable of reducing cardiovascular death and heart related hospitalization. Many peculiarities exist in the study leading to FDA approval. It was principally conducted in Eastern European countries, Russia, the Philippines, Venezuela, Brazil, Mexico and India. Only 5% of the patients resided in the United States. Actually Entresto basically combines the anti-hypertensive Diovan with a new compound Sacubirtil. Entresto with the maximum amount of Diovan was evaluated against a modest dose of another drug for high blood pressure rather than Diovan. So all of the benefits might actually stem from the Diovan component. Generic Diovan or valsartan costs less than $25 a month. Entresto’s cash price of $6000 a year or about $16 a day caused insurance companies initial hesitation which led to a lengthy authorization process. Due to the high drop-out rate, the benefits may much less than reported. Additionally it apparently works only in the milder forms of heart failure.
Excellent points. Thanks
Finally a honest breakdown professional review of this much hyped drug ...Thank you Dr Ken.
philsgoodify And here is a study that is even *MORE* honest! >>>> th-cam.com/video/cV9DKccKVWs/w-d-xo.html
Nobody mentions US DOJ fines for pushing Diovan (valsartan) and continued US DOJ scrutiny of entrsto (valsartan again). Read about the practice of evergreening in bigpharma
I feel like your the Jordan Peterson of medicine 😂. Thank you for being so thorough. I always had reservations with taking this med 1 bc I feel fine although my ej is 40-45. 2 I am young mom. This is very interesting and it helps in the decision making.
I always love your videos. Completely thorough with important info no one else presents. I was just put on this
Thank you for this information so vital to HF patients.
Thanks for review. Heart failure w reduced ejection fraction and cardiomyopathy..just started On Entresto. Hope it works
No, it does not work for me. Been on entresto since 2019, and not helping at all
Thank you Doctor Ken for these informative videos
Thanks doctor, Sorry to know you had passed away , RIP .
tHANK YOU DOCTOR FOR YOUR HONESTY.
Thank you so much for this powerful information because a lot of people these days are very health conscious and we really don't know what doctor to trust or what type of medicine they are given us we really appreciate your information enough research has not been done on this medication it may help some people but I think I'm going to pass on it my doctor is trying to give it to me but I don't think it's for me
That was a wild study. That isn't a reliable outcome. I cannot imagine trying to track this study? Thank you Dr.
I'VE BEEN ON ENTRESTO FOR A MONTH. MY DIGESTIVE SYSTEM HAS BEEN BADLY EFFECTED. MY FOOD TAKES LONGER TO DIGEST. IF I EAT BREAKFEST MY STOMACH FEELS FULL ALL DAY UNTIL THE NIGHT. ONE DAY I ATE BREAKFEST. THEN LUNCH, AND AFTER DINNER. NEVER WENT TO THE BATHROOM. NEXT DAY HAD BREAKFEST AGAIN AND LUNCH AND LATER DINNER AND STILL NEVER WENT. UNTIL THE NEXT DAY. STARTED NOTICING MY SHIT SMELLED LIKE THE SHIT IN BABY DIAPER. WHICH MEANS ONE THING IS HAS BADLY EFFECTED MY DIGESTIVE SYSTEM. BY LOGICAL REASONING A BABY DOES NOT HAVE FULLY DEVELOPED DIGESTIVE SYSTEM WHICH IS THE REASON BABY SHIT SMELLS THE WAY IT DOES. SO IT HAS EFFECTED THE STOMACH FUNCTION. NOW I'M GETTING MIGRAIN HEADACHE. WHEN I FIRST GOT SICK 2 1/2 YEARS AGO MY EJECTION WAS AT 25%. THE DOCTOR PUT ME ON DIGOXIN AND THE EJECTION FRACTION WENT UP TO 40-45% AND NEVER HAD NOT ONE SIDE EFFECT. DIGOXIN IS MADE FROM A NATURAL PLANT AND IS TRIED AND TRUE AND AROUND FOR YEARS USED WITH GREAT SUCCESS AND TESTED DURING A TIME IF ASPIRINS WERE INVENTED DURING THAT TIME. THE FDA WOULD HAVE NEVER ALLOWED ASPIRINS ON THE MARKET. THAT IS HOW STRICT THE FDA WAS UNTIL THESE CRIMINAL IN BIG PHARMA HIJACKED THE FDA. AFTER MY HEART GOT STRONGER MY DOCTOR THEN TOOK ME OFF THE DIGOXIN AND WATER PILLS AND I WAS FINE. UNTIL I ONCE AGAIN 2 YEARS LATER I INHALED IRON FROM A GRINDER WITH A BAD DUST MASK WHICH INFLAMED MY AIRWAYS. MY HEART FUNCTION WAS ALSO ONCE AGAIN EFFECTED AND HE PUT ME ON ENTRESTO. I GOING TO SEE HIM AND GO BACK ON DIGOXIN. ENSTRESTO IS ALSO HARD ON THE KIDNEYS AND EVENTUALLY IT WILL BLOW OUT YOUR KIDNEYS AND YOU'LL BE GETTING DIALYSIS FOR THE REST OF YOUR LIFE. TO SUM THIS ALL UP. THE OLD MEDICINES WERE EXTREMELY SAFE AND THOUROGHLY TESTED FOR MANY YEARS AND WORKED VERY WELL. SO THE PHARMACUETICAL COMPANIES COULDN'T JUSTIFY CHARGING LOTS OF MONEY FOR DRUGS MADE FROM NATURAL SOURCES WHICH COST NOTHING TO MAKE. INSTEAD THEY HAVE THROWN ALL THE GOOD DRUGS AWAY AND CREATED CHEMICALS THE NOT ONLY DESTROY YOUR BODY BUT ALSO CAN KILL YOU.
@@embededfabrication4482 ALL THESE NEW MEDICINES ARE VERY DANGEROUS AND ESPECIALLY WHEN TAKEN OVER LONG PERIODS OF TIME, THEY CAN DO TREMENDOUS DAMAGE TO THE BODY. TECHNICALLY, THERE IS NOTHING WRONG WITH ME. SINCE IRON IS A CONDUCTOR AND THE HEART WORKS ON ELECTRICAL IMPULSES. THE IRON I INHALED EFFECTED THE HEART RYTHMS (AFIB) AND THE EJECTION FRACTION. GETTING SICK THIS SECOND TIME AROUND CONCLUDED WHY THE FIRST TIME MY HEART WAS EFFECTED. WHEN MY EJECTION FRACTION THE FIRST TIME WENT FROM 20% TO 40%. THE DOCTOR TOLD ME HE NEVER THOUGHT I WOULD RECOVER. DOCTORS TODAY ARE EXTREMELY LIMITED. MY DOCTOR THE FIRST TIME CONCLUDED MY HEART WAS DAMAGED. BUT THAT IS NOT THE CASE. I CONCLUDED WHY THE EJECTION FRACTION DOUBLE WAS DUE TO THE FACT THE IRON LEVELS THE FIRST TIME I GOT SICK OVER THE COURSE OF THOSE 8 MONTHS AFTER. THE INJECTION FRACTION IMPROVMENT WAS DUE TO THE FACT THE IRON LEVELS DROPPED. WHERE THE LOWER LEVELS OF IRON NO LONGER EFFECTING THE EJECTION FRACTION. REALIZING THIS NOW I AM ONLY DRINK DISTILLED WATER TO CLEAN THE BODY OF THE IRON. WEEK AFTER WEEK OF DRINKING THIS DISTILLED WATER THE STRONGER AND STRONGER I FEEL. I TOLD MY DOCTOR I'M GOING THE GET CHELATED THROUGH A IV AND HE IS CURIOUS TO SEE HOW I IMPROVE. BUT FOR NOW I WILL CONTINUE THE DISTILLED WATER AND POSSIBLY PUT A REVERSE OSMOSIS SYSTEM UNDER MY KITCHEN SINK TO START DRINKING THAT. 4 YEARS AGO I CURED A FELLOW OF HEMOCHROMETOSIS WITH R.O WATER.
@@embededfabrication4482 ENSTRESTO IS A DANGEROUS DRUG. MY DIGESTION SYSTEM IMPROVED BUT IS NOT 100%. OVER TIME I ASSUME IT WILL IMPROVE. I HAD COMPLICATIONS USING ENSTRESTO FOR 3-4 WEEKS. IMAGINE THE DAMAGE IT WILL DO USING IT FOR YEARS. IT IS A PERVERTED SYSTEM WITH NO CURES AND DRUGS THAT DESTROY YOUR BODY. BECAUSE THEY PUT YOU ON THEM FOR A ENTIRE LIFETIME. AND BRING ALL SORTS OF OTHER PROBLEMS THAT DESTROY THE QUALITY OF YOUR LIFE. THEY TELL YOU TO TAKE BLOOD THINNERS LIKE ZERELTO, ELIQUIS FOR AFIB AND THE END RESULT IS CRANIAL HEMMORAGING. MANY PEOPLE HAVE DIED FROM IT IN ORDER TO SELL YOU 60 PILLS FOR $500. A BUNCH OF CROOKS WHO KILL YOU IN THE END. A DOCTOR FRIEND OF MINE WHO'S FATHER WAS A DOCTOR WAS PRESCRIBED ZERELTO AND IS NOW IN THE GROUND PUSHING UP DAILIES. I TAKE DIGOXIN AND ENALIPRIL FOR NOW AND THE OTHER PRESCRIBED DRUGS GO IN THE GARBAGE. I SERVICE A DOZEN DIALYSIS CENTERS HERE IN NEW YORK AND SEE WHAT THESE DRUGS HAVE DONE TO PEOPLES KIDNEYS FOR 20 YEARS AND I AM WELL AWARE OF THE RISKS OF SPENDING THE REST OF MY LIFE 3 TIMES A WEEK FOR 4 HOURS IN A DIALYSIS CHAIR.
WOW! Better life thru chemistry!!!!!
thank you - i did the google and was considering switching
But i have an ejection fraction of 55.....why my dr give me this drug
Thanks for the info.
Robert Clark You haven't heard nothing yet >>>> th-cam.com/video/cV9DKccKVWs/w-d-xo.html
Read also about Spironolactone (K sparing diuretic) and the newer and safer K sparing diuretic Finerenone (kerendia) given to patients with HF
I was taking Carvedilol and Lisinopril. My new Cardiologist had me drop the Lisinopril and begin taking Entresto. Mixed results...but overall, I feel MUCH BETTER, with more energy and I feel just better with the Entresto. (Side effect bothering me is on and off back ache, that can be reduced somewhat with a little Tylenol). But this drug is really expensive...absurdly expensive.
LOL, it's just valsartan. The company (novartis) is under US Dept of Justice investigations over marketing and kickbacks, it's a scam.
Entresto makes me lethagic and sleepy
@@brendaandrandyking4126 I asked my Cardiologist to take me off of Entresto a month ago, and he switched me to Losartan (starting 25mg twice a day). The good so far...overall itching has mostly stopped. The bad so far...I do not have as much energy taking Losartan as I did when taking Entresto. **However, sometimes I think I felt better before Entresto when I was taking an ACE, Lisinopril.** (at any rate, Entresto is no miracle drug to my point of view...and it might not be any better or as good as Valsartan alone.)
Yep drs get big bucks for prescribing entresto
Same, lisinopril made me cough nonstop but I feel so much more energetic once it was dropped.
Thank you Dr.
Very good and necessary video. I guessed that the numbers were cooked a bit, however more concerning to me is the reduced kidney function than any of the issues you brought up. Other than that, real people are reporting reduced HF symptoms which is exciting to me if it at least does no more harm than a normal ACE inhibitor.
only one problem.....the effect people are observing comes from plain ol low cost generic valsartan, the clinical trials even show this.
it's crimiunal the way they've confused people about this,
Like most drugs It's junk, that's why all the side effects, just as you wouldn't put kerosene in the gas tank of your car, likewise the human body was designed to be strengthened by nutrition not drugs, the medicine to take is the great Canadian Strauss Heart Drops, fantastic record, court approved medicine!
take that malarkey to a "wellness" page, we're here to listen to a real doctor.
@@anidnmeno you are stupid.
can my tolerance for entresto lower over time? I was taking it for 6months, then after a mri my body started to reject entresto and i started to get tingly feet/hands, dizzy,and breathing slower
Were you coughing profusely?
@@mmafanatic-tz5or sometimes. i thought it was sinus
Doctor
I am currently involved in a study in Alberta, as a blind test subject because of unique condition and a brief discussion. To which I agreed willingly. Beyond that, I try to maintain ignorance but invariably, I will still represent the sector like myself who are doing their own self- education.
Because like you, Alberta is skeptical of most existing studies. Therefore their own study
They currently buy it from Novartis at a negotiated price roughly at 10% of the US price.
Please contact me discretely, but I won't risk ruining my own sample by providing you with more than my own observations.
Novartis is currently under US department of justice investigations over entresto marketing and kickbacks.
Thankyou for the information....my sister is going to be given this drug ....not happy ☹️
Your talk about Entresto is really alarming. I've watched a few other videos and they bring up most of your points, although you go into greater detail. I was just prescribed this drug for heart failure brought on by a prolonged case of breakthrough covid-delta pneumonia. I'm a 63 year old female. There is NO WAY I can afford this drug so they will have to give it to me or my doctor will have to figure something else out. The fact that the study was done by the drug-maker makes me very suspicious of the results. And anything that could potentially contribute to developing Alzheimer's is a HUGE red flag for me. I'm very conflicted now on what to do. A reply would be much appreciated. I see that this post was from 2018 and I'm wondering if there is more data out from the last few years or if everything has been shut down due to covid.
Were you coughing profusely?
demand your doctor just prescribe a generic ARB, there are 8 or 9 to choose from, valsartan is only one of them. The truth is the clinical trials have yet to prove that entresto is any better than it's generic ARB component valsartan.
Novartis is currently under US department of justice investigation over entresto.
Novartis is also under investigations for falsification of clinical trial data for another drug they were trying to develop.
BTW, You just got a subscriber..
o noooo!!!!😱😱😱
Can Entresto improve ejection fraction
In my case, No
Well that explains my increased brain fog .
Why he is using the trade name of Vallartan ? He is very much biased
To emphasize they did nothing more than evergreen diovan with this sack you bite trill nonsense
Why is it so expensive to eat healthy and it requires more exercise I work at my job 60 hours a week and I'm a HVAC technician I take Losartan for High Blood Pressure but I still believe my body isn't that well? Plus Losartan is one of the worst drugs in my opinion but my doctor says that is fine since I'm 32 and 6'3" and 250lbs and I work on the field and get my blood circulating. But SIDE EFFECTS are a pain.
At my walmart its 804.00 fpr a month
Doc do i still need to take losartan?
is it harmful for heart attack patient (entresto tablets)?
Not a fair contrast. The study was done by the makers of Entresto. Second they didn't finalize the study because they said the study had so far been great so no need t complete, Nonsense!
the truth about entresto
th-cam.com/video/9D5gcxpTObA/w-d-xo.html
There are NUMEROUS problems with ending a trial early. These have been articulated in a number of good articles in the medical literature over the years so I won’t go over again. Furthermore analysis of trials ending early have shown in more than 75% of these trials, the perceived benefit is nullified in longer term observational data.Amazing how gullible physicians have been. “Credit” to the pharmaceutical industry for hoodwinking medics, academics and regulators.
Entresto is nothing more that an attempt by Novartis to extend the patent life of Diovan (Valsartan). There is nothing to prove that Entresto is any better than the now generically available Valsartan
Extremely interesting perspective! :)
Well I'm using it now. So retract your speculation or you will eventually look like a fool.
Wait for evidence but by then it's already too late.
You can't undo the internet.
It doesn't matter how they got it. It's already saving lives. So many in fact that many other countries are making it at a fraction the price.
Educate yourself. You can fix ignorance, but not stupidity.
try to study the Paradym HF trial and see how significantly reduces sudden death, mortality and hospitalisation compared to ACE. Then make such a ignorant comment and appearing like a fool sorry for the language
L
@@egotrueenemy8991 LOL, entresto didn't do that, this is the ruse that is being perpetrated against consumers, it was the mere substitustion of an ARB for and ACEi that showed the benefit for certain patients, something known for a long long time and......there are many ARBs to choose from, not just valsartan, it isn't even at the top of the prescribed list.
A recent trial sponsored by the NIH has actually shown sacubitril to be harmful.
beware people, novartis marketing has polluted the internet with aggressive marketing and lies.
Harvard professor responsible for billions in lost Healthcare dollars.
saverr de Medicamento Entresto pero español
My girlfriend use now Entresto and before the drug perindopril She is currently in the 2nd group of heart failure.
20kilovolt Could it be possible that it's time to try something other than a drug, just asking? >>>> th-cam.com/video/cV9DKccKVWs/w-d-xo.html
@@bigbaggy The drug works well. And there have been no serious heart complaints.
Pregnancy in 70-80-90 years old. Haaa Haaaa, 99% of medicine are not recommended for pregnant women.
This doctor is from last century needs to get educated
They put me on entresto big dose 97 103 and i had echocardiogram of 59 ejection fraction ...i have angina