A Fireside Chat with Eric Topol
ฝัง
- เผยแพร่เมื่อ 1 มี.ค. 2023
- Eric Topol, a graduate of UCSF’s medicine residency, has published over 1,300 peer-reviewed articles, is a member of the National Academy of Medicine, and is one of the top 10 most-cited researchers in medicine with more than 300,000 citations. For decades an international leader in cardiology, precision medicine, and digital health, during Covid he emerged as one of the world’s most trusted sources of information on the scientific and policy aspects of the pandemic. In this week’s Medical Grand Rounds, Eric will be in conversation with Bob Wachter, discussing the latest updates in Covid, as well as some of the new developments in artificial intelligence and digital transformation of health care.
Speaker:
Eric Topol, MD, founder and director of the Scripps Research Translational Institute, is a world-renowned cardiologist and geneticist. His principal scientific focus has been on the use of genomic and digital data, along with artificial intelligence, to individualize medicine. He has written three bestseller books on the future of medicine: The Creative Destruction of Medicine, The Patient Will See You Now, and Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again. He is the principal investigator to two large NIH grants, the All of Us Research Program that supports precision medicine and a Clinical and Translational Science (CTSA) Award that promotes innovation in medicine. Eric was the founder of a new medical school at Cleveland Clinic (Lerner College of Medicine), was commissioned by the UK to lead a review of their National Health Service, and is active clinically as a cardiologist. Additionally, he is editor-in-chief of Medscape, publishes the Substack newsletter Ground Truths, and maintains a strong presence on social media on Twitter (@erictopol) with over 675,000 followers.
Note: Closed captions will be available within 48-72 hours after posting.
Program
Bob Wachter: Introduction
00:01:50-01:00:22 - Eric Topol, director and founder, Scripps Research Translational Institute
See previous Medical Grand Rounds:
• February 23: Protecting the Legitimacy of Medical Expertise: Combating Misinformation in Medicine
• Protecting the Legitim...
• February 16: Addressing the Crisis of Clinician Burnout - A Conversation with Tait Shanafelt
• Addressing the Crisis ...
• February 9: ChatGPT: Will It Transform the World of Health Care?
• ChatGPT: Will It Trans...
• February 2: Covid-19 in 2023: A Conversation with White House Covid Coordinator Ashish Jha
• Covid-19 in 2023: A Co...
See all UCSF Covid-19 grand rounds, which have been viewed over 3M times, at • UCSF Department of Med...
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Dr. Topol and Dr. Wachter: Big thank you to both of you for all you've done during the pandemic. I want you to know your service and dedication have been greatly appreciated. I'm sure there're many like me who've been silent. Please don't let the foreign bots, the domestic blowhards on the parallel universe that is social media get you down.
Thank you so much for the COVID Grand Rounds and Fireside Chats.
You both have been such a vital source of information throughout this pandemic, I can't express enough appreciation for everything you've done, especially for people like me who don't work in medicine but are desperate for reasonable, experienced perspectives. Thank you so much for everything you do! While you don't owe us your mental health by any means, please know there are far more of us who are so deeply thankful than there are trolls!
This was incredibly helpful to me as I find it harder and harder to find trustworthy information as to where we are in terms of variants, vaccines, and how to access risk. I have shut down my Twitter account but check every few days, looking specifically to see if the two of you (and a number of other medical experts) have posted anything new. This discussion has truly brought me up to speed. I thank you both for continuing to try to cut through the misinformation.
LOL
Nice discussion. I hope both of you will continue to share on twitter and youtube. It's been very helpful. And, BTW, my daily emails from twitter usually include posts from Eric Topol and sometimes from Bob Wachter.
Hope you don't give up, Dr. Topol! Love reading your Twitter.
I really appreciate what you do. I follow you on Twitter but now primarily read your substack because I don't want to give Musk the views. I refer to you so many times when trying to help my family and friends navigate the pandemic, especially now trying to understand the new studies coming out about Long Covid and how it impacts our behavioral choices moving forward. Just wanted to thank you!
Dr. Topol is a national treasure. Thanks for this informative, helpful interview. It’s very distressing that you wonderful people, who are saving lives and helping so many, are abused by so many, ignorant, misinformed people. PLEASE DO NOT LEAVE TWITTER. Thanks for substack.
Excellent!
Please keep these You Tube lectures and sessions going.
Excelent dialogue.
So good, Doctors! I truly hope you both never leave Twitter. It's my go to place to get info from you both. Also getting the substack. I know the anti-vaxxers are a pain, but that's what the block button is for! Thanks for everything. You both have been great for us regular folks during the pandemic.
Thank you Dr. Topol you succinct ongoing review of the literature on Covid and many other topics is so invaluable. Dr. Wachter, Grand Rounds have been a wonderful ongoing education and medical update. UCSF, Pharmacy, Class of '83
Thank you for keeping us informed so we can make good decisions. It is hard to find the information we need. We are grateful.
The mask issue is why doctors are not scientists or engineers and should not be in charge of public health.
As a safety engineer for asbestos removal crews in schools I had to send workers home constantly for facemask violations. I loved smoke testing hotshot guys "thinking" instead of following protocol. Masking is hard. Touching your mask or adjusting it is a fail. Facial hair is a fail. Looseness is a fail. These guys took a 3 day course on masking with hazmat and dangerous materials in mind and they still needed me to keep on them daily. I never saw one person during the whole pandemic that wore an adequate mask correctly. From an industrial viewpoint it was theater at best.
Is there a way to make Twitter posts not available for a comment? Or sub stack?
A lot of us would be happy if you could just post the information that we can read. I think it would be great if comments could be disabled.
Really useful perspectives on a very wide range of topics that are upfront and urgent right now. Eric, please do not ever stop your literature annotation and curation on Twitter - so useful, thank you so much
Thank you both, you have guided my decisions for over 2 years. You are appreciated and science rocks ❤
Early in this pandemic I remember Eric Topol saying we need to "get smarter faster", this is true and always will be.
Dr. Wachter and Dr. Topol~~ please know that you are both immensely appreciated. I hope and pray that these TH-cam Grand Rounds continue postpandemic and that we (even in South Korea!) can all strive to be better doctors for all our patients through sharing our knowledge and experiences, and by encouraging each other through these challenging times. Thank you very much.
So appreciate your substack Dr Topol and I’ve come to solely rely on your information for guidance. I hope you will continue to reach us through there! Thank you so much!
We’re with you Dr Topol and Dr Wachtner, we’re here!
The Cochrane report describes population effects of masking, not individual effects. How anyone fails to see the difference is hard to understand. Any direct medical provider knows that we care about our patient's individual risk more than population risk. We know that masking as a populace is impossible to control. Protecting the vulnerable individual means taking direct action, and unfortunately that means that these individuals need to mask, and the people that interact with them need to mask.
Population effects should allow you to make policy. I think the Cochrane report shows that masking policy was garbage. Fauci knew this and then went 180. Go ahead and wear a mask; as far as I know it's not illegal.
Thank you Eric and Bob for all that you do!! Please keep up disseminating the info!
Thank you for this talk! And to echo everyone else, please Dr Topol - don't quit! Just block a bunch of them or just ignore. These trolls are the worst. I don't understand any of it, nor do I understand what is the malfunction with Vinay Prasad. What is the matter with that insane little demon? What a horrible thing he is. Thank you for this and please do more!
Vinay Prasad is seeking redemption for promoting the vaccines in the first place and for taking the booster shot. At least he is trying to cleanse his soul before dying.
Did crioglobuline like antybody occur after SARS COV2 infection?
If crioglobuline occur,that can increase blood viscousity at low blood temperature.
To decrease blood viscousity may be cysteine compounds can work by decreasing S-S bindings?(with secondary effects of overdosage)
Dr Topol, please continue posting on twitter, ignore the rude - they are everywhere. Your work is educating several people.
Must we avoid blood spread of lyposomes with mARN ?
To avoid blood spread of lyposomes with mARN, may be ,,aspirate before inject technique,,can be learned and used and also injected muscle must not be used some hours?
18:50 >> How well does infection work to build immunity ?
20:00 Eric Topol >> "Prior COVID is worth at least one shot..."
Thank you for a very informative session. I especially welcome how open Dr Topol was to say what he thinks while remaining precise. Far too many people are afraid to say what they think and it leads to much less insight.
Wonderful discussion! Please don’t stop informing those of us who want to be informed, Dr. Topol. Your guidance and knowledge have been invaluable since the early days of the pandemic. If you stop , as some have said- they win.
Sometimes better can be the enemy of the good
Another wonderful discussion, thank you so much. I also want to join those who say to both of you, please don’t stop doing Twitter, for as long as you can stand it. You have both helped my household, and all our friends to whom I communicate what I learn from you ,enormously. Very, very grateful to you both.
He blocks people for no good reason.
@@MegF142857 Oh probably for darn good reasons.
@@Turtledove2009 He obviously has something to hide. Duh!!
Thank you so much for this fireside chat! Dr. Topol, what sources do you use to track COVID rates in your area? I'd like to use them too.
I just asked this question of Anne Sosin - a public health practitioner at Dartmouth College. I know many, many people who have had Covid and never reported it to the state, so that number does not exist. Where can we go to find out hospitalizations and death rates for our state (numbers that should tell us something)? I want to know these numbers to make informed decisions.
37:36 why not suggest working on whatever is the immune system problem? Could it be from taking another drug that is causing a poor immune system? That's a side effect of so many drugs.
No mention of that at all, how do you get away with giving medical advice without seeing the patient? I've seen many doctors prefacing their comments online about doing not doing that.
Not one mention here about nutrition.
Please Dr. Topol please continue on some platform!
Very good interview. Thank you
Thank you both for a very valuable discussion. Would be helpful to know if a transcript is available.
Anything to say on the efficacy of convalescent plasma IF ADMINISTERED EARLY, especially for people who can't take Paxlovid?
Have you seen the most recent TWIV which is about convalescent plasma? It's encouraging. th-cam.com/video/ZNoFmZxEogQ/w-d-xo.html&ab_channel=VincentRacaniello
You might find the information on the litcovid database run by NIH.
Listen to recent TWiV 987 with Arturo Casadevall
Priceless
Thanks to both these fine gentlemen for guiding me through this pandemic.
You're obviously not very smart to need a "guide" for this so-called pandemic.
Ignore anti-vaxxer Lp78Ch. He trolls numerous medical channels.
Thank you for your work. Please keep advocating for the long Covid patients. Yes, we’re desperate for treatments. I really don’t care if you ditch twitter, but please go somewhere accessible if you do. TH-cam maybe?
Eric, don't give up on Twitter. It has become more of a vigilante atmosphere but a lot of people count on it.
Keep up the good work, you both. I haven’t gotten Covid either and have been masking for the last three years. The information is not just useful. It also helps justify why I’m still masking and taking precautions when dealing with others who think Covid is over.
A sane and informative discussion. Excellent information. As with regard to vaccine and boosters, I too have had 5 shots. I am happy to have had them as an option; but I am suspicious of the long-term effects or unreported side effects. While there are many reasons I have various health issues, I do have some reason to wonder about the vaccine effect on kidney function and perhaps liver as well, and the nature of the vaccine on exasperating dormant or small issues. I have noted that drugs such as repatha have indeed impacted my LDL, but not without raising ALT, taking a Repatha hiatus the drop in the ALT to well into normal was revealing. Couple that with the no LDL is too low crap that cardiologists seem to love, like an 11 is fine, is quite frankly nuts. So, it is complex, and we have not had full honesty, nor has the government required enough questions to be answered relative to the vaccines, specifically, the mRNA ones. Further, the availability of data for older persons as to efficacy is kind of really really hard to find, IF it really exists at all. It is always suspiciously buried and hard to get. There is seemingly zero out there about people who actually get covid and vaccine outcomes as opposed to BS measures per 100K of population. Further treatment options other than Paxlovid are nearly non-existent. Why no better treatment options? Why no improved vaccines? Why no prescribed testing cadence for non-presidents? Guidance is all half-assed at best. Hell, I never heard of a testing cadence until the uber geriatric got elected.
I congratulate the two gentlemen in the video for having a real discussion and being honest. Great work, despite the hordes with pitchforks and torches, albeit there are indeed some Frankensteins out there, so there is that, these gentlemen should not be the mob target, not that there should be a mob at all.
Best wishes!
In the world of data driven, data trained systems, data cleanliness is critical. Many times the possible new science or intriguing findings (not replicable) is being driven by dirty data or mistakes in data process/processing.
THis is super helpful.
You're both extremely helpful, offering tremendous benefit. All the observations about Twitter and alternatives are completely accurate unfortunately. I hope you don't stop, but I get your substack letters, Dr. Topol, and have found little use for the Twitter workings since the new owner made changes to enhance his own warped perception of scientific information to favor politically motivated conspiracies instead. Thank you for the guidance. The comments on the Cochrane study on mask were very on target as it does defy common sense itself and will of course, do harm.
Could You please talk about Bird flu H5N1?
Thank you for your thoughts and ideas. I have no idea why Prasad attacks you constantly.
Per Dr. Topol's suggestion, I tried to get a second bivalent booster at CVS and then at Walgreens. I explained that it's been almost six months since my first one, I'm 75, and have numerous comorbidities. Neither would give me one because the CDC has not authorized a second bivalent booster for anyone. I think it's unfortunate that this video is raising people's hopes of getting a second bivalent booster when this is in fact not possible, as far as I can tell.
Why would you want to put more poison in your body??
Ignore Lp78Ch. This anti-vaxxer trolls numerous medical channels.
The fearmongering _NEVER, EVER_ ends.
Where is the firing squad???
FUD. Fear, uncertainty, & doubt. These 3 things are the currency of the disinformation peddlers.
So you've come here for your regular dose of fear. Tsk tsk.
@@Turtledove2009 just to be clear, I love these UCSF lectures and despise disinformation. I was just trying to help other people identify it more easily.
@@steveaustin5344 I was referring to your friend @Lp78Ch. That sociopath up there.
@@Turtledove2009 Okay, you want to call names?? I haven't even started on YOU yet. Just you wait. You don't know what you got yourself into.
The desire to oversimplify everything, keeps people ignorant of reality. The desire to oversimplify the process by the CDC is not required by the medical/health system in the USA.
Why did you not ask him about COVAXIN VACCINE and the USA study that ended 12/22/23? Reuters reports that it met all the major requirements in this USA Clinical Trial. When will this be available? Why is the FDA dragging their feet?
BTW, the adjuvent in this vaccine was developed by the USA’s NIH
Almost nothing about long covid. Millions of people are disabled. People should be informed about severe consequences of COVID infection. More research is urgently needed. We need cure for long covid. Please, work on mitochondria dysfunction.