Coagulation Cascade | Intrinsic and Extrinsic Pathway

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  • เผยแพร่เมื่อ 11 ธ.ค. 2024
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    • Coagulation Cascade | ...
    Coagulation, also known as clotting, is the process by which bl00d changes from a liquid to a gel, forming a bl00d clot. It potentially results in hemostasis, the cessation of bl00d loss from a damaged vessel, followed by repair. The mechanism of coagulation involves activation, adhesion and aggregation of platelets along with deposition and maturation of fibrin. Disorders of coagulation are disease states which can result in bleeding (hemorrhage or bruising) or obstructive clotting (thrombosis).
    Coagulation begins almost instantly after an injury to the bl00d vessel has damaged the endothelium lining the bl00d vessel. Exposure of bl00d to the subendothelial space initiates two processes: changes in platelets, and the exposure of subendothelial tissue factor to plasma Factor VII, which ultimately leads to fibrin formation. Platelets immediately form a plug at the site of injury; this is called primary hemostasis. Secondary hemostasis occurs simultaneously: Additional coagulation factors or clotting factors beyond Factor VII (listed below) respond in a complex cascade to form fibrin strands, which strengthen the platelet plug.
    Coagulation is highly conserved throughout biology; in all mammals, coagulation involves both a cellular (platelet) and a protein (coagulation factor) component.The system in humans has been the most extensively researched and is the best understood.
    The coagulation cascade of secondary hemostasis has two initial pathways which lead to fibrin formation. These are the contact activation pathway (also known as the intrinsic pathway), and the tissue factor pathway (also known as the extrinsic pathway), which both lead to the same fundamental reactions that produce fibrin. It was previously thought that the two pathways of coagulation cascade were of equal importance, but it is now known that the primary pathway for the initiation of bl00d coagulation is the tissue factor (extrinsic) pathway. The pathways are a series of reactions, in which a zymogen (inactive enzyme precursor) of a serine protease and its glycoprotein co-factor are activated to become active components that then catalyze the next reaction in the cascade, ultimately resulting in cross-linked fibrin. Coagulation factors are generally indicated by Roman numerals, with a lowercase a appended to indicate an active form.
    The coagulation factors are generally serine proteases (enzymes), which act by cleaving downstream proteins. The exceptions are tissue factor, FV, FVIII, FXIII. Tissue factor, FV and FVIII are glycoproteins, and Factor XIII is a transglutaminase.[7] The coagulation factors circulate as inactive zymogens. The coagulation cascade is therefore classically divided into three pathways. The tissue factor and contact activation pathways both activate the "final common pathway" of factor X, thrombin and fibrin.
    #coagulation #hussainbiology #apbiology

ความคิดเห็น • 138

  • @deborahorina9916
    @deborahorina9916 11 หลายเดือนก่อน +2

    Thank you for going straight to the point, i was beginning to get even more confused with some videos i watched earlier

  • @RUNporcupine
    @RUNporcupine 3 ปีที่แล้ว +15

    This is a fantastic overview of the intrinsic and extrinsic pathways, thank you!

    • @hussainbiology
      @hussainbiology  3 ปีที่แล้ว

      thanks for appreciation..Glad it helps ✌️

  • @shivamprajapati827
    @shivamprajapati827 3 ปีที่แล้ว +1

    Within very short time...u gives enough information required..so thnks

  • @cheesecakes6303
    @cheesecakes6303 4 ปีที่แล้ว +54

    Thanks for saving me I was planning to drop this question

    • @hussainbiology
      @hussainbiology  4 ปีที่แล้ว +7

      thanks for appreciation..Glad to know that it helps ✌️

    • @avanikilledar11
      @avanikilledar11 ปีที่แล้ว +2

      Omg same physio test is tomorrow🤯

    • @hussainbiology
      @hussainbiology  ปีที่แล้ว

      @@avanikilledar11 all the best

  • @raymondlonginos5099
    @raymondlonginos5099 3 ปีที่แล้ว +6

    I loved it, this is exactly wha it was looking for without the extra fluff - thank you my dude

  • @avanikilledar11
    @avanikilledar11 ปีที่แล้ว +3

    4 yrs after uploading this video is still doing wonders🎉

    • @hussainbiology
      @hussainbiology  ปีที่แล้ว +1

      that is ur kindness and love towards me....
      ❤️❤️

  • @legendhero1378
    @legendhero1378 11 หลายเดือนก่อน +1

    شكرا اخي تحياتي من مصر ❤ جزاك الله خير

  • @pariweshbashyal8267
    @pariweshbashyal8267 2 ปีที่แล้ว +1

    This is a fantastic overview of the intrinsic and extrinsic pathways, thank you bro
    i try it to understand from long time i did it now thanks

    • @hussainbiology
      @hussainbiology  2 ปีที่แล้ว

      thanks for appreciation..Glad it helps ✌️

  • @KVpatel00
    @KVpatel00 3 ปีที่แล้ว +1

    Owoo
    YOU JUST....🔥🔥
    Thank you for this explanation ✨

  • @s.m.elinadhal5548
    @s.m.elinadhal5548 3 ปีที่แล้ว

    Finally a simplified vedio..Thanks a lot

  • @nahidsiddiqui4517
    @nahidsiddiqui4517 2 ปีที่แล้ว +1

    Thanks sir after watching this video I feel it is very easy question ..

    • @hussainbiology
      @hussainbiology  2 ปีที่แล้ว

      thanks for appreciation.. Glad it helps ✌️

  • @kaisbhat5890
    @kaisbhat5890 4 ปีที่แล้ว +1

    Thnks for understanding us in simple way .....

  • @sanaansari8224
    @sanaansari8224 4 ปีที่แล้ว +3

    Thank you very much.. ..
    I really need it for my exams preparation..
    Good job...

    • @hussainbiology
      @hussainbiology  4 ปีที่แล้ว

      Thanks Sana for appreciation..Glad to know that it helps.
      All the best for exams

    • @sanaansari8224
      @sanaansari8224 4 ปีที่แล้ว +1

      @@hussainbiology Thank you very much sir...

    • @hussainbiology
      @hussainbiology  4 ปีที่แล้ว

      You are welcome

  • @genomanase6308
    @genomanase6308 2 ปีที่แล้ว +1

    genious Dr Hussain

  • @zarish2667
    @zarish2667 5 ปีที่แล้ว +4

    Simple and to the point👌👌 thanks..

  • @eddydwn4529
    @eddydwn4529 2 ปีที่แล้ว +1

    Awesome,,you have made it simple

    • @hussainbiology
      @hussainbiology  2 ปีที่แล้ว

      thanks for appreciation..Glad it helps ✌️

  • @box7507
    @box7507 2 ปีที่แล้ว +1

    man that saved a lot of time tysm

    • @hussainbiology
      @hussainbiology  2 ปีที่แล้ว

      thanks for appreciation..Glad it helps....✌️

  • @enkhbatdashnyam1866
    @enkhbatdashnyam1866 2 ปีที่แล้ว +3

    Simply the best explanation , thank you so much.

    • @hussainbiology
      @hussainbiology  2 ปีที่แล้ว

      thanks for appreciation..Glad it helps....✌️

  • @SYEDMUHAMMADALYANRASHID
    @SYEDMUHAMMADALYANRASHID ปีที่แล้ว

    thank you for such amazing explanation

  • @captainlux409
    @captainlux409 3 ปีที่แล้ว +2

    How to easily remeber in what order which clotting factor activates the next? Fantastic video, thank you!

  • @muhammadzaid1876
    @muhammadzaid1876 ปีที่แล้ว

    God bless you ❤

  • @sorooshkhedri1348
    @sorooshkhedri1348 5 ปีที่แล้ว +2

    Guys save time and watch this ! Thank you man

  • @zaithwazamawa7430
    @zaithwazamawa7430 2 ปีที่แล้ว +1

    Straight forward

  • @fatherofmyson7854
    @fatherofmyson7854 2 ปีที่แล้ว +1

    Thank you 💞

  • @vitthal3791
    @vitthal3791 ปีที่แล้ว

    Best explanation

  • @muhammaddawood3969
    @muhammaddawood3969 3 ปีที่แล้ว +1

    I love this 💖 bro.... ماشاءاللہ۔۔۔

  • @ahmedirfan751
    @ahmedirfan751 2 ปีที่แล้ว

    Literally fantastic 💥

  • @DrAnkur-ce1tb
    @DrAnkur-ce1tb 3 ปีที่แล้ว +1

    If it is not acting in sequence, why do we need to remember in sequence 1 to 13

  • @mahtabyaqoob8878
    @mahtabyaqoob8878 ปีที่แล้ว

    Means a lot thank you so much love you love you love you helping me a lot

  • @prajwalabijja9842
    @prajwalabijja9842 3 ปีที่แล้ว +2

    Amazing I understood at one's

  • @yogipatil-6533
    @yogipatil-6533 2 ปีที่แล้ว +1

    Saved my 5 marks bro thank you 😂

    • @hussainbiology
      @hussainbiology  2 ปีที่แล้ว

      thanks for appreciation...Glad it helps ✌️

  • @tasmiaamanayshe6643
    @tasmiaamanayshe6643 ปีที่แล้ว +1

    Sooo much helpful!! Thank u soo soo much

    • @hussainbiology
      @hussainbiology  ปีที่แล้ว

      thanks for appreciation..Glad it helps ❤️

  • @tariqhassan7306
    @tariqhassan7306 3 ปีที่แล้ว +1

    Too excellent.

  • @bhuviyadav8094
    @bhuviyadav8094 2 ปีที่แล้ว +1

    Thank you so much sir ☺️

    • @hussainbiology
      @hussainbiology  2 ปีที่แล้ว

      thanks for appreciation..Glad it helps ✌️

  • @awaishafeezkarni8174
    @awaishafeezkarni8174 4 ปีที่แล้ว +5

    I hate to slow down his speed upto 0.25x so that my brain can start his Cascade 😂

  • @shamis727
    @shamis727 5 ปีที่แล้ว +2

    Masha Allah dr Thanks keep giong.

  • @mithila3556
    @mithila3556 3 ปีที่แล้ว +2

    Super clear!
    Thanks😫

    • @hussainbiology
      @hussainbiology  3 ปีที่แล้ว +1

      Thanks for appreciation....✌️

    • @mithila3556
      @mithila3556 3 ปีที่แล้ว +1

      @@hussainbiology I have an exam tomorrow and really thought of skipping the topic.. but this vid helped me☺

    • @hussainbiology
      @hussainbiology  3 ปีที่แล้ว +1

      @@mithila3556 All the best Mithila.... do well

    • @mithila3556
      @mithila3556 3 ปีที่แล้ว

      @@hussainbiology 😊✌🏻

  • @sultannkz8846
    @sultannkz8846 2 ปีที่แล้ว +1

    simple and helpful thanks

  • @omaramgad7789
    @omaramgad7789 5 หลายเดือนก่อน +1

    Hello Sir,
    May I ask what kind of markers/pens are you using, if you dont mind? I like them.

    • @hussainbiology
      @hussainbiology  5 หลายเดือนก่อน

      hi Omar....Yes why not... ask anything....
      I am using simple markers....like Luxor... DOMS....Artline etc

  • @azmatbatool1437
    @azmatbatool1437 2 ปีที่แล้ว +1

    Amazing

  • @deusdedithmasota3349
    @deusdedithmasota3349 3 ปีที่แล้ว

    Man you made me understand thanks man

  • @thanimaikadhalan5241
    @thanimaikadhalan5241 5 ปีที่แล้ว +2

    clearly explained thankyou so much

  • @alihashim2284
    @alihashim2284 3 ปีที่แล้ว

    Thank you so much sir
    Nice explanation

  • @poojalakhmani123
    @poojalakhmani123 4 ปีที่แล้ว

    Thanks bro you save me in my exam....

    • @hussainbiology
      @hussainbiology  4 ปีที่แล้ว

      thanks for appreciation..Glad to know that it helps...

  • @medarmy.crazymedicos1080
    @medarmy.crazymedicos1080 2 ปีที่แล้ว +1

    Thanku sir 🙏

  • @bandanakc6919
    @bandanakc6919 3 ปีที่แล้ว +1

    Thank you soo much 🙏🙏🙏❤️

    • @hussainbiology
      @hussainbiology  3 ปีที่แล้ว

      Thanks for appreciation..Glad to know that it helps ✌️

  • @sifatchowdhury2981
    @sifatchowdhury2981 ปีที่แล้ว +1

    Super cool

  • @aizayy3658
    @aizayy3658 5 ปีที่แล้ว +1

    Wao
    Amazing 🙈🙈🙊

    • @hussainbiology
      @hussainbiology  5 ปีที่แล้ว

      thanks for appreciation...Glad to know that it helps.

  • @lyrablack8621
    @lyrablack8621 3 ปีที่แล้ว +1

    Thanks!

  • @pavanfuke2635
    @pavanfuke2635 ปีที่แล้ว +2

    This is amazing 😅 I was read it 10 time but I don't understand .

    • @hussainbiology
      @hussainbiology  ปีที่แล้ว

      thanks for appreciation..Glad it helps ✌️

  • @mahammishra2174
    @mahammishra2174 5 ปีที่แล้ว +1

    Awesome.. Time saving ❤

  • @impeccableperspicacity
    @impeccableperspicacity ปีที่แล้ว +1

    life saver

  • @machipeurangkau1528
    @machipeurangkau1528 2 ปีที่แล้ว +1

    Sir .... Is coagulation cascade and coagulation of blood same?

  • @rubenrai8354
    @rubenrai8354 3 ปีที่แล้ว +1

    Oo today was our zoology 3rd sem home examination and what else thank u

    • @hussainbiology
      @hussainbiology  3 ปีที่แล้ว

      Oh great.. ✌️✌️✌️ Most welcome

  • @sarahmosaad7284
    @sarahmosaad7284 ปีที่แล้ว

    Thank you so much 😭♥️

  • @mdnematullah6429
    @mdnematullah6429 2 ปีที่แล้ว

    Thanks

  • @muneeram869
    @muneeram869 3 ปีที่แล้ว +1

    Pls tell me which are intrinsic factor and which are extrinsic factor

    • @hussainbiology
      @hussainbiology  3 ปีที่แล้ว

      It is actually Intrinsic and Extrinsic Mediated pathway....
      Intrinsic includes factors like IX ,X ,XI ,XII........
      Extrinsic includes factor VIII

  • @chaitalinarwade732
    @chaitalinarwade732 ปีที่แล้ว

    Last moment saviour

  • @inessmasiye9877
    @inessmasiye9877 2 ปีที่แล้ว

    Sir were does the tenase complex come in

  • @narimansaad4038
    @narimansaad4038 5 ปีที่แล้ว +1

    Thankss for the video!!!

  • @WaqasKhan-nn5mj
    @WaqasKhan-nn5mj 3 ปีที่แล้ว +1

    Nice

  • @SabaAkhtar-x2o
    @SabaAkhtar-x2o หลายเดือนก่อน +1

    Ab aap ki video k elawa koi video achi hi ni lgti 😅
    Bohat informative so keep it up

    • @hussainbiology
      @hussainbiology  หลายเดือนก่อน

      @@SabaAkhtar-x2o shukriya.... Aise he support aur pyar...

  • @safiya7211
    @safiya7211 5 ปีที่แล้ว +1

    Good👍👍👍

    • @hussainbiology
      @hussainbiology  5 ปีที่แล้ว

      Thanks for appreciation...Keep sharing and supporting

  • @RNayazTalks
    @RNayazTalks 2 ปีที่แล้ว

    what is factor 12? you should have explained that for a beginner first. what are factors? where these come from?

  • @masumrabbani9996
    @masumrabbani9996 4 ปีที่แล้ว +1

    Great!

  • @mirkaiser4398
    @mirkaiser4398 5 ปีที่แล้ว +1

    Informative

    • @hussainbiology
      @hussainbiology  5 ปีที่แล้ว

      Thanks brother for appreciation...Keep sharing and supporting

  • @manilalpatel5017
    @manilalpatel5017 3 ปีที่แล้ว

    Great 😍

  • @lakshsharma4928
    @lakshsharma4928 2 ปีที่แล้ว +1

    👌 wow

  • @sarar5624
    @sarar5624 3 ปีที่แล้ว +1

    So thrombin activates factor V and factor Va helps in activation of more thrombin? So can we consider this a cycle?

    • @hussainbiology
      @hussainbiology  3 ปีที่แล้ว +1

      Yes.. a Positive Feedback cycle .. 👍

  • @praveenn.19
    @praveenn.19 3 ปีที่แล้ว

    Tysm sir♥️

  • @hsbmk
    @hsbmk 3 ปีที่แล้ว +1

    Sir where are you from

    • @hussainbiology
      @hussainbiology  3 ปีที่แล้ว

      Kashmir ✌️✌️

    • @hsbmk
      @hsbmk 3 ปีที่แล้ว +1

      @@hussainbiology 👏 👏 mai basyav godnethi

    • @hussainbiology
      @hussainbiology  3 ปีที่แล้ว

      @@hsbmk 😊 Jaan gov....

  • @shaikh-oz7rf
    @shaikh-oz7rf ปีที่แล้ว +1

    👍👍

  • @bhagyashreesajjan130
    @bhagyashreesajjan130 3 ปีที่แล้ว

    Tq so much sir

  • @zaithwazamawa7430
    @zaithwazamawa7430 2 ปีที่แล้ว +1

    A+

  • @jdsurgeon4820
    @jdsurgeon4820 3 ปีที่แล้ว

    I think factor X is common not factor 2

  • @biology_mcqs3037
    @biology_mcqs3037 5 ปีที่แล้ว +1

    👍

  • @laissezfaire9614
    @laissezfaire9614 4 ปีที่แล้ว +1

    Excuse me sir, i have a question in mind... Can you please explain how does factor VIII help in the activation of X when it is "to be" activated by thrombin which is "after" the activation of X???
    Thanks in advance.....

    • @hussainbiology
      @hussainbiology  4 ปีที่แล้ว +2

      Since both mechanisms occur simultaneously .....

  • @tanu6464
    @tanu6464 3 ปีที่แล้ว +1

    ☺☺☺☺

  • @adarshanaacharya3792
    @adarshanaacharya3792 2 ปีที่แล้ว +1

    Love u

  • @sushreejena5568
    @sushreejena5568 5 ปีที่แล้ว

    Noo

  • @animes465
    @animes465 ปีที่แล้ว

    Hindi me sir please

  • @salesitinomasilago1863
    @salesitinomasilago1863 4 ปีที่แล้ว

    Pathetic....please review and then explain properly

  • @mehmoodbhai2483
    @mehmoodbhai2483 ปีที่แล้ว +1

    This is a fantastic overview of the intrinsic and extrinsic pathways, thank you!

  • @azmatbatool1437
    @azmatbatool1437 2 ปีที่แล้ว +1

    Amazing

  • @mehmoodbhai2483
    @mehmoodbhai2483 ปีที่แล้ว +1

    This is a fantastic overview of the intrinsic and extrinsic pathways, thank you!