Nardil (Phenelzine) is a tremendously effective medication, useful for all depressive and anxiety disorders. It is extremely safe, and I believe that, in most people, the side effects dissipate in time. However, it can take some time to start working (up to 6-8 weeks) and usually requires a dose of 60-90mg. I support your work, Dr. Gillman.
@@anlace3447 I do not require your CV, just a straightforward answer to a simple question: what is your knowledge and experience basis for the comments you make. I expect you will appreciate that readers cannot properly assess the value of comments if they do not have some idea of the credentials of the person making them
Parnate had saved me after years of taking medicines deemed "frontline medicines". MAOIs have been around for over half a century and have helped so many patients. I've been on 60mg/day for 13 years and it hasn't let me down. Great post doc!!! There should be more psychiatrists like yourself out there. Thank you
Thank you for the wealth of information on your website. Parnate has changed my life for the better after 30+ years of treatment resistant bipolar II. I am not affected by dietary restrictions, although I avoid fancy sausage and aged cheese. Breakfast sausage, pizza, etc. are not concerns for me personally. I just had two surgeries without anesthesia problems. I am taking adderall for ADD. I hope more experts in your field get on board with updating the research on MAOIs and saving the of people needlessly suffering from taking ineffective medications with nasty side effects.
I was on Nardil for 35 years with great success . Unfortunately Nardil was discontinued here in Canada Last year due to the pandemic . I was hospitalized to go off of the Nardil . .. . I was tried on two different SSRIs which were unsuccessful and caused a lot of distress. I have recently been put on an MAO inhibitor , with Little improvement in the past month
What is your opinion on moclobdemine , As this is the one the doctor has chosen to try me on now because it is an MAO I inhibitor. The other name for it is Manerix
Could you give a ballpark percentage figure on how much tranylcypromine raises Serotonin, Norepinephrine, and Dopamine levels above baseline? I've seen a variety of values given across the internet (obviously it's dosage dependent) and was wondering if you could provide some insight on that. Hoping to start a course of tranyl in the UK (NHS) within the next few months after being on around 6 or 7 other ADs with no success. Thanks for your brilliant website Dr. Gillman.
Did you have to battle to get Parnate on The NHS? I have tried mirtazapine, am now on moclobemide which worked far better than mirtazapine, but I feel the moclobemide is quite 'weak' maybe beacuse it is reversible. Are you getting parnate through a GP or psych?
@@theoneanton I will let you know on Tuesday when I talk to my GP, and as far as I'm aware GPs can't prescribe it and you'll have to be referred to a trained phych. I've already been referred to one which was when I was put on Venlafaxine as my most recent AD, but I'm coming off it as it's quite shit and the short half-life is troublesome.
@@robin1418 GP's should be able to prescribe it, although they may prefer you to see a psychiatrist (at least at first). I would personally steer clear of psychiatrists as much as possible. In my experience, GP's have been much more open to prescribing MAOI's, and ironically, they have given me better advice with re: antidepressants.
@@anlace3447 I had my session yesterday with my GP, and as expected was taken off Venlafaxine. I brought up the topic of MAOIs to him and he was fascinated that I inquired about them as he hasn't prescribed any for a long time and the psych service hasn't either. He was very interested in my comments and not dismissive at all, in fact quite the opposite. We had an interesting discussion about MAOIs for a good 5 mins where we talked about misconceptions and the current cost to the NHS, where there is some rather scummy price gouging going on. I live in a small town in the far north of England where services are far less stretched and my GP is the research lead of his practice so he's always willing to converse with you as a real person rather than just a dumb old patient who doesn't know what he'stalking about. I also told him about Dr Gillman and his website, and he said he'll definitely take a look. Nothing but positive experiences for me, my GP is stellar.
Dear Dr. Gillman, thanks a lot for your videos and homepage! I can relate very much to what you describe as "biological depression". However, I have a diagnosed dysthymia (broke out when I was 18, now I'm 28) with only very few and rather short lasting episodes of double depression. Nonetheless I'm absolutely not willing to accept my situation. Most antidepressants failed to lift my anhedonia and fatigue; bupropion helped for some time but not anymore. My question: Would you recommend Parnate for a dysthymic? Did you treat patients with this diagnosis? Greetings from Berlin, Germany
Would you recommend Parnate for a dysthymic -- yes. Especially since the concept of the same dysthymia is doubtful and often represents mild biological depression, for which TCP is appropriate.
Does anyone know if MAOI medications are available once again in Australia? Ive exausted all my options - so many SSRI's and SNRI's and Lamictal didnt help, the only thing that gives me a brief reprieve from depression is 10mg dexamphetamine a day and Seroquel 25mg at night. Im losing the fight after Zoloft failed to work for me after 8 years. Im understandably frightened but MAOI's seem to be last roll of the dice.
Absolutely. It's the physicians out there that have created the fears out there and the lack of experience to advise correctly. A brilliant psychiatrist knew my past and what types of medications I was on that had failed me. He prescribed Parnate and his words upon prescribing it to me where "don't worry, these will work".. To my amazement, on the 4th day, it was the first time in years that I felt a sense of euphoria as I felt peace and normality without debilitating anxiety. I've been on Parnate without issues for 13 years and was able to achieve the unavailable with the previous medications. Parnate is available in Australia, though finding the right psychiatrist to prescribe it is the most difficult part. I was lucky to have fallen in the right hands of a mature and extremely experienced psychiatrist. See someone who's been practising for 30 years and has seen it all!! Best of luck!! Parnate saved me.
Reasured to virtual zero side effects.. I am asking about its wdl on stopping and will there be poop-out ? Could you compare it with Paxil in your own view?
It is not feasible to give answers to individual questions like this, most of which are addressed on the website, or should 1stbe discussed with your treating doctor. It is generally best to read more on the website and then contact me through there if you feel further information is required. And if you’re going to do that consider a donation to help the cause.
Paxil= generally speaking, it's pretty ineffective-- like all of the SSRI cash cows. Paxil and all the other SSRI's don't even compare to the MAOI's. Poop out is rare (but not unheard of) with MAOI's- MAOIs (Nardil and Parnate) have worked decades (40+ years) in some patients with no significant decrease in therapeutic efficacy. Keep in mind, too, that MAOI's have been known to have euphoria as an initial s/effect. Perhaps some equate the waning of this side effect over time with poop out. Let me just leave with a qoute from a patient who compared SSRI's with MAOI's: --- ""The SSRIs that I tried seemed like toys in comparison (to MAOI Nardil). Maybe-sorta-kinda antidepressants. With an old MAOI like Nardil, lemmee tell you, there ain’t no half-steppin’ and no messin’ around. You won’t find yourself asking questions like “Gee... is it working yet?”. Nosirree. When Nardil kicks in - you know it. Nardil is p.o.t.e.n.t. """
@@bhaskartaneja6293 Selegeline is a MAOI. you can get the transdermal patch. However, I am fairly certain that you could get a script for either Nardil or Parnate in India and have the medication imported.
Any advice on taking Parnate with Stelazine? There used to be a compound antidepressant called Parstelin which was a life saver for me. Also, what is your advice on taking this combination permanently, and after age 60..especially for someone in good health generally? Thank you.
'advice on taking Parnate with Stelazine' -- yes, don't. Parnate (tranylcypromine) raises dopamine,, drugs like stelazine, an antipsychotic, block dopamine, so it just does not make sense.
Ken Gillman thank you. it’s very confusing as this combination has helped me through quite a few depressive episodes over many years. The combo of 1mg Stelazine to 10 mg Parnate (which was Parstelin) seems to help with anxiety and lift mood. I’m in the UK. It’s almost impossible to get advice from our health service or even privately on this. They simply prescribe it...and I’m the only person in our health centre on it...because it has enabled me to recover from quite debilitating episodes of depression and continue to work and live a fulfilled life. It was originally prescribed for me in Dublin as Parstelin back in the 80s..and had a hugely positive impact. SSRIs had an alarmingly negative affect on me when tried in the past.
I do not have time to answer questions from individuals about matters that are already dealt with in detail in the information on the website and in my Scientific papers - if after consulting the relevant material you have further questions or things you like explained, then contact me via the website.
Nardil (Phenelzine) is a tremendously effective medication, useful for all depressive and anxiety disorders. It is extremely safe, and I believe that, in most people, the side effects dissipate in time. However, it can take some time to start working (up to 6-8 weeks) and usually requires a dose of 60-90mg. I support your work, Dr. Gillman.
I have very severe anxiety an ocd would this be good for that?
@@Rebelz173 100% yes
I agree, but are you qualified to make such a statement?
@@psychotropicalresearch5653 yes Ken, I will send you my CV if you like lol
@@anlace3447 I do not require your CV, just a straightforward answer to a simple question: what is your knowledge and experience basis for the comments you make. I expect you will appreciate that readers cannot properly assess the value of comments if they do not have some idea of the credentials of the person making them
Thank you for your incredible service Dr Gillman! Please continue the fight to keep Nardil available in Australia.
Parnate had saved me after years of taking medicines deemed "frontline medicines".
MAOIs have been around for over half a century and have helped so many patients.
I've been on 60mg/day for 13 years and it hasn't let me down.
Great post doc!!!
There should be more psychiatrists like yourself out there. Thank you
They don't make them like you anymore! Thank you for this
Thank you for the wealth of information on your website. Parnate has changed my life for the better after 30+ years of treatment resistant bipolar II. I am not affected by dietary restrictions, although I avoid fancy sausage and aged cheese. Breakfast sausage, pizza, etc. are not concerns for me personally. I just had two surgeries without anesthesia problems. I am taking adderall for ADD. I hope more experts in your field get on board with updating the research on MAOIs and saving the of people needlessly suffering from taking ineffective medications with nasty side effects.
Adderall mixed with a MAOI? It seems to be a dangerous cocktail! Are you still OK?
More please. Thank you Dr. Gillman.
I was on Nardil for 35 years with great success .
Unfortunately Nardil was discontinued here in Canada Last year due to the pandemic .
I was hospitalized to go off of the Nardil . ..
.
I was tried on two different SSRIs which were unsuccessful and caused a lot of distress. I have recently been put on an MAO inhibitor , with Little improvement in the past month
What is your opinion on moclobdemine , As this is the one the doctor has chosen to try me on now because it is an MAO I inhibitor.
The other name for it is Manerix
thats very sad to hear
I'm praying for you, Jade.
U
@@jadelavender2348 How did you respond to Moclobemide?
Can't thank you enough for your advice and tips Ken over last few years. Michael from Scotland. :0)
thank you for posting this
Be aware of Nardil withdrawal symptoms. They are terrible to say the least.
Could you give a ballpark percentage figure on how much tranylcypromine raises Serotonin, Norepinephrine, and Dopamine levels above baseline? I've seen a variety of values given across the internet (obviously it's dosage dependent) and was wondering if you could provide some insight on that. Hoping to start a course of tranyl in the UK (NHS) within the next few months after being on around 6 or 7 other ADs with no success. Thanks for your brilliant website Dr. Gillman.
There is no accurate data in humans. But almost certainly more than anything else.
Did you have to battle to get Parnate on The NHS? I have tried mirtazapine, am now on moclobemide which worked far better than mirtazapine, but I feel the moclobemide is quite 'weak' maybe beacuse it is reversible. Are you getting parnate through a GP or psych?
@@theoneanton I will let you know on Tuesday when I talk to my GP, and as far as I'm aware GPs can't prescribe it and you'll have to be referred to a trained phych. I've already been referred to one which was when I was put on Venlafaxine as my most recent AD, but I'm coming off it as it's quite shit and the short half-life is troublesome.
@@robin1418 GP's should be able to prescribe it, although they may prefer you to see a psychiatrist (at least at first). I would personally steer clear of psychiatrists as much as possible. In my experience, GP's have been much more open to prescribing MAOI's, and ironically, they have given me better advice with re: antidepressants.
@@anlace3447 I had my session yesterday with my GP, and as expected was taken off Venlafaxine. I brought up the topic of MAOIs to him and he was fascinated that I inquired about them as he hasn't prescribed any for a long time and the psych service hasn't either. He was very interested in my comments and not dismissive at all, in fact quite the opposite. We had an interesting discussion about MAOIs for a good 5 mins where we talked about misconceptions and the current cost to the NHS, where there is some rather scummy price gouging going on. I live in a small town in the far north of England where services are far less stretched and my GP is the research lead of his practice so he's always willing to converse with you as a real person rather than just a dumb old patient who doesn't know what he'stalking about. I also told him about Dr Gillman and his website, and he said he'll definitely take a look. Nothing but positive experiences for me, my GP is stellar.
What is the maximum Parnate that the Dr has studied as being the safe maximum in extreme cases?
Can Trazadone be taken with MAOI’s?
Yes
Dear Dr. Gillman, thanks a lot for your videos and homepage! I can relate very much to what you describe as "biological depression". However, I have a diagnosed dysthymia (broke out when I was 18, now I'm 28) with only very few and rather short lasting episodes of double depression. Nonetheless I'm absolutely not willing to accept my situation. Most antidepressants failed to lift my anhedonia and fatigue; bupropion helped for some time but not anymore. My question: Would you recommend Parnate for a dysthymic? Did you treat patients with this diagnosis? Greetings from Berlin, Germany
Of course, I'm not asking for a recommendation for me personally, but rather in general for anhedonic chronic low grade depression.
Would you recommend Parnate for a dysthymic -- yes.
Especially since the concept of the same dysthymia is doubtful and often represents mild biological depression, for which TCP is appropriate.
Does anyone know if MAOI medications are available once again in Australia? Ive exausted all my options - so many SSRI's and SNRI's and Lamictal didnt help, the only thing that gives me a brief reprieve from depression is 10mg dexamphetamine a day and Seroquel 25mg at night. Im losing the fight after Zoloft failed to work for me after 8 years. Im understandably frightened but MAOI's seem to be last roll of the dice.
Yes they are, email me
Absolutely. It's the physicians out there that have created the fears out there and the lack of experience to advise correctly.
A brilliant psychiatrist knew my past and what types of medications I was on that had failed me.
He prescribed Parnate and his words upon prescribing it to me where "don't worry, these will work"..
To my amazement, on the 4th day, it was the first time in years that I felt a sense of euphoria as I felt peace and normality without debilitating anxiety.
I've been on Parnate without issues for 13 years and was able to achieve the unavailable with the previous medications.
Parnate is available in Australia, though finding the right psychiatrist to prescribe it is the most difficult part.
I was lucky to have fallen in the right hands of a mature and extremely experienced psychiatrist.
See someone who's been practising for 30 years and has seen it all!!
Best of luck!!
Parnate saved me.
What is your opinion on moclobdemine ( magnetic)
See website
shoot i might need to get omgad tattooed, perfect description
Reasured to virtual zero side effects.. I am asking about its wdl on stopping and will there be poop-out ?
Could you compare it with Paxil in your own view?
It is not feasible to give answers to individual questions like this, most of which are addressed on the website, or should 1stbe discussed with your treating doctor.
It is generally best to read more on the website and then contact me through there if you feel further information is required. And if you’re going to do that consider a donation to help the cause.
Paxil= generally speaking, it's pretty ineffective-- like all of the SSRI cash cows. Paxil and all the other SSRI's don't even compare to the MAOI's. Poop out is rare (but not unheard of) with MAOI's- MAOIs (Nardil and Parnate) have worked decades (40+ years) in some patients with no significant decrease in therapeutic efficacy. Keep in mind, too, that MAOI's have been known to have euphoria as an initial s/effect. Perhaps some equate the waning of this side effect over time with poop out. Let me just leave with a qoute from a patient who compared SSRI's with MAOI's: --- ""The SSRIs that I tried seemed like toys in comparison (to MAOI Nardil). Maybe-sorta-kinda antidepressants. With an old MAOI like Nardil, lemmee tell you, there ain’t no half-steppin’ and no messin’ around. You won’t find yourself asking questions like “Gee... is it working yet?”. Nosirree. When Nardil kicks in - you know it. Nardil is p.o.t.e.n.t. """
@@anlace3447 No MAOIs here in India. Only Moclobemide and selegiline
@@bhaskartaneja6293 Selegeline is a MAOI. you can get the transdermal patch. However, I am fairly certain that you could get a script for either Nardil or Parnate in India and have the medication imported.
@@anlace3447 Have you been on any MAOIs ? And other drugs prior to that ?
Any advice on taking Parnate with Stelazine? There used to be a compound antidepressant called Parstelin which was a life saver for me. Also, what is your advice on taking this combination permanently, and after age 60..especially for someone in good health generally? Thank you.
'advice on taking Parnate with Stelazine' -- yes, don't.
Parnate (tranylcypromine) raises dopamine,, drugs like stelazine, an antipsychotic, block dopamine, so it just does not make sense.
NB See 'Patient Stories, Bruno's Mum' on Web site
Ken Gillman thank you. it’s very confusing as this combination has helped me through quite a few depressive episodes over many years. The combo of 1mg Stelazine to 10 mg Parnate (which was Parstelin) seems to help with anxiety and lift mood. I’m in the UK. It’s almost impossible to get advice from our health service or even privately on this. They simply prescribe it...and I’m the only person in our health centre on it...because it has enabled me to recover from quite debilitating episodes of depression and continue to work and live a fulfilled life. It was originally prescribed for me in Dublin as Parstelin back in the 80s..and had a hugely positive impact. SSRIs had an alarmingly negative affect on me when tried in the past.
@@caroldoyle70 you may e-mail me through the website
I do not have time to answer questions from individuals about matters that are already dealt with in detail in the information on the website and in my Scientific papers - if after consulting the relevant material you have further questions or things you like explained, then contact me via the website.