Coagulation Cascade | Intrinsic and Extrinsic Pathway

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• Coagulation Cascade | ...
Coagulation, also known as clotting, is the process by which bl00d changes from a liquid to a gel, forming a bl00d clot. It potentially results in hemostasis, the cessation of bl00d loss from a damaged vessel, followed by repair. The mechanism of coagulation involves activation, adhesion and aggregation of platelets along with deposition and maturation of fibrin. Disorders of coagulation are disease states which can result in bleeding (hemorrhage or bruising) or obstructive clotting (thrombosis).
Coagulation begins almost instantly after an injury to the bl00d vessel has damaged the endothelium lining the bl00d vessel. Exposure of bl00d to the subendothelial space initiates two processes: changes in platelets, and the exposure of subendothelial tissue factor to plasma Factor VII, which ultimately leads to fibrin formation. Platelets immediately form a plug at the site of injury; this is called primary hemostasis. Secondary hemostasis occurs simultaneously: Additional coagulation factors or clotting factors beyond Factor VII (listed below) respond in a complex cascade to form fibrin strands, which strengthen the platelet plug.
Coagulation is highly conserved throughout biology; in all mammals, coagulation involves both a cellular (platelet) and a protein (coagulation factor) component.The system in humans has been the most extensively researched and is the best understood.
The coagulation cascade of secondary hemostasis has two initial pathways which lead to fibrin formation. These are the contact activation pathway (also known as the intrinsic pathway), and the tissue factor pathway (also known as the extrinsic pathway), which both lead to the same fundamental reactions that produce fibrin. It was previously thought that the two pathways of coagulation cascade were of equal importance, but it is now known that the primary pathway for the initiation of bl00d coagulation is the tissue factor (extrinsic) pathway. The pathways are a series of reactions, in which a zymogen (inactive enzyme precursor) of a serine protease and its glycoprotein co-factor are activated to become active components that then catalyze the next reaction in the cascade, ultimately resulting in cross-linked fibrin. Coagulation factors are generally indicated by Roman numerals, with a lowercase a appended to indicate an active form.
The coagulation factors are generally serine proteases (enzymes), which act by cleaving downstream proteins. The exceptions are tissue factor, FV, FVIII, FXIII. Tissue factor, FV and FVIII are glycoproteins, and Factor XIII is a transglutaminase.[7] The coagulation factors circulate as inactive zymogens. The coagulation cascade is therefore classically divided into three pathways. The tissue factor and contact activation pathways both activate the "final common pathway" of factor X, thrombin and fibrin.
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[@cheesecakes6303]

Thanks for saving me I was planning to drop this question

[@hussainbiology]

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[@avanikilledar11]

Omg same physio test is tomorrow🤯

[@hussainbiology]

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[@RUNporcupine]

This is a fantastic overview of the intrinsic and extrinsic pathways, thank you!

[@hussainbiology]

thanks for appreciation..Glad it helps ✌️

[@deborahorina9916]

Thank you for going straight to the point, i was beginning to get even more confused with some videos i watched earlier

[@avanikilledar11]

4 yrs after uploading this video is still doing wonders🎉

[@hussainbiology]

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❤️❤️

[@raymondlonginos5099]

I loved it, this is exactly wha it was looking for without the extra fluff - thank you my dude

[@shivamprajapati827]

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[@legendhero1378]

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[@pariweshbashyal8267]

This is a fantastic overview of the intrinsic and extrinsic pathways, thank you bro
i try it to understand from long time i did it now thanks

[@hussainbiology]

thanks for appreciation..Glad it helps ✌️

[@kaisbhat5890]

Thnks for understanding us in simple way .....

[@hussainbiology]

Thanks for appreciation

[@Kavitapatel2002]

Owoo
YOU JUST....🔥🔥
Thank you for this explanation ✨

[@s.m.elinadhal5548]

Finally a simplified vedio..Thanks a lot

[@enkhbatdashnyam1866]

Simply the best explanation , thank you so much.

[@hussainbiology]

thanks for appreciation..Glad it helps....✌️

[@zarish2667]

Simple and to the point👌👌 thanks..

[@hussainbiology]

thanks for appreciation

[@sanaansari8224]

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I really need it for my exams preparation..
Good job...

[@hussainbiology]

Thanks Sana for appreciation..Glad to know that it helps.
All the best for exams

[@sanaansari8224]

@@hussainbiology Thank you very much sir...

[@hussainbiology]

You are welcome

[@genomanase6308]

genious Dr Hussain

[@nahidsiddiqui4517]

Thanks sir after watching this video I feel it is very easy question ..

[@hussainbiology]

thanks for appreciation.. Glad it helps ✌️

[@tasmiaamanayshe6643]

Sooo much helpful!! Thank u soo soo much

[@hussainbiology]

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[@eddydwn4529]

Awesome,,you have made it simple

[@hussainbiology]

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[@box7507]

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[@hussainbiology]

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[@vitthal3791]

Best explanation

[@azmatbatool1437]

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[@prajwalabijja9842]

Amazing I understood at one's

[@hussainbiology]

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[@SYEDMUHAMMADALYANRASHID]

thank you for such amazing explanation

[@muhammadzaid1876]

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[@captainlux409]

How to easily remeber in what order which clotting factor activates the next? Fantastic video, thank you!

[@fatherofmyson7854]

Thank you 💞

[@hussainbiology]

You’re welcome 😊

[@sifatchowdhury2981]

Super cool

[@sorooshkhedri1348]

Guys save time and watch this ! Thank you man

[@DrAnkur-ce1tb]

If it is not acting in sequence, why do we need to remember in sequence 1 to 13

[@thanimaikadhalan5241]

clearly explained thankyou so much

[@bhuviyadav8094]

Thank you so much sir ☺️

[@hussainbiology]

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[@zaithwazamawa7430]

Straight forward

[@hussainbiology]

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[@hussainbiology]

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Literally fantastic 💥

[@shamis727]

Masha Allah dr Thanks keep giong.

[@hussainbiology]

Thanks Shamis for appreciation

[@muhammaddawood3969]

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[@tariqhassan7306]

Too excellent.

[@hussainbiology]

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[@deusdedithmasota3349]

Man you made me understand thanks man

[@mithila3556]

Super clear!
Thanks😫

[@hussainbiology]

Thanks for appreciation....✌️

[@mithila3556]

@@hussainbiology I have an exam tomorrow and really thought of skipping the topic.. but this vid helped me☺

[@hussainbiology]

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[@mithila3556]

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[@impeccableperspicacity]

life saver

[@mahammishra2174]

Awesome.. Time saving ❤

[@alihashim2284]

Thank you so much sir
Nice explanation

[@pavanfuke2635]

This is amazing 😅 I was read it 10 time but I don't understand .

[@hussainbiology]

thanks for appreciation..Glad it helps ✌️

[@medarmy.Rajput1080]

Thanku sir 🙏

[@hussainbiology]

most welcome

[@mdnematullah6429]

Thanks

[@chaitalinarwade732]

Last moment saviour

[@narimansaad4038]

Thankss for the video!!!

[@awaishafeezkarni8174]

I hate to slow down his speed upto 0.25x so that my brain can start his Cascade 😂

[@hussainbiology]

✌️✌️

[@yogipatil-6533]

Saved my 5 marks bro thank you 😂

[@hussainbiology]

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[@hussainbiology]

Thanks for appreciation..Glad to know that it helps ✌️

[@poojalakhmani123]

Thanks bro you save me in my exam....

[@hussainbiology]

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[@lyrablack8621]

Thanks!

[@hussainbiology]

most welcome

[@WaqasKhan-nn5mj]

Nice

[@RNayazTalks]

what is factor 12? you should have explained that for a beginner first. what are factors? where these come from?

[@mirkaiser4398]

Informative

[@hussainbiology]

Thanks brother for appreciation...Keep sharing and supporting

[@sarahmosaad7284]

Thank you so much 😭♥️

[@hussainbiology]

You're so welcome!

[@omaramgad7789]

Hello Sir,
May I ask what kind of markers/pens are you using, if you dont mind? I like them.

[@hussainbiology]

hi Omar....Yes why not... ask anything....
I am using simple markers....like Luxor... DOMS....Artline etc

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[@hussainbiology]

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[@manilalpatel5017]

Great 😍

[@machipeurangkau1528]

Sir .... Is coagulation cascade and coagulation of blood same?

[@hussainbiology]

yes

[@rubenrai8354]

Oo today was our zoology 3rd sem home examination and what else thank u

[@hussainbiology]

Oh great.. ✌️✌️✌️ Most welcome

[@bhagyashreesajjan130]

Tq so much sir

[@masumrabbani9996]

Great!

[@hussainbiology]

thanks for appreciation

[@safiya7211]

Good👍👍👍

[@hussainbiology]

Thanks for appreciation...Keep sharing and supporting

[@muneeram869]

Pls tell me which are intrinsic factor and which are extrinsic factor

[@hussainbiology]

It is actually Intrinsic and Extrinsic Mediated pathway....
Intrinsic includes factors like IX ,X ,XI ,XII........
Extrinsic includes factor VIII

[@praveenn.19]

Tysm sir♥️

[@zaithwazamawa7430]

A+

[@jdsurgeon4820]

I think factor X is common not factor 2

[@inessmasiye9877]

Sir were does the tenase complex come in

[@adarshanaacharya3792]

Love u

[@hussainbiology]

❤️..Lots of love....

[@shaikh-oz7rf]

👍👍

[@sarar5624]

So thrombin activates factor V and factor Va helps in activation of more thrombin? So can we consider this a cycle?

[@hussainbiology]

Yes.. a Positive Feedback cycle .. 👍

[@hsbmk]

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[@hussainbiology]

Kashmir ✌️✌️

[@hsbmk]

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[@hussainbiology]

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[@laissezfaire9614]

Excuse me sir, i have a question in mind... Can you please explain how does factor VIII help in the activation of X when it is "to be" activated by thrombin which is "after" the activation of X???
Thanks in advance.....

[@hussainbiology]

Since both mechanisms occur simultaneously .....

[@biology_mcqs3037]

👍

[@hussainbiology]

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[@sushreejena5568]

Noo

[@tanu6464]

☺☺☺☺

[@animes465]

Hindi me sir please

[@salesitinomasilago1863]

Pathetic....please review and then explain properly

[@mehmoodbhai2483]

This is a fantastic overview of the intrinsic and extrinsic pathways, thank you!

[@hussainbiology]

Glad you enjoyed it!

[@azmatbatool1437]

Amazing

[@mehmoodbhai2483]

This is a fantastic overview of the intrinsic and extrinsic pathways, thank you!

[@hussainbiology]

Glad you enjoyed it!