I think chemistry and biology is the most facinating thing. It's literally like discovering cheat codes for Life. There is so many layers to the knowledge and outcome of different scientific discoveries. The natural world is facinating.
If it's not working, chuck a fluorine in there to tighten stuff up and pull evrything in tight. Never fails to amaze me the increase bioactivity that comes with a safely incorporated F.
Another Banger! You surprised me again, I expected learning a little about pharmacokinetics. But the nuanced context of some of the inner workings of the pharmacological industry and by extension public health was unexpected, but very interesting. Well almost as unexpected as boron.
Hello, I greatly benefit from your videos; first and foremost, thank you for creating such high-quality content. I have a question: could you make a video explaining how molecules that act as anti-addiction agents, work?
Thank you!! Well there are many different mechanisms depending on the compound. I touch on some of them partially in other videos like the one on ibogaine. But I will keep it in mind for a general video perhaps!
I work in MedChem. The Brainpower behind just one target is amazing but often after 10s of millions have been spend the target gets cancelled bcs. no molecule that is good enough has been found. And Drugs that are really profitable are also not as common in spite of the company spending billions of Dollars in to pharmaceutical research.
Nice. Absolutely! And on the topic of profitability, funnily enough, sometimes simple "non-innovative" small molecules can drive billions in profit whereas more expensive agents (e.g., gene or cell therapies), commonly creating uproar in broader society upon hearing price points, do not even reach $1bn sales given low addressable patient pool. It definitely is a very complex but transformational field.
Cool video and channel. Do you have any thoughts on pyrazole chemistry and applications in the pharmaceutical industry? I just found your channel and got to look over your other videos!
@@totalsynthesisI'm an undergrad doing a research project on pnictogen chemistry, and coincidentally I'm using some pyrazole derivatives to make my ligands. (I'm actually applying for pharmacy school and it seems pretty lucky of me to stumble onto your channel lol)
The human remains at that Triangle Park place were the participants that would’ve made the study size a round number. For legal reasons this is a joke.
i have a sneaky suspicion I'm not part of the target audience of tis video... i just graduated year 12 top of my biology and chemistry classes, but i am not ashamed to admit that i am only understanding maybe 20% of the content. i got accepted to a bachelors degree of medicinal chemistry, is it a problem that i dont understand this yet?
I think chemistry and biology is the most facinating thing. It's literally like discovering cheat codes for Life. There is so many layers to the knowledge and outcome of different scientific discoveries. The natural world is facinating.
Agreed!!
100%
Excellent video. I was part of the medicinal chemistry team that discovered Daclatasvir at BMS.
Thanks - and hats off! 👏
If it's not working, chuck a fluorine in there to tighten stuff up and pull evrything in tight. Never fails to amaze me the increase bioactivity that comes with a safely incorporated F.
*F*acts 😎
Another Banger! You surprised me again, I expected learning a little about pharmacokinetics. But the nuanced context of some of the inner workings of the pharmacological industry and by extension public health was unexpected, but very interesting.
Well almost as unexpected as boron.
Best man, keep up the good work
This guy is a legitimate genius. You're lucky to have access to his mind.
Amazing work as always!🔥🔥🔥🔥
Very timely, my med chem exam is in a couple days. Learning about the design process was great revision and application of the course material :)
Good luck! 💪
woah boron in a pharmaceutical, thats not something you see very often
commented before i saw that exact response highlighted in the video lmao
@@fsen1999 😂😂 got'em
I was listening to your narrations and fell asleep with apple pie in the oven...
It baked for 2h but did not burn!
😅 I should start an ASMR channel
@@totalsynthesis thats never a bad idea. I enjoy falling asleep while listening about science I have no clue of.
Another excellent video, offers some great insight into drug developement
do they hide it's effectiveness and mischaracterize its purpose and effects so they can maintain an EUA?
Just git my bachelor's in biochem plan to get my PhD in Organic Chem and focus on medicinal chem/Pharmacology
Nice, good luck!
Great review, I worked at NIBR on antibiotics and antivirals.
Awesome
Memes are the only correct way to learn chemistry
Cool video, it was realy interesting to see the road and thouht process behind the development of a drug.
Thanks! Will do more drugs in future
Excellent!
Hello, I greatly benefit from your videos; first and foremost, thank you for creating such high-quality content. I have a question: could you make a video explaining how molecules that act as anti-addiction agents, work?
Thank you!! Well there are many different mechanisms depending on the compound. I touch on some of them partially in other videos like the one on ibogaine. But I will keep it in mind for a general video perhaps!
what is the polar part of the inhibitor some stuff is not clear
Yess i understand this completely
😂
Hola
I enjoy my low iq since i can laugh at keys dangling in front of me, endless entertainment
Based
Great video and explanations. Gilead is pronounced with a G like Gate not with the J sound. Gill-EE-add
I had HCV and was treated/cured with Mavyret.
Thank you - and great to hear!
@@totalsynthesis Keep these awesome videos coming
Gilyad?
When we expect hepatitis b cure?!
The ending is so sad. With all the time spent on optimization, some stupid unexpected effect killed it all.
I found this so interesting but this shit flew so far over my head. I wish I could understand it.
I work in MedChem. The Brainpower behind just one target is amazing but often after 10s of millions have been spend the target gets cancelled bcs. no molecule that is good enough has been found. And Drugs that are really profitable are also not as common in spite of the company spending billions of Dollars in to pharmaceutical research.
Nice. Absolutely! And on the topic of profitability, funnily enough, sometimes simple "non-innovative" small molecules can drive billions in profit whereas more expensive agents (e.g., gene or cell therapies), commonly creating uproar in broader society upon hearing price points, do not even reach $1bn sales given low addressable patient pool. It definitely is a very complex but transformational field.
Cool video and channel. Do you have any thoughts on pyrazole chemistry and applications in the pharmaceutical industry? I just found your channel and got to look over your other videos!
Thanks for watching!! Any reason why you are specifically interested in pyrazoles?
@@totalsynthesisI'm an undergrad doing a research project on pnictogen chemistry, and coincidentally I'm using some pyrazole derivatives to make my ligands.
(I'm actually applying for pharmacy school and it seems pretty lucky of me to stumble onto your channel lol)
i love ur channel
Thanks so much! Another video coming soon :)
The human remains at that Triangle Park place were the participants that would’ve made the study size a round number. For legal reasons this is a joke.
Got anything on PROTAC or targeted protein degradation (TPD) molecules?
Really exciting field - will consider for future videos
@@totalsynthesis Awesome. Thanks.
Beautiful
awesome to hear
When we expect cure hepatitis b?
i have a sneaky suspicion I'm not part of the target audience of tis video... i just graduated year 12 top of my biology and chemistry classes, but i am not ashamed to admit that i am only understanding maybe 20% of the content. i got accepted to a bachelors degree of medicinal chemistry, is it a problem that i dont understand this yet?
No no, welcome aboard! Many viewers dont understand it all I am sure, much of my vids are based on undergrad/BS/MS level content!
IQ 50 reporting in
god bless everybody don't get cancer or hepatitis C god speed
Wow..I didn't get anything
I am too dumb to understand.