Tom gave a fantastic presentation! I know Tom has been very passionate about the potential that young mitochondrial transplantation can have so it’s exciting to see this progress! Bravo!
Those of us who are suffering from Fluoroquinolone Adverse Effects, effects that have damaged our mitochondria - long term - are VERY interested in this research. I, for one, would be more than willing to be a test subject!! Any updates?? LOTS OF US WANT TO KNOW!
You grow fresh young mitochondria in a bioreactor tank then transfer them over to the patient. Mitochondria do not trigger an immune response and cells readily take them up when they find them in the bloodstream. In principle all you would have to do is inject a bunch of mitos into the bloodstream and the cells would absorb them.
Really exciting work, very encouraging. On various forums over the years I've posted the idea of creating synthetic mitochondria that could 'infect' patient cells & replace the native mitochondria - never got any replies.
the three Rs... reduce, reuse, recycle... aren't the platelet mitochondria being reused rather than recycled? In fact isn't that the point, the platelet is being recycled, but it's a waste to break up and remake the mitochondria so just reuse them? I'm sure he means reuse when he's talking, I just feel reuse is more precise...
Most proteins that appear in mitochondria are coded in the genomic DNA. Even if a fresh mitochondrion is introduced that houses a healthy complement of proteins, how long will that last in a less than healthy cell?
@@tombenson5957 What happens when you mix mitochondria from a different maternal lineage? Does that work or does that trigger an immune response? Should we be harvesting cells from young family members with common female lineage?
can argue that with extra mito, the animal is burning the candle at both end , and end up living half the life span. and likely the mice with extra mitochondrial live shorter life.
This suprisingly enough seems to be real! At least, the mechanism is as described, so it could work. Looking forward to some animal trials. Well worth watching this video and check out the research on the mechanisms.
Interesting. My first question. Where do the mitochondria come from? Are they grown in a lab or harvested? If harvested, where are they harvested from - blood/blood products, organs, bone marrow. Off the top of my head, my chief concern today is avoiding spike protein from Covid vaxxed people. If they can present 'clean' mitochondria and infuse these, this may be very promising. Lots of work to be done!
Crown loyalist Wall Street Episcopalians will not allow small people to have any such boost. Eugenics is the order of the day. People in Tuxedo Park New York and at Jupiter Island Florida can get it due to a very high price tag.
Honestly, I got a triple dose of stem cells 6 years ago, and I feel amazing. I'm almost 50, no wrinkles, the only sign of my age is a dad bod, and my beard is white. I shave that thing off, and I look anywhere between 30 and 45. Stem cells seem to be the key, at least if my experience is anything to go by.
Hi Daniel, stem cells are indeed a great therapy. Note that one of the things that stem cells do when you get them (according to the latest research) is - they donate mitochondria to your cells! So the stem cells in addiition to other things, are mitochondrial delivery vehicles! See 5:40 in the presentation.
@@tombenson5957 what's involved with the donation? Is it painful? I donate blood plasma to complete strangers, I don't laugh at the people who need plasma products.
After just a little thought on this process and how the human body has evolved to take care of itself, this all sounds too complex to understand by the people attempting this work. Maybe in a few decades or centuries this might come to pass? -- If you put a new engine in a very old car, what do you really have? lol
Wow never knew this was possible
Tom gave a fantastic presentation! I know Tom has been very passionate about the potential that young mitochondrial transplantation can have so it’s exciting to see this progress! Bravo!
Thanks Brent. Good to see your work in longevity as well!
@@tombenson5957 thanks
Hi Brent imagine seeing you here.
Those of us who are suffering from Fluoroquinolone Adverse Effects, effects that have damaged our mitochondria - long term - are VERY interested in this research. I, for one, would be more than willing to be a test subject!! Any updates?? LOTS OF US WANT TO KNOW!
Fluoroquinolone, a man-made drug that you chose to use ,... lol... Now you beg for help from another white-boy?
Very cool to hear updates on this.
Finally some practical progress
Hello, your followers from Iraq, what is your work?
Qual o seu trabalho?
Great job
Truly fascinating. Thank you.
Incredible, this therapy makes so much sense!
Only if you do not any cognitive abilities..
How to get new Mitochondrias?😁
You grow fresh young mitochondria in a bioreactor tank then transfer them over to the patient. Mitochondria do not trigger an immune response and cells readily take them up when they find them in the bloodstream. In principle all you would have to do is inject a bunch of mitos into the bloodstream and the cells would absorb them.
Pesquise sobre ubiquinol, pqq e principalmente sobre o ciclo circadiano satchin panda. No futuro teremos outras fontes.
Wondering if you can see a reversal of the Horvath clock (DNA Methylation)
wow just wow.
26 kb, pretty large, can they be utilized as a vector?
Hi Tom, would this work for fluroquinalone toxicity? Where the mitochondria have been damaged.
Really exciting work, very encouraging.
On various forums over the years I've posted the idea of creating synthetic mitochondria that could 'infect' patient cells & replace the native mitochondria - never got any replies.
Fantastic
how do you select healthy mitochondria before growing them in the bioreactor?
the three Rs... reduce, reuse, recycle... aren't the platelet mitochondria being reused rather than recycled? In fact isn't that the point, the platelet is being recycled, but it's a waste to break up and remake the mitochondria so just reuse them? I'm sure he means reuse when he's talking, I just feel reuse is more precise...
Most proteins that appear in mitochondria are coded in the genomic DNA. Even if a fresh mitochondrion is introduced that houses a healthy complement of proteins, how long will that last in a less than healthy cell?
Mitochondria is different in different organs.
The nucleus has better DNA repair
They should be trying this on pigs and dogs this year.
So where can I buy some lab-grown fresh young mitochondria?
We're working on it! :)
@@tombenson5957 What happens when you mix mitochondria from a different maternal lineage? Does that work or does that trigger an immune response? Should we be harvesting cells from young family members with common female lineage?
@@JacobAFarmer You are on the right track!
Great work Tom, any plans to test with Emulate "organ on chip" technology? thanks
We'll look at it!
Will this procedure change the DNA of your original mitochondria?
Nope, but replace a part of them
Why would the body not view these as a foreign entity and respond in that way?
Hi my son age 11 having mitochondria disorder is it cureable can you please advise will be thankful from india mumbai
We hope someday this is possible, but there is a lot of work still to do. Good luck to you and very best hopes for your son.
can argue that with extra mito, the animal is burning the candle at both end , and end up living half the life span. and likely the mice with extra mitochondrial live shorter life.
This suprisingly enough seems to be real!
At least, the mechanism is as described, so it could work.
Looking forward to some animal trials.
Well worth watching this video and check out the research on the mechanisms.
Looking forward to HUMAN trials. When is this stuff going to be available for humans?? I think I need a re-charge now...
Interesting. My first question. Where do the mitochondria come from? Are they grown in a lab or harvested? If harvested, where are they harvested from - blood/blood products, organs, bone marrow. Off the top of my head, my chief concern today is avoiding spike protein from Covid vaxxed people. If they can present 'clean' mitochondria and infuse these, this may be very promising. Lots of work to be done!
Crown loyalist Wall Street Episcopalians will not allow small people to have any such boost. Eugenics is the order of the day. People in Tuxedo Park New York and at Jupiter Island Florida can get it due to a very high price tag.
Honestly, I got a triple dose of stem cells 6 years ago, and I feel amazing. I'm almost 50, no wrinkles, the only sign of my age is a dad bod, and my beard is white. I shave that thing off, and I look anywhere between 30 and 45.
Stem cells seem to be the key, at least if my experience is anything to go by.
How did you get this? If you were in a RCT how do you know for sure which arm you were in?
Yes, do it. And they do good business with you.
Hi Daniel, stem cells are indeed a great therapy. Note that one of the things that stem cells do when you get them (according to the latest research) is - they donate mitochondria to your cells! So the stem cells in addiition to other things, are mitochondrial delivery vehicles! See 5:40 in the presentation.
What is unethical about teenagers donating mitochondria? I have some young cousins...
I asked my nephews. They laughed at me.
@@tombenson5957 what's involved with the donation? Is it painful? I donate blood plasma to complete strangers, I don't laugh at the people who need plasma products.
It seems obvious. Find some young kids with common maternal lineage. Offer them $100.
its not unethical. its unethical NOT to use our best technology and knowledge
After just a little thought on this process and how the human body has evolved to take care of itself, this all sounds too complex to understand by the people attempting this work. Maybe in a few decades or centuries this might come to pass?
--
If you put a new engine in a very old car, what do you really have? lol
I have an Idea... JUST EXERCISE AND EAT WHOLE FOODS!!!