The science behind Ketamine as a possible cure for depression - Albert Dahan
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- เผยแพร่เมื่อ 29 มิ.ย. 2016
- Like many other drugs, ketamine has multiple effects rendering it suitable for various indications including anesthesia, sedation, acute and chronic pain relief, and treatment of therapy-resistant depression.
Ketamine is a complex drug with a high affinity for various receptor systems including the NMDA receptor, opioid receptor system, and cytokine receptors such as the Innate Repair Receptor system (IRR). The activation of multiple receptor systems is translated into a variety of wanted effects that are useful in clinical practice.
Clinical effects include anesthesia due to a dissociation between the thalamus and limbic system (ie. Ketamine is a dissociative anesthetic), relief of acute pain due to inhibition of excitatory NMDA receptors at spinal and supraspinal sites, relief of chronic pain due to activity at NMDA, opioid and cytokine receptors (e.g. the IRR), rapid antidepressant effects, due to the enhancement of synaptogenesis at prefrontal cortical areas.
Notorious are ketamine’s side effects including addiction, psychedelic or schizotypical effects (hallucinations, paranoia, anxiety/panic attacks), cardiovascular, liver, and urogenital toxicity.
In clinical practice the occurrence of psychedelic effects is worrisome and various approaches are being developed to counteract these effects. As a recreational drug or drug of abuse, ketamine is prone to addiction and development of damage to various organs (liver, the urogenital system). Research in volunteers and patients in the LUMC has led to a wealth of information on ketamine’s analgesic and antidepressant behavior which will be discussed.
Dr. Dahan is a Full Professor of Anesthesiology at Leiden University Medical Center. He graduated from the Free University (VU) in Amsterdam (MD) and Leiden University (Ph.D.). He is head of Research at the Department of Anesthesiology. He founded and heads the Anesthesia & Pain Research Unit in 1995, a non-profit academic institute that performs outcome research in anesthesia and pain management aimed at improvement of care in anesthesia and pain treatment and the wide distribution of gained knowledge, in close cooperation with non-academic partners. The research on opioids and ketamine are among the major research topics of the Anesthesia & Pain Research Unit. With respect to ketamine, these studies focus on wanted effects (eg depression and pain) and (psychedelic) side effects. Prof. Dahan has published over 300 papers in peer-review journals. ***********
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I just started ketamine therapy. I've only done my first dose. It's one dose a week for just over 4 months.
I felt... NORMAL... For a non-suicidal human being for a solid 3.5 days. Then it sorta wore off.
I'm really looking forward to my next 17 doses and my integration therapy.
There is hope, my friend ❤️
I like his sense of humor, very low-key!
The void , the endless void of peace and forgiveness
Very informative. Thank you Dr.
Thanks for a great introduction to the uses/effects of ketamine.
I'm confused by some of the comments about this researcher being uninclined to self-experiment with ketamine. Do people expect their oncologist/surgeon/obstetrician to have undergone an unnecessary treatment of radiation, chemo, a surgery or a C-section in order to be qualified to administer that treatment? No.
Someone also commented that "His fear of the psychedelic effects makes me roll my eyes." I think the Dr pretty clearly explained that he's seen enough bad trips to know that they are something to be afraid of - but is still championing the therapeutic uses of ketamine, as well as further research. He also said that if he had a medical need to use ketamine, he would take it.
I like that he has an understanding of the good and bad potential effects. That's what you want in someone who's running studies, or treating you. It doesn't sound to me like he would have anything much to learn from self-experimentation that 10 years of administering it first hand and listening to his subjects and patients hasn't provided.
What do you think about intranasal ketamine use?
_I think he's just trying to keep his reputation squeaky clean it -- he's a doctor. He has hundreds of colleagues around the world. At the same time though, he gave a nonverbal indication -- he rolled his eyes -- when he said he has never tried it. The audience laughed. To me, he seems like a walking ketamine molecule, free from anxiety and depression, free to be himself. He is an outstanding physician by the way_
Well said.
@@Ketannabis it’s not supposed to be anywhere near effective as IV from what I’ve heard. Maybe more of a maintenance booster but IV is supposed to be superior for effectiveness.
You give info that nobody else has
Ketamine changed my life and healed my CPTSD. ❤
This is very interesting. I hope to see this medication help a lot of people suffering from mental illness in the near future 😊
Is it a approved drug or a supplement
Me too, I wish everyone will go for this medical treatment instead of committing suicide. I got tired of people committing suicides.
🥺
I hope
This is an amazing presentation! Bravo!
Thank you, Professor Dahan, MD. for such an informative video presentation. Concerning, Depression and Chronic Pain, these conditions are difficult to treat in addition to being very serious issues and I'm confident you have a heightened concern over them as well as I. And as far as Ketamine's concerned, it's a very good anaesthetic that's been around for years but every aspect must be respected, as well as your knowledge of it and other substances you're familiar with. I truly appreciate your frankness and how thorough you covered this subject. I believe I could greatly benefit from this, but for one, my needs would have to be addressed by a Dr. that's as knowledgeable as you, some of my needs would be difficult to address in my country, and most importantly, one has to be careful because Ketamine could harm certain organs and equally important, I personally feel it should be carefully administered and monitored by a professional such as you. Best of luck to you Dr Dahan and much gratitude.
In Louisville Kentucky it is administered by anesthesiologist. www.serenityhealthky.com also there are therapist there for after treatment
Ketamine is controversial when it comes to psychedelics, but I think it has so much potential,
It’s not a psychedelic
@@lilgravyvert9991 but it produces a psychedelic experience in high doses
I had my 3rd ketamine treatment yesterday and feel so raw today the day after almost suicidal. It’s been waves of feeling better then almost great then horrible again. Basically I’m scared.
Very good talk really 👏
Does anyone have numbers for what is a small dose?
How frequently is too frequent (once a day, week, month)?
Many unanswered questions..Those of us that have suffered from Major Depressive Disorder for over thirty years understand this..I will consider this option..Pending the monetary costs and insurance coverage...
Most insurance plans in 2021 will cover it.
May your journey end in comfort
Donde me la administro ?
This guy looks almost exactly like a Dutch therapist that I used to have. Must be a common look amongst Dutch men or something.
😅
After my infusion, the doctor gave me some business cards to hand out. No referral needed.
A large part of my life was in a hospital emergency department. Ketamine is an extremely powerful drug and I've never seen a prescription written for it. I have had fentanyl once for a heart cath and have since refused to repeat that experience.
They don't give scripts. It's a 1 time in-patient IV. It lasts about 40 minutes.
@@tanyaandrews1714 that's not true. U can have multiple visits.
@@mimi2613 I think she means "one time per medical encounter". Although the big chain clinics try to force you to pay up front for multiple infusions, I found a less greedy one that let me have 2, back to back on Thursday and Friday, and then boosters every few months. That is what has worked well for me.
Walks into doctor's office
Me - "Hi,can I have a script of Ketamine for my depression?"
Doctor - "Sir,you're gonna have to leave."
🤷♂️
It depends on where you live and your background with depression. I'll just say that much. :X
@@DeathToUsernames0101 There’s a therapy center in IDAHO! Shocked.
Me, today, walked into a Doctor’s office… “Sit right down here, Sir, and we’ll start you on your .5mg/ kg. infusion, for 40 minutes.”
Good information! You got a new sub.
Where can I get intranasal K. I got it from a doctor who no longer practices.
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Contact us for more details.
I am afraid to take Ketamine (the speaker actually said he would not use it himself -I'm not sure if he meant he would never volunteer or would not try it if he needed it for a health condition) My Pain management doctor recommends ketamine infusion in low doses for neuropathic pain. It is given in a clinical setting. Did anyone use it for NP? How did it work?
Is it as "frightful" as Dr. Dahan says..?
Don't be afraid! It's not scary its just a full body experience. It's quite cleansing for the soul really. A beautiful thing
I've been micro dosing for a year now and felt great on it.What will happen if I suddenly so taking it?
What dosage? Intranasal or IV?
@@valuetainer3437 Intranasal
You will get some nightmares and then wish you had more ketamine and then you will be normal healthy functioning adult
@@TcCT238 Ket makes me feel alive
@@Sash_Window same sis I use to binge use k but I micro dose now
He's very cool. Would love to meet him
Thanks Professor/Dr... excellence. may I correct 1.5 millions suicidal attempts a year 45k commit suicide / USA
he said worldwide, numb-nut
Brad Rolph 🤣🤣🤣🤣🤣
incredible research, so happy to have discovered this
David McGrail
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There are little orbs everywhere! At first I thought it was just dust , but dust dosent fly up !even when he moves to the brick wall one is really bright!
Aliens on ketamine
I have psicodélico thinking since I was born I am an artist so that is not an issue for me ! Just make it available please because depression is really disabling
His fear of the psychedelic effects makes me roll my eyes. The fear is part of the beneficial effect. This guy builds tvs for a living but hates movies .
I personally did not enjoy the dissociative feeling from IV Ketamine Therapy. You build tolerance to it and luckily I don’t get it anymore. In honesty when you first start treatment, some experiences can be a bit scary.
It’s amazing that he says all these “facts” but I took 6, 90 minutes treatments and did not have any negative effects and my chronic life long (68 years) depression is gone and am off SSRs. I took pcp in college years 45 years ago and it did not affect me in any way like ketamine did this year. My arthritis in my hands is about 30% gone and I can work with my hands again. I find it interesting this guy won’t take it but of his negative beliefs about the drug. I wonder if he has ever experienced depression or ptsd? I’m not finished watching yet so I’ll get back to it. I’ve met a doctor that’s never had depression that prescribes ketamine for depressed patients with great results.
You're thinking about psychedelics trips. The anti-depressant benefit from Ketamine is chemical
_not only do I find your statements quite negative, but they're wrong._
_He is not actually in disagreement with what you say. It's just that Physicians have to word things differently. Especially a psychiatrist. Can say something to set a chain of associations off in your mind. To the average person, who only sees the outside of the statement, it seems to mean one thing. But these people are very intelligent and know what words are_
@@inhalefarts In all likelihood the antidepressant effect is both biochemical (NMDA receptor, stops glutamate excitotoxicity, etc.) and 'dissociative' - which is really a more apt description for the mental state of low dose K than 'psychedelic'. You don't see little monsters crawling all over the walls of the room you're in or whatever crazy shit people see on shrooms, DMT or LSD. You see warm glowing lights and tunnels or visions from your life. It's like a pleasantly amp-up regular dream.
It’s not called a k-hole because you feel perpetually stuck falling... tbats terrifying !!! It’s more like feeling temporarily stuck in a pothole. Key word : “temporarily*. ... you retain mind. You know it’s temporary and some might find it relaxing.
Hyperbolic Honeybee
A tunnel
The hype is that ketamine treats depression but the question that is not answered anywhere, will the affects permanent or the depression will relapse...?
How do the people who abuse the drug get it.
ikeike2 their local drug dealer?
Asking for a friend?
Look for an MDMA dealer and he might have or be able to find a Ketamine source. MDMA is much easier to find than Ketamine so that approach would be your best bet.
An easier and probably slightly saver method (purity) is to order it from a dark net market, where you can easily find it. Street Ketamine (but also dark net Ketamine) can be impure and / or a drug cocktail. It might also not even be Ketamine.
The hardest way is to get it by knowing or being an animal vet (most of them use it) or a doctor. But it's very hard to steal it when you work there. What I've also heard of is people stealing hospital trash bags and with some luck scoring slightly expired Ketamine and a whole bunch of other drugs.
I'm just informing you and other people, I'm not telling anyone to commit a crime, especially not people who might abuse it. Anyways, Ketamine might be legalized or get tried in pilot projects where certain people can apply (depending on country). If you have depression you might be lucky enough to have it administered to you soon! I advise you to search the web; maybe you can sign up for such pilot projects already. Best of luck and stay safe!
What are you a cop...?
@@Donovaan point me in the right direction to find ketamine on the dark web? Im desperate.
The world need more Sponge Clinicians
Just wondering out of those here that have posted and used it, what country are you from? I'm in US, and is so terribly frustrating trying to get pain relief. Chronic pain truly begins to mess with your mind in a serious way. When anger sets in because no one will help you, well that is a very dark and dangerous place to be when the doctor is so uncaring that he wont HEAR you. With a stroke of his pen he could give you your life back....and wont.
We live in America
Land of the free
Home of the...prescribing OPIATES for pain
Sad reality
Try kratom and cbd for relief. I have fibromyalgia and chronic leg/back pain, currently on plaquenil and it's working wonders for longer periods, no opioids for me
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Where can I get ketamine on the dark web? Im desperate.
Get to the local university or college. Just need to know some students.
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I would HIGHLY not recommend doing that. You would need to have it safely infused in a clinic where you can be monitored. If you use pills or powder (and buying it from some unknown source - you don't know if it's pure, etc.)...you are opening yourself up to the risk of dependence and addiction. By having it infused in a clinic by professionals, you are getting the benefits safely.
Ellen Conner
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He really needs to try it because its obvious he doesnt understand its effects at all.
I’m not sure I agree that he should be required to take K to study it, but especially if he doesn’t suffer from depression/anx. These disorders are caused by skewed chemicals in the brain so it stands to reason that K would have a different effect on those who lack what they need chemically and those who don’t. Just as non-diabetic endocrinologists aren’t required to take insulin to study and understand it’s clinical effects on diabetics.
I used to get ketamine in little wax squares that I used to call Starbursts.
Did it help severe depression? If so, can I find it anywhere?
it did. But I don't know how my friend got them from his Dr. Also this was in Denver Colorado, so I imagine they can formulate it however anywhere as long as you have a prescription.
Is addictive? I will never use it . I have severe depression, rumination , panic attack etc . I prefer taking and antidepressant , dopamine , and mood stabilizer.
it's administered in clinic at 1/10th dose of recreational, and administered weeks or months apart after initial, very low chance of addiction
It didn’t work and cost a lot of money and disappointed 😢
Cure? I dint thing you can use word cure
Why not?
I was just giving it at the hospital for a maigraine. And was unresponsive and stopped breathing.
Colleen Batten Sabala it depends on the quality to which you where given. It truly works..
Try getting it from here 98.8%purity.
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there are risks with any and all medications, if administered at a reputable clinic, it is 1/10th dose and very low risk which has helped many people from lifelong suicidal ideation and ptsd
The Summerland I was in a major hospital in the medical center where I live. I am sure it has helped others, in my case, ketamine and I are not friends.
@@colleenbattensabala1128 Maybe you are allergic to Ketamine
I made 2 g of ketamine last six years I wish I could find some more I had MXE also but I can’t get that anymore either I don’t understand why the federal government decides to ban restrict these therapeutic substances yet they will legalize something like marijuana. So like inhaling something that’s on fire is really great for you know
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@@davidmason6781 no man scam artist quit scamming people.
Øøølh what!!! All drugs out there is misused !!! Why he only says that about ketamine ! Not Dolcontin or orther morphin products
Am I the only one concerned that this man is developing and promoting a drug that he himself just said he would NEVER take because he has seen what it can do to people?
s Onti I think when he says that he is referring to recreational use
This is not a promotion, it is a presentation on medical studies and observations. Huge difference.
s Onti yes you're right this guy just said that kind of means so great but he wouldn't take it so what does that mean we should take it we should get high on it we should use it for depression let's just put it in the alcoholic beverage Department bozos thanks for your great thoughts on this people don't know what they're getting to it's all scam anyway just get your own ketamine and Infuse it or snort it when you want that's what they want even if it helps my depression and yours sure why not another opiate another Oxycontin another drug on the war of drugs that will never be over until we Punk the pharmaceutical Industries and punk the CIA
s Onti ya no shit, he says thinks that freak you out, then he talks about how great it is. I swear I can’t win
@@niksatt4843 All Of These Excuses After Our Rights Began being Taken Away After 911, (most haven't a clue). If it's Not Broken Why Fix-It ? Why is it that No one speaks of the.Fact That Politicians and Related Elites, (Families included) !! Have EXCLUDED All Things Nonstandardized... which is Our Hellthcare system !! The CDC Made A Back Door Deal Years Ago Which Makes It LEGALLY Impossible To Sue Them If Your Child And Self DIE Or Become Permanently Disabled Directly As A Result Of Their Vaccines. Why Don't Most People Know This ? The Government And All Obama Directed Taxpayer Dollars too Has Not Only Effected "Opioids",. (they are Bio/nano chips....experimental. "They" have Also transformed Medication for Sleep !! Anxiety, And ADHD. Not ONE are Authentic, Effective, and W/O Severe Side-effects. We Need Lawyers, Juried Toxicologists, And Judges Courageous Enough To Hold Them Accountable. While The Majority of the world is Asleep and Has The Audacity To Criticise. Must be Brainwashing
this guy is so fucking funny
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2:00 don't get high on your own supply.
Anyone else out there want to opine on how f****** crazy ketamine is or how you love it because you really don't want to fight the Press you want to get high she just tell your doctor you're depressed as hell nothing works but you don't have any blow left okay bye bye CIA Lyndon B Johnson and me God bless those who read this that's crazy people have to think they have to stick together and When The War on Drugs laugh out loud louder louder there you go now you don't even need the f****** ketamine just send me your cash just pennies though I'm a monk
The one thing I can say is if you're going to get your brain fried because you're bipolar with electroshock therapy I'd go for the ketamine
Or a four-way hit a window pane clear light laugh out loud louder okay I've got to go drink some pot inject some ketamine and snort 4-way window pane hey works
@@joeybenoit6269 dude you are so bad at getting your message across. Everything you typed is impossible to follow. You must have a low ass IQ.
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😂😆is not for anyone. For me I enjoy the dissoiativ feeling, the strange feeling and walk like a cat or dog with shoes on. Made me not depressed long after use
You say it's the best anaesthetic, great possibilities as an anti depressant etc, yet you said you've never taken it and never will. ?? Sounds a little conflicting to me. You sing it's praises yet you'll never do it??? Seems illogical
Don't you think trying it yourself would improve your research?
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Wow first grass now Ketamine.I also want to get depressed!
Wow how narcissistic is the speaker that can't let the other gentleman with an opposing idea actually finish his own sentence, maybe he needs to take some kind of medication so that he can stop being so egotistical.
This guy needs his own medicine. Epic nerd...but very interesting.