LONGEVITY DEBATE: Partial Reprogramming vs. Replacement - YURI DEIGIN & JEAN HEBERT @ Lab Week
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- เผยแพร่เมื่อ 15 ต.ค. 2024
- Longevity Debate: Partial Reprogramming vs. Replacement - which strategy is best to defeat aging? Featuring Yuri Deigin & Jean Hebert
This exciting yet cordial debate between two aging research experts was held on 15.07.2024 during Protocol Labs' Lab Week at Edge Esmeralda co-organized by the Foresight Institute. The debate was meant to explore the pros and cons of two leading strategies to combat aging: Partial Reprogramming and Replacement.
🥊 In the red corner, representing Partial Reprogramming, is Yuri Deigin, a longevity biotech entrepreneur and the co-founder and CEO of YouthBio Therapeutics, dedicated to developing partial reprogramming gene therapies for Alzheimer's and other age-related diseases. With a background in drug development, Yuri has been working on translating partial reprogramming since its emergence, having founded the first ever partial reprogramming biotech company in 2017.
🥊 In the blue corner, representing Replacement, is Dr. Jean Hebert, a Professor of Neuroscience and Genetics at the Albert Einstein College of Medicine where he focuses on age-related brain degeneration in the adult neocortex. As the founder of BE Therapeutics and author of "Replacing Aging," Jean is one of the world’s leading researchers on brain cell and tissue replacement.
❇️ What is Partial Reprogramming?
Partial reprogramming involves transiently expressing specific genes (Yamanaka factors) to rejuvenate cells without fully converting them to a pluripotent state, effectively reversing age-related damage while maintaining their original identity. This approach has shown promise in extending lifespan in multiple mouse models, and produced various therapeutic benefits in over a dozen disease models, including Alzheimer’s, age-related cognitive decline, cardiovascular disease etc.
❇️ What is Replacement?
The Replacement strategy involves developing and implanting new tissues and organs to replace those deteriorated by aging. The ultimate goal is to replace the entire body via a head/brain transplant followed by gradual brain replacement, aiming to sustain neurological functions and overall health far beyond current lifespans.
🙏 Special thanks to Mikhail Batin for organizing, Xenia Kupriyanova for moderating, Dmitry Zaika for filming, and to our volunteer judges: Benjamin Anderson, Ada Nguyen, Anastasia Ershova, and Jonathan Hales.
To longevity and beyond! 🚀
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Speaker links:
YURI DEIGIN
Twitter: / ydeigin
LinkedIn: / yurideigin
Company: youthbiotx.com/
JEAN HEBERT
Twitter: / replacing_aging
LinkedIn: / jean-hebert-272aa0299
Company: www.betherapeu...
Very important debate that should be discussed on a much larger scale! Bravo gents!
@@BrentNally thank you! Our field could definitely use more debates
Can't watch it - too much background noise!
If we manage to rejuvenate/replenish the stem cells then would it be possible to "fix" the ECM by chemically breaking down the tissue for the body to heal?
I thought Jean was resistant to hearing Yuri’s actual argument which was more complex but also more compelling. Yuri wins imho
Thanks for your kind words! Jean brought a lot of valuable insights to the debate, and I respect his work immensely. The goal of such discussions is to make all of us think more deeply and improve our approaches.
Again thanks for watching and sharing your thoughts!
I don't think partial reprogramming claims to repair all aging damage, such as telomere length, ECM cross links, mitochondria. Those are parallel research efforts addressing those. Stem cell partial reprogramming to build a replacement organ that is immune compatible is (was?) being researched at Turn Bio. Perhaps that could be a bridge between the two approaches.
Indeed, partial reprogramming primarily aims to rejuvenate cells by upregulating more youthful gene expression, which aims to prevent damage from accumulating in the first place. That said, given that tissue histology of mice treated by partial reprogramming looks better than those of control mice, partial reprogramming could also have beneficial effects on the ECM.
Papers released previously showed partial preprogramming improved all of the “hallmarks of ageing” other than telomere length.
Seems clear that there will be interactions between all of the hallmarks
I made this point recently too
@@YuriDeigin It makes sense that the ECM would be effected by reprogramming, if cells start spitting out the correct proteins that would at least slow damage on that front.
Hebert being VERY sensible and conservative...
how does partial reprogramming address the issue of calcium plaque in the arteries won’t the calcium plaque still be there and heart attack still occur as no drug can remove calcium plaque yet?
Not sure but it seems to...to some extent anyway
@@Theodorus5 it does indeed
that’s awesome
My original answer seems to have disappeared, not sure what's going on with TH-cam comments.
Basically, the main goal of partial reprogramming is to PREVENT damage from building up by upregulating more youthful gene expression in cells and the organs they comprise. So while partial reprogramming doesn't directly remove cholesterol or calcified plaques from arteries, it would likely slow down or prevent plaque buildup.
So it's not age reversal
Iv'e just started to watch......I hope the 'replacement' being discussed is FULL replacement i.e. everything excluding the connectome information bearing parts of brain ultrastructure p.s. audio is terrible!
Sorry, the audio gets better after the first few minutes once AC is turned off